Staghorn Calculi

Renal calculi with a characteristic shape like antlers of a deer, formed as it extends into multiple calices of the RENAL PELVIS. A large number of staghorn calculi as well as other URINARY CALCULI are composed of STRUVITE.

Synonym
Staghorn Calculi

Excerpt	Reference
"ECIRS is safe and effective in treating partial staghorn calculi either in the prone split-leg position or in the Galdakao-modified supine Valdivia position, with comparable outcomes and no statistically significant difference between both positions."	( Abdelaal, MA; Abdrabuh, AM; Abouelgreed, TA; Aboutaleb, H; Amin, MM; Elatreisy, A; Ghoneimy, OM; Shalkamy, O, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	10 (58.82)	28.8240
2020's	7 (41.18)	9.53

Drug	Relationship Strength	Studies	Trials
uric acid	low	4	0
xanthine	low	1	0
furosemide	medium	1	1
spironolactone	medium	1	1
tricalcium phosphate	low	1	0
calcium oxalate	low	2	0
amikacin	low	1	0
tamsulosin	medium	1	1
sodium bicarbonate	low	1	0
cystine	low	1	0
struvite	low	5	0
potassium-magnesium citrate	medium	1	1
warfarin	low	1	0

Protein Targets (155)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
estrogen nuclear receptor alpha	5	0	0	5
peripheral myelin protein 22	2	0	0	2
histone acetyltransferase KAT2A isoform 1	1	0	0	1
lamin isoform A-delta10	1	0	0	1
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	2
Bile salt export pump	0	3	0	3
Canalicular multispecific organic anion transporter 1	0	2	0	2
Aminoglycoside 3'-phosphotransferase	0	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
GLI family zinc finger 3	3	0	0	3
progesterone receptor	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
estrogen-related nuclear receptor alpha	3	0	0	3
Histone H2A.x	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Glutamate receptor 2	2	0	0	2
RAR-related orphan receptor gamma	3	0	0	3
AR protein	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
estrogen receptor 2 (ER beta)	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
EWS/FLI fusion protein	2	0	0	2
farnesoid X nuclear receptor	2	0	0	2
aryl hydrocarbon receptor	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
thyroid hormone receptor beta isoform 2	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
geminin	2	0	0	2
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	1	0	2
Bile salt export pump	0	1	0	1
Carbonic anhydrase 1	0	2	0	3
Carbonic anhydrase 2	0	2	0	3
Albumin	0	1	1	2
Carbonic anhydrase 3	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Cytochrome P450 2C9	0	2	0	2
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 6	0	1	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Carbonic anhydrase 7	0	1	0	2
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Spike glycoprotein	2	0	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Carbonic anhydrase 9	0	2	0	3
Multidrug and toxin extrusion protein 1	0	2	0	2
Carbonic anhydrase 13	0	1	0	2
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	1	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	0	3
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
glp-1 receptor, partial	1	0	0	1
pregnane X receptor	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
TDP1 protein	1	0	0	1
Smad3	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	1	0	0	1
glucocorticoid receptor [Homo sapiens]	2	0	0	2
retinoid X nuclear receptor alpha	1	0	0	1
pregnane X nuclear receptor	2	0	0	2
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	1	0	0	1
peroxisome proliferator activated receptor gamma	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
IDH1	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
activating transcription factor 6	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
thyroid hormone receptor beta isoform a	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Vpr	1	0	0	1
Estrogen receptor	0	2	1	3
Glucocorticoid receptor	0	2	1	3
Cellular tumor antigen p53	2	0	0	2
Progesterone receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
Mineralocorticoid receptor	0	2	0	3
Androgen receptor	0	2	1	3
Androgen receptor	0	2	0	3
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Sodium-dependent serotonin transporter	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Estrogen receptor beta	0	1	1	2
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	0	1	1
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Alpha-1D adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 7	0	1	0	1
Alpha-1A adrenergic receptor	0	2	2	4
Alpha-1B adrenergic receptor	0	2	2	4
D(3) dopamine receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	2	0	2
Chain A, Beta-lactamase	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
PPM1D protein	1	0	0	1
Interferon beta	1	0	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Ricin	0	1	0	1
Cholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Adenosine receptor A2a	0	0	1	1
Adenosine receptor A2b	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Xanthine dehydrogenase/oxidase	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Treatment

Research

Studies (17)

Protein Targets (155)

Staghorn Calculi

Synonyms(1)

Research Excerpts

Treatment

Research

Studies (17)

Drugs Studied (19)

Protein Targets (155)