Page last updated: 2024-09-28

Spondylolysis

Deficient development or degeneration of a portion of the VERTEBRA, usually in the pars interarticularis (the bone bridge between the superior and inferior facet joints of the LUMBAR VERTEBRAE) leading to SPONDYLOLISTHESIS.

Synonyms(1)

Synonym
Spondylolysis

Research Excerpts

Overview

ExcerptReference
"Spondylolysis is a differential diagnosis to be considered in a positive scan for evaluation of back pain."( Carty, H; Oakley, RH, 1984)
"Spondylolysis is the main cause of low back pain (LBP) in young athletes."( Chosa, E; Kubo, S; Morita, Y; Nozaki, S; Sugimura, H; Tajima, T; Yamaguchi, N; Yokoe, T, 2020)

Research

Studies (46)

TimeframeStudies, This Condition (%)All Conditions %
pre-199014 (30.43)23.3326
1990's10 (21.74)12.5806
2000's9 (19.57)18.1394
2010's10 (21.74)28.8240
2020's3 (6.52)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
bupivacaine0low10
gabapentin0low10
glyphosate0low10
lidocaine0low30
thalidomide0low10
methylene blue0low10
meglumine0low10
technetium0low20
titanium0low20
acetylglucosamine0low10
ozone0medium11
trolamine salicylate0low40
deoxypyridinoline0low10
n-acetylglucosaminylasparagine0low10
metrizamide0low10
radium0low10
technetium tc 99m diphosphonate0low10
vendex0low10
salicylates0low10
transforming growth factor beta0medium41
technetium tc 99m medronate0low110

Protein Targets (312)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Putative glycosyltransferase WbgO0001
Cytochrome P450 3A40101
Cannabinoid receptor 10101
Killer cell lectin-like receptor subfamily B member 1A0101
Early activation antigen CD690101
Chain A, farnesyl pyrophosphate synthase0101
Geranylgeranyl pyrophosphate synthase0101
Farnesyl pyrophosphate synthase0202
Acetylcholinesterase0101
Hypoxanthine-guanine phosphoribosyltransferase0101
Farnesyl pyrophosphate synthase 0101
Farnesyl pyrophosphate synthase 0101
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20112
Potassium channel subfamily K member 90101
Bile salt export pump0101
Bile salt export pump0505
Solute carrier family 15 member 10101
USP1 protein, partial1001
thioredoxin glutathione reductase2002
aldehyde dehydrogenase 1 family, member A13003
thyroid stimulating hormone receptor2002
regulator of G-protein signaling 42002
EWS/FLI fusion protein2002
glucocorticoid receptor [Homo sapiens]3003
euchromatic histone-lysine N-methyltransferase 25005
Bloom syndrome protein isoform 14004
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
survival motor neuron protein isoform d2002
muscarinic acetylcholine receptor M12002
lamin isoform A-delta103003
Voltage-dependent calcium channel subunit alpha-2/delta-10101
ATP-dependent phosphofructokinase2002
Chain A, Ferritin light chain2002
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
thioredoxin reductase2002
ATAD5 protein, partial2002
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B3003
arylsulfatase A2002
D(1A) dopamine receptor1001
thyroid hormone receptor beta isoform a3003
transcriptional regulator ERG isoform 31001
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
geminin4004
peripheral myelin protein 221001
histone acetyltransferase KAT2A isoform 11001
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit pi1203
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-11203
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit delta1203
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-21214
Gamma-aminobutyric acid receptor subunit alpha-51203
Gamma-aminobutyric acid receptor subunit alpha-31203
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Gamma-aminobutyric acid receptor subunit gamma-11203
Gamma-aminobutyric acid receptor subunit alpha-21203
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit alpha-41203
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit gamma-31203
Gamma-aminobutyric acid receptor subunit rho-20011
Gamma-aminobutyric acid receptor subunit alpha-61203
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit alpha-11214
Gamma-aminobutyric acid receptor subunit beta-31203
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit beta-21214
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 432002
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
GABA theta subunit1203
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit epsilon1203
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Glutamine synthetase 0101
Cytochrome P450 71B10102
Glutamine synthetase 0101
2-dehydro-3-deoxyphosphooctonate aldolase0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Beta-lactamase2002
RAR-related orphan receptor gamma4004
GLS protein1001
TDP1 protein3003
Microtubule-associated protein tau2002
AR protein3003
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
IDH13003
chromobox protein homolog 11001
mitogen-activated protein kinase 12002
flap endonuclease 12002
cytochrome P450 3A4 isoform 11001
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 4 subunit alpha0101
Potassium voltage-gated channel subfamily H member 20101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Canalicular multispecific organic anion transporter 10101
Multidrug and toxin extrusion protein 10101
Sodium channel protein type 3 subunit alpha0101
estrogen nuclear receptor alpha3003
activating transcription factor 62002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain E, Fibrin beta chain0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Luciferase2002
T cell receptor, partial1001
acetylcholinesterase1001
luteinizing hormone receptor1001
glp-1 receptor, partial1001
integrase, partial0101
chaperonin-containing TCP-1 beta subunit homolog1001
lens epithelium-derived growth factor p750101
phosphopantetheinyl transferase2002
hypoxia-inducible factor 1 alpha subunit1001
Caspase 6, apoptosis-related cysteine peptidase0001
SMAD family member 21001
Fumarate hydratase1001
PPM1D protein1001
SMAD family member 31001
GLI family zinc finger 32002
TSHR protein1001
Apoptotic peptidase activating factor 10101
Smad31001
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)1001
hypothetical protein, conserved1001
nuclear receptor subfamily 1, group I, member 31001
progesterone receptor1001
isocitrate dehydrogenase 1, partial1001
cytochrome P450 family 3 subfamily A polypeptide 42002
retinoic acid nuclear receptor alpha variant 11001
retinoid X nuclear receptor alpha3003
estrogen-related nuclear receptor alpha1001
farnesoid X nuclear receptor2002
pregnane X nuclear receptor1001
G1001
cytochrome P450 2D62002
polyprotein1001
luciferase1001
peroxisome proliferator-activated receptor delta1001
peroxisome proliferator activated receptor gamma1001
caspase-31001
aryl hydrocarbon receptor1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
thyroid stimulating hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Histone H2A.x1001
serine-protein kinase ATM isoform a1001
neutrophil cytosol factor 10101
nuclear factor erythroid 2-related factor 2 isoform 21001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
caspase-9 isoform alpha precursor0101
thyroid hormone receptor beta isoform 22002
histone deacetylase 9 isoform 31001
heat shock protein beta-11001
huntingtin isoform 21001
pyruvate kinase PKM isoform a1001
DNA polymerase beta1001
caspase-3 isoform a preproprotein0101
protein AF-9 isoform a0001
nuclear factor erythroid 2-related factor 2 isoform 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Vpr1001
muscleblind-like protein 1 isoform 11001
replicative DNA helicase0001
recombinase A0011
POsterior Segregation0011
DNA repair protein RAD52 homolog isoform a0001
Glutathione reductase0101
Voltage-dependent calcium channel gamma-2 subunit1001
Glutathione reductase, mitochondrial0102
Glycoprotein hormones alpha chain1001
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Albumin0001
Cellular tumor antigen p531001
Amyloid-beta precursor protein0101
Dihydrolipoyl dehydrogenase, mitochondrial0102
Microtubule-associated protein tau0112
Alpha-1B adrenergic receptor0202
Glutamate receptor 21001
Amine oxidase [flavin-containing] A0101
Alpha-1D adrenergic receptor0202
Sodium-dependent noradrenaline transporter 0011
Cruzipain0101
Alpha-synuclein1001
Alpha-1A adrenergic receptor0202
Spike glycoprotein2002
Guanine nucleotide-binding protein G1001
Inositol monophosphatase 11001
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
Inositol hexakisphosphate kinase 11001
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Zinc finger protein mex-50011
cytochrome P450 2C9, partial1001
phosphoglycerate kinase1001
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
Cereblon isoform 40202
Prostaglandin G/H synthase 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Prostaglandin G/H synthase 20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Albumin0011
Alpha-2A adrenergic receptor0101
60 kDa heat shock protein, mitochondrial0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Sodium-dependent serotonin transporter0101
10 kDa heat shock protein, mitochondrial0101
D-alanyl-D-alanine dipeptidase0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Transporter0101
vitamin D3 receptor isoform VDRA1001
DNA polymerase kappa isoform 11001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]