Sphingolipid Storage Diseases

A group of inherited metabolic disorders characterized by the intralysosomal accumulation of SPHINGOLIPIDS primarily in the CENTRAL NERVOUS SYSTEM and to a variable degree in the visceral organs. They are classified by the enzyme defect in the degradation pathway and the substrate accumulation (or storage). Clinical features vary in subtypes but neurodegeneration is a common sign.

Synonym
Sphingolipidosis
Sphingolipidoses
Sphingolipid Storage Diseases

Excerpt	Reference
"Sphingolipidoses are a group of metabolic diseases in which lysosomal hydrolases dysfunction disrupt normal sphingolipids' metabolism, leading to excess accumulation in cellular compartments and excretion in urine."	( Ait Sab, I; Assiri, I; Bennaoui, F; Bourous, M; Bourrahouat, A; Bouskraoui, M; Elamiri, M; Elqadiry, R; Essaadouni, L; Fdil, N; Hammoud, M; Houël, E; Imad, N; Jakani, M; Lafhal, K; Maoulainine, F; Mrhar, S; Najeh, S; Nassih, H; Outzourit, A; Rada, N; Rodrigues, AMS; Sabir, E; Slitine Elidrissi, N; Stien, D, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	53 (51.46)	23.3326
1990's	17 (16.50)	12.5806
2000's	23 (22.33)	18.1394
2010's	8 (7.77)	28.8240
2020's	2 (1.94)	9.53

Drug	Relationship Strength	Studies
cysteine sulfinic acid	low	1
ammonium hydroxide	low	1
benzene	low	1
glycine	low	5
phosphorylcholine	low	1
urea	low	1
1-anilino-8-naphthalenesulfonate	low	1
prednisolone	low	1
dehydroepiandrosterone	low	1
alanine	low	3
aspartic acid	low	1
lysine	low	1
uridine diphosphate	low	1
galactose	low	6
lactose	low	1
phenylalanine	low	1
methylamine	low	1
taurocholic acid	low	2
uridine diphosphate glucose	low	1
fucose	low	2
sabinene	low	1
mannose	low	1
galactosamine	low	3
galactose	low	4
4-chloro-7-nitrobenzofurazan	low	1
trolamine salicylate	low	1
1-deoxynojirimycin	low	1
propiconazole	low	1
fomesafen	low	1
miglustat	low	1
glucose, (beta-d)-isomer	low	1
cholesteryl sulfate	low	1
n-formylglycine	low	1
arimoclomol	low	1
n-acetylneuraminic acid	low	1
mannose-6-phosphate	low	1
glucosamine	low	2
inositol 1,4,5-trisphosphate	low	1
strychnine	low	1
c(alpha)-formylglycine	low	3
glycosides	low	1
D-fructopyranose	low	1
dermatan sulfate	low	1
cystine	low	1
sphingosine	low	10
bilirubin	low	1
psychosine	low	2
sphingosine 1-phosphate	low	2
cysteine	low	1
sphingosine phosphorylcholine	low	1
cdw17 antigen	low	4
i(3)so3-galactosylceramide	low	8
2-hydroxy-9-cis-octadecenoic acid	low	1
g(m2) ganglioside	low	5
g(m1) ganglioside	low	4
acid phosphatase	low	5
oligonucleotides	low	1
phosphatidylcholines	low	1
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene	low	5
glycolipids	low	26
galactocerebroside	low	1
heparitin sulfate	low	3
warfarin	low	1
globotriaosylceramide	low	2
g(m3) ganglioside	low	2
vitamin b 12	low	1
eye	low	1
concanavalin a	low	1

Protein Targets (457)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	2	0	0	2
thioredoxin reductase	3	0	0	3
USP1 protein, partial	5	0	0	5
TDP1 protein	5	0	0	5
vitamin D3 receptor isoform VDRA	4	0	0	4
importin subunit beta-1 isoform 1	2	0	0	2
flap endonuclease 1	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
snurportin-1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	4	0	0	4
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
geminin	4	0	0	4
DNA polymerase kappa isoform 1	4	0	0	4
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
glucocerebrosidase	2	0	0	2
Alpha-mannosidase	0	1	0	1
alpha-galactosidase	2	0	0	2
Trehalase	0	2	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Trehalase	0	1	0	1
Maltase-glucoamylase, intestinal	0	2	0	2
Trehalase	0	2	0	2
Lysosomal acid glucosylceramidase	0	4	0	4
Alpha-galactosidase A	0	1	0	1
Alpha-glucosidase MAL62	0	1	0	1
Lactase-phlorizin hydrolase	0	2	0	2
Lysosomal alpha-glucosidase	0	4	0	4
Beta-glucosidase A	0	1	0	1
Sucrase-isomaltase, intestinal	0	2	0	2
Alpha-1B adrenergic receptor	0	1	0	1
Sucrase-isomaltase, intestinal	0	2	0	2
Alpha-1D adrenergic receptor	0	1	0	1
Beta-glucosidase	0	1	0	1
Protein-lysine 6-oxidase	0	4	0	4
Alpha-mannosidase 2	0	2	0	2
Glycogen debranching enzyme	0	2	0	2
Glycogen debranching enzyme	0	1	0	1
Alpha-glucosidase MAL32	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Oligo-1,6-glucosidase IMA1	0	1	0	1
Alpha-glucosidase MAL12	0	2	0	2
Oxysterols receptor LXR-beta	0	1	0	1
Spike glycoprotein	3	0	0	3
Alpha-amylase	0	1	0	1
Trehalose synthase/amylase TreS	0	1	0	1
Lactase-phlorizin hydrolase	0	2	0	2
Oxysterols receptor LXR-alpha	0	1	0	1
Neutral alpha-glucosidase AB	0	2	0	2
Ceramide glucosyltransferase	0	2	0	2
Lysosomal acid glucosylceramidase	0	1	0	1
Probable maltase-glucoamylase 2	0	1	0	1
Beta-glucosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	2	0	2
Cytosolic beta-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	2	0	2
Putative alpha-glucosidase	0	2	0	2
NPYLR7B	0	0	1	1
Replicase polyprotein 1ab	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Carbonic anhydrase 1	0	0	0	4
Carbonic anhydrase 2	0	0	0	4
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	4	1	6
Proton-coupled amino acid transporter 1	0	4	0	5
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	1	0	0	1
RAR-related orphan receptor gamma	8	0	0	8
GLI family zinc finger 3	7	0	0	7
AR protein	6	0	0	6
thioredoxin glutathione reductase	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
glucocorticoid receptor [Homo sapiens]	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
estrogen-related nuclear receptor alpha	7	0	0	7
estrogen nuclear receptor alpha	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
IDH1	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
chromobox protein homolog 1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
thyroid hormone receptor beta isoform 2	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	3	0	0	3
lamin isoform A-delta10	5	0	0	5
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Ferritin light chain	3	0	0	3
phosphopantetheinyl transferase	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
arylsulfatase A	3	0	0	3
Bloom syndrome protein isoform 1	4	0	0	4
cytochrome P450 2C19 precursor	1	0	0	1
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	5
Glutamate receptor ionotropic, NMDA 2B	0	3	1	5
Glutamate receptor ionotropic, NMDA 2C	0	3	1	5
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	3	1	5
Glutamate receptor ionotropic, NMDA 3B	0	3	1	5
Glutamate receptor ionotropic, NMDA 3A	0	3	1	5
Chain A, Integrase	0	1	0	1
Chain A, Integrase	0	1	0	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, GCN4P1	0	0	1	1
Chain B, GCN4P1	0	0	1	1
Chain C, GCN4P1	0	0	1	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, Replicase polyprotein 1ab	0	1	0	1
Chain A, 3C-like proteinase	0	1	0	1
pregnane X receptor	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
progesterone receptor	6	0	0	6
retinoid X nuclear receptor alpha	5	0	0	5
peroxisome proliferator-activated receptor delta	4	0	0	4
cellular tumor antigen p53 isoform a	1	0	0	1
Endolysin	0	0	1	1
Cellular tumor antigen p53	4	0	0	4
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Chain A, Cruzipain	2	0	0	2
Microtubule-associated protein tau	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	4
Solute carrier organic anion transporter family member 1B1	0	2	0	4
Cholesterol 24-hydroxylase	0	0	1	1
Smad3	1	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
estrogen receptor 2 (ER beta)	2	0	0	2
farnesoid X nuclear receptor	2	0	0	2
pregnane X nuclear receptor	7	0	0	7
cytochrome P450 2D6	1	0	0	1
peroxisome proliferator activated receptor gamma	4	0	0	4
aryl hydrocarbon receptor	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
thyroid stimulating hormone receptor	1	0	0	1
heat shock protein beta-1	1	0	0	1
Sex hormone-binding globulin	0	0	1	1
Beta-glucuronidase	0	1	0	1
Corticosteroid-binding globulin	0	2	0	2
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Alpha-synuclein	1	0	0	1
TAR DNA-binding protein 43	2	0	0	2
G-protein coupled bile acid receptor 1	0	0	2	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Luciferase	3	0	0	3
Histone H2A.x	2	0	0	2
Fucose-binding lectin PA-IIL	0	2	0	2
CD209 antigen	0	3	0	3
P-selectin	0	1	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	1	0	0	1
GLS protein	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
ATP-dependent phosphofructokinase	2	0	0	2
Glycine receptor subunit alpha-1	0	2	1	3
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	4
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, BETA-SPECTRIN	0	0	1	1
Chain A, Phospholipase C Delta-1	0	0	1	1
Chain A, Inositol 1,4,5-trisphosphate receptor type 1	0	0	1	1
Inositol-trisphosphate 3-kinase A	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 1	0	0	2	2
Inositol 1,4,5-trisphosphate receptor type 2	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 3	0	1	1	2
Inositol polyphosphate-5-phosphatase A	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 1	0	1	1	2
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
Glutathione reductase, mitochondrial	0	2	0	2
Cationic amino acid transporter 3	0	1	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
Alpha-mannosidase 2C1	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Sucrase-isomaltase	0	1	0	1
Ceramide glucosyltransferase	0	1	0	1
Cytochrome P450 3A4	0	2	0	2
Beta-galactosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	1	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
thyroid hormone receptor beta isoform a	4	0	0	4
peripheral myelin protein 22	1	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Carbonic anhydrase 12	0	0	0	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase	0	0	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase 9	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
luciferase	0	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	3	0	3
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Bile salt export pump	0	3	0	4
Interferon beta	2	0	0	2
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	2	1	8
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	3	0	3
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Cytochrome P450 2C9	0	2	0	2
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Glutamate receptor 2	2	0	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	1	0	1
Estrogen receptor beta	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	2	0	2
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Chain A, Beta-lactamase	2	0	0	2
glp-1 receptor, partial	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
nonstructural protein 1	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Histamine H2 receptor	1	0	0	1
heat shock protein 90, putative	0	0	0	1
endonuclease IV	2	0	0	2
ATAD5 protein, partial	1	0	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
DNA polymerase beta	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
bcl-2-related protein A1	0	1	0	1
streptokinase A precursor	0	0	1	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor beta	0	0	1	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	1	0	1
Sphingosine 1-phosphate receptor 2	0	1	1	2
Sphingosine 1-phosphate receptor 4	0	1	1	2
Sphingosine 1-phosphate receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	1	2
Sphingosine 1-phosphate receptor 3	0	1	1	2
Sphingosine 1-phosphate receptor 5	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	0	1
Glycine receptor subunit beta	0	1	0	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 10	0	0	1	2
Sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Solute carrier family 22 member 6	0	1	0	1
Bile salt export pump	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
ATP-binding cassette sub-family C member 3	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Ileal sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Ileal sodium/bile acid cotransporter	0	1	0	2
Sodium/bile acid cotransporter	0	1	0	2
Ileal sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Bile salt export pump	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	0	1	0	1
Seminal ribonuclease	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	0	0	1
Ribonucleoside-diphosphate reductase subunit M2	0	0	0	1
P2Y purinoceptor 2	0	0	2	2
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 4	0	0	1	1
Ribonuclease pancreatic	0	1	0	1
UDP-galactopyranose mutase	0	0	1	1
P2Y purinoceptor 6	0	0	2	2
P2Y purinoceptor 14	0	0	2	2
UDP-galactopyranose mutase	0	0	1	1
P2Y purinoceptor 6	0	0	1	1
Ribonucleoside-diphosphate reductase subunit M2 B	0	0	0	1
D(1A) dopamine receptor	1	0	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
PPM1D protein	1	0	0	1
EWS/FLI fusion protein	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Sphingolipid Storage Diseases

Synonyms(3)

Research Excerpts

Overview

Research

Studies (103)

Protein Targets (457)

Sphingolipid Storage Diseases

Synonyms(3)

Research Excerpts

Overview

Research

Studies (103)

Drugs Studied (83)

Protein Targets (457)