Page last updated: 2024-09-27

Specific Learning Disorder

Diagnosed when there are specific deficits in an individual’s ability to perceive or process information efficiently and accurately. This disorder first manifests during the years of formal schooling and is characterized by persistent and impairing difficulties with learning foundational academic skills in reading, writing, and/or math. The individual’s performance of the affected academic skills is well below average for age, or acceptable performance levels are achieved only with extraordinary effort. Specific learning disorder may occur in individuals identified as intellectually gifted and manifest only when the learning demands or assessment procedures (e.g., timed tests) pose barriers that cannot be overcome by their innate intelligence and compensatory strategies. For all individuals, specific learning disorder can produce lifelong impairments in activities dependent on the skills, including occupational performance. (from DSM-V)

Synonyms(1)

Synonym
Specific Learning Disorder

Research

Studies (3)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's2 (66.67)28.8240
2020's1 (33.33)9.53
DrugIndicatedRelationship StrengthStudiesTrials
pilocarpine0low10
(+)-erythravine0low10

Protein Targets (44)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
thioredoxin reductase1001
GLS protein1001
regulator of G-protein signaling 41001
cytochrome P450 family 3 subfamily A polypeptide 41001
arylsulfatase A1001
euchromatic histone-lysine N-methyltransferase 21001
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
chromobox protein homolog 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
cytochrome P450 3A4 isoform 11001
lamin isoform A-delta101001
Gamma-aminobutyric acid receptor subunit pi1001
Muscarinic acetylcholine receptor M20112
Muscarinic acetylcholine receptor M10203
Muscarinic acetylcholine receptor M30203
Muscarinic acetylcholine receptor M40203
Muscarinic acetylcholine receptor M50203
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M20203
Muscarinic acetylcholine receptor M10123
Cytochrome P450 2A60112
Muscarinic acetylcholine receptor M10011
Gamma-aminobutyric acid receptor subunit beta-11001
Muscarinic acetylcholine receptor DM10101
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Histamine H2 receptor1001
Spike glycoprotein1001
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Cytochrome P450 2A130112
GABA theta subunit1001
Gamma-aminobutyric acid receptor subunit epsilon1001
ATP-dependent phosphofructokinase1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]