Page last updated: 2024-09-27

Sinus Pericranii

Rare vascular anomaly involving a communication between the intracranial and extracranial venous circulation via diploe, the central spongy layer of cranial bone. It is often characterized by dilated venous structures on the scalp due to abnormal drainage from the intracranial venous sinuses. Sinus pericranii can be congenital or traumatic in origin.

Synonyms(1)

Synonym
Sinus Pericranii

Research Excerpts

Overview

ExcerptReference
"Sinus pericranii is a rare vascular anomaly."( Bhayani, R; Desai, K; Goel, A; Muzumdar, D, 2001)
"Sinus pericranii is a rare finding that has not, to our knowledge, been previously associated with PHACE syndrome."( Benjamin, L; Drosou, A; Linfante, I; Mallin, K; Schachner, LA; Thaller, SR; Trowers, A; Wakhloo, AK, 2006)
"Sinus pericranii is a rare vascular anomaly in which an abnormal communication exists between the extracranial venous system and the dural venous sinuses."( Joseph, S; Lo, PA; Rozen, WM, 2008)
"Sinus pericranii is a rare midline cranial venous anomaly."( Bessaguet, S; Brix, M; Iodice, A; Lebeau, J; Loury, J, 2009)
"Sinus pericranii is a communication between extra- and intracranial venous systems."( Bessaguet, S; Brix, M; Iodice, A; Lebeau, J; Loury, J, 2009)
"Sinus pericranii is a rare venous anomaly, which shows abnormal communication between the intracranial and extracranial venous systems."( Cheon, JE; Kim, IO; Kim, WS; Kim, YJ; Lim, YJ; Yeon, KM, 2011)
"Sinus pericranii is a rare vascular abnormality characterised by abnormal connections between the intra- and extracranial venous systems and is usually found in children."( Akram, H; Haliasos, N; Low, H; O'Donovan, D; Prezerakos, G, 2012)
"'Sinus pericranii' is an abnormal communication between the extracranial veins and the dural venous sinuses (usually the superior sagittal and the transverse sinuses)."( Anooshiravani, M; Dhouib, A; Hanquinet, S; Kanavaki, A; Zand, T, 2012)
"Sinus pericranii is a rare asymptomatic communication between the intracranial and extracranial venous drainage pathways."( Grahovac, G; Lambasa, S; Prgomet, S; Rajappa, P; Vilendecic, M; Zic, R, 2013)
"Excision of the sinus pericranii is possible if the sinus pericranii is not a major venous outflow channel of the brain, which can be evaluated by angiography."( Grahovac, G; Lambasa, S; Prgomet, S; Rajappa, P; Vilendecic, M; Zic, R, 2013)
"Sinus pericranii is a rare congenital disorder of the skull."( Kruse, RR; Prins, W; van den Brink, WA, 2015)

Treatment

ExcerptReference
"The necessity of treatment of sinus pericranii, due to its risk of catastrophic hemorrhage or scalp necrosis, makes its diagnosis imperative."( Bekelis, K; Burdette, T; Durham, S; Erkmen, K; Eskey, C; Labropoulos, N; Stotland, M, 2011)

Research

Studies (26)

TimeframeStudies, This Condition (%)All Conditions %
pre-19903 (11.54)23.3326
1990's0 (0.00)12.5806
2000's9 (34.62)18.1394
2010's12 (46.15)28.8240
2020's2 (7.69)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low190
dimethyl sulfoxide0low10
prednisolone0low10
gadolinium0low20
propiconazole0low20
phenylephrine hydrochloride0low10
gadolinium dtpa0low20

Protein Targets (267)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase2002
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
thioredoxin reductase3003
GALC protein2002
GLI family zinc finger 35005
nuclear receptor subfamily 1, group I, member 32002
cytochrome P450 family 3 subfamily A polypeptide 42002
glucocorticoid receptor [Homo sapiens]4004
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha4004
estrogen-related nuclear receptor alpha4004
Carbonic anhydrase 0101
Carbonic anhydrase 0101
arylsulfatase A1001
Carbonic anhydrase0101
euchromatic histone-lysine N-methyltransferase 22002
Bloom syndrome protein isoform 12002
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 14004
geminin3003
peripheral myelin protein 222002
survival motor neuron protein isoform d2002
muscleblind-like protein 1 isoform 11001
Gamma-aminobutyric acid receptor subunit pi0101
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Carbonic anhydrase0101
Solute carrier family 22 member 60202
Carbonic anhydrase 120316
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Bile salt export pump0303
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 10419
Carbonic anhydrase 20418
Carbonic anhydrase 20202
Cytochrome P450 1A20101
Carbonic anhydrase 30316
Cathepsin B0101
Cytochrome P450 3A40202
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2C80101
Cytochrome P450 2D60101
Cytochrome P450 2A60101
Cytochrome P450 2C9 0202
5-hydroxytryptamine receptor 2A0101
Androgen receptor0202
Gamma-aminobutyric acid receptor subunit beta-10101
Translocator protein0101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Cannabinoid receptor 10101
Arachidonate 5-lipoxygenase-activating protein0101
Cytochrome P450 2B60101
Carbonic anhydrase 40315
Carbonic anhydrase 60315
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit alpha-20101
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10101
Serum paraoxonase/arylesterase 10101
Dipeptidyl peptidase 40001
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit gamma-30101
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Adenosine receptor A2a0101
5-hydroxytryptamine receptor 2B0101
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0101
Cytochrome P450 2C190101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Carbonic anhydrase 5A, mitochondrial0316
Carbonic anhydrase0101
Kappa-type opioid receptor0101
Carbonic anhydrase 70315
Carbonic anhydrase0101
D(1A) dopamine receptor0101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0101
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit beta-20101
Cholinesterase0101
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B0101
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70101
Carbonic anhydrase 90316
Carbonic anhydrase0202
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase 30101
Carbonic anhydrase0102
Carbonic anhydrase0102
Carbonic anhydrase 0101
Sigma intracellular receptor 20101
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10101
Renin0101
Carbonic anhydrase 0101
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130214
GABA theta subunit0101
Canalicular multispecific organic anion transporter 10202
Carbonic anhydrase 40202
Carbonic anhydrase 150203
Acidic mammalian chitinase0101
Carbonic anhydrase 130304
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon0101
Carbonic anhydrase 0101
Carbonic anhydrase 140316
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial0316
Cereblon isoform 40202
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
Insulin-like growth factor-binding protein 50011
Choline O-acetyltransferase 0101
Protein cereblon0202
Chain A, 2-oxoglutarate Oxygenase2002
glp-1 receptor, partial2002
RAR-related orphan receptor gamma3003
TDP1 protein3003
AR protein3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
estrogen nuclear receptor alpha4004
peroxisome proliferator activated receptor gamma2002
IDH11001
thyroid stimulating hormone receptor1001
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
chromobox protein homolog 12002
Vpr1001
lamin isoform A-delta101001
5-hydroxytryptamine receptor 2A0011
Cellular tumor antigen p533003
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Spike glycoprotein1001
luciferase0001
hypoxia-inducible factor 1 alpha subunit1001
progesterone receptor2002
pregnane X nuclear receptor2002
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)1001
nuclear receptor subfamily 1, group I, member 21001
nuclear factor erythroid 2-related factor 2 isoform 21001
Voltage-dependent calcium channel gamma-2 subunit2002
Interferon beta1001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Glutamate receptor 22002
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Prostaglandin G/H synthase 20202
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Chain A, Ferritin light chain1001
pregnane X receptor1001
phosphopantetheinyl transferase1001
SMAD family member 21001
SMAD family member 31001
estrogen receptor 2 (ER beta)1001
nonstructural protein 11001
farnesoid X nuclear receptor1001
peroxisome proliferator-activated receptor delta1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
vitamin D3 receptor isoform VDRA1001
thyroid hormone receptor beta isoform 21001
heat shock protein HSP 90-alpha isoform 20001
DNA polymerase iota isoform a (long)1001
nuclear receptor ROR-gamma isoform 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Histamine H2 receptor1001
Guanine nucleotide-binding protein G1001
TAR DNA-binding protein 431001
heat shock protein 90, putative0001
chaperonin-containing TCP-1 beta subunit homolog1001
aldehyde dehydrogenase 1 family, member A11001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
histone acetyltransferase KAT2A isoform 11001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Bile salt export pump0101
Albumin0101
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Prostaglandin G/H synthase 10101
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]