Page last updated: 2024-09-28

Sinoatrial Nodal Reentry Tachycardia

Abnormally rapid heartbeats caused by reentry circuit in or around the SINOATRIAL NODE. It is characterized by sudden onset and offset episodes of tachycardia with a HEART RATE of 100-150 beats per minute. The P wave is identical to the sinus P wave but with a longer PR interval.

Synonyms(4)

Synonym
Tachycardia, Sinoatrial Nodal Reentry
Sinoatrial Nodal Reentry Tachycardia
Tachycardia, SA Nodal Reentrant
Sinus Node Reentrant Tachycardia

Research Excerpts

Overview

ExcerptReference
"Sinus node reentrant tachycardia is a relatively uncommon (5%-15%) form of recurrent paroxysmal supraventricular tachycardia (SVT)."( Belz, MK; Ellenbogen, KA; Sperry, RE; Stambler, BS; Wood, MA, 1993)

Research

Studies (26)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (7.69)23.3326
1990's15 (57.69)12.5806
2000's6 (23.08)18.1394
2010's2 (7.69)28.8240
2020's1 (3.85)9.53
DrugIndicatedRelationship StrengthStudiesTrials
n-methyl-3,4-methylenedioxyamphetamine0low10
amiodarone0low30
betaxolol0low10
verapamil0low20
flecainide0low10
halothane0low10
lidocaine0low10
isoflurane0low10
isoproterenol0low20
pilsicainide0low10
procainamide0low10
adenosine0low80
digoxin0low20
cardiovascular agents0low10

Protein Targets (427)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Structure of PAE2307 in complex with adenosine0011
Chain B, Structure of PAE2307 in complex with adenosine0011
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, tRNA (guanine-N(1)-)-methyltransferase0011
Chain A, Uncharacterized protein MJ08830011
AR protein8008
signal transducer and activator of transcription 6, interleukin-4 induced1001
regulator of G-protein signaling 44004
glucocorticoid receptor [Homo sapiens]4004
retinoid X nuclear receptor alpha3003
estrogen nuclear receptor alpha7007
NPYLR7B0022
arylsulfatase A3003
IDH13003
Histone H2A.x3003
glycogen synthase kinase-3 beta isoform 10011
mitogen-activated protein kinase 14004
flap endonuclease 14004
nuclear receptor ROR-gamma isoform 13003
peripheral myelin protein 223003
survival motor neuron protein isoform d2002
high affinity choline transporter 1 isoform a0101
Sodium/nucleoside cotransporter 10202
Calcium dependent protein kinase0101
Mitogen-activated protein kinase kinase kinase 70011
Sodium/nucleoside cotransporter 20202
Voltage-dependent calcium channel gamma-2 subunit3003
Rap guanine nucleotide exchange factor 31001
Purine nucleoside phosphorylase0101
Epidermal growth factor receptor0101
Phosphoglycerate kinase 1 0101
Adenosine deaminase0001
Avidin0011
Adenosine deaminase0001
Glyceraldehyde-3-phosphate dehydrogenase0202
Receptor tyrosine-protein kinase erbB-20202
Insulin receptor0001
Phosphoglycerate kinase 20101
Heat shock protein HSP 90-alpha0112
Platelet-derived growth factor receptor beta0001
Adenosine receptor A30539
Heat shock 70 kDa protein 1A 0101
Heat shock cognate 71 kDa protein0011
Fibroblast growth factor receptor 10001
Inosine-5'-monophosphate dehydrogenase 20101
Endoplasmin0112
Glutamate receptor 23003
Inosine-5'-monophosphate dehydrogenase 1 0101
Fibroblast growth factor receptor 20001
Fibroblast growth factor receptor 40001
Fibroblast growth factor receptor 30001
Streptavidin0011
Adenosylhomocysteinase0001
Adenosine receptor A10112
Adenosine receptor A30101
Adenosine receptor A2a0236
Adenosine receptor A2b0012
Adenosine receptor A2b0112
Adenylate kinase 2, mitochondrial0101
Adenosine receptor A10225
Adenosine receptor A2a0112
Adenylate kinase isoenzyme 1 0101
Phosphatidylinositol 4-kinase alpha0203
Adenosine receptor A10011
Adenosine kinase0001
Adenosine deaminase 0001
Equilibrative nucleoside transporter 20202
Phosphatidylinositol 4-kinase type 2-beta0203
Histone-lysine N-methyltransferase, H3 lysine-79 specific0101
Equilibrative nucleoside transporter 10202
Phosphatidylinositol 4-kinase type 2-alpha0203
Solute carrier family 28 member 30202
Adenosine kinase0102
Phosphatidylinositol 4-kinase beta0203
5-methylthioadenosine/S-adenosylhomocysteine deaminase0001
Adenosine transporter 10001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
acetylcholinesterase1001
phosphopantetheinyl transferase2002
hypoxia-inducible factor 1 alpha subunit1001
RAR-related orphan receptor gamma4004
SMAD family member 22002
ATAD5 protein, partial2002
Fumarate hydratase1001
USP1 protein, partial1001
NFKB1 protein, partial1001
PPM1D protein2002
SMAD family member 32002
TDP1 protein9009
Thrombopoietin1001
caspase 7, apoptosis-related cysteine protease1001
aldehyde dehydrogenase 1 family, member A14004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
thyroid stimulating hormone receptor2002
estrogen receptor 2 (ER beta)2002
nuclear receptor subfamily 1, group I, member 34004
progesterone receptor3003
EWS/FLI fusion protein5005
retinoic acid nuclear receptor alpha variant 13003
estrogen-related nuclear receptor alpha3003
farnesoid X nuclear receptor2002
pregnane X nuclear receptor3003
G2002
cytochrome P450 2D64004
polyprotein1001
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma3003
caspase-31001
euchromatic histone-lysine N-methyltransferase 25005
thyroid stimulating hormone receptor4004
v-jun sarcoma virus 17 oncogene homolog (avian)2002
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C9 precursor1001
D(1A) dopamine receptor2002
chromobox protein homolog 13003
thyroid hormone receptor beta isoform a2002
potassium voltage-gated channel subfamily H member 2 isoform d4004
thyroid hormone receptor beta isoform 25005
heat shock protein beta-11001
huntingtin isoform 22002
serine/threonine-protein kinase mTOR isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 15005
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
geminin4004
cytochrome P450 3A4 isoform 12002
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)2002
lamin isoform A-delta107007
Gamma-aminobutyric acid receptor subunit pi2125
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Solute carrier organic anion transporter family member 1A40203
Voltage-dependent L-type calcium channel subunit alpha-1F0404
5-hydroxytryptamine receptor 40606
Lysine-specific demethylase PHF20101
Bile salt export pump0909
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 2002
Thyroid hormone receptor alpha0101
Cellular tumor antigen p534004
Integrin beta-32002
Tyrosine-protein kinase Fyn0101
ATP-dependent translocase ABCB10303
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20314
Muscarinic acetylcholine receptor M40202
ATP-dependent translocase ABCB107217
Integrin alpha-IIb2002
Beta-1 adrenergic receptor07310
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0528
Cytochrome P450 2C80303
Thyroid hormone receptor alpha0101
Thyroid hormone receptor beta0101
Muscarinic acetylcholine receptor M10314
Beta-3 adrenergic receptor0527
D(2) dopamine receptor0415
Androgen receptor0202
Gamma-aminobutyric acid receptor subunit beta-12125
Alpha-1B adrenergic receptor0516
Lethal factor0101
Alpha-2B adrenergic receptor0214
Thyroid hormone receptor beta0101
Gamma-aminobutyric acid receptor subunit delta2125
Gamma-aminobutyric acid receptor subunit gamma-22125
Gamma-aminobutyric acid receptor subunit alpha-52125
Gamma-aminobutyric acid receptor subunit alpha-32125
Muscarinic acetylcholine receptor M30314
ATP-dependent translocase ABCB10304
Substance-K receptor0202
D(1A) dopamine receptor0415
D(4) dopamine receptor0303
Gamma-aminobutyric acid receptor subunit gamma-12125
Gamma-aminobutyric acid receptor subunit alpha-22125
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Sodium-dependent noradrenaline transporter 0415
Histamine H2 receptor0404
Endothelin-1 receptor0314
5-hydroxytryptamine receptor 2A0617
5-hydroxytryptamine receptor 2C0617
Gamma-aminobutyric acid receptor subunit alpha-42125
Gamma-aminobutyric acid receptor subunit gamma-32125
Lysine-specific demethylase 5A0101
Gamma-aminobutyric acid receptor subunit alpha-62125
B2 bradykinin receptor0202
Sodium-dependent serotonin transporter0819
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor0314
D(3) dopamine receptor0505
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0202
Squalene synthase0101
Delta-type opioid receptor0314
Kappa-type opioid receptor0314
5-hydroxytryptamine receptor 2B0617
C-C chemokine receptor type 20202
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0516
Histamine H2 receptor1012
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 60415
Carnitine O-palmitoyltransferase 1, liver isoform0101
C-C chemokine receptor type 40202
Spike glycoprotein2002
Gamma-aminobutyric acid receptor subunit alpha-12125
Gamma-aminobutyric acid receptor subunit beta-32125
Gamma-aminobutyric acid receptor subunit beta-22125
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0404
Sodium-dependent dopamine transporter 0415
Potassium voltage-gated channel subfamily H member 20707
Voltage-dependent L-type calcium channel subunit alpha-1S0404
Voltage-dependent L-type calcium channel subunit alpha-1C0606
Sodium channel protein type 5 subunit alpha0505
Squalene monooxygenase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0202
Lysine-specific demethylase 7A0101
GABA theta subunit2125
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Inositol hexakisphosphate kinase 12002
Canalicular multispecific organic anion transporter 10505
Sodium channel protein type 2 subunit alpha0101
Ataxin-24004
Sigma non-opioid intracellular receptor 10404
Gamma-aminobutyric acid receptor subunit epsilon2125
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Sodium channel protein type 3 subunit alpha0202
Sodium channel protein type 11 subunit alpha0101
Histone lysine demethylase PHF80101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial2002
ATP-dependent phosphofructokinase2002
cytochrome P450 family 3 subfamily A polypeptide 44004
Beta-1 adrenergic receptor 0136
hexokinase-4 isoform 12002
glucokinase regulatory protein2002
Cytochrome P450 2D60304
Beta-1 adrenergic receptor0439
5-hydroxytryptamine receptor 1A0427
Beta-2 adrenergic receptor 0123
Beta-2 adrenergic receptor0146
Chain A, Beta-lactamase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Cruzipain2002
interleukin 81001
PAX80001
GLI family zinc finger 34004
STAT3, partial0101
thioredoxin glutathione reductase1001
Smad31001
67.9K protein1001
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
alpha-galactosidase1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
activating transcription factor 63003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
NPC intracellular cholesterol transporter 1 precursor1001
tumor necrosis factor1001
nuclear factor erythroid 2-related factor 2 isoform 21001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
ras-related protein Rab-9A1001
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
Sodium/potassium-transporting ATPase subunit beta-1 0101
Cytochrome P450 3A40303
Replicase polyprotein 1ab0101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-10101
Nuclear receptor ROR-gamma1113
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4C10001
ATPase family AAA domain-containing protein 51001
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1B30101
Solute carrier organic anion transporter family member 1B10303
Cytochrome P450 2C9 0303
Potassium voltage-gated channel subfamily A member 50202
Cytochrome P450 2J20303
Potassium voltage-gated channel subfamily A member 10101
Potassium voltage-gated channel subfamily D member 20202
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Albumin0123
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit alpha-70101
glp-1 receptor, partial2002
thioredoxin reductase4004
GLS protein2002
Microtubule-associated protein tau2002
beta-2 adrenergic receptor1001
vitamin D3 receptor isoform VDRA1001
Bile salt export pump0303
Beta-2 adrenergic receptor0438
Beta-2 adrenergic receptor0416
Polyunsaturated fatty acid lipoxygenase ALOX150101
Beta-2 adrenergic receptor0011
Alpha-2B adrenergic receptor0213
Alpha-2C adrenergic receptor0213
Alpha-2A adrenergic receptor0213
Alpha-1D adrenergic receptor0314
Beta-adrenergic receptor kinase 10011
Alpha-1D adrenergic receptor0023
Beta-3 adrenergic receptor0011
Beta-3 adrenergic receptor0314
Vasopressin V1a receptor0011
Beta-1 adrenergic receptor0213
Alpha-1A adrenergic receptor0135
Alpha-1B adrenergic receptor0023
Glutamate receptor ionotropic, NMDA 1 0011
Beta-2 adrenergic receptor0202
Taste receptor type 2 member 380011
Taste receptor type 2 member 390011
Taste receptor type 2 member 400011
Taste receptor type 2 member 410011
Taste receptor type 2 member 430011
Taste receptor type 2 member 310011
Taste receptor type 2 member 450011
Taste receptor type 2 member 460011
Taste receptor type 2 member 300011
Taste receptor type 2 member 190011
Taste receptor type 2 member 200011
Taste receptor type 2 member 500011
Taste receptor type 2 member 600011
Oxytocin receptor0011
Glutamate receptor ionotropic, NMDA 2A 0011
Glutamate receptor ionotropic, NMDA 2B0011
Glutamate receptor ionotropic, NMDA 2C0011
Glutamate receptor ionotropic, NMDA 2D0011
Taste receptor type 2 member 420011
Glutamate receptor ionotropic, NMDA 3B0011
Taste receptor type 2 member 160011
Taste receptor type 2 member 140011
Taste receptor type 2 member 130011
Taste receptor type 2 member 100011
Taste receptor type 2 member 90011
Taste receptor type 2 member 80011
Taste receptor type 2 member 70011
Taste receptor type 2 member 50011
Taste receptor type 2 member 40011
Taste receptor type 2 member 30011
Taste receptor type 2 member 10011
Glutamate receptor ionotropic, NMDA 3A0011
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium channel subfamily K member 180101
Multidrug and toxin extrusion protein 10101
Aldo-keto reductase family 1 member B10101
Sodium-dependent dopamine transporter0011
Sodium-dependent serotonin transporter0112
Trace amine-associated receptor 10011
GALC protein1001
cytochrome P450 2C19 precursor1001
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0405
Sterol O-acyltransferase 10101
Solute carrier family 22 member 20101
Solute carrier family 22 member 30101
Acetylcholinesterase0202
Acetylcholinesterase 0101
DNA (cytosine-5)-methyltransferase 10101
Sterol O-acyltransferase 10101
Solute carrier family 22 member 10202
Solute carrier family 22 member 20202
Solute carrier family 22 member 40101
DNA (cytosine-5)-methyltransferase 3-like0101
DNA (cytosine-5)-methyltransferase 3A0101
Cytochrome P450 1A20101
5-hydroxytryptamine receptor 1A0101
Alpha-2C adrenergic receptor0124
D(3) dopamine receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 1B0404
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
Cytochrome P450 2C190101
5-hydroxytryptamine receptor 70112
Vasopressin V1a receptor0112
5-hydroxytryptamine receptor 70202
Sodium/bile acid cotransporter0101
Nuclear receptor subfamily 2 group E member 10022
glucocerebrosidase1001
lysosomal alpha-glucosidase preproprotein1001
Glycoprotein0101
Muscarinic acetylcholine receptor M20011
Catechol O-methyltransferase0101
Potassium voltage-gated channel subfamily A member 30101
Delta-type opioid receptor0101
Multidrug resistance-associated protein 1 0214
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
D(2) dopamine receptor0101
Chloroquine resistance transporter0101
Broad substrate specificity ATP-binding cassette transporter ABCG20112
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 20011
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 10011
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 40011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]