Silo Filler Disease

A form of alveolitis or PNEUMONITIS caused by hypersensitivity to high level of inhaled nitrogen oxides, decomposition products of silage.

Synonym
Silo Fillers' Disease
Silo Fillers Disease
Silo Filler's Disease
Silo Filler Disease

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	31 (79.49)	23.3326
1990's	3 (7.69)	12.5806
2000's	3 (7.69)	18.1394
2010's	1 (2.56)	28.8240
2020's	1 (2.56)	9.53

Drug	Relationship Strength	Studies
carbon monoxide	low	1
formic acid	low	1
diacetyl	low	1
methanol	low	1
nitrates	low	2
nitrites	low	1
nitrous oxide	low	4
ambroxol	low	2
chlorpheniramine	low	1
procaine	low	1
prednisolone	low	1
prednisone	low	4
penicillin g	low	1
methylene blue	low	1
phencyclidine	low	4
methylprednisolone	low	2
streptomycin	low	1
dihydrostreptomycin sulfate	low	1
uranium	low	1
cyanates	low	1
nitrogen dioxide	medium	17
beryllium	low	2
oxytetracycline, anhydrous	low	2

Protein Targets (332)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Smad3	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
cytochrome P450 2D6	3	0	0	3
glucocerebrosidase	1	0	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
chromobox protein homolog 1	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
lamin isoform A-delta10	1	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Lysosomal acid glucosylceramidase	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
TAR DNA-binding protein 43	2	0	0	2
arylsulfatase A	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
flap endonuclease 1	3	0	0	3
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	3
Bile salt export pump	0	6	0	6
Histamine H1 receptor	0	2	0	2
MBT domain-containing protein 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	3	0	3
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Ataxin-2	4	0	0	4
Chloroquine resistance transporter	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
ATP-dependent phosphofructokinase	3	0	0	3
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Carbonic anhydrase 4	0	3	0	3
Carbonic anhydrase 15	0	3	0	3
endonuclease IV	1	0	0	1
GLS protein	2	0	0	2
Thrombopoietin	1	0	0	1
thyroid stimulating hormone receptor	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	5	0	0	5
muscarinic acetylcholine receptor M1	2	0	0	2
Cocaine esterase	0	1	0	1
Coagulation factor XII	0	1	0	1
Cholinesterase	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
estrogen nuclear receptor alpha	5	0	0	5
glucocorticoid receptor [Homo sapiens]	5	0	0	5
thyroid hormone receptor beta isoform 2	3	0	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain E, Fibrin beta chain	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Ferritin light chain	1	0	0	1
Luciferase	1	0	0	1
T cell receptor, partial	1	0	0	1
acetylcholinesterase	2	0	0	2
luteinizing hormone receptor	1	0	0	1
glp-1 receptor, partial	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
phosphopantetheinyl transferase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
RAR-related orphan receptor gamma	2	0	0	2
SMAD family member 2	1	0	0	1
ATAD5 protein, partial	1	0	0	1
Fumarate hydratase	1	0	0	1
PPM1D protein	2	0	0	2
SMAD family member 3	1	0	0	1
TDP1 protein	3	0	0	3
GLI family zinc finger 3	4	0	0	4
Microtubule-associated protein tau	2	0	0	2
TSHR protein	1	0	0	1
AR protein	5	0	0	5
Apoptotic peptidase activating factor 1	0	1	0	1
thioredoxin glutathione reductase	3	0	0	3
caspase 7, apoptosis-related cysteine protease	1	0	0	1
estrogen receptor 2 (ER beta)	2	0	0	2
hypothetical protein, conserved	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
progesterone receptor	4	0	0	4
isocitrate dehydrogenase 1, partial	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	3	0	0	3
retinoid X nuclear receptor alpha	2	0	0	2
estrogen-related nuclear receptor alpha	4	0	0	4
farnesoid X nuclear receptor	1	0	0	1
pregnane X nuclear receptor	5	0	0	5
G	2	0	0	2
polyprotein	1	0	0	1
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
peroxisome proliferator-activated receptor delta	1	0	0	1
peroxisome proliferator activated receptor gamma	1	0	0	1
caspase-3	1	0	0	1
IDH1	2	0	0	2
aryl hydrocarbon receptor	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
thyroid stimulating hormone receptor	2	0	0	2
activating transcription factor 6	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	2	0	0	2
serine-protein kinase ATM isoform a	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
caspase-9 isoform alpha precursor	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	1	0	0	1
huntingtin isoform 2	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
DNA polymerase beta	2	0	0	2
mitogen-activated protein kinase 1	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	2	0	0	2
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
geminin	3	0	0	3
Vpr	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Glutathione reductase	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Glutathione reductase, mitochondrial	0	1	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Albumin	0	0	0	1
Cellular tumor antigen p53	3	0	0	3
Amyloid-beta precursor protein	0	1	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Glutamate receptor 2	2	0	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent noradrenaline transporter	0	0	1	1
Cruzipain	0	1	0	1
Alpha-synuclein	1	0	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Spike glycoprotein	1	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Inositol hexakisphosphate kinase 1	2	0	0	2
ATPase family AAA domain-containing protein 5	3	0	0	3
Zinc finger protein mex-5	0	0	1	1
cytochrome P450 2C9, partial	2	0	0	2
phosphoglycerate kinase	2	0	0	2
nonstructural protein 1	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Carbonic anhydrase	0	2	0	2
Sodium/iodide cotransporter	0	1	0	1
Chain A, Beta-lactamase	1	0	0	1
thioredoxin reductase	2	0	0	2
WRN	1	0	0	1
USP1 protein, partial	1	0	0	1
Valosin-containing protein	0	1	0	1
apical membrane antigen 1, AMA1	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
regulator of G-protein signaling 4	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
transcriptional regulator ERG isoform 3	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
snurportin-1	1	0	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA polymerase kappa isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	1	1
Solute carrier family 22 member 6	0	1	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	2
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase VIM-1	0	0	0	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Cytochrome P450 2B6	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Muscarinic acetylcholine receptor M4	0	0	1	2
Delta-type opioid receptor	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Mu-type opioid receptor	0	0	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	3
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Muscarinic acetylcholine receptor M5	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Cytochrome P450 2C9	0	1	0	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	1	0	1
Estrogen receptor beta	0	2	0	2
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
pregnane X receptor	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Bile salt export pump	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Protein-arginine deiminase type-4	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research

Studies (39)

Protein Targets (332)

Silo Filler Disease

Synonyms(4)

Research

Studies (39)

Drugs Studied (30)

Protein Targets (332)