| Protein | Potency Measurements | Inhibition Measurements | Activation Measurements | Drugs |
|---|
| hypoxia-inducible factor 1 alpha subunit | 2 | 0 | 0 | 2 |
| RAR-related orphan receptor gamma | 4 | 0 | 0 | 4 |
| SMAD family member 2 | 3 | 0 | 0 | 3 |
| SMAD family member 3 | 3 | 0 | 0 | 3 |
| TDP1 protein | 5 | 0 | 0 | 5 |
| GLI family zinc finger 3 | 5 | 0 | 0 | 5 |
| AR protein | 6 | 0 | 0 | 6 |
| estrogen receptor 2 (ER beta) | 4 | 0 | 0 | 4 |
| progesterone receptor | 5 | 0 | 0 | 5 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | 5 | 0 | 0 | 5 |
| glucocorticoid receptor [Homo sapiens] | 5 | 0 | 0 | 5 |
| retinoic acid nuclear receptor alpha variant 1 | 6 | 0 | 0 | 6 |
| retinoid X nuclear receptor alpha | 4 | 0 | 0 | 4 |
| estrogen-related nuclear receptor alpha | 6 | 0 | 0 | 6 |
| farnesoid X nuclear receptor | 3 | 0 | 0 | 3 |
| pregnane X nuclear receptor | 6 | 0 | 0 | 6 |
| estrogen nuclear receptor alpha | 7 | 0 | 0 | 7 |
| cytochrome P450 2D6 | 5 | 0 | 0 | 5 |
| peroxisome proliferator-activated receptor delta | 3 | 0 | 0 | 3 |
| peroxisome proliferator activated receptor gamma | 3 | 0 | 0 | 3 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | 3 | 0 | 0 | 3 |
| aryl hydrocarbon receptor | 2 | 0 | 0 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | 3 | 0 | 0 | 3 |
| thyroid stimulating hormone receptor | 3 | 0 | 0 | 3 |
| chromobox protein homolog 1 | 2 | 0 | 0 | 2 |
| thyroid hormone receptor beta isoform 2 | 4 | 0 | 0 | 4 |
| heat shock protein beta-1 | 3 | 0 | 0 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | 5 | 0 | 0 | 5 |
| Sex hormone-binding globulin | 0 | 0 | 2 | 2 |
| Beta-glucuronidase | 0 | 1 | 0 | 1 |
| Corticosteroid-binding globulin | 0 | 1 | 0 | 1 |
| Beta-glucuronidase | 0 | 1 | 0 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | 0 | 2 | 0 | 2 |
| Alpha-synuclein | 1 | 0 | 0 | 1 |
| TAR DNA-binding protein 43 | 3 | 0 | 0 | 3 |
| G-protein coupled bile acid receptor 1 | 0 | 0 | 1 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | 0 | 1 | 0 | 1 |
| NPC1-like intracellular cholesterol transporter 1 | 0 | 0 | 1 | 1 |
| thioredoxin reductase | 2 | 0 | 0 | 2 |
| pregnane X receptor | 2 | 0 | 0 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | 1 | 0 | 0 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | 4 | 0 | 0 | 4 |
| glucocerebrosidase | 1 | 0 | 0 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | 1 | 0 | 0 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | 2 | 0 | 0 | 2 |
| Histone H2A.x | 1 | 0 | 0 | 1 |
| thyroid hormone receptor beta isoform a | 1 | 0 | 0 | 1 |
| transcriptional regulator ERG isoform 3 | 2 | 0 | 0 | 2 |
| urokinase-type plasminogen activator precursor | 1 | 0 | 0 | 1 |
| plasminogen precursor | 1 | 0 | 0 | 1 |
| urokinase plasminogen activator surface receptor precursor | 1 | 0 | 0 | 1 |
| geminin | 2 | 0 | 0 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | 3 | 0 | 0 | 3 |
| Glucocorticoid receptor | 0 | 2 | 0 | 2 |
| Cellular tumor antigen p53 | 3 | 0 | 0 | 3 |
| Glycine receptor subunit alpha-1 | 0 | 2 | 0 | 2 |
| Androgen receptor | 0 | 5 | 0 | 5 |
| Glutamate receptor 2 | 3 | 0 | 0 | 3 |
| Glycine receptor subunit beta | 0 | 2 | 0 | 2 |
| Glycine receptor subunit alpha-2 | 0 | 2 | 0 | 2 |
| Glycine receptor subunit alpha-3 | 0 | 2 | 0 | 2 |
| Nuclear receptor ROR-gamma | 1 | 0 | 0 | 1 |
| ATPase family AAA domain-containing protein 5 | 1 | 0 | 0 | 1 |
| Ataxin-2 | 1 | 0 | 0 | 1 |
| Sodium-dependent noradrenaline transporter | 0 | 2 | 0 | 2 |
| Voltage-dependent calcium channel subunit alpha-2/delta-1 | 0 | 1 | 0 | 1 |
| Voltage-dependent calcium channel subunit alpha-2/delta-2 | 0 | 1 | 0 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | 1 | 0 | 0 | 1 |
| acetylcholinesterase | 2 | 0 | 0 | 2 |
| Smad3 | 1 | 0 | 0 | 1 |
| thyroid stimulating hormone receptor | 2 | 0 | 0 | 2 |
| EWS/FLI fusion protein | 1 | 0 | 0 | 1 |
| cytochrome P450 2D6 isoform 1 | 1 | 0 | 0 | 1 |
| peripheral myelin protein 22 isoform 1 | 1 | 0 | 0 | 1 |
| cytochrome P450 2C19 precursor | 2 | 0 | 0 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | 2 | 0 | 0 | 2 |
| peripheral myelin protein 22 | 2 | 0 | 0 | 2 |
| survival motor neuron protein isoform d | 1 | 0 | 0 | 1 |
| muscarinic acetylcholine receptor M1 | 1 | 0 | 0 | 1 |
| Solute carrier family 22 member 2 | 0 | 1 | 0 | 1 |
| ATP-binding cassette sub-family C member 3 | 0 | 3 | 0 | 3 |
| Multidrug resistance-associated protein 4 | 0 | 3 | 0 | 3 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 4 | 0 | 2 | 0 | 2 |
| Bile salt export pump | 0 | 3 | 0 | 3 |
| Albumin | 0 | 0 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | 0 | 1 | 0 | 1 |
| Muscarinic acetylcholine receptor M4 | 0 | 1 | 0 | 1 |
| ATP-dependent translocase ABCB1 | 0 | 0 | 0 | 1 |
| Cytochrome P450 3A4 | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 1A | 0 | 1 | 2 | 3 |
| 5-hydroxytryptamine receptor 2C | 0 | 2 | 0 | 2 |
| Muscarinic acetylcholine receptor M5 | 0 | 1 | 0 | 1 |
| Alpha-2A adrenergic receptor | 0 | 2 | 0 | 2 |
| Cytochrome P450 2D6 | 0 | 1 | 0 | 1 |
| Muscarinic acetylcholine receptor M1 | 0 | 1 | 0 | 1 |
| Angiotensin-converting enzyme | 0 | 2 | 0 | 2 |
| D(2) dopamine receptor | 0 | 2 | 0 | 2 |
| 5-hydroxytryptamine receptor 2A | 0 | 2 | 0 | 2 |
| Alpha-1B adrenergic receptor | 0 | 1 | 0 | 1 |
| Alpha-2B adrenergic receptor | 0 | 2 | 0 | 2 |
| Beta-1 adrenergic receptor | 0 | 1 | 0 | 1 |
| Alpha-2C adrenergic receptor | 0 | 2 | 0 | 2 |
| D | 0 | 1 | 0 | 1 |
| D(3) dopamine receptor | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 1A | 0 | 2 | 0 | 2 |
| Alpha-2B adrenergic receptor | 0 | 1 | 0 | 1 |
| Muscarinic acetylcholine receptor M3 | 0 | 2 | 0 | 2 |
| D(1A) dopamine receptor | 0 | 2 | 0 | 2 |
| D(4) dopamine receptor | 0 | 1 | 0 | 1 |
| Alpha-2C adrenergic receptor | 0 | 1 | 0 | 1 |
| Alpha-2A adrenergic receptor | 0 | 1 | 0 | 1 |
| Glycine receptor subunit alpha-1 | 0 | 0 | 1 | 1 |
| Alpha-1D adrenergic receptor | 0 | 1 | 0 | 1 |
| Sodium-dependent dopamine transporter | 0 | 1 | 0 | 1 |
| Histamine H2 receptor | 0 | 2 | 0 | 2 |
| Alpha-1D adrenergic receptor | 0 | 2 | 0 | 2 |
| 5-hydroxytryptamine receptor 2A | 0 | 2 | 0 | 2 |
| 5-hydroxytryptamine receptor 2C | 0 | 2 | 0 | 2 |
| 5-hydroxytryptamine receptor 1B | 0 | 2 | 0 | 2 |
| 5-hydroxytryptamine receptor 2B | 0 | 2 | 0 | 2 |
| Histamine H1 receptor | 0 | 1 | 0 | 1 |
| Sodium-dependent serotonin transporter | 0 | 3 | 0 | 3 |
| 5-hydroxytryptamine receptor 7 | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 2C | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 7 | 0 | 1 | 0 | 1 |
| Alpha-1A adrenergic receptor | 0 | 2 | 0 | 2 |
| 5-hydroxytryptamine receptor 2A | 0 | 1 | 0 | 1 |
| Histamine H1 receptor | 0 | 2 | 0 | 2 |
| Alpha-1B adrenergic receptor | 0 | 1 | 0 | 1 |
| D(3) dopamine receptor | 0 | 2 | 0 | 2 |
| 5-hydroxytryptamine receptor 2B | 0 | 2 | 0 | 2 |
| Alpha-1A adrenergic receptor | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 6 | 0 | 1 | 0 | 1 |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0 | 1 | 0 | 1 |
| Spike glycoprotein | 2 | 0 | 0 | 2 |
| D(2) dopamine receptor | 0 | 1 | 0 | 1 |
| D(2) dopamine receptor | 0 | 2 | 0 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 2B | 0 | 1 | 0 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | 0 | 3 | 0 | 3 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | 0 | 1 | 0 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | 0 | 2 | 0 | 2 |
| Sodium channel protein type 5 subunit alpha | 0 | 2 | 0 | 2 |
| Transporter | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 1A | 0 | 1 | 0 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | 0 | 2 | 0 | 2 |
| Multidrug and toxin extrusion protein 2 | 0 | 1 | 0 | 1 |
| Canalicular multispecific organic anion transporter 1 | 0 | 3 | 0 | 3 |
| Multidrug and toxin extrusion protein 1 | 0 | 1 | 0 | 1 |
| Transporter | 0 | 1 | 0 | 1 |
| Histamine H3 receptor | 0 | 1 | 0 | 1 |
| G | 4 | 0 | 0 | 4 |
| nuclear receptor subfamily 1, group I, member 2 | 2 | 0 | 0 | 2 |
| Carbonic anhydrase 12 | 0 | 0 | 0 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | 0 | 3 | 1 | 4 |
| Carbonic anhydrase 1 | 0 | 0 | 0 | 1 |
| Carbonic anhydrase 2 | 0 | 0 | 0 | 1 |
| Interferon beta | 4 | 0 | 0 | 4 |
| HLA class I histocompatibility antigen, B alpha chain | 4 | 0 | 0 | 4 |
| Carbonic anhydrase 3 | 0 | 0 | 0 | 1 |
| Carbonic anhydrase 4 | 0 | 0 | 0 | 1 |
| Carbonic anhydrase 6 | 0 | 0 | 0 | 1 |
| Carbonic anhydrase 5A, mitochondrial | 0 | 0 | 0 | 1 |
| Carbonic anhydrase 7 | 0 | 0 | 0 | 1 |
| Carbonic anhydrase 9 | 0 | 0 | 0 | 1 |
| Inositol hexakisphosphate kinase 1 | 4 | 0 | 0 | 4 |
| Carbonic anhydrase 13 | 0 | 0 | 0 | 1 |
| Carbonic anhydrase 14 | 0 | 0 | 0 | 1 |
| Carbonic anhydrase 5B, mitochondrial | 0 | 0 | 0 | 1 |
| cytochrome P450 2C9, partial | 4 | 0 | 0 | 4 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 0 | 1 | 0 | 1 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 0 | 1 | 0 | 1 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 0 | 1 | 0 | 1 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 0 | 1 | 0 | 1 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 0 | 1 | 0 | 1 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 0 | 1 | 0 | 1 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 0 | 1 | 0 | 1 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 0 | 1 | 0 | 1 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 0 | 1 | 0 | 1 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 0 | 1 | 0 | 1 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 0 | 1 | 0 | 1 |
| Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 0 | 1 | 0 | 1 |
| Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase | 0 | 1 | 0 | 1 |
| Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase | 0 | 1 | 0 | 1 |
| Chain A, Beta-lactamase | 1 | 0 | 0 | 1 |
| USP1 protein, partial | 2 | 0 | 0 | 2 |
| euchromatic histone-lysine N-methyltransferase 2 | 1 | 0 | 0 | 1 |
| Phosphodiesterase | 0 | 1 | 0 | 1 |
| importin subunit beta-1 isoform 1 | 1 | 0 | 0 | 1 |
| mitogen-activated protein kinase 1 | 1 | 0 | 0 | 1 |
| snurportin-1 | 1 | 0 | 0 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | 1 | 0 | 0 | 1 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | 0 | 1 | 0 | 1 |
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | 0 | 1 | 0 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | 0 | 1 | 1 | 2 |
| High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | 0 | 1 | 0 | 1 |
| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | 0 | 1 | 0 | 1 |
| High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B | 0 | 1 | 0 | 1 |
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | 0 | 1 | 0 | 1 |
| Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha | 0 | 1 | 0 | 1 |
| Cystic fibrosis transmembrane conductance regulator | 0 | 0 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | 0 | 1 | 0 | 1 |
| Potassium voltage-gated channel subfamily E member 1 | 0 | 1 | 0 | 1 |
| Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha | 0 | 1 | 0 | 1 |
| Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | 0 | 1 | 0 | 1 |
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | 0 | 1 | 0 | 1 |
| Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | 0 | 1 | 0 | 1 |
| Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta | 0 | 1 | 0 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 0 | 1 | 0 | 1 |
| Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta | 0 | 1 | 0 | 1 |
| Acetylcholinesterase | 0 | 1 | 0 | 1 |
| Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | 0 | 1 | 0 | 1 |
| Potassium voltage-gated channel subfamily KQT member 1 | 0 | 1 | 0 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | 0 | 1 | 0 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | 0 | 1 | 0 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | 0 | 1 | 0 | 1 |
| Synaptic vesicular amine transporter | 0 | 1 | 0 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 0 | 1 | 0 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | 0 | 1 | 0 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 0 | 1 | 0 | 1 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 0 | 1 | 0 | 1 |
| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 0 | 1 | 0 | 1 |
| Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | 0 | 1 | 0 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | 0 | 1 | 0 | 1 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | 0 | 1 | 0 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | 0 | 1 | 0 | 1 |
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | 0 | 1 | 0 | 1 |
| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | 0 | 1 | 0 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 7B | 0 | 1 | 0 | 1 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 0 | 1 | 0 | 1 |
| Nuclear receptor subfamily 2 group E member 1 | 0 | 0 | 1 | 1 |
| phosphopantetheinyl transferase | 1 | 0 | 0 | 1 |
| caspase 7, apoptosis-related cysteine protease | 1 | 0 | 0 | 1 |
| caspase-3 | 1 | 0 | 0 | 1 |
| activating transcription factor 6 | 1 | 0 | 0 | 1 |
| cytochrome P450 2C9 precursor | 1 | 0 | 0 | 1 |
| vitamin D3 receptor isoform VDRA | 1 | 0 | 0 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | 1 | 0 | 0 | 1 |
| cytochrome P450 3A4 isoform 1 | 1 | 0 | 0 | 1 |
| lamin isoform A-delta10 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | 1 | 0 | 0 | 1 |
| Steroid 17-alpha-hydroxylase/17,20 lyase | 0 | 1 | 0 | 1 |
| Androgen receptor | 0 | 1 | 0 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | 1 | 0 | 0 | 1 |
| Androgen receptor | 0 | 0 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | 1 | 0 | 0 | 1 |
| Histamine H2 receptor | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | 1 | 0 | 0 | 1 |
| Rap guanine nucleotide exchange factor 4 | 1 | 0 | 0 | 1 |
| GABA theta subunit | 1 | 0 | 0 | 1 |
| Neuropeptide FF receptor 2 | 0 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | 1 | 0 | 0 | 1 |
| Estrogen receptor | 0 | 2 | 0 | 2 |
| Cytochrome P450 2C19 | 0 | 1 | 0 | 1 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |