Page last updated: 2024-09-27

Sex Cord-Gonadal Stromal Tumors

Neoplasms derived from the primitive sex cord or gonadal stromal cells of the embryonic GONADS. They are classified by their presumed histogenesis and differentiation. From the sex cord, there are SERTOLI CELL TUMOR and GRANULOSA CELL TUMOR; from the gonadal stroma, LEYDIG CELL TUMOR and THECOMA. These tumors may be identified in either the OVARY or the TESTIS.

Synonyms(1)

Synonym
Sex Cord-Gonadal Stromal Tumors

Research

Studies (107)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (1.87)23.3326
1990's29 (27.10)12.5806
2000's26 (24.30)18.1394
2010's38 (35.51)28.8240
2020's12 (11.21)9.53
DrugIndicatedRelationship StrengthStudiesTrials
anastrozole0medium11
fluorouracil0low10
ifosfamide0medium31
ketoconazole0low10
mitotane0low10
activins0low50
spironolactone0low10
dehydroepiandrosterone0low10
9,10-dimethyl-1,2-benzanthracene0low10
17-alpha-hydroxyprogesterone0low10
4-vinyl-1-cyclohexene dioxide0low10
dehydroepiandrosterone sulfate0low10
turinabol0low10
fluorodeoxyglucose f180low10
myelopeptide 10low10
docetaxel anhydrous0low10
carboplatin0medium11
glycogen0low10
dactinomycin0low10
bromochloroacetic acid0low240
leuprolide0low10
tamoxifen0low50
dinoprostone0low10
panobinostat0low10
taxane0low10
mart-1 antigen0low30
sodium pertechnetate tc 99m0low10
transforming growth factor beta0low10
cyclin d10low20
bassianolide0low10
adrenomedullin0low10

Protein Targets (486)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
acetylcholinesterase4004
pregnane X receptor6006
SMAD family member 27007
SMAD family member 37007
TDP1 protein120012
GLI family zinc finger 3130013
Microtubule-associated protein tau5005
AR protein150015
progesterone receptor9009
glucocorticoid receptor [Homo sapiens]130013
retinoic acid nuclear receptor alpha variant 1130013
retinoid X nuclear receptor alpha120012
estrogen-related nuclear receptor alpha110011
farnesoid X nuclear receptor110011
pregnane X nuclear receptor120012
estrogen nuclear receptor alpha150015
G4004
vitamin D (1,25- dihydroxyvitamin D3) receptor100010
arylsulfatase A3003
euchromatic histone-lysine N-methyltransferase 27007
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
activating transcription factor 68008
nuclear receptor subfamily 1, group I, member 23003
chromobox protein homolog 19009
nuclear factor erythroid 2-related factor 2 isoform 1120012
geminin9009
survival motor neuron protein isoform d3003
histone acetyltransferase KAT2A isoform 12002
lamin isoform A-delta105005
Voltage-dependent calcium channel gamma-2 subunit7007
Interferon beta8008
HLA class I histocompatibility antigen, B alpha chain 4004
Glucocorticoid receptor0415
Sex hormone-binding globulin0022
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0202
Adenosine receptor A30606
Replicase polyprotein 1ab0112
Androgen receptor0607
Alpha-1B adrenergic receptor0606
Glutamate receptor 27007
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Mitogen-activated protein kinase 3 0101
Alpha-1A adrenergic receptor0606
Sodium-dependent dopamine transporter 0808
TAR DNA-binding protein 432002
Inositol hexakisphosphate kinase 14004
cytochrome P450 2C9, partial4004
ATP-dependent phosphofructokinase4004
bromodomain adjacent to zinc finger domain 2B4004
thyroid hormone receptor beta isoform a5005
Cellular tumor antigen p53120012
Chain A, Beta-lactamase4004
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, Cruzipain3003
Luciferase3003
acid sphingomyelinase1001
hypoxia-inducible factor 1 alpha subunit7007
RAR-related orphan receptor gamma100010
ATAD5 protein, partial2002
apical membrane antigen 1, AMA12002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
thyroid stimulating hormone receptor4004
estrogen receptor 2 (ER beta)8008
nuclear receptor subfamily 1, group I, member 39009
glucocerebrosidase2002
P531001
peroxisome proliferator-activated receptor delta9009
peroxisome proliferator activated receptor gamma100010
IDH15005
aryl hydrocarbon receptor3003
thyroid stimulating hormone receptor8008
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Caspase-74004
serine-protein kinase ATM isoform a2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
caspase-34004
thyroid hormone receptor beta isoform 2130013
heat shock protein beta-15005
mitogen-activated protein kinase 13003
nuclear factor NF-kappa-B p105 subunit isoform 12002
ras-related protein Rab-9A2002
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
nuclear receptor ROR-gamma isoform 13003
lethal(3)malignant brain tumor-like protein 1 isoform I2002
cytochrome P450 3A4 isoform 14004
caspase-1 isoform alpha precursor2002
Gamma-aminobutyric acid receptor subunit pi4004
Gamma-aminobutyric acid receptor subunit beta-14004
Gamma-aminobutyric acid receptor subunit delta4004
Gamma-aminobutyric acid receptor subunit gamma-24004
Gamma-aminobutyric acid receptor subunit alpha-54004
Gamma-aminobutyric acid receptor subunit alpha-34004
Gamma-aminobutyric acid receptor subunit gamma-14004
Gamma-aminobutyric acid receptor subunit alpha-24004
Gamma-aminobutyric acid receptor subunit alpha-44004
Gamma-aminobutyric acid receptor subunit gamma-34004
Gamma-aminobutyric acid receptor subunit alpha-64004
Nuclear receptor ROR-gamma4004
Caspase-72002
Gamma-aminobutyric acid receptor subunit alpha-14004
Gamma-aminobutyric acid receptor subunit beta-34004
Gamma-aminobutyric acid receptor subunit beta-24004
GABA theta subunit4004
ATPase family AAA domain-containing protein 57007
Ataxin-27007
Gamma-aminobutyric acid receptor subunit epsilon4004
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
cytochrome P450 family 3 subfamily A polypeptide 46006
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 409011
Bile salt export pump010010
Aromatase0505
Cytochrome P450 2C9 0202
Amine oxidase [flavin-containing] A 0101
UDP-glucuronosyltransferase 1A40203
Spike glycoprotein5016
Canalicular multispecific organic anion transporter 109010
aldehyde dehydrogenase 1 family, member A13003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
phosphopantetheinyl transferase3003
cytochrome P450 2D62002
vitamin D3 receptor isoform VDRA4004
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
DNA polymerase kappa isoform 11001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain2002
interleukin 82002
15-lipoxygenase, partial1001
USP1 protein, partial2002
caspase 7, apoptosis-related cysteine protease4004
caspase-34004
RAD510101
Histone H2A.x6006
Bloom syndrome protein isoform 12002
huntingtin isoform 22002
peripheral myelin protein 225005
ATP-dependent translocase ABCB108113
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Growth factor receptor-bound protein 20101
Pantothenate synthetase0101
Discoidin domain-containing receptor 20101
Growth factor receptor-bound protein 2 0101
Reverse transcriptase/RNaseH 0101
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
Beta-glucuronidase0101
Beta-glucuronidase0101
Glucose-6-phosphate 1-dehydrogenase0202
Alpha-synuclein2002
G-protein coupled bile acid receptor 10022
Glucose-6-phosphate 1-dehydrogenase 0101
NPC1-like intracellular cholesterol transporter 10011
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50002
Steryl-sulfatase0001
Multidrug resistance-associated protein 1 0001
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
ATP-binding cassette sub-family C member 110001
Solute carrier organic anion transporter family member 1B30405
Solute carrier family 22 member 110002
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1B20002
Solute carrier organic anion transporter family member 1B10203
regulator of G-protein signaling 42002
prostaglandin E2 receptor EP2 subtype1001
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0102
Cytochrome P450 3A40416
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin E2 receptor EP1 subtype0213
Prostaglandin E2 receptor EP1 subtype0101
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0213
Prostaglandin E2 receptor EP2 subtype0213
Prostacyclin receptor0213
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 60001
Solute carrier family 22 member 70001
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 200101
Solute carrier family 22 member 80001
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 70001
PPM1D protein4004
67.9K protein6006
Serum paraoxonase/arylesterase 10404
Kinesin-like protein KIF110101
Nucleotide-binding oligomerization domain-containing protein 20202
glp-1 receptor, partial4004
LMP1 [Human herpesvirus 4]0001
nuclear factor erythroid 2-related factor 2 isoform 23003
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
DNA polymerase iota isoform a (long)1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Prothrombin0001
Regulatory protein E20011
ATP-dependent translocase ABCB10303
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0117
Polyunsaturated fatty acid lipoxygenase ALOX150202
DNA topoisomerase 20001
ATP-dependent translocase ABCB10404
UDP-glucuronosyltransferase 1A1 0203
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0114
Integrase 0101
Similar to alpha-tubulin isoform 1 0114
Similar to alpha-tubulin isoform 1 0103
Glutamate receptor ionotropic, NMDA 3B0001
Glutamate receptor ionotropic, NMDA 3A0001
Chain A, Uracil Phosphoribosyltransferase0101
endonuclease IV1001
Skn7p0001
thioredoxin reductase2002
Thrombopoietin1001
EWS/FLI fusion protein3003
nonstructural protein 11001
peripheral myelin protein 22 isoform 11001
hemoglobin subunit beta1001
flap endonuclease 11001
serine/threonine-protein kinase mTOR isoform 12002
Vpr2002
muscleblind-like protein 1 isoform 11001
Solute carrier family 22 member 80001
Epidermal growth factor receptor0303
Amyloid-beta precursor protein1001
Thymidylate synthase0101
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
GALC protein1001
Estrogen receptor beta0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0202
Cytochrome P450 26A10101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0101
3',5'-cyclic-AMP phosphodiesterase 0101
Camphor 5-monooxygenase0001
Phospholipase A2, major isoenzyme0101
Chymotrypsinogen A0101
Beta-lactamase0101
Steroid 17-alpha-hydroxylase/17,20 lyase0202
Epoxide hydrolase 10001
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M20404
Cytochrome P450 2C11 0101
Steroid 21-hydroxylase0101
Alpha-2A adrenergic receptor0606
Cytochrome P450 2C80101
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
5-hydroxytryptamine receptor 2A0202
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2A20101
Cytochrome P450 11B1, mitochondrial 0101
Cytochrome P450 11B1, mitochondrial0101
Translocator protein0101
Alpha-2B adrenergic receptor0404
Cytochrome P450 7A1 0101
Cytochrome P450 11B2, mitochondrial0101
Estrogen receptor0101
Substance-K receptor0606
Sodium-dependent noradrenaline transporter 0606
Thromboxane-A synthase 0202
Histamine H2 receptor0404
Gonadotropin-releasing hormone receptor0314
Sodium-dependent serotonin transporter0606
Type-1 angiotensin II receptor0101
Malate dehydrogenase, cytoplasmic0101
Delta-type opioid receptor0606
Cytochrome P450 4F20101
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0202
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0101
Potassium voltage-gated channel subfamily H member 20303
Sodium/bile acid cotransporter0101
Lanosterol 14-alpha demethylase0213
Cytochrome P450 7A10101
Lanosterol 14-alpha demethylase 0202
Gonadotropin-releasing hormone receptor0101
HLA class I histocompatibility antigen, A alpha chain 0101
5-hydroxytryptamine receptor 2C0101
5-hydroxytryptamine receptor 2B0101
Gastrin/cholecystokinin type B receptor0101
Chain A, 2-oxoglutarate Oxygenase1001
Fumarate hydratase2002
polyprotein2002
potassium voltage-gated channel subfamily H member 2 isoform d1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
M-phase phosphoprotein 82002
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)2002
5-hydroxytryptamine receptor 2B0404
5-hydroxytryptamine receptor 60404
Peroxisome proliferator-activated receptor alpha1001
Rap guanine nucleotide exchange factor 41001
Genome polyprotein 0101
NPC intracellular cholesterol transporter 1 precursor2002
Tyrosine-protein kinase ABL10101
Tubulin alpha-1A chain0012
Tubulin beta chain0011
Tubulin beta-4A chain0113
Receptor tyrosine-protein kinase erbB-20202
Integrin beta-31102
Tyrosine-protein kinase Fyn0202
Integrin alpha-V 0101
Tubulin beta chain0113
60 kDa chaperonin0101
Tubulin alpha-3C chain0113
Botulinum neurotoxin type A 0101
Apoptosis regulator Bcl-20101
60 kDa heat shock protein, mitochondrial0101
Fibroblast growth factor receptor 10101
Proto-oncogene tyrosine-protein kinase Src0101
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
Cholecystokinin receptor type A0202
Melanocortin receptor 50404
UDP-glucuronosyltransferase 2B10 0101
10 kDa heat shock protein, mitochondrial0101
Tubulin alpha-1B chain0113
Tubulin alpha-4A chain0113
Tubulin beta-4B chain0113
Bcl-2-like protein 10101
Tyrosine-protein kinase Mer0101
Tubulin beta-3 chain0214
Tubulin beta-2A chain0113
Thiosulfate sulfurtransferase0101
Beta-tubulin 0101
Tubulin beta-8 chain0113
60 kDa chaperonin 0101
Tubulin alpha-3E chain0113
Tubulin alpha-1A chain0113
10 kDa chaperonin 0101
Tubulin alpha-1C chain0113
Tubulin beta-6 chain0113
Tubulin beta-2B chain0113
Tubulin beta-1 chain0113
Histone deacetylase 80101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0101
Histone deacetylase 30213
Bromodomain-containing protein 40101
Protein Tat0011
Leukotriene A-4 hydrolase0101
Cytochrome P450 3A50101
Phosphatidylinositol 3-kinase regulatory subunit alpha0101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
Histone deacetylase 40202
Histone deacetylase 10213
NAD-dependent protein deacetylase sirtuin-20202
Histone deacetylase 70202
Histone deacetylase 20213
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
NAD-dependent protein deacetylase sirtuin-10202
Histone deacetylase 80202
NAD-dependent protein deacetylase sirtuin-70101
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0202
Histone deacetylase 60213
Histone deacetylase 90202
Histone deacetylase 50202
Histone deacetylase 0101
Nuclear receptor corepressor 20101
Chain A, Mineralocorticoid receptor0101
Chain A, Mineralocorticoid receptor0101
Smad31001
Estrogen receptor0427
Progesterone receptor0314
Mineralocorticoid receptor 0203
Androgen receptor0213
Sodium-dependent serotonin transporter0101
Cytochrome P450 2C190101
Estrogen receptor beta0325
Multidrug and toxin extrusion protein 10101
Chain A, CES1 protein0101
DNA polymerase III, partial1001
thyrotropin-releasing hormone receptor1001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a1001
interferon gamma precursor0001
D(1A) dopamine receptor1001
transcriptional regulator ERG isoform 31001
ubiquitin-conjugating enzyme E2 N0101
streptokinase A precursor0011
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20011
5-hydroxytryptamine receptor 40202
Serine/threonine-protein kinase D30101
Lysosomal acid glucosylceramidase0011
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Estrogen receptor0012
Tyrosine-protein kinase Lck0101
Procathepsin L0011
Muscarinic acetylcholine receptor M40202
Integrin alpha-IIb1001
Beta-1 adrenergic receptor0202
Muscarinic acetylcholine receptor M50202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Muscarinic acetylcholine receptor M10202
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Beta-3 adrenergic receptor0202
D(2) dopamine receptor0202
Protein kinase C alpha type0101
5-hydroxytryptamine receptor 1A0202
Muscarinic acetylcholine receptor M30202
Cytochrome P450 2B60101
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
Prostaglandin G/H synthase 10101
Protein kinase C eta type0101
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Kappa-type opioid receptor0202
Protein kinase C iota type0101
Melanocortin receptor 30202
Histamine H2 receptor1001
D(1A) dopamine receptor1001
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Sigma non-opioid intracellular receptor 10202
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]