Page last updated: 2024-09-27

Severe Fever with Thrombocytopenia Syndrome

A tick-borne infection with SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME BUNYAVIRUS of the genus Phlebovirus. It is associated with fever, THROMBOCYTOPENIA; LEUKOCYTOPENIA, and multiorgan dysfunction. It is found in parts of Asia including China, Japan, Korea and Vietnam and can be transmitted from infected domestic animals and humans.

Synonyms(3)

Synonym
Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection
Severe Fever with Thrombocytopenia Syndrome
SFTS Virus Infection

Research

Studies (26)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's0 (0.00)28.8240
2020's26 (100.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
1-anilino-8-naphthalenesulfonate0low10
amodiaquine0low10
azathioprine0low10
harmaline0low10
loperamide0low10
tilorone0low10
thyroxine0low10
triiodothyronine0low10
serine0low10
levodopa0low10
methylprednisolone0low10
catechin0low10
pyrazines0medium32
3-hydroxyflavone0low10
ethylnitrosourea0low10
ribavirin0low20
piperacillin0low10
fluorodeoxyglucose f180low10
voriconazole0low10
tazobactam0low10
1-(2-chloroethyl)-3-(1-oxyl-2,2,6,6-tetramethylpiperidinyl)-1-nitrosourea0low10
favipiravir0medium32
caffeic acid0low10
selenium0low10
minocycline0low10
transforming growth factor beta0low10
thromboplastin0low10

Protein Targets (512)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain B, pheromone binding protein0011
Chain A, pheromone binding protein0011
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, RNA-directed RNA polymerase NS50101
acid sphingomyelinase1001
thioredoxin reductase6006
USP1 protein, partial4004
TDP1 protein110011
vitamin D3 receptor isoform VDRA1001
importin subunit beta-1 isoform 16006
flap endonuclease 13003
serine/threonine-protein kinase PLK12002
snurportin-16006
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
GTP-binding nuclear protein Ran isoform 14004
DNA polymerase eta isoform 15005
DNA polymerase iota isoform a (long)5005
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
geminin100010
DNA polymerase kappa isoform 18008
fibroblast growth factor 22 isoform 1 precursor0001
Mitogen-activated protein kinase 130101
Beta-lactamase0202
Transthyretin0125
Fatty acid-binding protein, intestinal0112
Fatty acid-binding protein, adipocyte0112
Cyclin-A20101
Cannabinoid receptor 10011
Cyclin-dependent kinase 20112
Choline O-acetyltransferase0101
Mitogen-activated protein kinase 120101
Guanine nucleotide-binding protein G1001
Fatty acid-binding protein 50011
Fatty acid-binding protein 50011
Mitogen-activated protein kinase 110101
Mitogen-activated protein kinase 140101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, 2-oxoglutarate Oxygenase6006
glp-1 receptor, partial2002
Smad32002
apical membrane antigen 1, AMA14004
cellular tumor antigen p53 isoform a3003
mitogen-activated protein kinase 13003
nuclear receptor ROR-gamma isoform 14004
cytochrome P450 3A4 isoform 16006
lamin isoform A-delta108008
Gamma-aminobutyric acid receptor subunit pi6017
Polyunsaturated fatty acid lipoxygenase ALOX15B2103
Carbonic anhydrase 120203
Carbonic anhydrase 10304
Carbonic anhydrase 20304
Integrin beta-31001
ATP-dependent translocase ABCB10113
Integrin alpha-IIb1001
Calmodulin-10101
Androgen receptor0202
Pyruvate kinase PKM0213
Gamma-aminobutyric acid receptor subunit beta-16017
Polyunsaturated fatty acid lipoxygenase ALOX150101
Polyunsaturated fatty acid lipoxygenase ALOX120101
Gamma-aminobutyric acid receptor subunit delta6017
Gamma-aminobutyric acid receptor subunit gamma-26017
Gamma-aminobutyric acid receptor subunit alpha-56017
Gamma-aminobutyric acid receptor subunit alpha-36017
Gamma-aminobutyric acid receptor subunit gamma-16017
Gamma-aminobutyric acid receptor subunit alpha-26017
Gamma-aminobutyric acid receptor subunit alpha-46017
Gamma-aminobutyric acid receptor subunit gamma-36017
Gamma-aminobutyric acid receptor subunit alpha-66017
Histamine H2 receptor2003
Xanthine dehydrogenase/oxidase0202
Fatty acid synthase0101
Gamma-aminobutyric acid receptor subunit alpha-16017
Gamma-aminobutyric acid receptor subunit beta-36017
Gamma-aminobutyric acid receptor subunit beta-26017
Cytochrome P450 1B10101
Carbonic anhydrase 90203
GABA theta subunit6017
Aurora kinase B0101
Gamma-aminobutyric acid receptor subunit epsilon6017
Dipeptidyl peptidase 30101
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Chain A, Histamine N-methyltransferase0101
Chain A, Histamine N-methyltransferase0101
Chain A, Histamine N-methyltransferase0101
Chain A, Histamine N-methyltransferase0101
cytochrome P450 family 3 subfamily A polypeptide 46006
cytochrome P450 2D62002
Spike glycoprotein0033
Replicase polyprotein 1ab0033
lysosomal alpha-glucosidase preproprotein3003
Transmembrane protease serine 20033
Bile salt export pump010010
Amyloid-beta precursor protein0213
Procathepsin L0033
Replicase polyprotein 1a0033
Replicase polyprotein 1ab0033
Replicase polyprotein 1ab0033
Replicase polyprotein 1ab0336
Cytochrome P450 2C80001
Cytochrome P450 2C9 0303
Nuclear receptor subfamily 4 group A member 20011
Cytochrome P450 2J20202
Spike glycoprotein2035
Angiotensin-converting enzyme 2 0033
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Ferritin light chain2002
interleukin 83003
acetylcholinesterase4004
phosphopantetheinyl transferase4004
RAR-related orphan receptor gamma6006
SMAD family member 22002
ATAD5 protein, partial3003
Fumarate hydratase2002
SMAD family member 32002
GLI family zinc finger 35005
Microtubule-associated protein tau5005
AR protein8008
thioredoxin glutathione reductase2002
nuclear receptor subfamily 1, group I, member 35005
EWS/FLI fusion protein6006
glucocorticoid receptor [Homo sapiens]7007
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha3003
estrogen-related nuclear receptor alpha8008
farnesoid X nuclear receptor5005
pregnane X nuclear receptor6006
estrogen nuclear receptor alpha100010
G5005
polyprotein2002
P531001
peroxisome proliferator-activated receptor delta5005
peroxisome proliferator activated receptor gamma5005
arylsulfatase A6006
IDH12002
euchromatic histone-lysine N-methyltransferase 26006
aryl hydrocarbon receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
thyroid stimulating hormone receptor2002
activating transcription factor 62002
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x4004
Bloom syndrome protein isoform 14004
peripheral myelin protein 22 isoform 14004
hemoglobin subunit beta1001
thyroid hormone receptor beta isoform 27007
heat shock protein beta-11001
nuclear factor erythroid 2-related factor 2 isoform 16006
peripheral myelin protein 225005
survival motor neuron protein isoform d4004
M-phase phosphoprotein 82002
muscleblind-like protein 1 isoform 14004
muscarinic acetylcholine receptor M15005
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Bile salt export pump0101
Voltage-dependent calcium channel gamma-2 subunit4004
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 5005
Cellular tumor antigen p536006
Glutamate receptor 25005
Nuclear receptor ROR-gamma2002
Inositol hexakisphosphate kinase 15005
Canalicular multispecific organic anion transporter 10606
ATPase family AAA domain-containing protein 53003
Ataxin-24004
Protein-arginine deiminase type-40303
cytochrome P450 2C9, partial5005
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
RNA polymerase beta subunit (EC 2.7.7.6), partial0101
endonuclease IV1001
90-kda heat shock protein beta HSP90 beta, partial0101
NFKB1 protein, partial1001
GLS protein4004
aldehyde dehydrogenase 1 family, member A14004
hypothetical protein, conserved1001
bromodomain adjacent to zinc finger domain 2B2002
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
alpha-galactosidase3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
thyroid hormone receptor beta isoform a3003
potassium voltage-gated channel subfamily H member 2 isoform d2002
DNA polymerase beta3003
heat shock protein HSP 90-alpha isoform 20101
Histone deacetylase 30202
Polyphenol oxidase 20102
Lipoxygenase 0101
Aldo-keto reductase family 1 member B100101
Epidermal growth factor receptor0303
Pancreatic triacylglycerol lipase0202
Neuraminidase0101
Interstitial collagenase0101
Prostaglandin G/H synthase 10112
Carbonic anhydrase 30102
Seed linoleate 13S-lipoxygenase-10101
72 kDa type IV collagenase0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Matrix metalloproteinase-90202
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10101
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Acetylcholinesterase0202
Carbonic anhydrase 40203
Prostaglandin G/H synthase 10202
Carbonic anhydrase 60203
Sucrase-isomaltase, intestinal0202
Adenosine receptor A10203
Dipeptidyl peptidase 40101
Adenosine receptor A2a0203
Type-1 angiotensin II receptor0101
Carbonic anhydrase 5A, mitochondrial0102
Tyrosine-protein phosphatase non-receptor type 70101
Prostaglandin G/H synthase 20202
Linoleate 9S-lipoxygenase-40101
Carbonic anhydrase 70102
Dual specificity protein phosphatase 30101
Histone deacetylase 40202
Anthrax toxin receptor 20101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Hyaluronidase-10101
Histone deacetylase 10202
Arginase-10101
BiP isoform A0101
Dihydroorotate dehydrogenase 0202
Lysosomal alpha-glucosidase0101
Integrase 0101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
Carbonic anhydrase 130102
Histone deacetylase 60202
Histone deacetylase 90202
Carbonic anhydrase 140102
Histone deacetylase 50202
Carbonic anhydrase 5B, mitochondrial0102
ATP-dependent phosphofructokinase4004
large T antigen0101
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
neuropeptide S receptor isoform A2002
Prostaglandin G/H synthase 1 0101
Arginase 0202
Prothrombin0123
Aldo-keto reductase family 1 member B10101
Mu-type opioid receptor0203
Delta-type opioid receptor0214
Kappa-type opioid receptor0203
Melatonin receptor type 1A0011
Melatonin receptor type 1B0011
Death-associated protein kinase 10101
Beta-secretase 10101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 30101
pregnane X receptor1001
progesterone receptor3003
lethal factor (plasmid)3003
Chain A, Beta-lactamase1001
Chain A, Cruzipain1001
thyroid stimulating hormone receptor3003
STE240001
serine-protein kinase ATM isoform a1001
cytochrome P450 2D6 isoform 12002
huntingtin isoform 22002
dual specificity tyrosine-phosphorylation-regulated kinase 1A0001
histone acetyltransferase KAT2A isoform 11001
caspase-1 isoform alpha precursor1001
Acetylcholinesterase0202
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A 0101
Amine oxidase [flavin-containing] A0101
Amine oxidase [flavin-containing] B0101
5-hydroxytryptamine receptor 5A0101
Caspase-71001
Inositol monophosphatase 12002
Luciferase2002
dopamine D1 receptor1001
15-lipoxygenase, partial2002
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
pyruvate kinase1001
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 13003
glucokinase regulatory protein1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
Plasma kallikrein0001
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Tyrosinase0101
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Solute carrier family 15 member 10202
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Glutamate receptor ionotropic, NMDA 3B0001
Monocarboxylate transporter 100001
Carbonic anhydrase 150001
Glutamate receptor ionotropic, NMDA 3A0001
phosphoglycerate kinase1001
PPM1D protein2002
Thrombopoietin2002
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
polyunsaturated fatty acid lipoxygenase ALOX121001
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
Menin0101
Cocaine esterase0202
Solute carrier family 22 member 1 0101
Beta-2 adrenergic receptor0202
Cytochrome P450 2D60101
D(2) dopamine receptor0101
D(4) dopamine receptor0101
Histamine H2 receptor0202
Sodium-dependent serotonin transporter0202
Delta-type opioid receptor0101
Mu-type opioid receptor0101
D(3) dopamine receptor0202
Nociceptin receptor0101
5-hydroxytryptamine receptor 2B0202
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 70101
Calmodulin 0112
Disintegrin and metalloproteinase domain-containing protein 171001
Mu-type opioid receptor0011
Angiopoietin-1 receptor0011
Potassium voltage-gated channel subfamily H member 20202
Sodium channel protein type 5 subunit alpha0101
Sigma non-opioid intracellular receptor 10202
hypoxia-inducible factor 1 alpha subunit1001
nonstructural protein 11001
nuclear receptor subfamily 1, group I, member 21001
nuclear factor erythroid 2-related factor 2 isoform 22002
Nuclear receptor subfamily 1 group I member 20022
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Androgen receptor0202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Nuclear receptor subfamily 1 group I member 20011
Albumin0011
Stromelysin-10101
Matrilysin0101
Multidrug transporter MdfA0101
Protein mono-ADP-ribosyltransferase PARP150101
Beta-lactamase 0102
Beta-lactamase 0202
Beta-lactamase 0102
Beta-lactamase 0102
Beta-lactamase 0001
Beta-lactamase 0102
Beta-lactamase 0001
Beta-lactamase 0102
Metallo-beta-lactamase type 20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0102
Beta-lactamase 0001
Beta-lactamase 0001
Voltage-dependent L-type calcium channel subunit alpha-1F0303
Beta-lactamase SHV-10102
Beta-lactamase SHV-10203
Beta-lactamase0102
Beta-lactamase OXA-70001
Kappa-type opioid receptor0001
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0102
Beta-lactamase 0102
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0102
Beta-lactamase 0001
Class D beta-lactamase0102
Beta-lactamase 0102
Beta-lactamase 0102
Beta-lactamase 0001
Metallo-b-lactamase 0002
BlaVIM-1 0001
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0203
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0002
Beta-lactamase VIM-1 0001
NS5 0011
glycogen synthase kinase-3 beta isoform 10011
Rap guanine nucleotide exchange factor 32002
Polymerase basic protein 20011
RNA-directed RNA polymerase catalytic subunit0011
Polymerase acidic protein0011
Adenosine receptor A30101
Adenosylhomocysteinase0002
Adenosine receptor A2a0101
Adenosine receptor A10303
Adenosine receptor A10101
Genome polyprotein0011
Neutral amino acid transporter A0101
Cholinesterase0101
Neutral amino acid transporter B(0)0101
Proton-coupled amino acid transporter 10101
Amino acid transporter0101
Beta-lactamase 0101
Beta-lactamase 0101
B2 bradykinin receptor0101
Beta-lactamase0101
Beta-lactamase0101
Beta-lactamase0101
Beta-lactamase0203
Beta-lactamase OXA-10102
5-hydroxytryptamine receptor 1A0101
Cytochrome P450 2B60202
Metallo-beta-lactamase type 20101
Angiotensin-converting enzyme0101
Metallo-beta-lactamase L1 type 30101
Beta-lactamase TEM0202
Beta-lactamase0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
Solute carrier organic anion transporter family member 1A40103
Solute carrier organic anion transporter family member 1A50002
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0044
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 1A30002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10002
estrogen receptor 2 (ER beta)1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
cystic fibrosis transmembrane conductance regulator0101
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Neuronal acetylcholine receptor subunit beta-20011
Neuronal acetylcholine receptor subunit beta-40011
Neuronal acetylcholine receptor subunit alpha-30011
Neuronal acetylcholine receptor subunit alpha-70011
Neuronal acetylcholine receptor subunit alpha-40011
DNA primase0101
Neuronal acetylcholine receptor subunit alpha-70011
glucocerebrosidase1001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-10101
Thyroid hormone receptor beta0101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sigma non-opioid intracellular receptor 10011
Solute carrier organic anion transporter family member 4C10001
Gamma-aminobutyric acid receptor subunit gamma-10101
Solute carrier organic anion transporter family member 4A10001
Gamma-aminobutyric acid receptor subunit gamma-30101
Solute carrier organic anion transporter family member 1C10101
Solute carrier organic anion transporter family member 1B30001
Gamma-aminobutyric acid receptor subunit theta0101
Sterol 14-alpha-demethylase0011
14-alpha sterol demethylase 0011
Cholesterol side-chain cleavage enzyme, mitochondrial 0011
Cytochrome P450 3A40101
Lanosterol 14-alpha demethylase0011
Cytochrome P450 2C190101
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Sterol 14-alpha demethylase0011
14-alpha sterol demethylase 0011
14-alpha sterol demethylase 0011
Cholesterol 24-hydroxylase0213
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]