Page last updated: 2024-09-27

Schnitzler Syndrome

An extremely rare condition manifested as monoclonal IMMUNOGLOBULIN M dysproteinemia without features of lymphoproliferative disease, but with chronic urticaria, fever of unknown origin, disabling bone pain, hyperostosis, and increased erythrocyte sedimentation rate.

Synonyms(1)

Synonym
Schnitzler Syndrome

Research Excerpts

Overview

ExcerptReference
"Schnitzler syndrome is a rare disease characterized by a chronic urticarial rash and a monoclonal gammopathy."( Brasch, J; Eiling, E; Kreiselmaier, I; Möller, M; Schwarz, T, 2007)
"Schnitzler syndrome is characterized by chronic urticarial rash and monoclonal IgM gammopathy and is sometimes associated with periodic fever, arthralgias, and bone pain."( Arnulf, B; Asli, B; Bienvenu, B; Brouet, JC; Cordoliani, F; Fermand, JP; Malphettes, M; Rybojad, M; Uzunhan, Y, 2007)
"Schnitzler syndrome is a rare disease of adult-onset with main features including chronic urticarial rash, recurrent fever, arthralgia or arthritis, monoclonal gammopathy of undetermined significance (MGUS), and marked systemic inflammation."( Chu, CQ, 2022)
"Schnitzler syndrome is a rare adult-onset acquired autoinflammatory disorder typically characterized by chronic urticarial rash and immunoglobulin M (IgM) (rarely IgG) monoclonal gammopathy."( Huang, Y; Li, J; Li, L; Mao, X; Wang, B; Wang, Y; Yu, F, 2022)

Research

Studies (38)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's15 (39.47)18.1394
2010's14 (36.84)28.8240
2020's9 (23.68)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low40
4-aminobenzoic acid0low10
aspirin0low20
azathioprine0low20
dapsone0low20
doxepin0low10
pamidronate0low10
thalidomide0low20
prednisolone0low30
prednisone0low70
colchicine0low60
congo red0low10
trolamine salicylate0low20
pefloxacin0low20
fluorodeoxyglucose f180low10
bendamustine hydrochloride0low10
methotrexate0low40
tofacitinib0low10
vx 7650low10
pci 327650low40
piperidines0low50
cyclosporine0low30
technetium tc 99m medronate0low10

Protein Targets (905)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE8008
Genome polyprotein 0011
USP1 protein, partial3003
AR protein120012
thyroid stimulating hormone receptor4004
glucocorticoid receptor [Homo sapiens]110011
retinoic acid nuclear receptor alpha variant 16006
estrogen nuclear receptor alpha120012
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
Histone H2A.x4004
chromobox protein homolog 13003
transcriptional regulator ERG isoform 32002
geminin8008
Polyphenol oxidase 20101
Cellular tumor antigen p537007
Thiopurine S-methyltransferase0101
Succinate-semialdehyde dehydrogenase, mitochondrial0101
4-aminobutyrate aminotransferase, mitochondrial0101
Cytochrome P450 1B10101
Dihydropteroate synthase 0011
Chain A, Toluene-4-monooxygenase system protein A0101
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
RAR-related orphan receptor gamma7007
TDP1 protein100010
nuclear receptor subfamily 1, group I, member 36006
cytochrome P450 family 3 subfamily A polypeptide 48008
estrogen-related nuclear receptor alpha110011
pregnane X nuclear receptor6006
nuclear factor erythroid 2-related factor 2 isoform 26006
heat shock protein beta-12002
importin subunit beta-1 isoform 12002
snurportin-12002
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
lamin isoform A-delta107007
Voltage-dependent calcium channel gamma-2 subunit6006
Bile salt export pump012012
Cyclin-dependent kinase 10123
Heat shock protein HSP 90-beta0101
Glutamate receptor 26006
Xanthine dehydrogenase/oxidase0101
TAR DNA-binding protein 432002
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20213
ATPase family AAA domain-containing protein 56006
Ataxin-26006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase2002
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 84004
thioredoxin reductase5005
GLS protein1001
aldehyde dehydrogenase 1 family, member A14004
hypothetical protein, conserved1001
EWS/FLI fusion protein6006
cytochrome P450 2D62002
glucocerebrosidase2002
peroxisome proliferator-activated receptor delta5005
Rac1 protein0011
IDH15005
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
euchromatic histone-lysine N-methyltransferase 25005
Bloom syndrome protein isoform 14004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
DNA polymerase iota isoform a (long)3003
DNA polymerase kappa isoform 12002
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)2002
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010011
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0437
Carbonic anhydrase 10202
Carbonic anhydrase 20213
Fatty acid-binding protein, liver0202
Integrin beta-31102
Myeloperoxidase0202
Prostaglandin G/H synthase 10202
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb1102
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 20314
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma5005
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-13104
Prostaglandin G/H synthase 20202
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Canalicular multispecific organic anion transporter 1010010
Sigma non-opioid intracellular receptor 10314
Sigma non-opioid intracellular receptor 10011
Chain A, Ferritin light chain3003
acetylcholinesterase3003
phosphopantetheinyl transferase2002
SMAD family member 21001
ATAD5 protein, partial3003
Fumarate hydratase3003
SMAD family member 31001
GLI family zinc finger 37007
Microtubule-associated protein tau2002
thioredoxin glutathione reductase2002
retinoid X nuclear receptor alpha7007
farnesoid X nuclear receptor4004
G3003
polyprotein3003
P531001
peroxisome proliferator activated receptor gamma5005
arylsulfatase A2002
aryl hydrocarbon receptor4004
thyroid stimulating hormone receptor2002
activating transcription factor 63003
v-jun sarcoma virus 17 oncogene homolog (avian)5005
peripheral myelin protein 22 isoform 11001
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a3003
thyroid hormone receptor beta isoform 26006
nuclear factor erythroid 2-related factor 2 isoform 14004
peripheral myelin protein 223003
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 82002
muscleblind-like protein 1 isoform 15005
Gamma-aminobutyric acid receptor subunit pi3003
Bile salt export pump0303
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 3003
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
GABA theta subunit3003
Inositol hexakisphosphate kinase 13003
Gamma-aminobutyric acid receptor subunit epsilon3003
Protein-arginine deiminase type-40202
cytochrome P450 2C9, partial3003
Chain A, Beta-lactamase1001
Luciferase2002
endonuclease IV1001
PAX80001
pregnane X receptor2002
hypoxia-inducible factor 1 alpha subunit4004
PPM1D protein4004
Thrombopoietin1001
Smad33003
estrogen receptor 2 (ER beta)4004
67.9K protein4004
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
nuclear receptor subfamily 1, group I, member 23003
cytochrome P450 2D6 isoform 11001
nuclear receptor subfamily 0 group B member 10101
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor2002
thyroid hormone receptor beta isoform a2002
atrial natriuretic peptide receptor 2 precursor1001
flap endonuclease 12002
ras-related protein Rab-9A1001
steroidogenic factor 10101
caspase-1 isoform alpha precursor2002
neuropeptide S receptor isoform A1001
Solute carrier family 22 member 30202
Tubulin alpha-1A chain0213
Tubulin beta chain0213
Plasma kallikrein0001
Tubulin beta-4A chain0225
ATP-dependent translocase ABCB10101
Tubulin beta chain0225
ATP-dependent translocase ABCB10102
Cytochrome P450 3A40304
Tubulin alpha-3C chain0225
Serine/threonine-protein kinase pim-10123
ATP-dependent translocase ABCB10101
Histamine H2 receptor2104
Tubulin alpha-1B chain0225
Tubulin alpha-4A chain0225
Tubulin beta-4B chain0225
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0225
Tubulin beta-2A chain0225
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0225
Tubulin beta-2B chain0202
Tubulin alpha-3E chain0225
Tubulin alpha-1A chain0225
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
CREB-binding protein1001
Tubulin alpha-1C chain0225
Tubulin beta-6 chain0225
Tubulin beta-2B chain0225
Tubulin beta-1 chain0225
ATP-dependent phosphofructokinase3003
B2 bradykinin receptor0101
Dihydrofolate reductase0204
Dihydrofolate reductase0202
Chymotrypsinogen A0001
Beta-lactamase0101
Amyloid-beta precursor protein0202
Beta-lactamase0001
5-hydroxytryptamine receptor 2A0203
Beta-galactosidase0102
5-hydroxytryptamine receptor 1A0404
Choline O-acetyltransferase0101
Ectonucleotide pyrophosphatase/phosphodiesterase family member 20202
PH domain leucine-rich repeat-containing protein phosphatase 20101
Chymotrypsin-C0101
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase 0101
bromodomain adjacent to zinc finger domain 2B2002
Dihydrofolate reductase0303
5-hydroxytryptamine receptor 60303
Solute carrier family 22 member 1 0101
5-hydroxytryptamine receptor 40202
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40303
5-hydroxytryptamine receptor 2C0203
Muscarinic acetylcholine receptor M50303
Alpha-2A adrenergic receptor0303
Muscarinic acetylcholine receptor M10303
Alpha-2B adrenergic receptor0303
Alpha-2C adrenergic receptor0303
Muscarinic acetylcholine receptor M30303
D(1A) dopamine receptor0202
Sodium-dependent noradrenaline transporter 0202
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0404
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 60101
Histamine H1 receptor0012
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0202
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Histamine H1 receptor0202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 4 0101
Histamine H3 receptor0001
5-hydroxytryptamine receptor 3B0101
Genome polyprotein 0101
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Spike glycoprotein2013
Potassium voltage-gated channel subfamily H member 20303
Sigma intracellular receptor 20101
Cyclic GMP-AMP synthase0101
Angiotensin-converting enzyme 2 0011
Toll-like receptor 90101
Toll-like receptor 70101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
dopamine D1 receptor1001
ClpP1001
15-lipoxygenase, partial1001
progesterone receptor4004
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
vitamin D3 receptor isoform VDRA2002
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
histone acetyltransferase KAT2A isoform 12002
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10033
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20235
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80001
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Broad substrate specificity ATP-binding cassette transporter ABCG20001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
nonstructural protein 11001
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10606
Androgen receptor0303
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Nuclear receptor subfamily 1 group I member 20011
Geranylgeranyl pyrophosphate synthase0101
Farnesyl pyrophosphate synthase0202
Hypoxanthine-guanine phosphoribosyltransferase0101
Farnesyl pyrophosphate synthase 0101
tyrosine-protein kinase Yes2002
Bone morphogenetic protein receptor type-1B0022
Cell division cycle 7-related protein kinase0011
Serine/threonine-protein kinase PLK40022
ATP-dependent RNA helicase DDX3X0022
Pyridoxal kinase0022
Citron Rho-interacting kinase0022
Serine/threonine-protein kinase Chk10123
Aurora kinase A0022
Cyclin-G-associated kinase0022
Ephrin type-B receptor 60022
Peroxisomal acyl-coenzyme A oxidase 30022
Receptor-interacting serine/threonine-protein kinase 20022
Mitotic checkpoint serine/threonine-protein kinase BUB10022
Testosterone 17-beta-dehydrogenase 30101
Dynamin-like 120 kDa protein, mitochondrial0022
Putative nucleoside diphosphate kinase0011
Tyrosine-protein kinase JAK20529
Rho-associated protein kinase 20123
Serine/threonine-protein kinase ULK10022
Serine/threonine-protein kinase/endoribonuclease IRE10022
Ribosomal protein S6 kinase alpha-50123
U5 small nuclear ribonucleoprotein 200 kDa helicase0022
Ribosomal protein S6 kinase alpha-40022
Serine/threonine-protein kinase 160022
Serine/threonine-protein kinase 100022
Serine/threonine-protein kinase D30022
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60022
Mitogen-activated protein kinase kinase kinase kinase 40022
Serine/threonine-protein kinase LATS10022
Serine/threonine-protein kinase PAK 40022
Receptor tyrosine-protein kinase erbB-20224
High affinity nerve growth factor receptor0022
Guanine nucleotide-binding protein G(i) subunit alpha-20011
ADP/ATP translocase 20022
Cytochrome P450 1A20101
Protein kinase C beta type0022
Insulin receptor0123
Tyrosine-protein kinase Lck0224
Tyrosine-protein kinase Fyn0123
Glycogen phosphorylase, liver form0022
Tyrosine-protein kinase Fes/Fps0022
Macrophage colony-stimulating factor 1 receptor0112
Adenine phosphoribosyltransferase0011
Tyrosine-protein kinase Yes0123
Tyrosine-protein kinase Lyn0123
Proto-oncogene tyrosine-protein kinase receptor Ret0123
Insulin-like growth factor 1 receptor0022
Signal recognition particle receptor subunit alpha0022
Cytochrome c1, heme protein, mitochondrial0022
Hepatocyte growth factor receptor0022
Tyrosine-protein kinase HCK0123
Platelet-derived growth factor receptor beta0123
Tyrosine-protein kinase Fgr0112
Serine/threonine-protein kinase A-Raf0022
Cytochrome P450 2C80203
Cytochrome P450 2D60202
Glycogen phosphorylase, brain form0022
Breakpoint cluster region protein0022
Fibroblast growth factor receptor 10022
DNA topoisomerase 2-alpha0022
Cytochrome P450 2C9 0203
Cyclin-dependent kinase 40022
ADP/ATP translocase 30022
Inosine-5'-monophosphate dehydrogenase 20011
Proto-oncogene tyrosine-protein kinase Src0123
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Serine/threonine-protein kinase B-raf0022
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0022
Ribosyldihydronicotinamide dehydrogenase [quinone]0022
Tyrosine-protein kinase Fer0022
Protein kinase C alpha type0123
cAMP-dependent protein kinase catalytic subunit alpha0022
General transcription and DNA repair factor IIH helicase subunit XPD0022
Casein kinase II subunit alpha'0022
Ras-related protein Rab-6A0022
Cytochrome P450 2B60102
Ephrin type-A receptor 10022
Receptor tyrosine-protein kinase erbB-30112
Multifunctional protein ADE20022
Nucleoside diphosphate kinase B0011
cAMP-dependent protein kinase catalytic subunit gamma0022
cAMP-dependent protein kinase catalytic subunit beta0022
Ferrochelatase, mitochondrial0022
Ribosomal protein S6 kinase beta-10123
Tyrosine-protein kinase JAK105310
G1/S-specific cyclin-E10101
Beta-adrenergic receptor kinase 10022
Probable ATP-dependent RNA helicase DDX60022
Mitogen-activated protein kinase 3 0022
MAP/microtubule affinity-regulating kinase 30022
Deoxycytidine kinase0022
Mitogen-activated protein kinase 10022
Ephrin type-A receptor 20123
Ephrin type-B receptor 20022
Non-receptor tyrosine-protein kinase TYK20338
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0022
Heme oxygenase 20022
S-adenosylmethionine synthase isoform type-20022
DnaJ homolog subfamily A member 10022
RAC-alpha serine/threonine-protein kinase0123
RAC-beta serine/threonine-protein kinase0022
Cytochrome P450 2C190203
Dual specificity protein kinase TTK0022
DNA replication licensing factor MCM40011
Myosin-100011
Dual specificity mitogen-activated protein kinase kinase 20123
Receptor-type tyrosine-protein kinase FLT30224
Bone morphogenetic protein receptor type-1A0022
Activin receptor type-1B0022
TGF-beta receptor type-10022
TGF-beta receptor type-20022
Tyrosine-protein kinase CSK0224
Glycine--tRNA ligase0022
Protein kinase C iota type0022
Exosome RNA helicase MTR40022
Tyrosine-protein kinase Tec0224
Tyrosine-protein kinase TXK0224
Tyrosine-protein kinase ABL20022
Tyrosine-protein kinase FRK0123
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase SYK0123
26S proteasome regulatory subunit 6B0022
Mitogen-activated protein kinase 80123
Mitogen-activated protein kinase 90022
Dual specificity mitogen-activated protein kinase kinase 30022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Casein kinase I isoform delta0022
MAP kinase-activated protein kinase 20123
Elongation factor Tu, mitochondrial0022
Choline-phosphate cytidylyltransferase A0011
Casein kinase I isoform epsilon0022
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0022
Dual specificity protein kinase CLK10022
Dual specificity protein kinase CLK20022
Glycogen synthase kinase-3 alpha0022
Glycogen synthase kinase-3 beta0123
Cyclin-dependent kinase 70022
Cyclin-dependent kinase 90022
Ras-related protein Rab-27A0011
Tyrosine-protein kinase Blk0224
Interleukin-1 receptor-associated kinase 10022
Ribosomal protein S6 kinase alpha-30123
Cytoplasmic tyrosine-protein kinase BMX0325
cAMP-dependent protein kinase catalytic subunit PRKX0022
Serine/threonine-protein kinase Nek20022
Serine/threonine-protein kinase Nek30022
Tyrosine-protein kinase JAK304310
Dual specificity mitogen-activated protein kinase kinase 60022
Serine/threonine-protein kinase PLK10022
LIM domain kinase 10022
LIM domain kinase 20022
Mitogen-activated protein kinase 100022
Tyrosine--tRNA ligase, cytoplasmic0022
5'-AMP-activated protein kinase subunit gamma-10022
Ephrin type-B receptor 30022
Ephrin type-A receptor 50022
Ephrin type-B receptor 40022
Ephrin type-A receptor 40022
Adenylate kinase 2, mitochondrial0022
Adenosine kinase0022
Ras-related protein Rab-100022
Actin-related protein 30022
Actin-related protein 20011
GTP-binding nuclear protein Ran0022
Casein kinase I isoform gamma-20022
Cyclin-dependent kinase 30022
Cyclin-dependent kinase 60022
Cyclin-dependent-like kinase 5 0123
Cyclin-dependent kinase 160022
Cyclin-dependent kinase 170022
ATP-dependent 6-phosphofructokinase, platelet type0022
Dual specificity mitogen-activated protein kinase kinase 10022
DNA topoisomerase 2-beta0022
Protein kinase C theta type0022
Activin receptor type-10022
Macrophage-stimulating protein receptor0022
Focal adhesion kinase 10022
Protein kinase C delta type0022
Tyrosine-protein kinase BTK0336
Activated CDC42 kinase 10022
Epithelial discoidin domain-containing receptor 10022
Tyrosine-protein kinase ITK/TSK0224
Mitogen-activated protein kinase kinase kinase kinase 20022
Tyrosine-protein kinase Mer0022
Serine/threonine-protein kinase 40022
5'-AMP-activated protein kinase catalytic subunit alpha-10022
Dual specificity mitogen-activated protein kinase kinase 50022
Mitogen-activated protein kinase 70022
Serine/threonine-protein kinase PAK 20022
Serine/threonine-protein kinase 30022
Mitogen-activated protein kinase kinase kinase 10022
Integrin-linked protein kinase0022
Rho-associated protein kinase 10022
Non-receptor tyrosine-protein kinase TNK10022
Calcium/calmodulin-dependent protein kinase type II subunit gamma0022
Calcium/calmodulin-dependent protein kinase type II subunit delta0022
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0022
Activin receptor type-2B0022
Bone morphogenetic protein receptor type-20022
Protein-tyrosine kinase 60123
cGMP-dependent protein kinase 1 0022
Cyclin-dependent kinase 130022
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0022
Protein-tyrosine kinase 2-beta0022
Maternal embryonic leucine zipper kinase0022
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40022
Serine/threonine-protein kinase 380022
Receptor tyrosine-protein kinase erbB-40224
Ephrin type-A receptor 70022
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10123
Myosin light chain kinase, smooth muscle0022
Mitogen-activated protein kinase 110123
Serine/threonine-protein kinase STK110022
Serine/threonine-protein kinase N10022
Serine/threonine-protein kinase N20022
Mitogen-activated protein kinase 140123
Calcium/calmodulin-dependent protein kinase type IV0022
Mitogen-activated protein kinase kinase kinase 110022
MAP kinase-activated protein kinase 30011
Discoidin domain-containing receptor 20022
AP2-associated protein kinase 10022
Myosin light chain kinase 30022
Putative heat shock protein HSP 90-beta 20022
Rab-like protein 30022
Sigma intracellular receptor 20202
Serine/threonine-protein kinase MRCK alpha0022
Serine/threonine-protein kinase MRCK gamma0022
Acyl-CoA dehydrogenase family member 100022
Serine/threonine-protein kinase ULK30022
Uncharacterized protein FLJ452520022
Acyl-CoA dehydrogenase family member 110011
Serine/threonine-protein kinase/endoribonuclease IRE20022
Serine/threonine-protein kinase MARK20022
ATP-dependent RNA helicase DHX300022
Serine/threonine-protein kinase TAO10022
STE20-related kinase adapter protein alpha0022
Myosin-140022
AarF domain-containing protein kinase 10022
ATP-dependent RNA helicase DDX420011
Mitogen-activated protein kinase kinase kinase kinase 30022
MAP kinase-activated protein kinase 50123
Misshapen-like kinase 10022
Atypical kinase COQ8A, mitochondrial0022
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0022
Mitogen-activated protein kinase 150022
Serine/threonine-protein kinase Nek90022
Serine/threonine-protein kinase Nek70022
ATP-dependent RNA helicase DDX10022
Nuclear receptor subfamily 4 group A member 30101
Mitogen-activated protein kinase kinase kinase kinase 10022
Aurora kinase B0022
MAP/microtubule affinity-regulating kinase 40022
Calcium/calmodulin-dependent protein kinase type 1G0022
Serine/threonine-protein kinase Nek10022
PAS domain-containing serine/threonine-protein kinase0022
Calcium/calmodulin-dependent protein kinase kinase 20022
EKC/KEOPS complex subunit TP53RK0022
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0022
Mitogen-activated protein kinase kinase kinase 50022
Mitogen-activated protein kinase kinase kinase 30022
Eukaryotic translation initiation factor 2-alpha kinase 10022
Peroxiredoxin-like 2A0101
Nucleolar GTP-binding protein 10022
Serine/threonine-protein kinase D20022
NUAK family SNF1-like kinase 20022
RNA cytidine acetyltransferase0022
Serine/threonine-protein kinase SIK20022
STE20-like serine/threonine-protein kinase 0022
Serine/threonine-protein kinase TAO30022
dCTP pyrophosphatase 10022
Dual specificity protein kinase CLK40022
Platelet glycoprotein VI0101
Casein kinase I isoform gamma-10022
Serine/threonine-protein kinase PAK 60022
Phenylalanine--tRNA ligase beta subunit0022
BMP-2-inducible protein kinase0022
Obg-like ATPase 10011
Midasin0022
Interleukin-1 receptor-associated kinase 40022
Mitogen-activated protein kinase kinase kinase 200022
Cyclin-dependent kinase 120022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130022
Serine/threonine-protein kinase 260022
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0022
Serine/threonine-protein kinase NLK0022
5'-AMP-activated protein kinase subunit gamma-20022
Serine/threonine-protein kinase TBK10123
Septin-90022
Ribosomal protein S6 kinase alpha-60022
TRAF2 and NCK-interacting protein kinase0022
Serine/threonine-protein kinase TAO20022
Serine/threonine-protein kinase ICK0022
RAC-gamma serine/threonine-protein kinase0022
Serine/threonine-protein kinase SIK30022
Mitogen-activated protein kinase kinase kinase 20022
Thyroid hormone receptor-associated protein 30022
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0022
Mitogen-activated protein kinase kinase kinase kinase 50022
Receptor-interacting serine/threonine-protein kinase 30022
Serine/threonine-protein kinase MRCK beta0022
Interleukin-1 receptor-associated kinase 30022
Serine/threonine-protein kinase 240022
Casein kinase I isoform gamma-30022
Mitogen-activated protein kinase kinase kinase 40022
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
nuclear receptor ROR-gamma isoform 11001
Cereblon isoform 40202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase JAK20101
Leukotriene C4 synthase0011
Serine/threonine-protein kinase Sgk10101
Membrane-associated progesterone receptor component 10011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0011
Serine/threonine-protein kinase 250011
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0011
Serine/threonine-protein kinase RIO30011
Dual specificity mitogen-activated protein kinase kinase 70112
Inhibitor of nuclear factor kappa-B kinase subunit beta0011
Peripheral plasma membrane protein CASK0011
Serine/threonine-protein kinase DCLK10011
Inhibitor of nuclear factor kappa-B kinase subunit alpha0011
Muscle, skeletal receptor tyrosine-protein kinase0011
Mitogen-activated protein kinase 130112
3-phosphoinositide-dependent protein kinase 10011
Mitogen-activated protein kinase kinase kinase 130011
Death-associated protein kinase 30011
Mitogen-activated protein kinase kinase kinase 70011
NUAK family SNF1-like kinase 10011
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0011
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0011
Serine/threonine-protein kinase PAK 30011
Cyclin-dependent kinase-like 50011
Serine/threonine-protein kinase 17B0011
Cyclin-dependent kinase 140011
Serine/threonine-protein kinase OSR10011
Serine/threonine-protein kinase Chk20011
RAF proto-oncogene serine/threonine-protein kinase0011
Proto-oncogene tyrosine-protein kinase ROS0011
Wee1-like protein kinase 20011
Uncharacterized serine/threonine-protein kinase SBK30011
Mast/stem cell growth factor receptor Kit0011
Cytochrome P450 2A60101
Myosin light chain kinase, smooth muscle0011
Insulin receptor-related protein0011
Platelet-derived growth factor receptor alpha0011
Vascular endothelial growth factor receptor 1 0011
Interferon-induced, double-stranded RNA-activated protein kinase0011
Serine/threonine-protein kinase MAK0011
Cyclin-dependent kinase 11B0011
Fibroblast growth factor receptor 20011
Fibroblast growth factor receptor 40011
Fibroblast growth factor receptor 30011
Protein kinase C eta type0011
Activin receptor type-2A0011
Ephrin type-A receptor 30011
Ephrin type-A receptor 80011
Leukocyte tyrosine kinase receptor0011
Tyrosine-protein kinase receptor UFO0011
Mitogen-activated protein kinase 40011
G protein-coupled receptor kinase 40011
Tyrosine-protein kinase receptor Tie-10011
Vascular endothelial growth factor receptor 30011
Vascular endothelial growth factor receptor 20011
Serine/threonine-protein kinase receptor R30011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0112
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0011
Serine/threonine-protein kinase mTOR0011
Megakaryocyte-associated tyrosine-protein kinase0011
Tyrosine-protein kinase ZAP-700011
Dual specificity mitogen-activated protein kinase kinase 40011
Casein kinase I isoform alpha0011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0011
Cyclin-dependent kinase 80011
Cysteine--tRNA ligase, cytoplasmic0011
Dual specificity protein kinase CLK30011
Serine/threonine-protein kinase Nek40011
Death-associated protein kinase 10011
Mitogen-activated protein kinase 120112
5'-AMP-activated protein kinase catalytic subunit alpha-20011
Ephrin type-B receptor 10011
Hormonally up-regulated neu tumor-associated kinase0011
Serine/threonine-protein kinase SIK10011
Receptor-interacting serine/threonine-protein kinase 40011
Cell division control protein 2 homolog0011
Calcium-dependent protein kinase 10011
Tubulin alpha-1A chain0011
Casein kinase II subunit alpha0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0011
SRSF protein kinase 20011
Mitogen-activated protein kinase kinase kinase 90011
Serine/threonine-protein kinase PknB0011
Cyclin-dependent kinase-like 10011
Glutamate receptor ionotropic, NMDA 2B0101
Protein kinase C epsilon type0011
Angiopoietin-1 receptor0011
Mitogen-activated protein kinase kinase kinase 100011
Tyrosine-protein kinase receptor TYRO30011
Cyclin-dependent kinase 180011
Myotonin-protein kinase0011
Mitogen-activated protein kinase kinase kinase 120011
Serine/threonine-protein kinase PAK 10011
cGMP-dependent protein kinase 20011
Serine/threonine-protein kinase PRP4 homolog0011
Serine/threonine-protein kinase ATR0011
Receptor-interacting serine/threonine-protein kinase 10011
Calcium/calmodulin-dependent protein kinase type II subunit beta0011
Calcium/calmodulin-dependent protein kinase type 10011
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
Serine/threonine-protein kinase D10011
Ribosomal protein S6 kinase alpha-20011
Dual specificity testis-specific protein kinase 10011
Rhodopsin kinase GRK10011
NT-3 growth factor receptor0011
BDNF/NT-3 growth factors receptor0011
Mitogen-activated protein kinase 60011
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0011
Uncharacterized aarF domain-containing protein kinase 50011
Serine/threonine-protein kinase SBK10011
Mitogen-activated protein kinase kinase kinase 190011
Serine/threonine-protein kinase TNNI3K0011
Tyrosine-protein kinase JAK30101
Tyrosine-protein kinase JAK20101
Tyrosine-protein kinase JAK30101
Serine/threonine-protein kinase Nek50011
Dual serine/threonine and tyrosine protein kinase0011
Mitogen-activated protein kinase kinase kinase 150011
Serine/threonine-protein kinase tousled-like 20011
Serine/threonine-protein kinase 32C0011
Serine/threonine-protein kinase pim-30011
Serine/threonine-protein kinase VRK20011
Myosin light chain kinase family member 40011
Homeodomain-interacting protein kinase 10011
Calcium/calmodulin-dependent protein kinase type 1D0011
Cyclin-dependent kinase-like 30011
Serine/threonine-protein kinase BRSK20011
Serine/threonine-protein kinase NIM10011
Serine/threonine-protein kinase ULK20011
Serine/threonine-protein kinase DCLK20011
Calcium/calmodulin-dependent protein kinase kinase 10011
Casein kinase I isoform alpha-like0011
Homeodomain-interacting protein kinase 40011
Myosin-IIIa0011
Ankyrin repeat and protein kinase domain-containing protein 10011
Serine/threonine-protein kinase Nek110011
Serine/threonine-protein kinase BRSK10011
Serine/threonine-protein kinase 350011
Rhodopsin kinase GRK70011
Serine/threonine-protein kinase 32A0011
Myosin-IIIb0011
Dual specificity tyrosine-phosphorylation-regulated kinase 20011
Cyclin-dependent kinase-like 20011
Serine/threonine-protein kinase Sgk30011
Atypical kinase COQ8B, mitochondrial0011
Cyclin-dependent kinase 150011
Dual specificity testis-specific protein kinase 20011
SRSF protein kinase 10011
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0011
Serine/threonine-protein kinase RIO10011
MAP kinase-interacting serine/threonine-protein kinase 10011
Serine/threonine-protein kinase RIO20011
Cyclin-dependent kinase 190011
Transient receptor potential cation channel subfamily M member 60011
Testis-specific serine/threonine-protein kinase 10011
Serine/threonine-protein kinase 330011
Serine/threonine-protein kinase DCLK30011
Myosin light chain kinase 2, skeletal/cardiac muscle0011
Homeodomain-interacting protein kinase 20011
Tyrosine-protein kinase Srms0011
Homeodomain-interacting protein kinase 30011
Serine/threonine-protein kinase PLK30011
MAP kinase-interacting serine/threonine-protein kinase 20011
Serine/threonine-protein kinase Nek60011
SNF-related serine/threonine-protein kinase0011
Serine/threonine-protein kinase LATS20011
Serine/threonine-protein kinase 360011
Serine/threonine-protein kinase 32B0011
Serine/threonine-protein kinase PLK20011
Serine/threonine-protein kinase MARK10011
Serine/threonine-protein kinase pim-20011
Serine/threonine-protein kinase PAK 50011
eIF-2-alpha kinase GCN20011
Phosphatidylinositol 4-kinase beta0011
Serine/threonine-protein kinase 17A0011
STE20/SPS1-related proline-alanine-rich protein kinase0011
Ephrin type-A receptor 60011
Death-associated protein kinase 20011
Serine/threonine-protein kinase tousled-like 10011
Long-chain-fatty-acid--CoA ligase 50011
ALK tyrosine kinase receptor0011
SRSF protein kinase 30011
Cyclin-dependent kinase 11A0011
Aurora kinase C0011
Calcium/calmodulin-dependent protein kinase type II subunit alpha0011
Serine/threonine-protein kinase 38-like0011
Microtubule-associated serine/threonine-protein kinase 10011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]