Retinocochleocerebral Vasculopathy

A rare disorder consisting of microangiopathy of brain, retina, and inner ear ARTERIOLES. It is characterized by the clinical triad of encephalopathy, BRANCH RETINAL ARTERY OCCLUSION and VERTIGO/hearing loss.

Synonym
Retinocochleocerebral Vasculopathy
Susac Syndrome
Susac's Syndrome

Excerpt	Reference
"Susac's syndrome is the clinical triad of encephalopathy, branch retinal artery occlusions and sensorineural hearing loss (Susac 1994) [1]."	( Barnett, MH; Fulham, MJ; Garsia, RJ; Halmagyi, GM; Hardy, TA; Harrisberg, B; Lewis, SJ, 2011)
"Susac's syndrome is a microangiopathy of the retina, inner ear and brain manifesting as a triad of encephalopathy, hearing loss and branch retinal artery occlusion."	( Malhotra, A; Needham, M; Reyneke, E, 2013)
"Susac syndrome is a rare entity, and its etiology is not yet fully elucidated."	( Del Mar Ramirez Fernandez, M; Di Fazio, V; Duprez, T; Hantson, P; Samyn, N; van Pesch, V, 2015)
"Susac's syndrome is a rare autoimmune disease, which is characterized by microangiopathic changes that affects the brain, retina, and cochlea."	( Çabalar, M; Kaya, H; Tuğcu, B; Yayla, V; Yazıcı, ZM; Yurtsever, B, 2015)
"Susac syndrome (retinocochleocerebral vasculopathy) is an autoimmune endotheliopathy affecting the precapillary arterioles of the brain, retina, and inner ear."	( Gertner, E; Rosenbloom, MH, 2016)
"Susac syndrome is an endotheliopathy affecting the arterioles of the brain, retina, and inner ear."	( Czaplicka, E; Grygiel-Górniak, B; Puszczewicz, M, 2016)
"Susac syndrome is a rare condition characterized by the clinical triad of central nervous system (CNS) dysfunction, sensorineural hearing impairment, and branch retinal artery occlusion (BRAO)."	( Chapman, J; Huna-Baron, R; Manor, RS; Sharon, T; Sheinfeld, R; Shoenfeld, Y; Vishnevskia-Dai, V; Zloto, O, 2016)
"Susac syndrome is a rare disease characterized by the clinical triad of encephalopathy, branch retinal artery occlusion, and sensorineural hearing loss."	( Ben Ghorbel, I; Ben Salem, T; Houman, MH; Kefi, A; Khanfir, M; Khedher, M; Lamloum, M; Said, F, 2017)
"Susac's syndrome is an uncommon autoimmune microangiopathy characterised mainly by encephalopathy, hearing loss and branch retinal artery occlusions."	( Cevher, AZ; Demir, MK; Hacımustafaoğlu, AM; Kenangil, G; Onat Demirci, N, 2019)
"Susac syndrome is a rare disorder caused by autoimmune-mediated occlusions of microvessels in the brain, retina and inner ear."	( Aranda Martínez, A; Paviolo, JP, 2019)
"Susac syndrome is a rare, probably immune-mediated endotheliopathy presenting with encephalopathy, sensorineural hearing loss and retinal arterial occlusions."	( Catarino, A; Gil-Gouveia, R; Marto, N; Vilela, P, 2019)

Excerpt	Reference
"The data recorded for all Susac syndrome patients treated at the Sheba Medical Center between 1998 and 2014 included demographics, clinical signs at presentation and during the disease course, imaging findings, treatment, and prognosis."	( Chapman, J; Huna-Baron, R; Manor, RS; Sharon, T; Sheinfeld, R; Shoenfeld, Y; Vishnevskia-Dai, V; Zloto, O, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	1 (2.44)	18.1394
2010's	34 (82.93)	28.8240
2020's	6 (14.63)	9.53

Drug	Relationship Strength	Studies
aspirin	low	3
azathioprine	low	3
ketoconazole	low	1
prednisolone	low	3
prednisone	low	4
methylprednisolone	low	18
fluorescein	low	2
levamisole	low	1
methotrexate	low	2
cocaine	low	1
mycophenolic acid	low	4
amphotericin b	low	1
chlorhexidine	low	1
indocyanine green	low	1
apyrase	low	1
eye	low	2

Protein Targets (476)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, Cruzipain	2	0	0	2
interleukin 8	4	0	0	4
phosphopantetheinyl transferase	4	0	0	4
GLS protein	2	0	0	2
glucocorticoid receptor [Homo sapiens]	11	0	0	11
farnesoid X nuclear receptor	7	0	0	7
peroxisome proliferator-activated receptor delta	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
peripheral myelin protein 22	5	0	0	5
lamin isoform A-delta10	6	0	0	6
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 3A4	0	3	0	4
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	3	0	3
Cytochrome P450 2C19	0	1	0	1
Nuclear receptor ROR-gamma	6	0	0	6
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
thioredoxin reductase	5	0	0	5
AR protein	10	0	0	10
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
thyroid stimulating hormone receptor	2	0	0	2
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
EWS/FLI fusion protein	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
estrogen-related nuclear receptor alpha	11	0	0	11
estrogen nuclear receptor alpha	11	0	0	11
cytochrome P450 2D6	3	0	0	3
glucocerebrosidase	2	0	0	2
Rac1 protein	0	0	1	1
IDH1	5	0	0	5
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	8	0	0	8
Bloom syndrome protein isoform 1	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	3	0	0	3
DNA polymerase kappa isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	3	0	0	3
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	7
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Bile salt export pump	0	8	0	8
Epidermal growth factor receptor	0	1	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	1	3
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	2	1	0	3
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	2	1	0	3
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	1	0	5
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	6	0	6
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, Ferritin light chain	3	0	0	3
acetylcholinesterase	5	0	0	5
RAR-related orphan receptor gamma	5	0	0	5
SMAD family member 2	5	0	0	5
ATAD5 protein, partial	3	0	0	3
Fumarate hydratase	1	0	0	1
SMAD family member 3	5	0	0	5
TDP1 protein	6	0	0	6
GLI family zinc finger 3	6	0	0	6
Microtubule-associated protein tau	3	0	0	3
thioredoxin glutathione reductase	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
retinoid X nuclear receptor alpha	6	0	0	6
pregnane X nuclear receptor	7	0	0	7
G	3	0	0	3
polyprotein	1	0	0	1
P53	1	0	0	1
peroxisome proliferator activated receptor gamma	6	0	0	6
arylsulfatase A	2	0	0	2
aryl hydrocarbon receptor	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
thyroid stimulating hormone receptor	2	0	0	2
activating transcription factor 6	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	4	0	0	4
peripheral myelin protein 22 isoform 1	2	0	0	2
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
thyroid hormone receptor beta isoform 2	6	0	0	6
heat shock protein beta-1	4	0	0	4
geminin	6	0	0	6
survival motor neuron protein isoform d	3	0	0	3
cytochrome P450 3A4 isoform 1	4	0	0	4
M-phase phosphoprotein 8	2	0	0	2
muscleblind-like protein 1 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	4	0	0	4
Bile salt export pump	0	4	0	4
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Cellular tumor antigen p53	8	0	0	8
Gamma-aminobutyric acid receptor subunit beta-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit delta	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	4	0	0	4
Glutamate receptor 2	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-2	4	0	0	4
GABA theta subunit	4	0	0	4
Inositol hexakisphosphate kinase 1	3	0	0	3
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	8	0	0	8
Gamma-aminobutyric acid receptor subunit epsilon	4	0	0	4
Protein-arginine deiminase type-4	0	2	0	2
cytochrome P450 2C9, partial	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
Luciferase	2	0	0	2
acid sphingomyelinase	2	0	0	2
PAX8	0	0	0	1
glp-1 receptor, partial	3	0	0	3
15-lipoxygenase, partial	2	0	0	2
pregnane X receptor	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
USP1 protein, partial	2	0	0	2
caspase 7, apoptosis-related cysteine protease	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
PINK1	1	0	0	1
estrogen receptor 2 (ER beta)	5	0	0	5
progesterone receptor	8	0	0	8
67.9K protein	3	0	0	3
Parkin	1	0	0	1
heat shock protein 90	0	0	1	1
caspase-3	1	0	0	1
calcineurin A1, putative	0	0	1	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
cytochrome P450 2D6 isoform 1	1	0	0	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
perilipin-5	0	1	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
perilipin-1	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
huntingtin isoform 2	1	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
mitogen-activated protein kinase 1	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
flap endonuclease 1	3	0	0	3
protein AF-9 isoform a	0	0	0	1
snurportin-1	2	0	0	2
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
bcl-2-related protein A1	0	1	0	1
urokinase plasminogen activator surface receptor precursor	2	0	0	2
nuclear receptor ROR-gamma isoform 1	2	0	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
72 kDa type IV collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Trypanothione reductase	0	1	0	1
Alpha-synuclein	2	0	0	2
Histamine H2 receptor	1	0	0	1
Spike glycoprotein	2	0	0	2
TAR DNA-binding protein 43	3	0	0	3
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Spermine oxidase	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Amyloid-beta precursor protein	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	3	0	4
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Liver carboxylesterase 1	0	1	0	2
Sodium-dependent noradrenaline transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent serotonin transporter	0	3	0	4
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	2	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Estrogen receptor beta	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Epoxide hydrolase 1	0	0	0	1
Aldo-keto reductase family 1 member B1	0	3	0	3
Muscarinic acetylcholine receptor M2	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Cytochrome P450 2C8	0	1	0	1
Aromatase	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Translocator protein	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Cytochrome P450 7A1	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Estrogen receptor	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Substance-K receptor	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
Thromboxane-A synthase	0	1	0	1
Histamine H2 receptor	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	1	2
Type-1 angiotensin II receptor	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	1	3
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
dopamine D1 receptor	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
ATP-dependent phosphofructokinase	3	0	0	3
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
chromobox protein homolog 1	2	0	0	2
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
PPM1D protein	1	0	0	1
nonstructural protein 1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	2	0	2
Estrogen receptor beta	0	2	0	2
NFKB1 protein, partial	1	0	0	1
Smad3	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Cocaine esterase	0	1	0	1
Histone deacetylase 3	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
UDP-glucuronosyltransferase 1-6	0	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Retinocochleocerebral Vasculopathy

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (41)

Protein Targets (476)

Retinocochleocerebral Vasculopathy

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (41)

Drugs Studied (19)

Protein Targets (476)