Page last updated: 2024-09-27

Reticulocytosis

An increase in circulating RETICULOCYTES, which is among the simplest and most reliable signs of accelerated ERYTHROCYTE production. Reticulocytosis occurs during active BLOOD regeneration (stimulation of red bone marrow) and in certain types of ANEMIA, particularly CONGENITAL HEMOLYTIC ANEMIA.

Synonyms(1)

Synonym
Reticulocytosis

Research Excerpts

Overview

ExcerptReference
"Inappropriately low reticulocytosis is observed in malaria patients suggesting that insufficient erythropoiesis is a major factor."( Chang, KH; Stevenson, MM, 2004)
"Transient reticulocytosis is commonly observed in iron-deficient anemic hosts after treatment with iron supplementation, and is also associated with short-term hemolysis caused by PHZ treatment."( Cao, Y; Feng, Y; Jiang, Y; Liu, J; Pang, W; Qi, Z; Shang, H; Zhu, X, 2015)

Research

Studies (47)

TimeframeStudies, This Condition (%)All Conditions %
pre-199012 (25.53)23.3326
1990's0 (0.00)12.5806
2000's14 (29.79)18.1394
2010's16 (34.04)28.8240
2020's5 (10.64)9.53
DrugIndicatedRelationship StrengthStudiesTrials
chlorine0low10
melatonin0low10
nitrites0low10
thymine0low10
acetaminophen0low10
carbamazepine0low10
ibuprofen0low20
iodoacetic acid0low10
thyroxine0low20
sucrose0low10
cytidine monophosphate0low10
arginine0low10
phenylhydrazine0low60
pyrimidine0low10
nandrolone0low10
d-alpha tocopherol0low10
tocopherols0low10
thiamphenicol0low10
tramadol0low10
peroxynitrous acid0low10
n-phenylprotoporphyrin ix0low10
cortisone0low20
bilirubin0medium61
sq-233770low10
carfilzomib0low10
losartan potassium0medium102
virginiamycin0low10
quinupristin-dalfopristin0low10
hyaluronoglucosaminidase0low10
epoetin alfa0low10
inosinic acid0low10

Protein Targets (383)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma6006
ATAD5 protein, partial2002
GLS protein4004
Microtubule-associated protein tau3003
Smad32002
aldehyde dehydrogenase 1 family, member A15005
thyroid stimulating hormone receptor3003
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor4004
EWS/FLI fusion protein5005
retinoic acid nuclear receptor alpha variant 18008
retinoid X nuclear receptor alpha5005
estrogen-related nuclear receptor alpha100010
estrogen nuclear receptor alpha120012
peroxisome proliferator activated receptor gamma5005
aryl hydrocarbon receptor5005
chromobox protein homolog 18008
thyroid hormone receptor beta isoform 26006
peripheral myelin protein 222002
cytochrome P450 3A4 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3003
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Solute carrier family 22 member 60202
Carbonic anhydrase 120101
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0303
Voltage-dependent calcium channel gamma-2 subunit2002
Bile salt export pump0707
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10303
Carbonic anhydrase 20415
Myoglobin0101
Cytochrome P450 1A10113
Cytochrome P450 1A20203
Prostaglandin G/H synthase 10303
Carbonic anhydrase 30101
Cytochrome P450 3A40203
Cytochrome P450 2D60303
Cytochrome P450 2C9 0505
Polyunsaturated fatty acid lipoxygenase ALOX150202
Gamma-aminobutyric acid receptor subunit beta-13003
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 22002
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0102
Carbonic anhydrase 40303
Prostaglandin G/H synthase 10202
Carbonic anhydrase 60101
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20203
Carbonic anhydrase 70101
Nuclear receptor ROR-gamma2002
Cytochrome P450 2J20303
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Carbonic anhydrase 90213
GABA theta subunit3003
Canalicular multispecific organic anion transporter 10404
Carbonic anhydrase 150303
Carbonic anhydrase 130101
Gamma-aminobutyric acid receptor subunit epsilon3003
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
toxin B0001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase5005
phosphopantetheinyl transferase3003
NFKB1 protein, partial2002
alpha-galactosidase1001
euchromatic histone-lysine N-methyltransferase 26006
cytochrome P450 2C19 precursor1001
flap endonuclease 12002
DNA polymerase iota isoform a (long)1001
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)1001
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase2002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, Cruzipain1001
USP1 protein, partial5005
vitamin D3 receptor isoform VDRA2002
DNA polymerase kappa isoform 14004
caspase-1 isoform alpha precursor1001
lamin isoform A-delta107007
Caspase-71001
Inositol monophosphatase 11001
Solute carrier organic anion transporter family member 1B30203
Solute carrier organic anion transporter family member 1B10204
Chain A, Beta-lactamase1001
acetylcholinesterase2002
TDP1 protein7007
AR protein8008
glucocorticoid receptor [Homo sapiens]5005
pregnane X nuclear receptor7007
IDH12002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyroid hormone receptor beta isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 21001
mitogen-activated protein kinase 11001
geminin5005
Vpr1001
Albumin0022
Major prion protein0011
Cellular tumor antigen p536006
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
UDP-glucuronosyltransferase 2B70002
Cytochrome P450 2B60011
Sodium channel protein type 4 subunit alpha0102
Potassium voltage-gated channel subfamily H member 20202
Sodium channel protein type 9 subunit alpha0202
Frizzled-80011
P2X purinoceptor 40101
Proteasome subunit beta type-110101
Fumarate hydratase1001
PPM1D protein1001
GLI family zinc finger 34004
caspase 7, apoptosis-related cysteine protease2002
estrogen receptor 2 (ER beta)3003
cytochrome P450 family 3 subfamily A polypeptide 43003
farnesoid X nuclear receptor1001
polyprotein1001
peroxisome proliferator-activated receptor delta4004
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
caspase-32002
Caspase-71001
caspase-31001
heat shock protein beta-13003
nuclear factor erythroid 2-related factor 2 isoform 16006
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140101
Proteasome subunit alpha type-70101
26S proteasome non-ATPase regulatory subunit 30101
Interferon beta3003
Cathepsin B0101
Cathepsin G0101
Lysosomal protective protein0101
26S proteasome regulatory subunit 6A0101
Proteasome subunit beta type-10101
Proteasome subunit beta type-20101
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50101
26S proteasome regulatory subunit 70101
Proteasome subunit beta type-10101
Proteasome subunit beta type-100101
26S proteasome regulatory subunit 6B0101
26S proteasome non-ATPase regulatory subunit 80101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20101
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
Spike glycoprotein1001
26S proteasome complex subunit SEM10101
Proteasome subunit alpha type-60101
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
Glutathione S-transferase omega-10101
26S proteasome non-ATPase regulatory subunit 20101
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
Proteasome subunit alpha-type 80101
ATPase family AAA domain-containing protein 51001
Proteasome subunit beta type-70101
26S proteasome non-ATPase regulatory subunit 10101
Ataxin-21001
26S proteasome non-ATPase regulatory subunit 130101
Carbonic anhydrase0202
endonuclease IV1001
dopamine D1 receptor1001
pregnane X receptor1001
regulator of G-protein signaling 42002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)2002
peripheral myelin protein 22 isoform 12002
atrial natriuretic peptide receptor 1 precursor1001
survival motor neuron protein isoform d1001
M-phase phosphoprotein 82002
Glucocorticoid receptor0202
Sex hormone-binding globulin0022
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 432002
Multidrug and toxin extrusion protein 10101
Orotidine 5'-phosphate decarboxylase0101
Seminal ribonuclease0101
Uridine 5'-monophosphate synthase0101
Beta-galactoside alpha-2,6-sialyltransferase 10101
UMP-CMP kinase 0001
Ribonuclease pancreatic0101
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase0101
Orotidine 5'-phosphate decarboxylase 0101
activating transcription factor 61001
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 11001
Rap guanine nucleotide exchange factor 33003
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Luciferase2002
nonstructural protein 11001
67.9K protein1001
arylsulfatase A1001
transcriptional regulator ERG isoform 31001
muscleblind-like protein 1 isoform 11001
Acid-sensing ion channel 30101
Solute carrier organic anion transporter family member 1A40102
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Dihydrofolate reductase0101
Epidermal growth factor receptor0101
Fatty acid-binding protein, liver0101
Albumin0112
Albumin0101
Cholinesterase0202
Fatty acid-binding protein, intestinal0101
Polyunsaturated fatty acid 5-lipoxygenase0102
Acetylcholinesterase0202
Prostaglandin G/H synthase 10101
Adenosine receptor A10101
Caspase-10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 2 0102
UDP-glucuronosyltransferase 1A30001
Aldo-keto reductase family 1 member C30101
Caspase-30101
Solute carrier organic anion transporter family member 1A10101
Caspase-40101
4-aminobutyrate aminotransferase, mitochondrial0101
Caspase-50101
Caspase-90101
Acid-sensing ion channel 10101
Prostaglandin G/H synthase 20202
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10101
Prostaglandin G/H synthase 20101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0102
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Dehydrogenase/reductase SDR family member 90101
Chain A, Hypoxanthine Phosphoribosyltransferase0101
Chain A, HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE0101
Chain A, hypoxanthine phosphoribosyltransferase0011
Chain A, hypoxanthine phosphoribosyltransferase0011
Chain A, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE0011
Chain B, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE0011
Chain A, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE0011
Chain A, Hypoxanthine-guanine phosphoribosyltransferase0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Hypoxanthine-guanine phosphoribosyltransferase0101
Inosine-5'-monophosphate dehydrogenase0001
Inosine-5'-monophosphate dehydrogenase 20102
Inosine-5'-monophosphate dehydrogenase 1 0102
Type-1A angiotensin II receptor 0101
Type-1B angiotensin II receptor0202
Type-2 angiotensin II receptor0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
5-hydroxytryptamine receptor 1A0101
Type-1 angiotensin II receptor0101
interleukin 81001
ClpP1001
Bloom syndrome protein isoform 11001
cytochrome P450 2D6 isoform 11001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
ras-related protein Rab-9A1001
Cytochrome P450 1A2 0101
Myeloperoxidase0101
Cytochrome P450 2C11 0101
Aromatase0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Metabotropic glutamate receptor 10101
Acetylcholinesterase 0101
Mu-type opioid receptor0101
Nociceptin receptor0101
Alpha-1A adrenergic receptor0101
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear factor erythroid 2-related factor 20001
Cytochrome P450 1B10101
Palmitoleoyl-protein carboxylesterase NOTUM0101
Carboxylic ester hydrolase 0101
Histamine H3 receptor0101
SMAD family member 21001
SMAD family member 31001
glucocerebrosidase1001
Histone H2A.x2002
Solute carrier family 22 member 1 0202
Androgen receptor0202
5-hydroxytryptamine receptor 70101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial0101
histone acetyltransferase KAT2A isoform 11001
Indoleamine 2,3-dioxygenase 10101
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2C190101
Mu-type opioid receptor0101
Histone acetyltransferase KAT80101
Chain A, MALTOPORIN0011
Chain B, MALTOPORIN0011
cytochrome P450 2D61001
streptokinase A precursor0011
Estrogen receptor0011
Estrogen receptor beta0011
Thymidine phosphorylase0101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
apical membrane antigen 1, AMA11001
G1001
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50001
HLA class I histocompatibility antigen, B alpha chain 1001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Inositol hexakisphosphate kinase 11001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
cytochrome P450 2C9, partial1001
glp-1 receptor, partial1001
Mu-type opioid receptor0112
Delta-type opioid receptor0101
Kappa-type opioid receptor0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]