CKD-MBD

Synonym
Renal Osteodystrophy
CKD-MBD
Renal Rickets
Osteodystrophy, Renal
Rickets, Renal

Excerpt	Reference
"Renal osteodystrophy is more prevalent in children than in adults and often more severe."	( Baluarte, HJ; Foley, CM; Grover, WD; Gruskin, AB; Hiner, LB, 1977)
"Therefore, renal osteodystrophy is not as extensive as it was ten years ago, but it still continues to be an unavoidable complication of renal insufficiency."	( Baldt, M; Breitenseher, M; Helbich, T; Kainberger, F; Kovarik, J; Seidl, G; Traindl, O, 1992)
"The diagnosis of renal osteodystrophy is straightforward when the disease has reached an advanced stage and the pathology is extremely difficult to treat, whereas it is considerably more complex during the early stages."	( Angelitti, A; Clemenzia, G; Gallo, G; Maggi, S; Persichetti, S; Ponzio, R; Punzo, G; Sagliaschi, G; Tozzo, C, 1992)
"Renal osteodystrophy is a metabolic bone disease resulted from chronic renal failure."	( Yu, YF, 1991)
"Renal osteodystrophy is a complex disorder that can produce a variety of histologic changes in bone."	( Duarte, ME; Goodman, WG, 1991)
"Renal osteodystrophy is multifactorial."	( Tzamaloukas, AH, 1990)
"Renal osteodystrophy is defined in the light of bone histology and the clinical and roentgenologic signs are described."	( Binswanger, U, 1989)
"Renal osteodystrophy is a common and incapacitating complication of chronic renal failure in children."	( Gauthier, B; Trachtman, H, 1987)
"In these patients renal osteodystrophy is a chronic condition with a prolonged time course."	( Baillod, RA; Farrow, S; Moorhead, JF; Tatler, GL; Varghese, Z; Wills, MR; Young, WB, 1973)
"The generic term "Renal Osteodystrophy" is used to denote a complex of skeletal and metabolic impairments found in nephropathic patients."	( Ciarambino, A; Giraldi, A, 1982)
"Growth arrest and renal osteodystrophy is a major problem in renal insufficiency of children."	( Bulla, M; Delling, G; Hofmann, H; Offermann, G; Stock, GJ, 1980)
"Renal osteodystrophy is the main cause of the initial osteopenia."	( Flury, W; Haldimann, B, 1981)
"The generic term "Renal Osteodystrophy" is used to denote a complex of skeletal and metabolic impairments found in nephropathic patients."	( Ciarambino, A; Giraldi, A, 1982)
"Renal osteodystrophy is an early complication of renal failure associated with significant morbidity."	( Brookhyser, J; Pahre, SN, 1995)
"Renal osteodystrophy is not a uniform disease."	( Malluche, HH; Monier-Faugere, MC, 1994)
"Renal osteodystrophy is a debilitating complication of chronic renal failure and secondary hyperparathyroidism (2HPTH) is one of its central features."	( Rahamimov, R; Silver, J, 1994)
"Renal osteodystrophy is a metabolic bone disease of chronic renal failure."	( Hu, YX; Yu, YF; Zhu, P, 1993)
"This model of renal osteodystrophy is similar to human secondary hyperparathyroidism with regard to the enhanced bone resorption, but differs by the marked decrease in bone formation."	( Bernheim, J; Moscovici, A; Popovtzer, MM; Rubinger, D, 1996)
"The various forms of renal osteodystrophy are predominant hyperparathyroid bone disease, mixed uremic osteodystrophy, low turnover osteomalacia, and adynamic bone disease."	( Cannata, J; Caorsi, H; Douthat, W; Ferreira, A; Jarava, C; Jorgetti, V; López, BD; Menendez, P; Moreira, E; Olaizola, I; Palma, A; Ribeiro, S, 2000)
"Renal osteodystrophy is the major complication in patients with end-stage renal failure."	( Fujimura, A; Saito, T; Sugimoto, K; Tsuruoka, S; Wakaumi, M, 2003)
"Renal osteodystrophy is the term used to describe the many different patterns of the skeletal abnormalities that occur in patients with chronic kidney disease."	( Gonzalez, E; Martin, K; Slatopolsky, E, 2003)
"Renal osteodystrophy is a process whereby renal failure causes profound bone disease."	( Elgazzar, A; Reczek, J, 2003)
"Renal osteodystrophy is a metabolic bone disease and a common complication of end-stage chronic renal failure and maintenance dialysis treatment."	( Hayabuchi, N; Hiromatsu, Y; Ishibashi, M; Kurata, S; Nishida, H, 2004)
"Renal osteodystrophy is one of the major complications in patients with chronic renal failure."	( Akagi, S; Ichikawa, H; Kihara, T; Kohmoto, H; Kumagai, I; Makino, H; Morimoto, H; Nakao, K; Wada, J; Yano, A, 2004)
"Renal osteodystrophy is a common complication of uremic patients, mainly when they are in long-term regular dialysis treatment."	( Brancaccio, D; Dellavia, C; Ferrario, VF; Galassi, A; Sforza, C, 2005)
"Renal osteodystrophy is an important complication of chronic kidney disease characterized by abnormal bone turnover with varied bone histologic changes."	( Abraham, G; Chandrasekaran, V; Padma, G; Sankarasubbaiyan, S; Soundararajan, P, 2005)
"Renal osteodystrophy is a common complication of end-stage renal disease (ESRD) and is a major cause of morbidity in patients with ESRD."	( Denton, J; Freemont, AJ; Hoyland, JA, 2005)
"Renal osteodystrophy is a common complication of chronic renal failure and renal replacement therapy."	( Małyszko, J; Małyszko, JS; Myśliwiec, M; Pawlak, K; Wołczyński, S, 2006)
"Renal osteodystrophy is a significant complication in chronic kidney disease."	( Kalantar-Zadeh, K; Kovesdy, CP; Mehrotra, R, 2008)
"Renal osteodystrophy is characterized by abnormalities in bone turnover, mineralization, and bone volume."	( Malluche, HH; Mawad, H; Monier-Faugere, MC, 2008)
"Management of renal osteodystrophy is progressing relentlessly, in particular, since the discovery of new phosphate binders, vitamin D derivates and calcium agonist."	( Bardin, T; Richette, P, 2009)
"The pathogenesis of renal osteodystrophy is under strong influence of the fibroblast growth factor 23/Klotho system, which is able to enhance phosphate excretion and reduce calcitriol synthesis in the kidney."	( Kemper, MJ; van Husen, M, 2014)
"Renal osteodystrophy is a systemic disorder associated with chronic kidney disease (CKD) with abnormal values of biochemical parameters related to bone and mineral metabolism."	( Bencova, V; Cernohorska, B; Gazovic, V; Maris, K; Nemethova, D; Spustova, V; Straussova, Z, 2014)
"Renal osteodystrophy is the damage of bone morphology by CKD and treatment and occurred abnormal bone metabolism through renal dysfunction."	( Ito, M; Tanaka, S, 2015)
"Renal osteodystrophy is a feature of chronic kidney disease (CKD), with increasing prevalence as CKD progresses."	( Brandenburg, VM; Vervloet, MG, 2017)
"The physiology of renal osteodystrophy is complex and recently more factors have been found that complicate the mineral metabolism."	( Ott, SM, 2019)
"The diagnosis of renal osteodystrophy is challenging."	( Aaltonen, L; Koivuviita, N; Kröger, H; Löyttyniemi, E; Metsärinne, K; Seppänen, M; Tong, X, 2020)
"Renal osteodystrophy is a specific form of metabolic bone disease defined by the presence of osteomalacia and associated hyperparathyroidism secondary to a malfunction in, or absence of, renal parenchyma."	( Aaron, RK; Gohh, R; Modest, JM; Sheth, H, 2022)
"Renal osteodystrophy is a state of impaired bone quality and strength."	( Agarwal, S; Aponte, MA; Brown, DD; Dempster, D; Fusaro, M; Guo, XE; Kamanda-Kosseh, M; Kumar, J; Levy, RV; McMahon, DJ; Melamed, ML; Misof, BM; Nickolas, TL; Reidy, K; Zhou, H, 2023)

Excerpt	Reference
"Renal osteodystrophy has many skeletal pathologic features, eg, fibroosteoclasia (osteitis fibrosa), osteomalacia, osteopenia, pseudofracture, cyst formation, and osteosclerosis."	( Coburn, JW; Nortman, DF, 1978)
"The study of renal osteodystrophy has certainly advanced our knowledge of mineral metabolism, with clarification of the metabolism and action of PTH and vitamin D metabolism and identification of the pathogenic role for aluminum."	( Coburn, JW; Henry, DA, 1984)
"This bone disease (renal osteodystrophy) has been variously attributed to hyperparathyroidism, vitamin D deficiency, aluminium toxicity, iron toxicity, uraemia, and a host of other aetiologies."	( Hercz, G; Pei, Y; Segre, G; Sherrard, DJ, 1996)
"The term "renal osteodystrophy" has recently been replaced with "CKD-mineral and bone disorder (CKD-MBD)", which includes vascular calcification as well as bone abnormalities."	( Fukagawa, M; Komaba, H; Tanaka, M, 2008)
"Although lesions of renal osteodystrophy have traditionally been defined by bone turnover, alterations in skeletal mineralization and volume are also prevalent and may contribute to significant morbidity in patients with chronic kidney disease (CKD)."	( Bakkaloglu, SA; Elashoff, RM; Gales, B; Pereira, RC; Salusky, IB; Wang, HJ; Wesseling-Perry, K, 2010)
"The term "renal osteodystrophy" has recently been replaced with "CKD-mineral and bone disorder (CKD-MBD)", which includes vascular calcification as well as bone abnormalities."	( Koiwa, F; Taketani, Y; Yokoyama, K, 2017)

Excerpt	Reference
"Renal osteodystrophy affects all patients with end-stage renal failure, resulting in significant skeletal and extra-skeletal morbidity."	( Hoyland, JA; Picton, ML, 1999)
"Renal osteodystrophy affects patients with chronic kidney disease, those undergoing dialysis, and renal transplant patients."	( Aaron, RK; Gohh, R; Modest, JM; Sheth, H, 2022)

Excerpt	Reference
"The prophylaxis and treatment of renal osteodystrophy are based on pathophysiological principles."	( Flury, W; Haldimann, B, 1977)
"Two children suffering from renal osteodystrophy were treated by 1 alpha hydroxycholecalciferol (1 alpha OHD3) 1 microgr."	( Chantraine, JM; Davin, JC; Heynen, G; Lambrechts, L, 1979)
"Patients with severe symptomatic renal osteodystrophy were treated with either 1,25(OH)2D3 or 1 alpha(OH)D3."	( Baylink, DJ; Brickman, AS; Coburn, JW; Norman, AW; Sherrard, DJ; Singer, FR; Wong, EG, 1977)
"Ten patients with renal osteodystrophy were treated with 1alpha-hydroxyvitamin D3 for 18 months."	( Catto, GR; Junor, BJ, 1977)
"During treatment of renal osteodystrophy with 1alpha-hydroxyvitamin D3 in eleven patients, regional changes in the skeleton have been compared with long-term calcium balance as assessed by whole-body calcium."	( Al-Hiti, K; Dabek, JT; Naik, RB; Robinson, BH, 1977)
"Three children with azotaemic renal osteodystrophy were treated with 1,25-dihydroxycholecalciferol (1,25(OH)2D3)."	( Dellagrammatikas, H; Ellis, HA; Norman, AW; Pierides, AM; Scott, JE, 1977)
"Fourteen patients with renal osteodystrophy were treated for at least one year with 1-alpha-hydroxycholecalciferol (1-alpha-OHD3) in a dose varying from 1 microgram/week to 3 microgram/day."	( Brownjohn, AM; Goodwin, FJ; Hately, W; Marsh, FP; O'Riordan, JL; Papapoulos, SE, 1977)
"The diagnosis of renal osteodystrophy is straightforward when the disease has reached an advanced stage and the pathology is extremely difficult to treat, whereas it is considerably more complex during the early stages."	( Angelitti, A; Clemenzia, G; Gallo, G; Maggi, S; Persichetti, S; Ponzio, R; Punzo, G; Sagliaschi, G; Tozzo, C, 1992)
"A marked improvement of renal osteodystrophy was achieved after a combined treatment with keto acids and vitamin D in patients with chronic renal failure."	( Fröhling, PT; Kokot, F; Lindenau, K; Schmicker, R; Vetter, K, 1987)
"Results of diagnosis and treatment of renal osteodystrophy are discussed concerning 162 patients with chronic renal failure treated by hemodialysis."	( Babarykin, DA; Chernevskis, KhK; Il'inskiĭ, IM; Rozental', RL; Tikhomirova, TE, 1986)
"Finally, healing of renal osteodystrophy was radiologically evident after six months of therapy."	( Chan, JC; Kodroff, MB; Landwehr, DM, 1981)
"Thus, adynamic renal osteodystrophy develops in a substantial number of patients during intermittent calcitriol therapy."	( Belin, TR; Chon, Y; Gales, B; Goodman, WG; Ramirez, JA; Salusky, IB; Segre, GV, 1994)
"The main goal in treating renal osteodystrophy is the lowering of PTH activity by correcting hyperphosphatemia and administration of calcitriol given either orally or intravenously."	( Brunner, FP; Kiss, D, 1996)
"Prevention, diagnosis and treatment of renal osteodystrophy are continually evolving."	( Barreto, S; Cannata Andía, JB; Díaz-Corte, C; Gómez Alonso, C; Naves Díaz, ML, 1998)
"calcitriol for treating renal osteodystrophy in hemodialysis patients; others suggest that these routes of administration are equivalent."	( Arora, N; Gadallah, MF; Moles, K; Ramdeen, G; Schaeffer-Pautz, A; Torres, C, 2000)
"However, most studies on renal osteodystrophy have not taken into account the role of oestrogen deficiency, its interaction, and the possible benefits of hormone replacement therapy (HRT) in uremic women."	( Cannata Andía, JB; Caramelo, C; Díaz López, JB; Ramos, B; Rodríguez García, M; Rodríguez Rodríguez, A, 2003)
"Prevention and treatment of renal osteodystrophy (ROD) are great challenges for pediatric nephrologists."	( Tasic, V, 2005)
"We investigated the treatment of renal osteodystrophy (ROD) in Japan and problems concerning the K/DOQI Guidelines."	( Hosoya, T; Imamura, N; Ishida, M; Kasai, K; Katoh, N; Kimua, Y; Kono, T; Kubo, H; Murai, S; Saika, S; Shoji, R; Takasu, S; Wakabayashi, T; Yokoyama, K; Yoshida, Y; Yumita, S, 2006)
"To investigate the evolution of renal osteodystrophy in patients on maintenance dialysis, treated with lanthanum carbonate (LC) vs."	( Confer, S; Malluche, HH; Mawad, H; Monier-Faugere, MC; Pratt, RD; Siami, GA; Smith, M; Swanepoel, C; Wang, GH, 2008)
"The effects of treatment modalities for renal osteodystrophy on bone should be analyzed with respect to these abnormalities."	( Malluche, HH; Mawad, H; Monier-Faugere, MC, 2008)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	863 (48.32)	23.3326
1990's	328 (18.37)	12.5806
2000's	281 (15.73)	18.1394
2010's	205 (11.48)	28.8240
2020's	109 (6.10)	9.53

Drug	Relationship Strength	Studies	Trials
acetic acid	low	3	0
adenine	low	6	0
allantoin	low	1	0
carnitine	medium	1	1
choline	low	2	0
citric acid, anhydrous	low	1	0
chlorine	low	4	0
creatine	low	2	0
lactic acid	low	1	0
formaldehyde	low	1	0
glycine	low	3	0
glycolic acid	low	1	0
hydrogen carbonate	medium	25	3
iodine	medium	1	1
niacinamide	low	2	0
niacin	low	1	0
phenylpyruvic acid	low	2	0
thiosulfates	low	1	0
thiamine	low	1	0
uric acid	medium	5	1
urea	low	7	0
aminopropionitrile	low	1	0
phenytoin	low	1	0
acetazolamide	low	1	0
aurintricarboxylic acid	low	4	0
azathioprine	low	5	0
chlorambucil	low	1	0
cimetidine	low	1	0
4-cresol	low	1	0
deferoxamine	low	24	0
erythrosine	low	1	0
etidronate	low	9	0
hydrochlorothiazide	low	3	0
ifosfamide	low	3	0
indomethacin	low	1	0
ipriflavone	low	1	0
metformin	low	1	0
activins	low	6	0
oxidopamine	low	1	0
pamidronate	low	4	0
phenobarbital	low	2	0
propranolol	medium	8	2
sodium fluoride	low	4	0
risedronic acid	low	1	0
succinylacetone	low	1	0
prednisolone	low	3	0
reserpine	low	1	0
thymidine	low	1	0
hydroxyproline	low	30	0
thyroxine	low	1	0
spironolactone	low	2	0
aldosterone	low	3	0
penicillamine	low	1	0
prednisone	low	10	0
lysine	medium	2	1
sucrose	medium	1	1
galactose	low	1	0
levodopa	low	1	0
edetic acid	low	5	0
tyrosine	low	5	0
calcium acetate	medium	9	2
methionine	low	1	0
histidine	low	1	0
medroxyprogesterone acetate	low	1	0
arginine	medium	2	1
vinyl chloride	low	1	0
tromethamine	low	1	0
isoprene	low	2	0
methylprednisolone	low	1	0
thiophenes	low	1	0
nitrilotriacetic acid	low	1	0
thiazoles	low	2	0
pyrazines	low	1	0
calcium gluconate	medium	2	1
nandrolone	low	1	0
limestone	medium	65	12
copper gluconate	low	2	0
magnesium carbonate	low	2	0
acetylcysteine	low	1	0
durapatite	low	1	0
amiloride	low	1	0
carbonates	low	3	0
norleucine	low	1	0
lanthanum	medium	22	6
scandium	low	1	0
technetium	medium	32	1
titanium	low	1	0
americium	low	2	0
cadmium	low	2	0
gadolinium	low	3	0
zirconium	low	1	0
sodium pyrophosphate	low	1	0
calcium phosphate, dibasic, anhydrous	medium	3	1
calcium phosphate, monobasic, anhydrous	medium	3	1
tricalcium phosphate	medium	10	1
sodium thiosulfate	low	1	0
fluorine	low	1	0
calcium pyrophosphate	low	1	0
trolamine salicylate	medium	10	1
ammonium chloride	low	3	0
ferric nitrilotriacetate	low	1	0
fluorides	medium	11	1
bromocriptine	low	1	0
phenyl acetate	medium	13	3
cetylpyridinium chloride anhydrous	low	1	0
calcium oxalate	low	8	0
1-carboxyglutamic acid	low	2	0
captopril	low	1	0
ibandronic acid	low	1	0
ferric citrate	medium	3	1
aluminum phosphate	medium	1	1
fluorexon	low	1	0
testosterone undecanoate	low	1	0
fluorodeoxyglucose f18	low	2	0
zoledronic acid	medium	3	2
homocysteine	low	1	0
pyridinoline	medium	8	1
deoxypyridinoline	medium	7	1
pentosidine	medium	2	1
weddellite	low	1	0
technetium tc 99m hydroxymethylene diphosphonate	medium	6	3
technetium tc 99m etidronate	low	6	0
proline	low	4	0
cinacalcet	medium	45	6
nps-568	low	5	0
technetium tc 99m (sn)methylenediphosphonate	low	1	0
calcium pyrophosphate	medium	3	1
lanthanum carbonate	medium	19	5
biotin	low	1	0
angiotensin ii	low	3	0
organophosphonates	low	2	0
ketosteril	low	1	0
alagebrium	low	1	0
cortisone	low	3	0
cellulose triacetate	low	1	0
fluorocholine	low	2	0
n-acetylneuraminic acid	low	1	0
elastin	low	1	0
tartaric acid	low	1	0
indican	low	2	0
eplerenone	low	1	0
tretinoin	low	1	0
retinol	low	4	0
ferric hydroxide	low	1	0
sodium bicarbonate	medium	2	1
pyrophosphate	medium	12	1
thiouracil	low	1	0
succimer	low	1	0
nadp	low	1	0
hydroxylysine	low	1	0
cystine	low	4	0
17-ketosteroids	low	1	0
osteoprotegerin	medium	21	1
dinoprostone	low	1	0
calcitriol	medium	261	29
vitamin k semiquinone radical	low	6	0
vitamin d 2	medium	50	5
cholecalciferol	medium	70	11
paricalcitol	medium	14	2
menatetrenone	low	1	0
menaquinone 6	low	2	0
phenylephrine hydrochloride	low	1	0
hydromorphone	low	1	0
vitamin k 1	low	1	0
lead	low	1	0
tin	low	1	0
aluminum	medium	201	4
strontium	low	5	0
thallium	low	1	0
silicon	low	1	0
phosphorus	medium	327	23
strontium radioisotopes	low	1	0
25-hydroxyvitamin d 2	low	1	0
radium	low	2	0
oxalates	low	7	0
aluminum hydroxide, magnesium hydroxide, drug combination	low	1	0
whewellite	low	1	0
maxacalcitol	medium	8	1
24,25-dihydroxyvitamin d 3	medium	20	1
1-hydroxyprevitamin d3	medium	2	1
technetium tc 99m pyrophosphate	medium	4	1
technetium tc 99m diphosphonate	low	1	0
aluminum oxide	low	1	0
calcium bicarbonate	low	1	0
nps r-467	low	1	0
losartan potassium	low	12	0
dihydrotachysterol	medium	35	4
acid phosphatase	low	16	0
jaw	low	7	0
nad	low	1	0
calcitonin	low	4	0
glucagon	low	1	0
natriuretic peptide, c-type	low	2	0
cellulose	low	1	0
technetium tc 99m sestamibi	low	6	0
sodium pertechnetate tc 99m	low	1	0
cardiovascular agents	low	2	0
glycolipids	low	1	0
interleukin-8	low	1	0
lp533401	low	1	0
natriuretic peptide, brain	low	1	0
heme	low	1	0
ascorbic acid	low	1	0
tetracycline	low	8	0
warfarin	low	2	0
transforming growth factor beta	low	14	0
phytoestrogens	low	1	0
caseins	low	3	0
ferric oxide, saccharated	medium	2	1
cyclosporine	low	2	0
technetium tc 99m medronate	medium	32	3
muramidase	low	1	0
exudates	low	1	0
technetium tc 99m dimercaptosuccinic acid	medium	4	1
folic acid	low	1	0
allopurinol	medium	2	1
chromazurol b	low	2	0
eye	low	1	0
abaloparatide	low	1	0
leptin	low	3	0

Protein Targets (1,149)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
interleukin 8	11	0	0	11
RAR-related orphan receptor gamma	28	0	0	28
TDP1 protein	31	0	0	31
AR protein	44	0	0	44
progesterone receptor	17	0	0	17
retinoic acid nuclear receptor alpha variant 1	35	0	0	35
retinoid X nuclear receptor alpha	24	0	0	24
estrogen nuclear receptor alpha	58	0	0	58
aryl hydrocarbon receptor	17	0	0	17
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	24	0	0	24
thyroid stimulating hormone receptor	11	0	0	11
thyroid hormone receptor beta isoform 2	27	0	0	27
nuclear factor erythroid 2-related factor 2 isoform 1	29	0	0	29
Sulfotransferase 1A1	0	0	0	1
Acetylcholinesterase	0	2	0	2
Nuclear receptor ROR-gamma	9	1	1	11
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	12	0	0	12
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	11	0	0	11
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	5	0	5
thioredoxin reductase	19	0	0	19
GALC protein	5	0	0	5
GLI family zinc finger 3	32	0	0	32
nuclear receptor subfamily 1, group I, member 3	20	0	0	20
cytochrome P450 family 3 subfamily A polypeptide 4	21	0	0	21
glucocorticoid receptor [Homo sapiens]	42	0	0	42
estrogen-related nuclear receptor alpha	38	0	0	38
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
arylsulfatase A	10	0	0	10
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	36	0	0	36
Bloom syndrome protein isoform 1	14	0	0	14
thyroid hormone receptor beta isoform a	18	0	0	18
geminin	36	0	0	36
peripheral myelin protein 22	18	0	0	18
survival motor neuron protein isoform d	12	0	0	12
muscleblind-like protein 1 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	9	3	1	13
ATP-binding cassette sub-family C member 3	0	23	0	23
Multidrug resistance-associated protein 4	0	23	0	25
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	6	0	6
Carbonic anhydrase 12	0	5	1	12
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	34	0	34
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	3	0	3
Carbonic anhydrase 1	0	14	1	23
Carbonic anhydrase 2	0	16	2	25
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	2	1	4
Carbonic anhydrase 3	0	3	1	9
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	6	2	10
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2D6	0	5	1	6
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	9	2	12
5-hydroxytryptamine receptor 2A	0	1	0	1
Androgen receptor	0	13	0	14
Gamma-aminobutyric acid receptor subunit beta-1	9	3	1	13
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	9	3	1	13
Gamma-aminobutyric acid receptor subunit gamma-2	9	3	1	13
Gamma-aminobutyric acid receptor subunit alpha-5	9	3	1	13
Gamma-aminobutyric acid receptor subunit alpha-3	9	3	1	13
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 4	0	9	1	14
Carbonic anhydrase 6	0	4	1	9
Gamma-aminobutyric acid receptor subunit gamma-1	9	3	1	13
Gamma-aminobutyric acid receptor subunit alpha-2	9	3	1	13
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	0	5
Serum paraoxonase/arylesterase 1	0	3	0	3
Dipeptidyl peptidase 4	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	9	3	1	13
Gamma-aminobutyric acid receptor subunit gamma-3	9	3	1	13
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	9	3	1	13
Adenosine receptor A2a	0	2	0	5
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	3	0	3
Delta-type opioid receptor	0	2	0	2
Cytochrome P450 2C19	0	4	1	5
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	6	0	7
Carbonic anhydrase 5A, mitochondrial	0	4	1	10
Carbonic anhydrase	0	8	0	11
Kappa-type opioid receptor	0	2	1	3
Carbonic anhydrase 7	0	4	1	9
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	4
D(2) dopamine receptor	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	9	3	1	13
Gamma-aminobutyric acid receptor subunit beta-3	9	3	1	13
Gamma-aminobutyric acid receptor subunit beta-2	9	3	1	13
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	2	1	3
Fatty-acid amide hydrolase 1	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	3	1	7
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase 9	0	7	2	15
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	4
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	5
GABA theta subunit	9	3	1	13
Canalicular multispecific organic anion transporter 1	0	23	0	23
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 15	0	5	0	9
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	4	0	7
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	9	3	1	13
Carbonic anhydrase	0	4	0	4
Carbonic anhydrase 14	0	4	1	11
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	4	1	10
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	1	1	2
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	10	0	0	10
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
acetylcholinesterase	12	0	0	12
dopamine D1 receptor	4	0	0	4
15-lipoxygenase, partial	7	0	0	7
pregnane X receptor	8	0	0	8
phosphopantetheinyl transferase	14	0	0	14
USP1 protein, partial	13	0	0	13
NFKB1 protein, partial	3	0	0	3
Microtubule-associated protein tau	16	0	0	16
Thrombopoietin	5	0	0	5
regulator of G-protein signaling 4	9	0	0	9
farnesoid X nuclear receptor	15	0	0	15
vitamin D (1,25- dihydroxyvitamin D3) receptor	20	0	0	20
D(1A) dopamine receptor	3	0	0	3
heat shock protein beta-1	8	0	0	8
flap endonuclease 1	8	0	0	8
muscarinic acetylcholine receptor M1	10	0	0	10
Histone deacetylase 3	0	1	0	1
Histone deacetylase 4	0	1	0	1
Guanine nucleotide-binding protein G	6	0	0	6
Histone deacetylase 1	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Ataxin-2	13	0	0	13
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
ATP-dependent phosphofructokinase	16	0	0	16
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	22	0	0	22
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
pregnane X nuclear receptor	24	0	0	24
nuclear factor erythroid 2-related factor 2 isoform 2	12	0	0	12
importin subunit beta-1 isoform 1	5	0	0	5
snurportin-1	5	0	0	5
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
lamin isoform A-delta10	24	0	0	24
Voltage-dependent calcium channel gamma-2 subunit	18	0	0	18
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	20	0	0	20
Xanthine dehydrogenase/oxidase	0	4	0	4
TAR DNA-binding protein 43	5	0	0	5
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	11	0	0	11
Sex hormone-binding globulin	0	0	4	4
Corticosteroid-binding globulin	0	4	0	4
Mineralocorticoid receptor	0	8	4	13
Mineralocorticoid receptor	0	3	0	3
Solute carrier organic anion transporter family member 1A1	0	0	0	1
RGS12	2	0	0	2
estrogen receptor 2 (ER beta)	12	0	0	12
vitamin D3 receptor isoform VDRA	18	0	0	18
Alpha-synuclein	4	6	0	10
thyroid stimulating hormone receptor	13	0	0	13
IDH1	12	0	0	12
transcriptional regulator ERG isoform 3	3	0	0	3
ras-related protein Rab-9A	3	0	0	3
Polyphenol oxidase 2	0	3	0	5
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Cellular tumor antigen p53	27	0	0	27
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	2	2	4
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Purine nucleoside phosphorylase	0	0	1	1
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	1
Chain U, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, HADH2 protein	10	0	0	10
Chain B, HADH2 protein	10	0	0	10
acid sphingomyelinase	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	20	0	0	20
glucocerebrosidase	5	0	0	5
alpha-galactosidase	4	0	0	4
cytochrome P450 2D6 isoform 1	3	0	0	3
lysosomal alpha-glucosidase preproprotein	5	0	0	5
cytochrome P450 2C19 precursor	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
huntingtin isoform 2	3	0	0	3
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 1	0	8	0	12
Prothrombin	0	2	0	2
Coagulation factor X	0	1	0	1
Plasminogen	0	1	0	1
Urokinase-type plasminogen activator	0	2	0	2
Tissue-type plasminogen activator	0	2	0	2
Cationic trypsin	0	1	0	1
Coagulation factor XI	0	1	0	1
Plasma kallikrein	0	1	0	4
Vitamin K-dependent protein C	0	1	0	1
Urokinase-type plasminogen activator	0	2	0	2
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Sodium/hydrogen exchanger 1	0	2	0	2
Sodium/hydrogen exchanger 3	0	2	0	2
Trypsin-3	0	1	0	1
Amiloride-sensitive sodium channel subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 7	0	3	0	3
Sodium/hydrogen exchanger 2	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	3	0	3
Sodium/hydrogen exchanger 5	0	2	0	2
Solute carrier family 22 member 1	0	6	0	8
Solute carrier family 22 member 2	0	5	0	6
Acid-sensing ion channel 3	0	1	0	1
Sodium/hydrogen exchanger	0	1	0	1
ATAD5 protein, partial	12	0	0	12
Lysyl oxidase homolog 2	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
DNA polymerase kappa isoform 1	13	0	0	13
histone acetyltransferase KAT2A isoform 1	13	0	0	13
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	3	1	4
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	4	0	4
Type-1 angiotensin II receptor	0	3	3	6
Type-2 angiotensin II receptor	0	3	0	3
Type-2 angiotensin II receptor	0	2	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
GLS protein	10	0	0	10
chromobox protein homolog 1	21	0	0	21
DNA polymerase iota isoform a (long)	15	0	0	15
lethal factor (plasmid)	6	0	0	6
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	11	0	0	11
lethal(3)malignant brain tumor-like protein 1 isoform I	4	0	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Alpha-2B adrenergic receptor	0	2	2	5
Spike glycoprotein	10	0	0	10
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	1	0	2
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	1	0	2
Solute carrier family 23 member 1	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	10	0	0	10
Chain A, Ferritin light chain	9	0	0	9
Chain A, Cruzipain	7	0	0	7
Luciferase	10	0	0	10
endonuclease IV	4	0	0	4
ClpP	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
DNA polymerase III, partial	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
nonstructural protein 1	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	9	0	0	9
galactokinase	1	0	0	1
hexokinase-4 isoform 1	2	0	0	2
peripheral myelin protein 22 isoform 1	9	0	0	9
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
cytochrome P450 2C9 precursor	4	0	0	4
runt-related transcription factor 1 isoform AML1b	2	0	0	2
glucokinase regulatory protein	2	0	0	2
core-binding factor subunit beta isoform 2	2	0	0	2
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
DNA polymerase beta	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
eyes absent homolog 2 isoform a	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
DNA polymerase eta isoform 1	5	0	0	5
M-phase phosphoprotein 8	9	0	0	9
pyruvate kinase PKM isoform b	1	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Myc proto-oncogene protein	0	1	0	1
Complement component C9	0	1	0	1
Ornithine decarboxylase	1	0	0	2
60 kDa chaperonin	0	4	0	4
60 kDa heat shock protein, mitochondrial	0	4	0	4
Glutamate receptor 1	2	0	0	2
Glutamate receptor 3	2	0	0	2
Glutamate receptor 4	2	0	0	2
Cruzipain	0	2	0	2
DNA-(apurinic or apyrimidinic site) endonuclease	0	1	0	1
DNA-3-methyladenine glycosylase	0	1	0	1
Ribonuclease T	0	0	0	2
Cystathionine gamma-lyase	0	3	1	5
Cystathionine beta-synthase	0	1	0	1
DNA repair protein RAD52 homolog	0	2	0	2
Dual specificity mitogen-activated protein kinase kinase 3	0	1	0	1
Histamine H2 receptor	5	2	1	8
10 kDa heat shock protein, mitochondrial	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Inositol monophosphatase 1	3	0	0	3
Cell death-related nuclease 4	0	0	0	2
Thiosulfate sulfurtransferase	0	4	0	4
60 kDa chaperonin	0	4	0	4
10 kDa chaperonin	0	4	0	4
Cystathionine gamma-lyase	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
DNA polymerase iota	0	1	0	1
DNA polymerase eta	0	1	0	1
Cysteine protease ATG4B	0	1	0	1
phosphoglycerate kinase	2	0	0	2
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
large T antigen	0	2	0	2
SMAD family member 2	10	0	0	10
Fumarate hydratase	4	0	0	4
SMAD family member 3	10	0	0	10
EWS/FLI fusion protein	12	0	0	12
G	17	0	0	17
polyprotein	4	0	0	4
P53	1	0	0	1
peroxisome proliferator-activated receptor delta	14	0	0	14
peroxisome proliferator activated receptor gamma	18	0	0	18
activating transcription factor 6	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	16	0	0	16
Histone H2A.x	9	0	0	9
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
cytochrome P450 3A4 isoform 1	9	0	0	9
Bile salt export pump	0	3	0	3
Interferon beta	21	0	0	21
HLA class I histocompatibility antigen, B alpha chain	17	0	0	17
Inositol hexakisphosphate kinase 1	17	0	0	17
Protein-arginine deiminase type-4	0	4	0	4
cytochrome P450 2C9, partial	17	0	0	17
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
apical membrane antigen 1, AMA1	6	0	0	6
nonstructural protein 1	0	2	0	2
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Genome polyprotein	0	2	2	4
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
5-hydroxytryptamine receptor 4	0	4	0	4
ATP-dependent translocase ABCB1	0	3	0	3
ATP-dependent translocase ABCB1	0	8	0	8
Beta-1 adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2A adrenergic receptor	0	3	2	6
D(2) dopamine receptor	0	3	2	5
Alpha-2C adrenergic receptor	0	3	2	6
D	0	1	0	1
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	6	1	8
Alpha-2B adrenergic receptor	0	1	1	2
ATP-dependent translocase ABCB1	0	3	0	3
D(1A) dopamine receptor	0	3	1	4
Alpha-2C adrenergic receptor	0	1	1	2
Alpha-2A adrenergic receptor	0	1	1	2
Alpha-1D adrenergic receptor	0	2	1	4
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	5	2	7
5-hydroxytryptamine receptor 2C	0	4	2	6
5-hydroxytryptamine receptor 1B	0	5	0	5
D(4) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	6	1	7
5-hydroxytryptamine receptor 6	0	4	1	5
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
PPM1D protein	4	0	0	4
mitogen-activated protein kinase 1	7	0	0	7
nuclear receptor ROR-gamma isoform 1	10	0	0	10
Vitamin D-binding protein	0	0	1	1
Androgen receptor	0	8	5	13
Vitamin D3 receptor	0	2	4	10
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	2	5	7
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
Metallo-beta-lactamase type 2	0	1	1	2
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Neprilysin	0	1	0	1
Neprilysin	0	1	0	1
Leukotriene A-4 hydrolase	0	2	1	3
EEF1AKMT4-ECE2 readthrough transcript protein	0	1	0	1
Angiotensin-converting enzyme	0	4	1	5
Angiotensin-converting enzyme	0	2	0	3
Leukotriene A-4 hydrolase	0	1	0	1
Thymidine phosphorylase	0	0	1	2
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	4	1	5
Endothelin-converting enzyme 1	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	3	0	3
Angiotensin-converting enzyme	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	1
Beta-lactamase	0	3	0	4
Beta-lactamase	0	3	0	3
Angiotensin-converting enzyme 2	0	2	0	2
Beta-lactamase class B VIM-2	0	1	1	2
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
caspase 7, apoptosis-related cysteine protease	5	0	0	5
67.9K protein	5	0	0	5
caspase-3	5	0	0	5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
thyrotropin-releasing hormone receptor	4	0	0	4
Caspase-2	0	0	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
Glycine receptor subunit alpha-1	0	0	3	3
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	3	0	6
Solute carrier family 22 member 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	2	2	0	4
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	2	2	0	4
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
cytochrome P450 2D6	9	0	0	9
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Histamine H2 receptor	0	4	0	4
Histamine H1 receptor	0	0	2	2
Potassium-transporting ATPase subunit beta	0	1	0	1
Cytochrome P450 2J2	0	4	0	4
Aldehyde oxidase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	4
Multidrug and toxin extrusion protein 2	0	1	0	1
Solute carrier family 22 member 8	0	4	0	7
Multidrug and toxin extrusion protein 1	0	6	0	6
Histamine H4 receptor	0	1	0	1
Solute carrier family 22 member 11	0	1	0	3
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
Smad3	4	0	0	4
PINK1	2	0	0	2
Parkin	4	0	0	4
Extracellular calcium-sensing receptor	0	0	2	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
Glucocorticoid receptor	0	14	5	24
Glycine receptor subunit alpha-1	0	12	0	12
Glycine receptor subunit beta	0	12	0	12
Glycine receptor subunit alpha-2	0	12	0	12
Glycine receptor subunit alpha-3	0	12	0	12
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	4	0	4
Lysine-specific demethylase 4A	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	0	1	1
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
Eyes absent homolog 2	0	2	0	2
Amyloid-beta precursor protein	0	4	0	4
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Estrogen receptor	0	6	3	9
Progesterone receptor	0	8	3	12
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Estrogen receptor beta	0	5	3	8
hypothetical protein, conserved	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
glp-1 receptor, partial	5	0	0	5
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	2
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	2	0	3
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	7
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	6
Glutamate receptor ionotropic, NMDA 2C	0	2	1	6
Large neutral amino acids transporter small subunit 1	0	5	0	5
Glutamate receptor ionotropic, NMDA 2D	0	2	1	6
Glutamate receptor ionotropic, NMDA 3B	0	2	1	6
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Glutamate receptor ionotropic, NMDA 3A	0	2	1	6
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	3
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Hsf1 protein	0	0	1	1
Albumin	0	2	3	5
Solute carrier family 22 member 3	0	0	0	1
Mu-type opioid receptor	0	4	2	6
Delta-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	2	2	4
Glutamine synthetase	0	1	0	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	6	0	7
Farnesyl pyrophosphate synthase	0	8	0	8
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
neuropeptide S receptor isoform A	3	0	0	3
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Prostaglandin G/H synthase 2	0	1	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Phospholipase A2, major isoenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	3
Procathepsin L	0	1	0	1
Interleukin-8	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Caspase-1	0	0	0	1
Substance-P receptor	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Aldo-keto reductase family 1 member C3	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	2	0	2
Prostaglandin D2 receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	3
histone deacetylase 9 isoform 3	2	0	0	2
BRCA1	1	0	0	1
SUMO-1-specific protease	0	1	0	1
SUMO1/sentrin specific peptidase 7	0	1	0	1
STAT3, partial	0	0	1	1
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	7	0	0	7
caspase-3 isoform a preproprotein	0	1	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	0	1	1
sentrin-specific protease 8	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Macrophage migration inhibitory factor	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Chymotrypsinogen A	0	1	0	1
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
SLC16A10 protein	0	0	0	2
Monocarboxylate transporter 10	0	0	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Androgen receptor	0	0	1	1
Rap guanine nucleotide exchange factor 3	7	0	0	7
Vitamin K-dependent gamma-carboxylase	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
Transporter	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	5	0	5
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	2	0	0	2
5-hydroxytryptamine receptor 2A	0	0	1	1
C-terminal-binding protein 2	0	1	0	1
Gamma-aminobutyric acid	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain D, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, Beta-arrestin 1	0	0	1	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Glutamate 5-kinase	0	0	0	1
Beta-1 adrenergic receptor	0	1	1	3
Beta-2 adrenergic receptor	0	2	1	3
Muscarinic acetylcholine receptor M2	0	2	1	3
Adenosine receptor A3	0	3	1	4
Beta-2 adrenergic receptor	0	2	0	3
Muscarinic acetylcholine receptor M1	0	1	1	2
Beta-3 adrenergic receptor	0	2	1	3
Alpha-1B adrenergic receptor	0	4	1	5
Beta-1 adrenergic receptor	0	2	1	4
Muscarinic acetylcholine receptor M3	0	1	1	2
Alpha-1D adrenergic receptor	0	3	1	4
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Sodium-dependent serotonin transporter	0	2	0	2
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Vasopressin V1a receptor	0	1	1	2
Alpha-1A adrenergic receptor	0	4	1	5
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Sigma non-opioid intracellular receptor 1	0	2	0	2
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Quinolone resistance protein NorA	0	1	0	2
DNA topoisomerase 1	0	1	0	1
Chromaffin granule amine transporter	0	1	0	1
Caspase-7	1	0	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Butyrophilin subfamily 3 member A1	0	1	2	4
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
H	0	2	0	2
Phosphotransferase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Lysine-specific demethylase 4E	0	1	0	1
Lysine-specific demethylase 6B	0	1	0	1
Gamma-butyrobetaine dioxygenase	0	1	0	1
Lysine-specific demethylase 5C	0	1	0	1
Histone lysine demethylase PHF8	0	1	0	1
Lysine-specific demethylase 2A	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Chain A, Prostatic Acid Phosphatase	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	2	0	2
Stromelysin-1	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	2	0	2
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Taste receptor type 2 member 38	0	0	1	2
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(5)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (1,786)

Protein Targets (1,149)

CKD-MBD

Synonyms(5)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (1,786)

Drugs Studied (255)

Protein Targets (1,149)