Page last updated: 2024-09-28

Afferent Pupillary Defect

Conditions which affect the structure or function of the pupil of the eye, including disorders of innervation to the pupillary constrictor or dilator muscles, and disorders of pupillary reflexes.

Synonyms(22)

Synonym
Wernicke Hemianopic Pupil
Occluded Pupils
Fixed Pupils
Marcus-Gunn Pupil
Afferent Pupillary Defect
Deformed Pupil
Ectopic Pupil
Wernicke's Hemianopic Pupil
Pupillary Disorders
Pupillary Sphincter Rupture
Pupillary Sector Paralysis
Pupillary Paralysis
Pupillary Occlusion
Sector Pupil Palsy
Efferent Pupillary Defect
Pupillary Functions, Abnormal
Pupil Malformations
Pupillary Anomaly
Pupil Reaction Absent
Keyhole Pupil
Non-Syphilitic Argyll-Robertson Pupil
Pupil Disorders

Research Excerpts

Treatment

ExcerptReference
"The presence of a relative afferent pupillary defect was the main predictor of post-treatment VA of 20/200 or worse (adjusted odds ratio: 19."( Aryasit, O; Aunruan, S; Sanghan, N, 2021)

Research

Studies (316)

TimeframeStudies, This Condition (%)All Conditions %
pre-199039 (12.34)23.3326
1990's56 (17.72)12.5806
2000's85 (26.90)18.1394
2010's104 (32.91)28.8240
2020's32 (10.13)9.53
DrugIndicatedRelationship StrengthStudiesTrials
cytosine0low30
lactic acid0low10
iodine0low20
methanol0low10
pyridoxal phosphate0low10
pyridoxine 5-phosphate0low10
acetazolamide0low30
albendazole0low10
apraclonidine0low30
aspirin0low20
carbamazepine0low10
clonidine0low30
cyclopentolate0low30
foscarnet0low10
furosemide0low10
glutaral0low10
haloperidol0low10
lidocaine0low10
2-propanol0low1470
lorazepam0low20
losartan0low10
mepivacaine0low10
metformin0low10
methadone0low10
metoclopramide0low10
midazolam0low10
midodrine0low10
apnea0low10
orphenadrine0low10
pholedrine0low10
sevoflurane0low10
tetraethylammonium0low10
tolazoline0low10
tropicamide0medium51
mitomycin0low10
prednisolone0low60
phentolamine0medium11
thyroxine0low10
carbachol0low10
prednisolone acetate0low10
prednisone0low60
penicillin g0low10
pilocarpine0low80
lysine0low10
phenylephrine0medium61
mannitol0medium21
valine0low10
perflutren0low10
methylprednisolone0low60
diethylpropion0low10
quinoxalines0low10
pyridostigmine bromide0low10
cyclohexanol0low10
framycetin0low10
thiazoles0low10
xanthinol niacinate0low10
kainic acid0low10
methamphetamine0low10
ethylnitrosourea0low20
thioflavin t0low10
sulfur hexafluoride0low10
n-methylaspartate0low10
argon0low10
cadmium0low10
iodine0low10
4-methoxyamphetamine0low10
glutamic acid0low10
timolol0low10
etoposide0low10
substance p0low10
propiconazole0low170
fomesafen0low10
cidofovir anhydrous0low10
venlafaxine hydrochloride0low10
homocysteine0low10
tamsulosin0low20
atropine0medium121
organophosphonates0low30
solifenacin succinate0low10
carboplatin0low10
glycogen0low60
fibrin0low70
rocuronium0low10
cocaine0medium61
mycophenolic acid0low10
dipyrone0low10
retinaldehyde0low10
capsaicin0low10
D-fructopyranose0low10
thiopental0low10
phenylephrine hydrochloride0low10
naloxone0low20
topiramate0low10
morphine0low20
deamino arginine vasopressin0low20
strontium0low10
ramipril0low10
strontium radioisotopes0low10
9-cis-retinal0low10
g(m1) ganglioside0low10
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane0low10
brimonidine tartrate0low10
indocyanine green0low20
scopolamine hydrobromide0low50
hyaluronoglucosaminidase0low10
acyclovir0low40
ganciclovir0low20
valacyclovir0low10
eye0low240

Protein Targets (1,017)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Sodium-dependent dopamine transporter 0606
hypoxia-inducible factor 1 alpha subunit130013
RAR-related orphan receptor gamma250025
GLI family zinc finger 3260026
AR protein310031
aldehyde dehydrogenase 1 family, member A1150015
retinoic acid nuclear receptor alpha variant 1210021
retinoid X nuclear receptor alpha180018
estrogen nuclear receptor alpha400040
peroxisome proliferator-activated receptor delta130013
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a190019
activating transcription factor 6100010
v-jun sarcoma virus 17 oncogene homolog (avian)130013
Histone H2A.x9009
thyroid hormone receptor beta isoform a6006
heat shock protein beta-15005
nuclear factor erythroid 2-related factor 2 isoform 1210021
lamin isoform A-delta10260026
Voltage-dependent calcium channel gamma-2 subunit130013
Glutamate receptor 2136221
5-hydroxytryptamine receptor 2C0718
5-hydroxytryptamine receptor 2A0718
5-hydroxytryptamine receptor 1A010212
5-hydroxytryptamine receptor 1B0819
5-hydroxytryptamine receptor 1D0415
5-hydroxytryptamine receptor 1F0415
5-hydroxytryptamine receptor 2B0718
5-hydroxytryptamine receptor 60112
Sodium-dependent serotonin transporter09211
Sodium-dependent serotonin transporter0708
5-hydroxytryptamine receptor 7 0213
5-hydroxytryptamine receptor 5A0112
5-hydroxytryptamine receptor 5B0112
5-hydroxytryptamine receptor 3A0314
5-hydroxytryptamine receptor 4 0214
5-hydroxytryptamine receptor 3B0314
Aldo-keto reductase family 1 member B100004
Aldo-keto reductase family 1 member B10103
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase100010
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0002
Carbonic anhydrase 0202
thioredoxin reductase210021
GALC protein3003
nuclear receptor subfamily 1, group I, member 3150015
cytochrome P450 family 3 subfamily A polypeptide 4160016
glucocorticoid receptor [Homo sapiens]290029
estrogen-related nuclear receptor alpha290029
Carbonic anhydrase 0202
Carbonic anhydrase 0202
arylsulfatase A120012
Carbonic anhydrase0202
euchromatic histone-lysine N-methyltransferase 2280028
Bloom syndrome protein isoform 19009
geminin250025
peripheral myelin protein 22130013
survival motor neuron protein isoform d7007
muscleblind-like protein 1 isoform 14004
Gamma-aminobutyric acid receptor subunit pi93113
ATP-binding cassette sub-family C member 3022022
Multidrug resistance-associated protein 4022022
Carbonic anhydrase0202
Solute carrier family 22 member 60507
Carbonic anhydrase 1205110
Prolyl endopeptidase0202
Carbonic anhydrase-related protein 110103
Bile salt export pump037037
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 1010119
Carbonic anhydrase 2011219
Carbonic anhydrase 20202
Cytochrome P450 1A20202
Carbonic anhydrase 30518
Cathepsin B0101
Cytochrome P450 3A408111
Steryl-sulfatase0101
Polyunsaturated fatty acid 5-lipoxygenase0303
Cytochrome P450 2C80202
Cytochrome P450 2D60707
Cytochrome P450 2A60213
Cytochrome P450 2C9 011011
Androgen receptor0404
Gamma-aminobutyric acid receptor subunit beta-193113
Translocator protein0213
Gamma-aminobutyric acid receptor subunit delta93113
Gamma-aminobutyric acid receptor subunit gamma-293113
Gamma-aminobutyric acid receptor subunit alpha-593113
Gamma-aminobutyric acid receptor subunit alpha-393113
Cannabinoid receptor 10101
Arachidonate 5-lipoxygenase-activating protein0202
Cytochrome P450 2B60215
Carbonic anhydrase 407111
Carbonic anhydrase 60519
Gamma-aminobutyric acid receptor subunit gamma-193113
Gamma-aminobutyric acid receptor subunit alpha-293113
Carbonic anhydrase 5A, mitochondrial0202
Adenosine receptor A10303
Serum paraoxonase/arylesterase 10303
Dipeptidyl peptidase 40102
Gamma-aminobutyric acid receptor subunit alpha-493113
Gamma-aminobutyric acid receptor subunit gamma-393113
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-693113
Adenosine receptor A2a0336
Delta-type opioid receptor06110
Cytochrome P450 2C190404
Delta-type opioid receptor07311
Mu-type opioid receptor07313
Carbonic anhydrase 5A, mitochondrial06212
Carbonic anhydrase0303
Kappa-type opioid receptor0618
Carbonic anhydrase 70519
Carbonic anhydrase0101
D(1A) dopamine receptor1203
Corticosteroid 11-beta-dehydrogenase isozyme 10202
Carbonic anhydrase0202
D(2) dopamine receptor08210
Gamma-aminobutyric acid receptor subunit alpha-194114
Gamma-aminobutyric acid receptor subunit beta-393113
Gamma-aminobutyric acid receptor subunit beta-293113
Cholinesterase0101
Carbonic anhydrase 0202
Mu-type opioid receptor0718
Fatty-acid amide hydrolase 10404
Beta-carbonic anhydrase 10202
Carbonic anhydrase 20202
Glutamate receptor ionotropic, NMDA 2B010315
Squalene synthase0202
Neuronal acetylcholine receptor subunit alpha-70303
Carbonic anhydrase 906111
Carbonic anhydrase0202
Carbonic anhydrase, alpha family 0202
Carbonic anhydrase 0202
Carbonic anhydrase 30101
Carbonic anhydrase0203
Carbonic anhydrase0203
Carbonic anhydrase 0202
Sigma intracellular receptor 20202
Delta carbonic anhydrase0202
Sigma non-opioid intracellular receptor 10314
Renin0101
Carbonic anhydrase 0202
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130315
GABA theta subunit93113
Canalicular multispecific organic anion transporter 1023024
Carbonic anhydrase 40404
Carbonic anhydrase 150405
Acidic mammalian chitinase0101
Carbonic anhydrase 130508
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon93113
Carbonic anhydrase 0101
Carbonic anhydrase 1405110
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial05110
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein8008
Chain B, HADH2 protein8008
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain6006
Thymidine kinase 0303
phosphopantetheinyl transferase9009
GLS protein130013
TDP1 protein260026
Smad33003
thyroid stimulating hormone receptor120012
EWS/FLI fusion protein130013
hemoglobin subunit beta2002
atrial natriuretic peptide receptor 1 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Solute carrier family 22 member 1 010015
Bile salt export pump0404
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20002
Cytochrome P450 2J20606
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0022
Solute carrier family 22 member 60205
Thymidine kinase 0101
Solute carrier family 22 member 80204
Thymidine kinase0101
Luciferase5005
glp-1 receptor, partial9009
ATAD5 protein, partial6006
Fumarate hydratase4004
caspase 7, apoptosis-related cysteine protease5005
progesterone receptor180018
farnesoid X nuclear receptor9009
pregnane X nuclear receptor210021
polyprotein4004
67.9K protein7007
peroxisome proliferator activated receptor gamma160016
vitamin D (1,25- dihydroxyvitamin D3) receptor110011
caspase-35005
IDH1130013
aryl hydrocarbon receptor100010
nuclear receptor subfamily 1, group I, member 26006
cellular tumor antigen p53 isoform a3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
chromobox protein homolog 1140014
nuclear factor erythroid 2-related factor 2 isoform 2120012
transcriptional regulator ERG isoform 33003
thyroid hormone receptor beta isoform 2170017
histone deacetylase 9 isoform 32002
mitogen-activated protein kinase 14004
urokinase-type plasminogen activator precursor6006
plasminogen precursor6006
urokinase plasminogen activator surface receptor precursor6006
Vif0001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
neuropeptide S receptor isoform A2002
Interferon beta9009
Cellular tumor antigen p53180018
Integrin beta-33115
Integrin alpha-IIb3115
Methionine aminopeptidase0101
Inositol monophosphatase 13003
ATPase family AAA domain-containing protein 5110011
Ataxin-2120012
Microtubule-associated protein tau6006
D(1A) dopamine receptor6006
NFKB1 protein, partial7007
regulator of G-protein signaling 47007
muscarinic acetylcholine receptor M1100010
Alpha-2A adrenergic receptor014520
Alpha-2B adrenergic receptor010314
Alpha-2C adrenergic receptor010415
Alpha-2B adrenergic receptor011415
Alpha-1D adrenergic receptor011415
Adenosine receptor A2b0022
Alpha-1A adrenergic receptor08614
Alpha-1B adrenergic receptor08614
ATP-dependent phosphofructokinase120012
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE150015
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
alpha-galactosidase2002
cytochrome P450 2C19 precursor4004
flap endonuclease 13003
DNA polymerase iota isoform a (long)100010
lethal factor (plasmid)6006
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30202
Chain A, Phospholipase A2 isoform 30011
Chain A, 2-oxoglutarate Oxygenase8008
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 85005
hypothetical protein, conserved1001
cytochrome P450 2D6130013
glucocerebrosidase3003
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
DNA polymerase kappa isoform 15005
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0202
Fatty acid-binding protein, liver0303
Myeloperoxidase0202
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10404
Substance-P receptor0202
Prostaglandin G/H synthase 20404
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma5005
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Sigma non-opioid intracellular receptor 10819
Sigma non-opioid intracellular receptor 10314
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta1001
short transient receptor potential channel 6 isoform 10011
5-hydroxytryptamine receptor 4010010
Muscarinic acetylcholine receptor M2012420
Muscarinic acetylcholine receptor M4011317
Muscarinic acetylcholine receptor M1013220
Muscarinic acetylcholine receptor M3011217
Muscarinic acetylcholine receptor M4011116
Muscarinic acetylcholine receptor M5011116
Muscarinic acetylcholine receptor M5012318
Muscarinic acetylcholine receptor M2012219
Muscarinic acetylcholine receptor M1014523
Muscarinic acetylcholine receptor M10124
Muscarinic acetylcholine receptor M3011317
5-hydroxytryptamine receptor 2C010010
Muscarinic acetylcholine receptor M40101
Histamine H2 receptor5007
5-hydroxytryptamine receptor 70607
Reverse transcriptase/RNaseH 0113
Muscarinic acetylcholine receptor0314
Potassium channel subfamily K member 30303
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20213
Potassium channel subfamily K member 90101
USP1 protein, partial9009
histone acetyltransferase KAT2A isoform 19009
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Integrin alpha-50101
Acetylcholine receptor subunit beta0101
UDP-glucuronosyltransferase 2B70305
Neuronal acetylcholine receptor subunit beta-20102
UDP-glucuronosyltransferase 1-60202
UDP-glucuronosyltransferase 1A1 0305
UDP-glucuronosyltransferase 1A40203
Sodium-dependent noradrenaline transporter 09110
Sodium-dependent dopamine transporter0505
Neuronal acetylcholine receptor subunit beta-40102
Neuronal acetylcholine receptor subunit alpha-30101
UDP-glucuronosyltransferase 2B10 0202
Neuronal acetylcholine receptor subunit alpha-70101
Neuronal acetylcholine receptor subunit alpha-40102
Acetylcholine receptor subunit delta0101
15-lipoxygenase, partial4004
estrogen receptor 2 (ER beta)110011
nuclear receptor ROR-gamma isoform 18008
cytochrome P450 3A4 isoform 19009
transient receptor potential cation channel subfamily V member 12002
Transient receptor potential cation channel subfamily V member 10314
Lysine-specific histone demethylase 1A0101
NADH-ubiquinone oxidoreductase chain 10101
Cannabinoid receptor 10101
Acetylcholinesterase0404
Cannabinoid receptor 2 0101
Spike glycoprotein120012
Potassium voltage-gated channel subfamily A member 10202
Corticotropin-releasing factor receptor 20101
Transient receptor potential cation channel subfamily V member 10214
Transient receptor potential cation channel subfamily V member 40112
Transient receptor potential cation channel subfamily V member 20112
acetylcholinesterase150015
thyroid stimulating hormone receptor6006
thyrotropin-releasing hormone receptor2002
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-41102
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-21102
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-50101
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Muscarinic acetylcholine receptor M30013
Muscarinic acetylcholine receptor M20003
Neuronal acetylcholine receptor subunit alpha-100101
Vpr3003
Albumin0044
Major prion protein0022
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0303
Sodium channel protein type 3 subunit alpha0202
Sodium channel protein type 4 subunit alpha0304
Potassium voltage-gated channel subfamily H member 2011011
Sodium channel protein type 9 subunit alpha0404
Frizzled-80011
P2X purinoceptor 40101
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
G5005
vitamin D3 receptor isoform VDRA3003
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
HLA class I histocompatibility antigen, B alpha chain 5005
Inositol hexakisphosphate kinase 15005
cytochrome P450 2C9, partial5005
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Thymidine kinase0001
Chain A, Cruzipain2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)9009
Beta-1 adrenergic receptor 0022
Alpha-1B adrenergic receptor 0022
cytochrome P450 2D6 isoform 16006
cytochrome P450 2C9 precursor3003
Membrane primary amine oxidase 0101
5-hydroxytryptamine receptor 3A0011
Solute carrier family 22 member 30404
5-hydroxytryptamine receptor 1A0404
Alpha-1B adrenergic receptor08311
Alpha-1A adrenergic receptor0325
D0505
D(3) dopamine receptor0505
Amine oxidase [flavin-containing] A0101
Alpha-2C adrenergic receptor09413
Alpha-2A adrenergic receptor09413
Alpha-1D adrenergic receptor09313
D(1B) dopamine receptor0404
Amine oxidase [flavin-containing] B0101
Alpha-2B adrenergic receptor0002
D(4) dopamine receptor0404
Alpha-1A adrenergic receptor09413
Alpha-2C adrenergic receptor0002
Alpha-2A adrenergic receptor0002
Alpha-2A adrenergic receptor0101
Nischarin0202
Solute carrier family 22 member 10204
Multidrug and toxin extrusion protein 10606
Nischarin0202
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Amyloid-beta precursor protein1304
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Tryptophan 5-hydroxylase 10202
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Liver carboxylesterase 10001
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Glutamate receptor ionotropic, NMDA 1 08313
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit epsilon0101
Glutamate receptor ionotropic, NMDA 2A 08313
Glutamate receptor ionotropic, NMDA 2C08313
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sodium-dependent dopamine transporter0202
Glutamate receptor ionotropic, NMDA 2D08313
Gamma-aminobutyric acid receptor subunit gamma-10101
Glutamate receptor ionotropic, NMDA 3B08313
Gamma-aminobutyric acid receptor subunit gamma-30101
Leukotriene B4 receptor 20101
Glutamate receptor ionotropic, NMDA 3A08313
Gamma-aminobutyric acid receptor subunit theta0101
Transporter0202
Deoxycytidine kinase0001
Vasopressin V2 receptor0112
Oxytocin receptor0011
Vasopressin V1a receptor0112
Vasopressin V1b receptor0112
Translocator protein0101
Vasopressin V2 receptor 0112
polyunsaturated fatty acid lipoxygenase ALOX121001
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
pregnane X receptor5005
SMAD family member 25005
SMAD family member 35005
LMP1 [Human herpesvirus 4]0001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a7007
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Prothrombin0012
Regulatory protein E20011
ATP-dependent translocase ABCB10303
ATP-dependent translocase ABCB107010
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0117
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
ATP-dependent translocase ABCB10303
Caspase-30101
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Solute carrier organic anion transporter family member 1B30404
Chain A, Uracil Phosphoribosyltransferase0101
endonuclease IV5005
Skn7p0001
Thrombopoietin2002
nonstructural protein 14004
peripheral myelin protein 22 isoform 12002
huntingtin isoform 21001
serine/threonine-protein kinase mTOR isoform 12002
Solute carrier family 22 member 80103
Thymidylate synthase0101
Aromatase0101
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Chain A, probable fosfomycin resistance protein0011
Chain B, probable fosfomycin resistance protein0011
DNA polymerase catalytic subunit0101
DNA polymerase catalytic subunit0101
DNA polymerase alpha catalytic subunit0101
DNA polymerase delta catalytic subunit0101
Menin0011
Lecithin retinol acyltransferase0101
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Lethal factor0101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Protein Rev 0011
Aminoglycoside 3'-phosphotransferase 0001
Tyrosyl-DNA phosphodiesterase 10101
Albumin0213
Glucose-6-phosphate 1-dehydrogenase0101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Adenosine receptor A10101
6-phosphogluconate dehydrogenase, decarboxylating0202
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0101
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Broad substrate specificity ATP-binding cassette transporter ABCG20202
ClpP2002
Transitional endoplasmic reticulum ATPase0101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor2002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60124
Glutamate receptor ionotropic, NMDA 2D0202
Excitatory amino acid transporter 40101
Glutamate receptor ionotropic, NMDA 3B0202
Glutathione reductase, mitochondrial0404
Bifunctional aspartokinase/homoserine dehydrogenase 10101
ATP-citrate synthase 0101
Glutamate receptor 10628
Glutamate receptor 30628
Glutamate receptor 40628
Glutamate receptor ionotropic, kainate 10527
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10325
Metabotropic glutamate receptor 50124
Glutamate receptor ionotropic, kainate 20538
Glutamate receptor 10325
Glutamate receptor 20325
Glutamate receptor 30123
Glutamate receptor ionotropic, kainate 30505
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40314
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Glutamate receptor ionotropic, kainate 40505
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, kainate 20325
Glutamate receptor ionotropic, kainate 30303
Glutamate receptor ionotropic, NMDA 2B0202
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, kainate 50303
Carbonic anhydrase-like protein, putative0001
Glutamate receptor ionotropic, kainate 50505
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0202
Alpha-ketoglutarate-dependent dioxygenase FTO0101
potassium voltage-gated channel subfamily H member 2 isoform d7007
Adenylate cyclase type 1 0101
Cocaine esterase0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
UDP-glucuronosyltransferase 1A90103
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Aldo-keto reductase family 1 member B10404
Beta-2 adrenergic receptor0202
Angiotensin-converting enzyme0404
Integrin alpha-40101
D(2) dopamine receptor0619
Carbonyl reductase [NADPH] 10001
Beta-1 adrenergic receptor0303
D(2) dopamine receptor0303
D(1A) dopamine receptor0203
D(4) dopamine receptor0316
D(1B) dopamine receptor0203
Adenylate cyclase type 30101
5-hydroxytryptamine receptor 3A0202
Histamine H2 receptor0404
Beta-3 adrenergic receptor0101
Adenylate cyclase type 20101
Adenylate cyclase type 40101
5-hydroxytryptamine receptor 2A0808
Histamine H1 receptor0202
C-8 sterol isomerase0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70202
Kappa-type opioid receptor0438
5-hydroxytryptamine receptor 2A0101
Histamine H1 receptor0505
Mu-type opioid receptor08313
D(3) dopamine receptor0619
Sodium channel protein type 1 subunit alpha0101
Adenylate cyclase type 80101
5-hydroxytryptamine receptor 2B0808
5-hydroxytryptamine receptor 2A0101
5-hydroxytryptamine receptor 60303
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
5-hydroxytryptamine receptor 2B0101
Adenylate cyclase type 60101
Adenylate cyclase type 50101
TAR DNA-binding protein 435005
5-hydroxytryptamine receptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20101
Zinc finger protein 6640101
Vesicular acetylcholine transporter0101
Transporter0101
Cholecystokinin receptor type A0101
Protease 0303
Adenylyl cyclase 7 0101
D0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0202
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Chain A, Glutamate receptor 20011
Chain A, Glutamate receptor 20011
Chain C, Glutamate receptor 20011
Chain A, JmjC domain-containing histone demethylation protein 3A3003
importin subunit beta-1 isoform 11001
snurportin-11001
Glutamate receptor ionotropic, kainate 40101
Potassium voltage-gated channel subfamily A member 50101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Translocator protein0101
Neprilysin0101
Angiotensin-converting enzyme 0202
Atrial natriuretic peptide receptor 30101
Thromboxane A2 receptor 0102
Type-1A angiotensin II receptor 0213
Type-1B angiotensin II receptor0202
Type-1 angiotensin II receptor0215
Type-1 angiotensin II receptor0112
Type-2 angiotensin II receptor0202
Type-2 angiotensin II receptor0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Platelet glycoprotein VI0113
Type-1 angiotensin II receptor0112
Solute carrier organic anion transporter family member 1B10203
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Solute carrier family 22 member 20304
Dihydrofolate reductase0101
Delta-type opioid receptor0529
Kappa-type opioid receptor05310
Mas-related G-protein coupled receptor member X20033
Aldehyde oxidase 1 0101
Solute carrier family 22 member 30102
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] B0101
Synaptic vesicular amine transporter0101
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10112
PPM1D protein3003
bromodomain adjacent to zinc finger domain 2B2002
Nuclear receptor subfamily 1 group I member 20022
Glucocorticoid receptor08215
Glycine receptor subunit alpha-10808
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Nuclear receptor subfamily 1 group I member 20011
5-hydroxytryptamine receptor 3E0011
5-hydroxytryptamine receptor 3B0011
5-hydroxytryptamine receptor 3A0011
Lactoperoxidase0101
5-hydroxytryptamine receptor 3D0011
5-hydroxytryptamine receptor 3C0011
5-hydroxytryptamine receptor 3B0101
Indoleamine 2,3-dioxygenase 10101
Opioid receptor, delta 1b 0101
Acetylcholinesterase0101
Opioid receptor homologue0101
Acyl-CoA desaturase 10101
Histidine decarboxylase0022
Proteinase-activated receptor 10112
Kappa-type opioid receptor0316
UDP-glucuronosyltransferase 1A30001
Mu-type opioid receptor0317
Nociceptin receptor0101
Mu-type opioid receptor0101
Beta-2 adrenergic receptor0213
Mu-type opioid receptor0101
Chain A, Inosine-5'-Monophosphate Dehydrogenase 20101
Inosine-5'-monophosphate dehydrogenase 20202
Inosine-5'-monophosphate dehydrogenase 1 0202
Peroxisome proliferator-activated receptor gamma0033
Alpha-synuclein1102
Inosine-5'-monophosphate dehydrogenase0102
UDP-glucuronosyltransferase 1A70001
UDP-glucuronosyltransferase 1A100001
UDP-glucuronosyltransferase 1A80002
Adenosine receptor A10101
Multidrug and toxin extrusion protein 20101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
streptokinase A precursor0011
Beta-lactamase0001
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Solute carrier family 15 member 10304
Beta-lactamase TEM0102
Guanine nucleotide-binding protein G2002
Beta-lactamase0001
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 15 member 20202
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Solute carrier family 22 member 80102
Beta-lactamase VIM-1 0001
Hsf1 protein0011
estrogen receptor beta isoform 10101
Alpha-1A adrenergic receptor0123
Alpha-1B adrenergic receptor0303
Nuclear receptor subfamily 3 group C member 3 0202
dopamine D1 receptor1001
ras-related protein Rab-9A1001
Beta-2 adrenergic receptor0213
Beta-1 adrenergic receptor0213
Beta-3 adrenergic receptor0213
POU domain, class 2, transcription factor 10001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Muscarinic acetylcholine receptor DM10101
Cytochrome P450 2A130112
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
thioredoxin glutathione reductase3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
heat shock protein 90, putative0001
M-phase phosphoprotein 81001
Receptor-type tyrosine-protein phosphatase beta0001
Low molecular weight phosphotyrosine protein phosphatase0101
P2X purinoceptor 10011
P2X purinoceptor 10101
P2X purinoceptor 40011
Trans-sialidase0101
Trans-sialidase0101
P2X purinoceptor 20011
Chain A, Cellular retinoic acid-binding protein 20011
Chain A, Cellular retinoic acid-binding protein 20011
Caspase-71001
caspase-31001
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Solute carrier family 22 member 70001
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
Substance-P receptor0202
Neuromedin-K receptor0011
Substance-K receptor0112
Substance-K receptor0202
Substance-P receptor0213
Neuromedin-K receptor0112
Substance-K receptor0101
Substance-K receptor0101
Growth hormone secretagogue receptor type 10011
Alpha-1D adrenergic receptor0101
Alpha-1B adrenergic receptor0101
Alpha-1A adrenergic receptor0101
Solute carrier family 22 member 10203
Solute carrier family 22 member 20102
Solute carrier family 22 member 50001
Solute carrier family 22 member 40001
Solute carrier family 22 member 20102
Solute carrier family 22 member 40101
Solute carrier family 22 member 30001
Solute carrier family 22 member 50001
Solute carrier family 22 member 40001
Cholinesterase0101
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
apical membrane antigen 1, AMA11001
serine/threonine-protein kinase PLK11001
DNA polymerase eta isoform 11001
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1B0101
Chain A, Carbonic anhydrase 10101
Carbonic anhydrase 20101
Solute carrier family 15 member 10101
Valacyclovir hydrolase0001
Chain A, Arginase 10101
Large neutral amino acids transporter small subunit 10101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]