Colonic Pseudo-Obstruction

Functional obstruction of the COLON leading to MEGACOLON in the absence of obvious COLONIC DISEASES or mechanical obstruction. When this condition is acquired, acute, and coexisting with another medical condition (trauma, surgery, serious injuries or illness, or medication), it is called Ogilvie's syndrome.

Synonym
Pseudo-Obstruction, Colonic
Ogilvie Syndrome
Ogilvie's Syndrome
Colonic Pseudo-Obstruction
Pseudoobstruction, Colonic
Ogilvie Disease

Excerpt	Reference
"Ogilvie's Syndrome is an infrequent complication of lumbar disc surgery, characterized by acute paralytic ileum as a result of acute colonic dilatation without mechanical obstruction."	( Mosquera-Betancourt, G; Varela Hernández, A; Vega-Basulto, SD, 2002)
"Ogilvie syndrome is characterized by dilatation of the large intestine in the absence of mechanical obstruction, usually occurring in adult patients with serious underlying medical conditions and rarely seen in children."	( Baker, JN; Coleman, JL; Johnson, LM; Spraker, HL, 2012)
"Ogilvie's syndrome is a rare and potentially fatal disease that can easily be mistaken for postoperative ileus."	( Hooten, KG; Larson, SD; Oliveria, SF; Pincus, DW, 2014)
"Ogilvie's syndrome is a rare but potentially fatal complication that can mimic a postoperative ileus."	( Beckman, JM; Januszewski, J; Kanter, AS; Keem, SK; Oskuian, RJ; Smith, W; Taylor, W; Uribe, JS, 2017)
"Diagnosis of Ogilvie's syndrome is based on clinical and radiologic grounds, and can be treated conservatively or with interventions such as acetylcholinesterase inhibitors (such as neostigmine), decompressive procedures including colonoscopy, and even surgery."	( Haj, M; Rockey, DC, 2018)

Excerpt	Reference
"With the theory that Ogilvie's syndrome is caused by sympathetic inhibition of contractility in the colon as a basis, 18 patients with acute colonic pseudo-obstruction were enrolled in a treatment program assessing the safety and efficacy of sympathetic blockade, by epidural anesthesia, in those who failed conservative management."	( Lee, JT; Singleton, BC; Taylor, BM, 1988)
"Acute pseudobstruction of the colon (Ogilvie's syndrome) has been treated by different surgical, endoscopic and radiological procedures, but a high proportion of recurrences has been reported."	( Artal, A; Freile, E; Lanas, A, 1994)
"Intestinal pseudo-obstruction (Ogilvie's syndrome) has previously been reported in 2 patients with theophylline toxicity treated with activated charcoal (AC), mechanical ventilation and opioid induced sedation."	( Brubacher, JR; Hoffman, RS; Levine, B, 1996)
"Acute colonic pseudoobstruction (ACPO) most commonly develops after surgery, with narcotic administration, or in association with severe illness."	( Baron, TH; Harewood, GC; Loftus, CG, 2002)
"Administration of PEG in patients with Ogilvie's syndrome after initial resolution of colonic dilation may increase the sustained response rate after initial therapeutic intervention."	( Avgerinos, A; Bergele, C; Mantides, A; Nastos, H; Sgouros, SN; Stefanidis, G; Vassiliadis, K; Vlachogiannakos, J, 2006)
"Neostigmine is a treatment option for colonic pseudoobstruction."	( Rausch, ME; Rosen, T; Troiano, NH, 2007)
"Diagnosis of Ogilvie's syndrome is based on clinical and radiologic grounds, and can be treated conservatively or with interventions such as acetylcholinesterase inhibitors (such as neostigmine), decompressive procedures including colonoscopy, and even surgery."	( Haj, M; Rockey, DC, 2018)
"Postoperatively, he developed OIC and Ogilvie syndrome, then following treatment with methylnaltrexone experienced an acute bowel perforation."	( Blackney, KA; Edwards, DA; Kamdar, NV; Liu, CA, 2019)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	6 (3.30)	23.3326
1990's	49 (26.92)	12.5806
2000's	63 (34.62)	18.1394
2010's	53 (29.12)	28.8240
2020's	11 (6.04)	9.53

Drug	Relationship Strength	Studies	Trials
methane	low	1	0
dalteparin	low	1	0
nitrates	low	1	0
nitrites	low	1	0
theophylline	low	1	0
aspirin	low	1	0
bupivacaine	low	2	0
cisapride	low	10	0
clonidine	low	1	0
diclofenac	low	1	0
doxepin	low	1	0
fentanyl	low	1	0
fluorouracil	low	1	0
guanethidine	low	1	0
hydroxyurea	low	1	0
imipramine	low	1	0
ketorolac	medium	1	1
kynurenic acid	low	1	0
loperamide	low	1	0
maprotiline	low	1	0
methadone	low	1	0
metoclopramide	medium	2	1
metronidazole	low	1	0
neostigmine	medium	89	6
nifedipine	low	2	0
nimodipine	low	2	0
omeprazole	low	2	0
oxotremorine	low	1	0
propranolol	low	1	0
thiothixene	low	1	0
ticlopidine	low	1	0
tolmetin	medium	1	1
trihexyphenidyl	low	1	0
phentolamine	low	1	0
sorbitol	low	1	0
thyroxine	low	2	0
prednisone	low	1	0
methacholine chloride	low	1	0
cytarabine	low	1	0
pantothenic acid	low	1	0
pyridostigmine bromide	low	3	0
diatrizoate meglumine	low	1	0
docusate	low	1	0
glycopyrrolate	low	2	0
clopenthixol	low	1	0
erythromycin	medium	13	1
benzohexonium	low	1	0
amiloride	low	1	0
iodinated glycerol	low	1	0
n-methylaspartate	low	1	0
phosphoric acid, trisodium salt	low	1	0
barium sulfate	low	6	0
daunorubicin	low	1	0
amitraz	low	1	0
substance p	low	1	0
clopidogrel	low	1	0
nicotine	low	1	0
methotrexate	low	1	0
dexpanthenol	low	1	0
benzofurans	medium	3	1
tretinoin	low	1	0
mycophenolic acid	low	1	0
clindamycin	low	1	0
benztropine	low	1	0
pica	low	1	0
prucalopride	medium	2	1
dinoprost	low	1	0
codeine	low	2	0
hydromorphone	low	2	0
naloxone	low	2	0
oxycodone	low	2	0
dexmedetomidine	low	3	0
naltrexone	low	2	0
methylnaltrexone	low	2	0
clopenthixol decanoate	low	1	0
mocetinostat	low	1	0
lactulose	medium	1	1
td-5108	medium	3	1
cromolyn sodium	medium	1	1
motilin	low	1	0
piperidines	low	10	0
vasoactive intestinal peptide	low	2	0
warfarin	low	1	0
phenprocoumon	low	1	0
acyclovir	low	2	0
levoleucovorin	low	1	0
clozapine	low	2	0
ganciclovir	low	2	0
allopurinol	low	1	0
tegaserod	low	1	0

Protein Targets (1,115)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	14	0	0	14
Chain B, HADH2 protein	14	0	0	14
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Ferritin light chain	9	0	0	9
Thymidine kinase	0	2	0	2
thioredoxin reductase	21	0	0	21
phosphopantetheinyl transferase	11	0	0	11
GLS protein	14	0	0	14
TDP1 protein	36	0	0	36
Smad3	5	0	0	5
thyroid stimulating hormone receptor	15	0	0	15
EWS/FLI fusion protein	23	0	0	23
arylsulfatase A	13	0	0	13
euchromatic histone-lysine N-methyltransferase 2	37	0	0	37
activating transcription factor 6	11	0	0	11
Histone H2A.x	10	0	0	10
Bloom syndrome protein isoform 1	15	0	0	15
hemoglobin subunit beta	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
lamin isoform A-delta10	28	0	0	28
Solute carrier family 22 member 1	0	16	0	23
ATP-binding cassette sub-family C member 3	0	30	0	30
Multidrug resistance-associated protein 4	0	30	0	31
Solute carrier family 22 member 6	0	1	0	2
Bile salt export pump	0	7	0	7
Bile salt export pump	0	44	0	44
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	2
POU domain, class 2, transcription factor 2	0	0	0	2
Cytochrome P450 2C9	0	13	1	16
Cytochrome P450 2J2	0	11	0	12
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Purine nucleoside phosphorylase	0	0	3	3
Solute carrier family 22 member 6	0	1	0	5
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	3
Canalicular multispecific organic anion transporter 1	0	31	0	31
Thymidine kinase	0	2	0	2
interleukin 8	5	0	0	5
AR protein	33	0	0	33
estrogen receptor 2 (ER beta)	14	0	0	14
progesterone receptor	18	0	0	18
glucocorticoid receptor [Homo sapiens]	27	0	0	27
estrogen-related nuclear receptor alpha	26	0	0	26
estrogen nuclear receptor alpha	37	0	0	37
IDH1	9	0	0	9
transcriptional regulator ERG isoform 3	3	0	0	3
thyroid hormone receptor beta isoform 2	29	0	0	29
ras-related protein Rab-9A	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	26	0	0	26
geminin	30	0	0	30
survival motor neuron protein isoform d	14	0	0	14
Polyphenol oxidase 2	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	16	0	0	16
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Cellular tumor antigen p53	25	0	0	25
Glutamate receptor 2	16	3	0	20
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	5	4	10
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
TAR DNA-binding protein 43	7	0	0	7
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	17	0	0	17
Chain U, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	13	0	0	13
acid sphingomyelinase	3	0	0	3
acetylcholinesterase	16	0	0	16
aldehyde dehydrogenase 1 family, member A1	21	0	0	21
regulator of G-protein signaling 4	12	0	0	12
glucocerebrosidase	5	0	0	5
alpha-galactosidase	4	0	0	4
cytochrome P450 2D6 isoform 1	12	0	0	12
lysosomal alpha-glucosidase preproprotein	3	0	0	3
cytochrome P450 2C19 precursor	11	0	0	11
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
huntingtin isoform 2	6	0	0	6
Membrane primary amine oxidase	0	2	0	2
Prothrombin	0	1	0	1
Coagulation factor X	0	1	0	1
Plasminogen	0	1	0	1
Urokinase-type plasminogen activator	0	2	0	2
Tissue-type plasminogen activator	0	2	0	2
Cationic trypsin	0	1	0	1
Coagulation factor XI	0	1	0	1
Plasma kallikrein	0	1	0	1
Vitamin K-dependent protein C	0	1	0	1
Urokinase-type plasminogen activator	0	2	0	2
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	3
Sodium/hydrogen exchanger 1	0	2	0	2
Sodium/hydrogen exchanger 3	0	2	0	2
Trypsin-3	0	1	0	1
Amiloride-sensitive sodium channel subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 7	0	7	0	7
Sodium/hydrogen exchanger 2	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	22	0	22
Sodium channel protein type 5 subunit alpha	0	6	0	6
Sodium/hydrogen exchanger 5	0	2	0	2
Solute carrier family 22 member 1	0	4	0	4
Solute carrier family 22 member 2	0	3	0	3
Acid-sensing ion channel 3	0	1	0	1
Sodium/hydrogen exchanger	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	12	0	0	12
RAR-related orphan receptor gamma	25	0	0	25
GLI family zinc finger 3	24	0	0	24
nuclear receptor subfamily 1, group I, member 3	24	0	0	24
cytochrome P450 family 3 subfamily A polypeptide 4	20	0	0	20
retinoic acid nuclear receptor alpha variant 1	24	0	0	24
retinoid X nuclear receptor alpha	16	0	0	16
farnesoid X nuclear receptor	15	0	0	15
pregnane X nuclear receptor	21	0	0	21
cytochrome P450 2D6	23	0	0	23
peroxisome proliferator activated receptor gamma	19	0	0	19
vitamin D (1,25- dihydroxyvitamin D3) receptor	18	0	0	18
aryl hydrocarbon receptor	11	0	0	11
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	8	0	0	8
v-jun sarcoma virus 17 oncogene homolog (avian)	15	0	0	15
thyroid hormone receptor beta isoform a	9	0	0	9
potassium voltage-gated channel subfamily H member 2 isoform d	13	0	0	13
heat shock protein beta-1	8	0	0	8
cytochrome P450 3A4 isoform 1	14	0	0	14
Gamma-aminobutyric acid receptor subunit pi	14	2	1	17
Alpha-2A adrenergic receptor	0	26	6	34
Gamma-aminobutyric acid receptor subunit beta-1	14	2	1	17
Gamma-aminobutyric acid receptor subunit delta	14	2	1	17
Gamma-aminobutyric acid receptor subunit gamma-2	14	2	1	17
Gamma-aminobutyric acid receptor subunit alpha-5	14	2	1	17
Gamma-aminobutyric acid receptor subunit alpha-3	14	2	1	17
Gamma-aminobutyric acid receptor subunit gamma-1	14	2	1	17
Gamma-aminobutyric acid receptor subunit alpha-2	14	2	1	17
Gamma-aminobutyric acid receptor subunit alpha-4	14	2	1	17
Gamma-aminobutyric acid receptor subunit gamma-3	14	2	1	17
Gamma-aminobutyric acid receptor subunit alpha-6	14	2	1	17
Gamma-aminobutyric acid receptor subunit alpha-1	14	3	1	18
Gamma-aminobutyric acid receptor subunit beta-3	14	2	1	17
Gamma-aminobutyric acid receptor subunit beta-2	14	2	1	17
Peroxisome proliferator-activated receptor alpha	1	0	0	1
GABA theta subunit	14	2	1	17
Gamma-aminobutyric acid receptor subunit epsilon	14	2	1	17
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	2	0	0	2
peroxisome proliferator-activated receptor delta	18	0	0	18
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
DNA polymerase iota isoform a (long)	14	0	0	14
DNA polymerase kappa isoform 1	8	0	0	8
muscarinic acetylcholine receptor M1	11	0	0	11
lethal factor (plasmid)	9	0	0	9
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Prostaglandin G/H synthase 2	0	3	0	3
Epidermal growth factor receptor	0	3	0	3
Carbonic anhydrase 1	0	6	0	6
Carbonic anhydrase 2	0	7	1	9
Fatty acid-binding protein, liver	0	3	0	3
Integrin beta-3	4	1	0	5
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	4	1	0	5
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	6	0	6
Adenosine receptor A1	0	5	0	6
Adenosine receptor A2a	0	4	2	8
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	7	0	7
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	5	1	1	7
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	21	1	22
Sigma non-opioid intracellular receptor 1	0	4	1	5
Chain A, Cruzipain	4	0	0	4
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
caspase 7, apoptosis-related cysteine protease	8	0	0	8
caspase-3	8	0	0	8
Caspase-7	4	0	0	4
vitamin D3 receptor isoform VDRA	13	0	0	13
caspase-3	4	0	0	4
Solute carrier organic anion transporter family member 2B1	0	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	3	0	3
ATP-dependent translocase ABCB1	0	14	0	18
Insulin receptor	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	3	0	3
Histone deacetylase 1	0	4	0	4
Histone deacetylase 2	0	3	0	3
Solute carrier organic anion transporter family member 1B3	0	0	0	2
Histone deacetylase 6	0	3	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	6
Solute carrier organic anion transporter family member 1B1	0	1	0	3
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	9	0	0	9
Transmembrane protease serine 2	0	0	2	2
5-hydroxytryptamine receptor 4	0	22	3	25
Procathepsin L	0	0	2	2
Aldo-keto reductase family 1 member B1	0	10	0	10
Muscarinic acetylcholine receptor M2	0	19	4	24
Muscarinic acetylcholine receptor M4	0	16	3	20
Muscarinic acetylcholine receptor M1	0	8	0	8
Muscarinic acetylcholine receptor M5	0	15	2	18
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	2	2	4
Muscarinic acetylcholine receptor M2	0	8	0	8
Muscarinic acetylcholine receptor M1	0	16	5	22
Alpha-2B adrenergic receptor	0	20	3	25
Alpha-2C adrenergic receptor	0	20	5	27
Muscarinic acetylcholine receptor M3	0	17	4	22
Sodium-dependent noradrenaline transporter	0	13	0	13
Sodium-dependent dopamine transporter	0	5	0	5
Histamine H2 receptor	0	12	0	12
Alpha-1D adrenergic receptor	0	18	3	22
5-hydroxytryptamine receptor 2A	0	22	1	25
5-hydroxytryptamine receptor 2C	0	23	2	25
Sodium-dependent serotonin transporter	0	19	0	19
Sodium-dependent serotonin transporter	0	6	0	6
Histamine H1 receptor	0	14	3	19
D(3) dopamine receptor	0	18	0	20
5-hydroxytryptamine receptor 2B	0	24	2	26
Histamine H2 receptor	12	2	0	16
5-hydroxytryptamine receptor 6	0	13	1	15
Spike glycoprotein	20	0	2	22
Sodium-dependent dopamine transporter	0	8	0	8
Angiotensin-converting enzyme 2	0	0	2	2
USP1 protein, partial	13	0	0	13
chromobox protein homolog 1	18	0	0	18
flap endonuclease 1	5	0	0	5
Alpha-1A adrenergic receptor	0	8	4	13
Alpha-1B adrenergic receptor	0	7	3	11
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	3	3
Potassium channel subfamily K member 9	0	1	0	1
Microtubule-associated protein tau	12	0	0	12
67.9K protein	6	0	0	6
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
thyrotropin-releasing hormone receptor	3	0	0	3
mitogen-activated protein kinase 1	7	0	0	7
nuclear receptor ROR-gamma isoform 1	12	0	0	12
Caspase-2	0	0	1	1
Inositol monophosphatase 1	12	0	0	12
ATPase family AAA domain-containing protein 5	10	0	0	10
Ataxin-2	17	0	0	17
5-hydroxytryptamine receptor 3E	0	5	1	6
thyroid stimulating hormone receptor	9	0	0	9
Voltage-dependent L-type calcium channel subunit alpha-1F	0	8	0	8
5-hydroxytryptamine receptor 3B	0	5	1	6
Beta-2 adrenergic receptor	0	5	1	6
Beta-1 adrenergic receptor	0	3	1	4
Cytochrome P450 3A4	0	15	3	21
5-hydroxytryptamine receptor 1A	0	8	1	9
5-hydroxytryptamine receptor 2C	0	10	0	11
Cytochrome P450 2D6	0	14	1	17
Angiotensin-converting enzyme	0	7	0	7
Beta-3 adrenergic receptor	0	3	1	4
D(2) dopamine receptor	0	16	1	20
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	13	0	13
Alpha-1B adrenergic receptor	0	16	4	20
D	0	8	0	8
5-hydroxytryptamine receptor 1A	0	14	1	16
Alpha-2B adrenergic receptor	0	13	4	17
D(1A) dopamine receptor	0	10	1	12
Alpha-2C adrenergic receptor	0	13	4	17
Alpha-2A adrenergic receptor	0	13	4	17
Alpha-1D adrenergic receptor	0	13	4	18
5-hydroxytryptamine receptor 1B	0	12	0	12
5-hydroxytryptamine receptor 1D	0	7	0	7
Gastrin/cholecystokinin type B receptor	0	1	0	1
5-hydroxytryptamine receptor 1F	0	7	0	7
5-hydroxytryptamine receptor 2B	0	9	1	10
5-hydroxytryptamine receptor 7	0	7	1	8
5-hydroxytryptamine receptor 3A	0	7	0	7
Alpha-1A adrenergic receptor	0	17	5	22
5-hydroxytryptamine receptor 3A	0	7	1	8
D(2) dopamine receptor	0	10	1	11
Voltage-dependent L-type calcium channel subunit alpha-1D	0	8	0	8
5-hydroxytryptamine receptor 4	0	5	4	9
Voltage-dependent L-type calcium channel subunit alpha-1S	0	8	0	8
Voltage-dependent L-type calcium channel subunit alpha-1C	0	9	0	10
Neutral alpha-glucosidase AB	0	1	0	1
5-hydroxytryptamine receptor 4	0	3	2	7
Nuclear receptor subfamily 3 group C member 3	0	7	0	7
5-hydroxytryptamine receptor 3D	0	5	1	6
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 3C	0	5	1	6
5-hydroxytryptamine receptor 3B	0	7	0	7
Heparanase	0	0	1	1
Protein-arginine deiminase type-4	0	2	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
Beta-1 adrenergic receptor	0	2	2	5
Alpha-1B adrenergic receptor	0	0	2	2
cytochrome P450 2C9 precursor	5	0	0	5
5-hydroxytryptamine receptor 3A	0	1	1	2
Solute carrier family 22 member 3	0	3	0	5
Alpha-1A adrenergic receptor	0	2	2	4
D(3) dopamine receptor	0	9	0	9
D(1B) dopamine receptor	0	5	0	5
Amine oxidase [flavin-containing] B	0	2	0	2
Adenosine receptor A2b	0	1	1	3
Alpha-2B adrenergic receptor	0	0	0	1
D(4) dopamine receptor	0	6	0	6
Delta-type opioid receptor	0	10	2	15
Mu-type opioid receptor	0	10	3	14
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Multidrug and toxin extrusion protein 1	0	4	0	4
Nischarin	0	2	0	2
nonstructural protein 1	6	0	0	6
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Cytochrome P450 2C8	0	4	0	4
Cytochrome P450 2B6	0	4	0	4
Liver carboxylesterase 1	0	0	0	1
Cytochrome P450 2C19	0	7	1	11
Rap guanine nucleotide exchange factor 4	2	0	0	2
P2Y purinoceptor 12	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
Luciferase	11	0	0	11
ATAD5 protein, partial	10	0	0	10
Fumarate hydratase	8	0	0	8
NFKB1 protein, partial	4	0	0	4
G	14	0	0	14
polyprotein	8	0	0	8
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
Adenylate cyclase type 1	0	1	0	1
peripheral myelin protein 22 isoform 1	6	0	0	6
D(1A) dopamine receptor	9	0	0	9
DNA polymerase beta	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	5	0	0	5
short transient receptor potential channel 6 isoform 1	0	0	1	1
peripheral myelin protein 22	15	0	0	15
M-phase phosphoprotein 8	8	0	0	8
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Interferon beta	17	0	0	17
HLA class I histocompatibility antigen, B alpha chain	14	0	0	14
Albumin	0	0	3	3
Muscarinic acetylcholine receptor M3	0	7	0	7
Muscarinic acetylcholine receptor M4	0	8	0	8
Muscarinic acetylcholine receptor M5	0	8	0	8
Calmodulin-1	0	1	0	1
Beta-2 adrenergic receptor	0	4	0	5
Beta-1 adrenergic receptor	0	3	1	5
D(2) dopamine receptor	0	3	0	3
Endothelin receptor type B	0	1	0	1
D(4) dopamine receptor	0	7	0	9
D(1B) dopamine receptor	0	2	0	3
Adenylate cyclase type 3	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	2	0	5
5-hydroxytryptamine receptor 3A	0	2	0	2
Endothelin receptor type B	0	1	0	1
Beta-3 adrenergic receptor	0	3	0	3
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
Histamine H1 receptor	0	2	0	3
Histamine H1 receptor	0	4	0	4
5-hydroxytryptamine receptor 7	0	3	0	3
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
D(2) dopamine receptor	0	2	0	2
Calmodulin	0	1	2	3
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
Transporter	0	2	0	2
Cholecystokinin receptor type A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Adenylyl cyclase 7	0	1	0	1
Inositol hexakisphosphate kinase 1	14	0	0	14
D	0	2	0	2
Histamine H4 receptor	0	1	1	2
Transporter	0	5	1	7
Histamine H3 receptor	0	2	0	2
cytochrome P450 2C9, partial	14	0	0	14
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	4
Kappa-type opioid receptor	0	6	3	11
Mu-type opioid receptor	0	18	10	32
Delta-type opioid receptor	0	18	8	30
Kappa-type opioid receptor	0	16	8	29
Mu-type opioid receptor	0	7	3	14
Cytochrome P450 2D4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	4	4
endonuclease IV	6	0	0	6
glp-1 receptor, partial	8	0	0	8
LMP1 [Human herpesvirus 4]	0	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	3	0	4
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
D(1A) dopamine receptor	4	0	0	4
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
ATP-dependent phosphofructokinase	12	0	0	12
Matrix metalloproteinase-9	0	1	0	1
Isocitrate lyase	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
PPM1D protein	5	0	0	5
cellular tumor antigen p53 isoform a	7	0	0	7
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Transthyretin	0	2	1	6
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Glutamate receptor 1	1	3	0	5
Glutamate receptor 3	1	3	0	5
Glutamate receptor 4	1	3	0	5
Platelet-activating factor receptor	1	0	0	2
Multidrug resistance-associated protein 1	0	2	0	4
Reverse transcriptase/RNaseH	0	1	0	1
Histone deacetylase 8	0	2	0	2
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	2	2	4
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Hsf1 protein	0	0	3	4
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Dihydrofolate reductase	0	3	0	4
Cytochrome c oxidase subunit 2	0	1	0	1
Albumin	0	3	4	7
Interleukin-8	0	2	0	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	2	1	3
Aldo-keto reductase family 1 member B1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	5	0	7
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	3
UDP-glucuronosyltransferase 2B10	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 9	0	3	0	4
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	2
UDP-glucuronosyltransferase 1A10	0	1	0	2
Solute carrier family 22 member 2	0	1	0	2
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	1	2
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	1	3
Prostaglandin E2 receptor EP3 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 11	0	0	0	2
Solute carrier family 22 member 7	0	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 5B	0	2	0	2
Chain A, Beta-lactamase	7	0	0	7
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	4	0	0	4
streptokinase A precursor	0	0	2	2
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
30S ribosomal protein S6	0	1	1	2
30S ribosomal protein S7	0	1	1	2
50S ribosomal protein L15	0	1	1	2
ATP-dependent translocase ABCB1	0	5	0	5
60 kDa chaperonin	0	2	0	2
50S ribosomal protein L10	0	1	1	2
50S ribosomal protein L11	0	1	1	2
50S ribosomal protein L7/L12	0	1	1	2
50S ribosomal protein L19	0	1	1	2
50S ribosomal protein L1	0	1	1	2
50S ribosomal protein L20	0	1	1	2
50S ribosomal protein L27	0	1	1	2
50S ribosomal protein L28	0	1	1	2
50S ribosomal protein L29	0	1	1	2
50S ribosomal protein L31	0	1	1	2
50S ribosomal protein L31 type B	0	1	1	2
50S ribosomal protein L32	0	1	1	2
50S ribosomal protein L33	0	1	1	2
50S ribosomal protein L34	0	1	1	2
50S ribosomal protein L35	0	1	1	2
50S ribosomal protein L36	0	1	1	2
30S ribosomal protein S10	0	1	1	2
30S ribosomal protein S11	0	1	1	2
30S ribosomal protein S12	0	1	1	2
30S ribosomal protein S13	0	1	1	2
30S ribosomal protein S16	0	1	1	2
30S ribosomal protein S18	0	1	1	2
30S ribosomal protein S19	0	1	1	2
30S ribosomal protein S20	0	1	1	2
30S ribosomal protein S2	0	1	1	2
30S ribosomal protein S3	0	1	1	2
30S ribosomal protein S4	0	1	1	2
30S ribosomal protein S5	0	1	1	2
30S ribosomal protein S8	0	1	1	2
30S ribosomal protein S9	0	1	1	2
50S ribosomal protein L13	0	1	1	2
50S ribosomal protein L14	0	1	1	2
50S ribosomal protein L16	0	1	1	2
50S ribosomal protein L23	0	1	1	2
30S ribosomal protein S15	0	1	1	2
50S ribosomal protein L17	0	1	1	2
50S ribosomal protein L21	0	1	1	2
50S ribosomal protein L30	0	1	1	2
50S ribosomal protein L6	0	1	1	2
30S ribosomal protein S14	0	1	1	2
30S ribosomal protein S17	0	1	1	2
30S ribosomal protein S1	0	1	1	2
50S ribosomal protein L18	0	1	1	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	5	0	5
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
50S ribosomal protein L2	0	1	1	2
50S ribosomal protein L3	0	1	1	2
50S ribosomal protein L24	0	1	1	2
50S ribosomal protein L4	0	1	1	2
50S ribosomal protein L22	0	1	1	2
10 kDa heat shock protein, mitochondrial	0	2	0	2
50S ribosomal protein L5	0	1	1	2
30S ribosomal protein S21	0	1	1	2
50S ribosomal protein L25	0	1	1	2
Cytochrome P450 1B1	0	1	0	1
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	4	1	5
50S ribosomal protein L36 2	0	1	1	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Delta-type opioid receptor	0	12	4	17
Mu-type opioid receptor	0	12	5	20
Kappa-type opioid receptor	0	8	4	13
Kappa-type opioid receptor	0	10	1	12
Sigma non-opioid intracellular receptor 1	0	5	0	5
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
pregnane X receptor	5	0	0	5
Thrombopoietin	4	0	0	4
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
Vpr	1	0	0	1
muscleblind-like protein 1 isoform 1	4	0	0	4
Solute carrier family 22 member 8	0	0	0	1
Amyloid-beta precursor protein	1	1	0	2
Aromatase	0	3	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
ClpP	4	0	0	4
Transitional endoplasmic reticulum ATPase	0	1	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Stromelysin-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Urease subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Carbonic anhydrase 4	0	4	0	4
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Urease subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Snq2p	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Sodium-dependent noradrenaline transporter	0	1	0	1
Major prion protein	0	0	1	1
Cytochrome P450 1A2	0	3	1	5
Sphingomyelin phosphodiesterase	0	1	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	5	1	8
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	4	1	7
Glutamate receptor ionotropic, NMDA 2B	0	4	1	7
Glutamate receptor ionotropic, NMDA 2C	0	4	1	7
Voltage-dependent N-type calcium channel subunit alpha-1B	0	3	0	3
Sodium channel protein type 7 subunit alpha	0	2	0	2
Envelope glycoprotein	0	0	1	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	4	1	7
Multidrug and toxin extrusion protein 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	4	1	7
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	4	1	7
Sodium channel protein type 11 subunit alpha	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	2	0	2
Estrogen receptor beta	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
Epoxide hydrolase 1	0	0	0	1
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Translocator protein	0	2	1	3
Cytochrome P450 7A1	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Estrogen receptor	0	1	0	1
Substance-K receptor	0	4	0	4
Thromboxane-A synthase	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	1	2
Type-1 angiotensin II receptor	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
Caspase-1	0	1	0	1
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Cell division control protein 42 homolog	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Parkin	4	0	0	4
Mitogen-activated protein kinase 13	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	0	3
Aryl hydrocarbon receptor	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-7	0	3	2	5
Glutamate receptor ionotropic, kainate 2	0	2	0	3
Glutamate receptor ionotropic, kainate 3	0	2	0	3
Mitogen-activated protein kinase 12	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	3
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
Glutamate receptor ionotropic, kainate 5	0	2	0	3
Vesicular glutamate transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
G-protein coupled receptor 35	0	2	1	3
Histamine H3 receptor	0	0	1	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	2	0	2
15-lipoxygenase, partial	3	0	0	3
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
Menin	0	1	0	1
Cocaine esterase	0	2	0	2
Nociceptin receptor	0	2	0	2
Angiopoietin-1 receptor	0	0	1	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	1	2
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	1	2
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	1	2
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
GALC protein	1	0	0	1
galanin receptor type 3	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	3	4
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Acetylcholinesterase	0	4	0	4
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	3	0	3
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	3	1	6
Mu-type opioid receptor	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Alpha-synuclein	1	1	0	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A8	0	0	0	3
Adenosine receptor A1	0	5	1	8
Cholinesterase	0	2	0	2
Cholinesterase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	2	5
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	2	5
Acetylcholine receptor subunit beta	0	2	1	3
Cytochrome P450 2A6	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Neuronal acetylcholine receptor subunit beta-4	0	2	2	5
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Muscarinic acetylcholine receptor M4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	5
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	3	3
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
beta-2 adrenergic receptor	1	0	0	1
tumor necrosis factor	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
eyes absent homolog 2 isoform a	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Adenosine receptor A3	0	7	1	8
Phospholipase A2, membrane associated	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	3	0	3
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
neuropeptide S receptor isoform A	2	0	0	2
Voltage-dependent L-type calcium channel subunit beta-4	0	1	0	1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	1	0	1
Voltage-dependent calcium channel gamma-3 subunit	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Voltage-dependent L-type calcium channel subunit beta-3	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel gamma-7 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel gamma-1 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Voltage-dependent R-type calcium channel subunit alpha-1E	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-3	0	1	0	1
Voltage-dependent calcium channel gamma-8 subunit	0	1	0	1
Bile acid receptor	0	2	0	2
Voltage-dependent calcium channel gamma-6 subunit	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
Voltage-dependent calcium channel gamma-4 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-5 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	0	1	0	1
Carbonic anhydrase	0	2	0	2
Sodium/iodide cotransporter	0	1	0	1
Carbonic anhydrase 15	0	2	0	2
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Mcl-1	0	1	0	1
apical membrane antigen 1, AMA1	2	0	0	2
pyruvate kinase PKM isoform a	1	0	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
Fatty acid synthase	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Muscarinic acetylcholine receptor	0	2	0	2
MCOLN3 protein	0	0	1	1
transient receptor potential cation channel, subfamily N, member 1	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Mineralocorticoid receptor	0	0	1	1
Type II pantothenate kinase	0	0	0	1
Type III pantothenate kinase	0	0	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Protease	0	3	0	3
estrogen receptor beta isoform 1	0	1	0	1
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
thioredoxin glutathione reductase	2	0	0	2
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Endothelin-1 receptor	0	1	1	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Prolyl 4-hydroxylase, beta polypeptide	0	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Estrogen receptor	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Estrogen receptor	0	1	0	1
Gastric inhibitory polypeptide receptor	0	1	0	1
Estrogen receptor beta	0	1	0	1
Estrogen receptor beta	0	1	0	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
5-hydroxytryptamine receptor 1D	0	2	0	2
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Renin	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A1	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Vasopressin V2 receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Adenosine receptor A2b	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	0	1	1
Endochitinase B1	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	2	4	6
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Lactoylglutathione lyase	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Nuclear receptor ROR-beta	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(6)

Research Excerpts

Overview

Treatment

Research

Studies (182)

Protein Targets (1,115)

Colonic Pseudo-Obstruction

Synonyms(6)

Research Excerpts

Overview

Treatment

Research

Studies (182)

Drugs Studied (100)

Protein Targets (1,115)