Page last updated: 2024-09-27

Pragmatic Communication Disorder

Persistent difficulties in the social uses of verbal and nonverbal communications. (DSM-V)

Synonyms(2)

Synonym
Pragmatic Communication Disorder
Social Communication Disorder

Research

Studies (7)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's6 (85.71)28.8240
2020's1 (14.29)9.53
DrugIndicatedRelationship StrengthStudiesTrials
creatine0low10
clonazepam0low10
valproic acid0low10
nifedipine0low10
cycloserine0medium11
aripiprazole0low10
oxytocin0low10

Protein Targets (327)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, JmjC domain-containing histone demethylation protein 3A2002
5-hydroxytryptamine receptor 3E0101
acetylcholinesterase2002
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma3003
SMAD family member 21001
Fumarate hydratase2002
USP1 protein, partial2002
PPM1D protein1001
SMAD family member 31001
TDP1 protein2002
GLI family zinc finger 32002
Microtubule-associated protein tau2002
AR protein2002
estrogen receptor 2 (ER beta)1001
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor2002
EWS/FLI fusion protein1001
glucocorticoid receptor [Homo sapiens]3003
retinoic acid nuclear receptor alpha variant 13003
retinoid X nuclear receptor alpha2002
estrogen-related nuclear receptor alpha3003
farnesoid X nuclear receptor3003
pregnane X nuclear receptor2002
estrogen nuclear receptor alpha3003
G2002
cytochrome P450 2D62002
polyprotein2002
67.9K protein2002
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
euchromatic histone-lysine N-methyltransferase 23003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
thyroid stimulating hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)2002
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
nuclear factor erythroid 2-related factor 2 isoform 21001
potassium voltage-gated channel subfamily H member 2 isoform d2002
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 23003
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 13003
nuclear receptor ROR-gamma isoform 12002
geminin2002
peripheral myelin protein 222002
histone acetyltransferase KAT2A isoform 11001
5-hydroxytryptamine receptor 2A0011
neuropeptide S receptor isoform A1001
Solute carrier family 22 member 20101
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
5-hydroxytryptamine receptor 3A0101
Voltage-dependent calcium channel gamma-2 subunit2002
5-hydroxytryptamine receptor 3B0101
Bile salt export pump0404
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Cellular tumor antigen p533003
ATP-dependent translocase ABCB10202
Cytochrome P450 3A40202
5-hydroxytryptamine receptor 1A0112
5-hydroxytryptamine receptor 2C0101
Neuronal acetylcholine receptor subunit alpha-41102
Neuronal acetylcholine receptor subunit beta-21102
D(2) dopamine receptor0213
5-hydroxytryptamine receptor 2A0303
Alpha-1B adrenergic receptor0303
Alpha-2C adrenergic receptor0101
D0101
5-hydroxytryptamine receptor 1A0101
Glutamate receptor 22002
Muscarinic acetylcholine receptor M30102
D(1A) dopamine receptor0101
D(4) dopamine receptor0101
D(1B) dopamine receptor0101
Alpha-1D adrenergic receptor0101
Alpha-1D adrenergic receptor0101
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0404
D(4) dopamine receptor0101
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0202
Histamine H1 receptor0202
Alpha-1B adrenergic receptor0101
D(3) dopamine receptor0112
5-hydroxytryptamine receptor 2B0101
Alpha-1A adrenergic receptor0303
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 60101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Spike glycoprotein2002
D(2) dopamine receptor0101
Inositol monophosphatase 12002
Potassium voltage-gated channel subfamily H member 20404
5-hydroxytryptamine receptor 3D0101
Multidrug and toxin extrusion protein 20101
5-hydroxytryptamine receptor 3C0101
Inositol hexakisphosphate kinase 12002
Canalicular multispecific organic anion transporter 10202
Multidrug and toxin extrusion protein 10101
Histamine H3 receptor0101
cytochrome P450 2C9, partial2002
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit pi2103
Gamma-aminobutyric acid receptor subunit delta0202
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-12103
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit delta2103
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit gamma-22103
Gamma-aminobutyric acid receptor subunit alpha-52103
Gamma-aminobutyric acid receptor subunit alpha-32103
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit gamma-12103
Gamma-aminobutyric acid receptor subunit alpha-22103
Gamma-aminobutyric acid receptor subunit alpha-42103
Gamma-aminobutyric acid receptor subunit beta-30202
Gamma-aminobutyric acid receptor subunit gamma-32103
Gamma-aminobutyric acid receptor subunit alpha-62103
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50202
Gamma-aminobutyric acid receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit alpha-12103
Gamma-aminobutyric acid receptor subunit beta-32103
Gamma-aminobutyric acid receptor subunit beta-22103
Gamma-aminobutyric acid receptor subunit epsilon0202
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit gamma-10202
GABA theta subunit2103
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit epsilon2103
Gamma-aminobutyric acid receptor subunit theta0202
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10202
Chain A, N-methyl-D-aspartate Receptor Subunit 10101
Chain A, N-methyl-D-aspartate Receptor Subunit 10101
Chain A, N-methyl-D-aspartate Receptor Subunit 10101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
thyroid stimulating hormone receptor2002
regulator of G-protein signaling 42002
cytochrome P450 family 3 subfamily A polypeptide 42002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
Bloom syndrome protein isoform 12002
cytochrome P450 2C9 precursor2002
chromobox protein homolog 12002
mitogen-activated protein kinase 12002
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 12002
M-phase phosphoprotein 82002
muscarinic acetylcholine receptor M12002
lamin isoform A-delta102002
Bile salt export pump0303
Glutamate receptor ionotropic, NMDA 1 0112
Histamine H2 receptor2002
Glutamate receptor ionotropic, NMDA 2A 0112
Glutamate receptor ionotropic, NMDA 2B0112
Glutamate receptor ionotropic, NMDA 2C0112
D-alanine--D-alanine ligase0101
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase 0101
Glutamate receptor ionotropic, NMDA 2D0112
Glutamate receptor ionotropic, NMDA 3B0112
Glutamate receptor ionotropic, NMDA 3A0112
ATP-dependent phosphofructokinase2002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Beta-lactamase1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, 2-oxoglutarate Oxygenase1001
Luciferase2002
thioredoxin reductase1001
pregnane X receptor2002
phosphopantetheinyl transferase1001
ATAD5 protein, partial1001
NFKB1 protein, partial1001
GLS protein1001
Thrombopoietin1001
Smad31001
aldehyde dehydrogenase 1 family, member A11001
hypothetical protein, conserved1001
nonstructural protein 11001
Parkin1001
bromodomain adjacent to zinc finger domain 2B1001
IDH11001
aryl hydrocarbon receptor1001
beta-2 adrenergic receptor1001
cytochrome P450 2D6 isoform 11001
peripheral myelin protein 22 isoform 11001
cellular tumor antigen p53 isoform a1001
tumor necrosis factor1001
polyunsaturated fatty acid lipoxygenase ALOX121001
cytochrome P450 2C19 precursor1001
D(1A) dopamine receptor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
perilipin-50101
vitamin D3 receptor isoform VDRA1001
perilipin-10101
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 11001
serine/threonine-protein kinase PLK11001
eyes absent homolog 2 isoform a1001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
muscleblind-like protein 1 isoform 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
5-hydroxytryptamine receptor 40202
Potassium channel subfamily K member 20011
Glutathione reductase, mitochondrial0202
Integrin beta-31001
Cytochrome P450 1A20101
Muscarinic acetylcholine receptor M20001
Muscarinic acetylcholine receptor M40001
Integrin alpha-IIb1001
Muscarinic acetylcholine receptor M50001
Adenosine receptor A30202
Muscarinic acetylcholine receptor M10001
Cytochrome P450 2C9 0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Phospholipase A2, membrane associated0001
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Potassium voltage-gated channel subfamily A member 50101
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Thromboxane-A synthase 0101
Platelet-activating factor receptor0001
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Indoleamine 2,3-dioxygenase 10101
Adenosine receptor A2a0101
Adenosine receptor A10202
Adenosine receptor A2a0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
C-C chemokine receptor type 20202
Nuclear receptor ROR-gamma2002
Cytochrome P450 2J20101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Potassium voltage-gated channel subfamily A member 10101
C-terminal-binding protein 11001
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0203
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Sodium channel protein type 5 subunit alpha0101
Leukotriene B4 receptor 10001
Myosin light chain kinase, smooth muscle0101
Sodium channel protein type 9 subunit alpha0101
Transient receptor potential cation channel subfamily A member 10011
Potassium channel subfamily K member 2 0101
Beta-2 adrenergic receptor0001
Indoleamine 2,3-dioxygenase 20101
ATPase family AAA domain-containing protein 52002
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Sodium channel protein type 2 subunit alpha0101
Ataxin-22002
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Leukotriene B4 receptor 20001
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Vasopressin V2 receptor0112
Oxytocin receptor0224
Vasopressin V1a receptor0101
Vasopressin V1a receptor0213
Vasopressin V1b receptor0112
Vasopressin V1b receptor0101
Oxytocin receptor0101
Oxytocin receptor0011
Vasopressin V2 receptor 0101
thyroid hormone receptor beta isoform a1001
Cocaine esterase0101
Histone deacetylase 30202
UDP-glucuronosyltransferase 1A90001
Aldo-keto reductase family 1 member B10101
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 2B70102
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Sigma non-opioid intracellular receptor 10101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]