Page last updated: 2024-09-27

Postthrombotic Syndrome

A condition caused by one or more episodes of DEEP VEIN THROMBOSIS, usually the blood clots are lodged in the legs. Clinical features include EDEMA; PAIN; aching; heaviness; and MUSCLE CRAMP in the leg. When severe leg swelling leads to skin breakdown, it is called venous STASIS ULCER.

Synonyms(2)

Synonym
Postthrombotic Syndrome
Venous Stasis Syndrome

Research Excerpts

Research

Studies (145)

TimeframeStudies, This Condition (%)All Conditions %
pre-199027 (18.62)23.3326
1990's0 (0.00)12.5806
2000's7 (4.83)18.1394
2010's77 (53.10)28.8240
2020's34 (23.45)9.53
DrugIndicatedRelationship StrengthStudiesTrials
beta-alanine0low10
methane0low10
coumarin0medium11
dalteparin0medium95
niacin0low20
aspirin0medium41
chlorothiazide0low10
iodixanol0low10
iohexol0low10
procaine0low10
tetraethylammonium0low10
ticlopidine0medium21
aldosterone0low10
dehydroepiandrosterone0low10
thiophenes0low10
ephedrine0medium11
dihydroergotamine0low10
hesperidin0medium11
sulfur hexafluoride0low10
transferrin0low10
permethrin0low10
octenidine0low10
clopidogrel0medium11
fibrinogen0low30
carbapenems0low10
dabigatran0medium21
fibrin0low40
elastin0low10
arginine vasopressin0low10
polidocanol0low10
nitinol0low80
hidrosmin0low10
vitamin k semiquinone radical0medium113
alprostadil0low10
rutin0low80
diosmin0medium32
fondaparinux0low10
troxerutin0low10
glucuronyl glucosamine glycan sulfate0medium31
rivaroxaban0medium257
pituitrin0low10
cardiovascular agents0low10
warfarin0medium257
phenprocoumon0low10
transforming growth factor beta0low30
hyaluronoglucosaminidase0low10
thromboplastin0low30
defibrotide0low10
leptin0low10

Protein Targets (388)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
AR protein100010
glucocorticoid receptor [Homo sapiens]110011
thyroid hormone receptor beta isoform a5005
nuclear factor erythroid 2-related factor 2 isoform 21001
geminin8008
Sex hormone-binding globulin0022
Corticosteroid-binding globulin0202
Mineralocorticoid receptor 0123
Androgen receptor0101
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10001
Guanine nucleotide-binding protein G1001
TDP1 protein6006
estrogen nuclear receptor alpha130013
peroxisome proliferator activated receptor gamma5005
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40506
Bile salt export pump010010
Cellular tumor antigen p536006
Thromboxane-A synthase 0101
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP1 subtype0101
Prostacyclin receptor0112
Nuclear receptor subfamily 4 group A member 20011
Solute carrier organic anion transporter family member 2A10001
Nuclear receptor subfamily 4 group A member 20011
Nuclear receptor subfamily 4 group A member 20011
Prostaglandin E2 receptor EP2 subtype0112
Canalicular multispecific organic anion transporter 10505
Solute carrier organic anion transporter family member 2A10001
Solute carrier organic anion transporter family member 2B10101
Solute carrier organic anion transporter family member 3A10001
vitamin D3 receptor isoform VDRA2002
peripheral myelin protein 225005
Translocator protein0011
Vasopressin V2 receptor0214
Oxytocin receptor0112
Vasopressin V1a receptor0022
Vasopressin V1a receptor0112
Vasopressin V1b receptor0112
Vasopressin V2 receptor0011
Vasopressin V1b receptor0113
Translocator protein0102
Oxytocin receptor0101
Vasopressin V2 receptor 0112
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase3003
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 81001
thioredoxin reductase5005
GLS protein4004
aldehyde dehydrogenase 1 family, member A14004
thyroid stimulating hormone receptor4004
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 47007
EWS/FLI fusion protein6006
retinoic acid nuclear receptor alpha variant 19009
estrogen-related nuclear receptor alpha100010
cytochrome P450 2D65005
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta3003
Rac1 protein0011
IDH11001
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
euchromatic histone-lysine N-methyltransferase 27007
Bloom syndrome protein isoform 12002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
DNA polymerase iota isoform a (long)6006
DNA polymerase kappa isoform 14004
muscarinic acetylcholine receptor M14004
lethal factor (plasmid)2002
Prostaglandin-H2 D-isomerase0101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0101
Carbonic anhydrase 10304
Carbonic anhydrase 20304
Fatty acid-binding protein, liver0101
Integrin beta-30101
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb0101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0304
Prostaglandin G/H synthase 20202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma1001
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-12103
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Sigma non-opioid intracellular receptor 10213
Sigma non-opioid intracellular receptor 10011
regulator of G-protein signaling 43003
Cytochrome P450 3A40303
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Glutamate receptor ionotropic, NMDA 1 0101
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0101
Proton-coupled amino acid transporter 10101
Glutamate receptor ionotropic, NMDA 3B0101
Sodium- and chloride-dependent GABA transporter 20101
Glutamate receptor ionotropic, NMDA 3A0101
Chain A, Beta-lactamase5005
acetylcholinesterase5005
USP1 protein, partial6006
NFKB1 protein, partial2002
nonstructural protein 12002
arylsulfatase A1001
transcriptional regulator ERG isoform 31001
nuclear factor erythroid 2-related factor 2 isoform 18008
cytochrome P450 3A4 isoform 12002
lamin isoform A-delta104004
Gamma-aminobutyric acid receptor subunit pi2002
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
GABA theta subunit2002
Gamma-aminobutyric acid receptor subunit epsilon2002
ATP-dependent phosphofructokinase5005
ORF730011
chromobox protein homolog 16006
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
Cytochrome P450 2C80202
Cytochrome P450 2B60303
Liver carboxylesterase 10001
Sodium-dependent serotonin transporter0202
Cytochrome P450 2C190303
Rap guanine nucleotide exchange factor 41001
P2Y purinoceptor 120101
pregnane X receptor2002
GALC protein1001
retinoid X nuclear receptor alpha4004
farnesoid X nuclear receptor5005
pregnane X nuclear receptor7007
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
nuclear receptor subfamily 1, group I, member 22002
glycogen synthase kinase-3 alpha0001
muscleblind-like protein 1 isoform 12002
Exportin-10101
Carbonic anhydrase 120102
Glyceraldehyde-3-phosphate dehydrogenase0101
NAD-dependent histone deacetylase SIR20103
Carbonic anhydrase 30101
Cytochrome P450 2A60001
Aldo-keto reductase family 1 member B10101
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
Amine oxidase [flavin-containing] B0101
Cytochrome P450 2A50001
Amine oxidase [flavin-containing] A 0101
Acetylcholinesterase0101
Acetylcholinesterase0202
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40101
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal0101
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Carbonic anhydrase 5A, mitochondrial0101
UDP-glucuronosyltransferase 2B10 0101
Carbonic anhydrase 70101
Quinone oxidoreductase0001
Beta-secretase 10101
Sorbitol dehydrogenase0101
Induced myeloid leukemia cell differentiation protein Mcl-10202
Carbonic anhydrase 90102
Zn finger protein 0101
Dihydroorotate dehydrogenase 0202
Carbonic anhydrase 130101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
G3003
Solute carrier family 22 member 20304
Prothrombin0303
Coagulation factor X0404
Plasminogen0101
Coagulation factor XII0202
Tissue-type plasminogen activator0101
Interferon beta5005
HLA class I histocompatibility antigen, B alpha chain 3003
Vitamin K-dependent protein C0101
Serine protease hepsin0101
Trypsin-10101
Trypsin-20101
Muscarinic acetylcholine receptor M10101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Trypsin-30101
Multidrug and toxin extrusion protein 20202
Inositol hexakisphosphate kinase 13003
Multidrug and toxin extrusion protein 10303
cytochrome P450 2C9, partial3003
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma6006
SMAD family member 23003
SMAD family member 33003
GLI family zinc finger 35005
estrogen receptor 2 (ER beta)3003
progesterone receptor4004
aryl hydrocarbon receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
thyroid stimulating hormone receptor6006
thyroid hormone receptor beta isoform 25005
heat shock protein beta-13003
Beta-glucuronidase0101
Beta-glucuronidase0101
Glucose-6-phosphate 1-dehydrogenase0202
Alpha-synuclein1001
TAR DNA-binding protein 431001
G-protein coupled bile acid receptor 10011
Glucose-6-phosphate 1-dehydrogenase 0101
NPC1-like intracellular cholesterol transporter 10011
dopamine D1 receptor1001
ATAD5 protein, partial4004
caspase 7, apoptosis-related cysteine protease2002
nuclear receptor subfamily 1, group I, member 35005
caspase-32002
Histone H2A.x3003
Caspase-71001
D(1A) dopamine receptor1001
caspase-31001
5-hydroxytryptamine receptor 40202
Voltage-dependent calcium channel gamma-2 subunit2002
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10101
Alpha-2A adrenergic receptor0505
Replicase polyprotein 1ab0101
Replicase polyprotein 1ab0101
D(2) dopamine receptor0202
Alpha-1B adrenergic receptor0011
Alpha-2B adrenergic receptor0404
Alpha-2C adrenergic receptor0505
5-hydroxytryptamine receptor 1A0202
Alpha-2B adrenergic receptor0112
Glutamate receptor 22002
ATP-dependent translocase ABCB10101
D(1A) dopamine receptor0202
Alpha-2C adrenergic receptor0112
Alpha-2A adrenergic receptor0112
Alpha-1D adrenergic receptor0011
Alpha-1D adrenergic receptor0213
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
Alpha-1A adrenergic receptor0011
Alpha-1B adrenergic receptor0011
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0011
5-hydroxytryptamine receptor 60202
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Chain A, JmjC domain-containing histone demethylation protein 3A5005
Luciferase2002
PPM1D protein2002
DNA polymerase beta3003
flap endonuclease 11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 12002
histone acetyltransferase KAT2A isoform 13003
Inhibitor of nuclear factor kappa-B kinase subunit beta0101
Lysine-specific histone demethylase 1A0303
Aurora kinase B0101
67.9K protein1001
Neuraminidase 0303
bromodomain adjacent to zinc finger domain 2B3003
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 10101
Calmodulin-10101
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Nischarin0101
Substance-K receptor0202
Heparanase0011
Spike glycoprotein4004
glp-1 receptor, partial2002
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)3003
lysosomal alpha-glucosidase preproprotein2002
Polyphenol oxidase 20202
Amyloid-beta precursor protein0101
Neuronal acetylcholine receptor subunit alpha-41001
Cholesteryl ester transfer protein0101
Cytochrome P450 2C9 0314
Neuronal acetylcholine receptor subunit beta-21001
D-amino-acid oxidase0101
Xanthine dehydrogenase/oxidase0202
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
Hydroxycarboxylic acid receptor 20213
D-aspartate oxidase0101
Hydroxycarboxylic acid receptor 20112
apical membrane antigen 1, AMA11001
serine-protein kinase ATM isoform a1001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Gag-Pol polyprotein0101
Cytochrome P450 2D60202
Gag-Pol polyprotein0101
Protease 0303
phosphopantetheinyl transferase1001
potassium voltage-gated channel subfamily H member 2 isoform d2002
huntingtin isoform 21001
nuclear receptor ROR-gamma isoform 11001
cytochrome P450 2D6 isoform 12002
Chain A, Activated Factor Xa Heavy Chain0101
Suppressor of tumorigenicity 14 protein0101
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Genome polyprotein 0101
Microtubule-associated protein tau1001
thioredoxin glutathione reductase2002
glycogen synthase kinase-3 beta isoform 10011
mitogen-activated protein kinase 11001
L-lactate dehydrogenase A chain0101
Chymotrypsinogen A0101
Albumin0101
Neuraminidase0101
Beta-lactamase0101
Aldo-keto reductase family 1 member B10101
Sialidase0101
Cystic fibrosis transmembrane conductance regulator0011
Dipeptidyl peptidase 40101
Bifunctional epoxide hydrolase 20101
Prolyl endopeptidase0101
Mitogen-activated protein kinase 100101
Mitogen-activated protein kinase 140101
Neuromedin-U receptor 20011
Solute carrier family 22 member 10203
Solute carrier family 22 member 1 0103
Solute carrier family 22 member 20102
Solute carrier family 22 member 50001
Solute carrier family 22 member 30202
Solute carrier family 22 member 30001
5-hydroxytryptamine receptor 70001
Potassium voltage-gated channel subfamily A member 10101
Solute carrier family 22 member 10102
Solute carrier family 22 member 40001
Solute carrier family 22 member 20102
Solute carrier family 22 member 40101
Solute carrier family 22 member 30001
Solute carrier family 22 member 50001
Solute carrier family 22 member 40001
Chain A, Ferritin light chain2002
cytochrome P450 2C19 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Bile salt export pump0101
Cytochrome P450 2J20101
Disintegrin and metalloproteinase domain-containing protein 171001
Rap guanine nucleotide exchange factor 31001
Albumin0011
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]