Postphlebitic Disease

A condition characterized by a chronically swollen limb, often a leg with stasis dermatitis and ulcerations. This syndrome can appear soon after phlebitis or years later. Postphlebitic syndrome is the result of damaged or incompetent venous valves in the limbs. Distended, tortuous VARICOSE VEINS are usually present. Leg pain may occur after long period of standing.

Synonyms(3)

Synonym
Postphlebitic Syndrome
Postphlebitic Disease
Postphlebitic Ulcer

Research Excerpts

Overview

Excerpt	Reference
"The postphlebitic syndrome is a significant management problem that affects a large number of patients."	( Hiatt, WR, 1992)

Research

Studies (134)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	43 (32.09)	23.3326
1990's	53 (39.55)	12.5806
2000's	32 (23.88)	18.1394
2010's	3 (2.24)	28.8240
2020's	3 (2.24)	9.53

Drug	Relationship Strength	Studies	Trials
iodine	low	1	0
papaverine	low	1	0
pentoxifylline	low	1	0
phenylbutazone	low	1	0
adenosine diphosphate	low	1	0
thiophenes	low	1	0
hesperidin	low	1	0
zinc oxide	low	1	0
d-alpha tocopherol	low	1	0
technetium	low	1	0
fibrinogen	low	5	0
dabigatran	low	1	0
fibrin	low	5	0
sanorg 34006	low	2	0
vitamin k semiquinone radical	medium	4	2
alprostadil	medium	2	1
rutin	medium	2	2
diosmin	medium	1	1
fondaparinux	low	2	0
troxerutin	medium	1	1
beta-escin	low	2	0
beta-escin	low	1	0
gadolinium dtpa	low	1	0
rivaroxaban	low	1	0
apixaban	low	1	0
phosphatidylcholines	low	1	0
interleukin-8	low	1	0
acenocoumarol	low	1	0
warfarin	medium	12	2
phenprocoumon	medium	2	1
teca	low	1	0
orabase	low	1	0
hypoxanthine	low	1	0
inosine	low	1	0

Protein Targets (433)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Luciferase	6	0	0	6
RAR-related orphan receptor gamma	6	0	0	6
retinoid X nuclear receptor alpha	5	0	0	5
G	6	0	0	6
peroxisome proliferator activated receptor gamma	9	0	0	9
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
thyroid stimulating hormone receptor	5	0	0	5
chromobox protein homolog 1	4	0	0	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
geminin	6	0	0	6
muscleblind-like protein 1 isoform 1	5	0	0	5
Interferon beta	9	0	0	9
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Guanine nucleotide-binding protein G	1	0	0	1
Inositol hexakisphosphate kinase 1	6	0	0	6
cytochrome P450 2C9, partial	6	0	0	6
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
regulator of G-protein signaling 4	5	0	0	5
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	0	1	1
Delta-type opioid receptor	0	0	1	1
Kappa-type opioid receptor	0	0	1	1
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	4	0	0	4
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
TDP1 protein	7	0	0	7
AR protein	10	0	0	10
glucocorticoid receptor [Homo sapiens]	6	0	0	6
estrogen nuclear receptor alpha	14	0	0	14
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	7
Bile salt export pump	0	11	0	11
Cellular tumor antigen p53	7	0	0	7
Thromboxane-A synthase	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostacyclin receptor	0	1	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	6	0	6
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)	0	1	0	1
EWS/FLI fusion protein	7	0	0	7
Coagulation factor X	0	1	0	1
Prothrombin	0	4	0	4
Coagulation factor X	0	6	0	6
Trypsin-1	0	2	0	2
Trypsin-2	0	2	0	2
Trypsin-3	0	2	0	2
Spike glycoprotein	6	0	0	6
Dihydroorotate dehydrogenase	0	2	0	2
Protease	0	1	0	1
USP1 protein, partial	5	0	0	5
Microtubule-associated protein tau	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
estrogen-related nuclear receptor alpha	10	0	0	10
activating transcription factor 6	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
heat shock protein beta-1	3	0	0	3
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
lamin isoform A-delta10	6	0	0	6
Rap guanine nucleotide exchange factor 3	3	0	0	3
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
cytochrome P450 2D6	3	0	0	3
Solute carrier family 22 member 2	0	2	0	2
Plasminogen	0	1	0	1
Coagulation factor XII	0	2	0	2
Tissue-type plasminogen activator	0	1	0	1
Vitamin K-dependent protein C	0	1	0	1
Serine protease hepsin	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Multidrug and toxin extrusion protein 2	0	2	0	2
Multidrug and toxin extrusion protein 1	0	2	0	2
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
Chain A, Beta-lactamase	5	0	0	5
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
acetylcholinesterase	5	0	0	5
ATAD5 protein, partial	4	0	0	4
PPM1D protein	3	0	0	3
GLI family zinc finger 3	7	0	0	7
aryl hydrocarbon receptor	3	0	0	3
Histone H2A.x	5	0	0	5
DNA polymerase beta	3	0	0	3
flap endonuclease 1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	5	0	0	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	5	0	0	5
DNA polymerase kappa isoform 1	4	0	0	4
histone acetyltransferase KAT2A isoform 1	6	0	0	6
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	0	1
Lysine-specific histone demethylase 1A	0	3	0	3
Aurora kinase B	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Chain A, Ferritin light chain	3	0	0	3
acid sphingomyelinase	1	0	0	1
thioredoxin reductase	6	0	0	6
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
SMAD family member 2	2	0	0	2
Fumarate hydratase	3	0	0	3
NFKB1 protein, partial	3	0	0	3
SMAD family member 3	2	0	0	2
Thrombopoietin	2	0	0	2
Smad3	2	0	0	2
DNA polymerase III, partial	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
thyroid stimulating hormone receptor	4	0	0	4
estrogen receptor 2 (ER beta)	1	0	0	1
progesterone receptor	5	0	0	5
isocitrate dehydrogenase 1, partial	1	0	0	1
nonstructural protein 1	2	0	0	2
LANA	0	0	0	1
farnesoid X nuclear receptor	2	0	0	2
pregnane X nuclear receptor	5	0	0	5
NPYLR7B	0	0	1	1
polyprotein	3	0	0	3
67.9K protein	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
peroxisome proliferator-activated receptor delta	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
IDH1	2	0	0	2
thyrotropin-releasing hormone receptor	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
serine-protein kinase ATM isoform a	1	0	0	1
Bloom syndrome protein isoform 1	3	0	0	3
cytochrome P450 2D6 isoform 1	3	0	0	3
lysosomal alpha-glucosidase preproprotein	3	0	0	3
peripheral myelin protein 22 isoform 1	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	3	0	0	3
D(1A) dopamine receptor	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
thyroid hormone receptor beta isoform a	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
thyroid hormone receptor beta isoform 2	4	0	0	4
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
serine/threonine-protein kinase PLK1	1	0	0	1
eyes absent homolog 2 isoform a	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tumor susceptibility gene 101 protein	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
peripheral myelin protein 22	3	0	0	3
survival motor neuron protein isoform d	5	0	0	5
cytochrome P450 3A4 isoform 1	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
muscarinic acetylcholine receptor M1	4	0	0	4
lethal factor (plasmid)	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
kelch-like ECH-associated protein 1	0	0	0	2
neuropeptide S receptor isoform A	2	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	3	0	0	3
Solute carrier family 22 member 1	0	3	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	3	0	3
cGMP-specific 3',5'-cyclic phosphodiesterase	0	3	0	3
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
ATP-dependent translocase ABCB1	0	3	1	11
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	3	0	0	3
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	3	0	0	3
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Glutamate receptor 2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	3	0	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	3	0	0	3
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Histamine H2 receptor	3	0	0	3
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	2	0	2
Caspase-7	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	3	0	0	3
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
TAR DNA-binding protein 43	2	0	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	3	0	3
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	4	0	4
Exopolyphosphatase PRUNE1	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
GABA theta subunit	3	0	0	3
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	2	0	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	3	0	0	3
Single-stranded DNA cytosine deaminase	1	0	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	1	3
Phosphodiesterase	0	2	0	2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Genome polyprotein	0	2	1	3
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
phosphopantetheinyl transferase	4	0	0	4
GLS protein	4	0	0	4
thioredoxin glutathione reductase	3	0	0	3
hypothetical protein, conserved	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
vitamin D3 receptor isoform VDRA	3	0	0	3
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
relaxin receptor 1 isoform 1	2	0	0	2
Flavin reductase (NADPH)	0	0	1	1
ATP-dependent phosphofructokinase	4	0	0	4
large T antigen	0	1	0	1
Neuraminidase	0	3	0	3
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Calmodulin-1	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Substance-P receptor	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Nischarin	0	1	0	1
Substance-K receptor	0	2	0	2
Heparanase	0	0	1	1
Chain A, Purine-nucleoside Phosphorylase	0	1	0	1
Chain C, Xanthine dehydrogenase/oxidase	0	0	1	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Purine nucleoside phosphorylase	0	0	1	2
Chain A, ADENOSINE DEAMINASE	0	1	0	1
Chain A, ADENOSINE DEAMINASE	0	1	0	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
Purine nucleoside phosphorylase	0	0	0	1
Adenosylhomocysteinase	0	1	0	2
Adenosine deaminase	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Type II pantothenate kinase	0	0	0	1
Type III pantothenate kinase	0	0	0	1
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
glp-1 receptor, partial	2	0	0	2
15-lipoxygenase, partial	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
glucokinase regulatory protein	1	0	0	1
mitogen-activated protein kinase 1	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Acetylcholinesterase	0	3	0	3
Cytochrome P450 2C19	0	1	0	1
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
CREB-binding protein	1	0	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
endonuclease IV	1	0	0	1
dopamine D1 receptor	1	0	0	1
arylsulfatase A	1	0	0	1
vasopressin V1b receptor	1	0	0	1
Tumor necrosis factor	0	1	0	1
Cholinesterase	0	1	0	1
Adenosine receptor A2b	0	1	0	1
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Protease	0	3	0	3
pregnane X receptor	1	0	0	1
Estrogen receptor 1	0	1	0	1
Parkin	1	0	0	1
fMet-Leu-Phe receptor	0	1	0	1
M-phase phosphoprotein 8	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cytochrome P450 2C9	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Polyphenol oxidase 2	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Albumin	0	1	0	1
Neuraminidase	0	1	0	1
Beta-lactamase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Cytochrome P450 3A4	0	2	0	2
Alpha-2A adrenergic receptor	0	3	0	3
Sialidase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Alpha-2C adrenergic receptor	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Neuromedin-U receptor 2	0	0	1	1
glucocerebrosidase	1	0	0	1
huntingtin isoform 2	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Bile salt export pump	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Albumin	0	0	2	2
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	2
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Multidrug resistance-associated protein 1	0	2	1	4
Mu-type opioid receptor	0	1	0	1
D(3) dopamine receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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