Page last updated: 2024-09-28

Postphlebitic Disease

A condition characterized by a chronically swollen limb, often a leg with stasis dermatitis and ulcerations. This syndrome can appear soon after phlebitis or years later. Postphlebitic syndrome is the result of damaged or incompetent venous valves in the limbs. Distended, tortuous VARICOSE VEINS are usually present. Leg pain may occur after long period of standing.

Synonyms(3)

Synonym
Postphlebitic Syndrome
Postphlebitic Disease
Postphlebitic Ulcer

Research Excerpts

Overview

ExcerptReference
"The postphlebitic syndrome is a significant management problem that affects a large number of patients."( Hiatt, WR, 1992)

Research

Studies (134)

TimeframeStudies, This Condition (%)All Conditions %
pre-199043 (32.09)23.3326
1990's53 (39.55)12.5806
2000's32 (23.88)18.1394
2010's3 (2.24)28.8240
2020's3 (2.24)9.53
DrugIndicatedRelationship StrengthStudiesTrials
iodine0low10
papaverine0low10
pentoxifylline0low10
phenylbutazone0low10
adenosine diphosphate0low10
thiophenes0low10
hesperidin0low10
zinc oxide0low10
d-alpha tocopherol0low10
technetium0low10
fibrinogen0low50
dabigatran0low10
fibrin0low50
sanorg 340060low20
vitamin k semiquinone radical0medium42
alprostadil0medium21
rutin0medium22
diosmin0medium11
fondaparinux0low20
troxerutin0medium11
beta-escin0low20
beta-escin0low10
gadolinium dtpa0low10
rivaroxaban0low10
apixaban0low10
phosphatidylcholines0low10
interleukin-80low10
acenocoumarol0low10
warfarin0medium122
phenprocoumon0medium21
teca0low10
orabase0low10
hypoxanthine0low10
inosine0low10

Protein Targets (433)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Luciferase6006
RAR-related orphan receptor gamma6006
retinoid X nuclear receptor alpha5005
G6006
peroxisome proliferator activated receptor gamma9009
euchromatic histone-lysine N-methyltransferase 2100010
thyroid stimulating hormone receptor5005
chromobox protein homolog 14004
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
geminin6006
muscleblind-like protein 1 isoform 15005
Interferon beta9009
HLA class I histocompatibility antigen, B alpha chain 6006
Guanine nucleotide-binding protein G1001
Inositol hexakisphosphate kinase 16006
cytochrome P450 2C9, partial6006
Chain A, Heat Shock Protein 900011
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE0011
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE0011
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, Myosin Ie Heavy Chain0011
Chain A, Preprotein translocase secA0011
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Phosphoribosylformylglycinamidine synthase0101
Chain A, nucleoside diphosphate kinase A0011
Chain B, nucleoside diphosphate kinase A0011
Chain D, DNA polymerase III subunit gamma0011
Chain D, DNA polymerase III subunit gamma0011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30011
Chain A, Kinesin-like protein KIF110101
regulator of G-protein signaling 45005
HPr kinase/phosphorylase0011
Mitogen-activated protein kinase kinase kinase 70011
ATP-dependent molecular chaperone HSP820001
Heat shock protein HSP 90-alpha0113
Heat shock protein HSP 90-beta0113
2-dehydropantoate 2-reductase0112
Heat shock 70 kDa protein 1A 0112
Endoplasmic reticulum chaperone BiP0011
Heat shock cognate 71 kDa protein0011
Pyruvate kinase PKM 0001
Pyruvate kinase PKLR 0001
Endoplasmin0001
Heat shock cognate 71 kDa protein0011
5'-nucleotidase0101
Mu-type opioid receptor0011
Delta-type opioid receptor0011
Kappa-type opioid receptor0011
Endoplasmin0112
P2Y purinoceptor 20011
Phosphatidylinositol 4-kinase alpha0202
P2X purinoceptor 10011
P2Y purinoceptor 10011
P2Y purinoceptor 10011
P2X purinoceptor 10011
P2X purinoceptor 40011
P2X purinoceptor 50011
P2X purinoceptor 60011
P2X purinoceptor 30011
Inositol monophosphatase 14004
Heat shock protein 75 kDa, mitochondrial0101
P2Y purinoceptor 60011
Phosphatidylinositol 4-kinase type 2-beta0202
P2Y purinoceptor 110011
Phosphatidylinositol 4-kinase type 2-alpha0202
P2Y purinoceptor 120011
Sensor protein kinase WalK0101
Phosphatidylinositol 4-kinase beta0202
P2X purinoceptor 20011
TDP1 protein7007
AR protein100010
glucocorticoid receptor [Homo sapiens]6006
estrogen nuclear receptor alpha140014
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40607
Bile salt export pump011011
Cellular tumor antigen p537007
Thromboxane-A synthase 0101
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP1 subtype0101
Prostacyclin receptor0112
Nuclear receptor subfamily 4 group A member 20011
Solute carrier organic anion transporter family member 2A10001
Nuclear receptor subfamily 4 group A member 20011
Nuclear receptor subfamily 4 group A member 20011
Prostaglandin E2 receptor EP2 subtype0112
Canalicular multispecific organic anion transporter 10606
Solute carrier organic anion transporter family member 2A10001
Solute carrier organic anion transporter family member 2B10101
Solute carrier organic anion transporter family member 3A10001
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)0101
EWS/FLI fusion protein7007
Coagulation factor X0101
Prothrombin0404
Coagulation factor X0606
Trypsin-10202
Trypsin-20202
Trypsin-30202
Spike glycoprotein6006
Dihydroorotate dehydrogenase 0202
Protease 0101
USP1 protein, partial5005
Microtubule-associated protein tau4004
cytochrome P450 family 3 subfamily A polypeptide 48008
retinoic acid nuclear receptor alpha variant 16006
estrogen-related nuclear receptor alpha100010
activating transcription factor 67007
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
heat shock protein beta-13003
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 12002
lamin isoform A-delta106006
Rap guanine nucleotide exchange factor 33003
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
cytochrome P450 2D63003
Solute carrier family 22 member 20202
Plasminogen0101
Coagulation factor XII0202
Tissue-type plasminogen activator0101
Vitamin K-dependent protein C0101
Serine protease hepsin0101
Muscarinic acetylcholine receptor M10101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Multidrug and toxin extrusion protein 20202
Multidrug and toxin extrusion protein 10202
nuclear receptor subfamily 1, group I, member 34004
Chain A, Beta-lactamase5005
Chain A, JmjC domain-containing histone demethylation protein 3A2002
acetylcholinesterase5005
ATAD5 protein, partial4004
PPM1D protein3003
GLI family zinc finger 37007
aryl hydrocarbon receptor3003
Histone H2A.x5005
DNA polymerase beta3003
flap endonuclease 11001
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
nuclear factor erythroid 2-related factor 2 isoform 15005
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)5005
DNA polymerase kappa isoform 14004
histone acetyltransferase KAT2A isoform 16006
Inhibitor of nuclear factor kappa-B kinase subunit beta0101
Lysine-specific histone demethylase 1A0303
Aurora kinase B0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, Ferritin light chain3003
acid sphingomyelinase1001
thioredoxin reductase6006
RGS121001
90-kda heat shock protein beta HSP90 beta, partial0101
hypoxia-inducible factor 1 alpha subunit3003
SMAD family member 22002
Fumarate hydratase3003
NFKB1 protein, partial3003
SMAD family member 32002
Thrombopoietin2002
Smad32002
DNA polymerase III, partial1001
aldehyde dehydrogenase 1 family, member A15005
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
thyroid stimulating hormone receptor4004
estrogen receptor 2 (ER beta)1001
progesterone receptor5005
isocitrate dehydrogenase 1, partial1001
nonstructural protein 12002
LANA0001
farnesoid X nuclear receptor2002
pregnane X nuclear receptor5005
NPYLR7B0011
polyprotein3003
67.9K protein1001
bromodomain adjacent to zinc finger domain 2B4004
peroxisome proliferator-activated receptor delta2002
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
IDH12002
thyrotropin-releasing hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)4004
serine-protein kinase ATM isoform a1001
Bloom syndrome protein isoform 13003
cytochrome P450 2D6 isoform 13003
lysosomal alpha-glucosidase preproprotein3003
peripheral myelin protein 22 isoform 12002
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor3003
D(1A) dopamine receptor2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
thyroid hormone receptor beta isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 22003
potassium voltage-gated channel subfamily H member 2 isoform d2002
thyroid hormone receptor beta isoform 24004
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a4004
serine/threonine-protein kinase PLK11001
eyes absent homolog 2 isoform a2002
heat shock protein HSP 90-alpha isoform 20101
tumor susceptibility gene 101 protein1001
nuclear receptor ROR-gamma isoform 12002
peripheral myelin protein 223003
survival motor neuron protein isoform d5005
cytochrome P450 3A4 isoform 13003
caspase-1 isoform alpha precursor1001
muscarinic acetylcholine receptor M14004
lethal factor (plasmid)1001
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
kelch-like ECH-associated protein 10002
neuropeptide S receptor isoform A2002
cGMP-dependent 3',5'-cyclic phosphodiesterase0303
Gamma-aminobutyric acid receptor subunit pi3003
Solute carrier family 22 member 1 0303
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Multidrug resistance-associated protein 50101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0303
cGMP-specific 3',5'-cyclic phosphodiesterase0303
3',5'-cyclic-AMP phosphodiesterase 0202
Voltage-dependent calcium channel gamma-2 subunit3003
ATP-dependent translocase ABCB103111
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-13003
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha0101
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Glutamate receptor 23003
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0303
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta0101
Histamine H2 receptor3003
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0202
Caspase-71001
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Disintegrin and metalloproteinase domain-containing protein 173003
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0303
TAR DNA-binding protein 432002
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0303
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0202
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0404
Exopolyphosphatase PRUNE10101
Rap guanine nucleotide exchange factor 41001
GABA theta subunit3003
ATPase family AAA domain-containing protein 51001
Ataxin-22002
Equilibrative nucleoside transporter 10202
Gamma-aminobutyric acid receptor subunit epsilon3003
Single-stranded DNA cytosine deaminase1001
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 7B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20213
Phosphodiesterase 0202
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0203
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Genome polyprotein 0213
chaperonin-containing TCP-1 beta subunit homolog1001
phosphopantetheinyl transferase4004
GLS protein4004
thioredoxin glutathione reductase3003
hypothetical protein, conserved1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
vitamin D3 receptor isoform VDRA3003
lethal(3)malignant brain tumor-like protein 1 isoform I1001
relaxin receptor 1 isoform 12002
Flavin reductase (NADPH)0011
ATP-dependent phosphofructokinase4004
large T antigen0101
Neuraminidase 0303
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 10101
Calmodulin-10101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Substance-P receptor0202
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Nischarin0101
Substance-K receptor0202
Heparanase0011
Chain A, Purine-nucleoside Phosphorylase0101
Chain C, Xanthine dehydrogenase/oxidase0011
Hypoxanthine-guanine phosphoribosyltransferase0001
Purine nucleoside phosphorylase 0012
Chain A, ADENOSINE DEAMINASE0101
Chain A, ADENOSINE DEAMINASE0101
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
glycogen synthase kinase-3 beta isoform 10022
Purine nucleoside phosphorylase0001
Adenosylhomocysteinase0102
Adenosine deaminase 0101
histone deacetylase 9 isoform 31001
Type II pantothenate kinase0001
Type III pantothenate kinase0001
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0101
glp-1 receptor, partial2002
15-lipoxygenase, partial1001
hexokinase-4 isoform 11001
polyunsaturated fatty acid lipoxygenase ALOX121001
atrial natriuretic peptide receptor 1 precursor1001
glucokinase regulatory protein1001
mitogen-activated protein kinase 13003
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
Vascular endothelial growth factor receptor 1 0101
Acetylcholinesterase0303
Cytochrome P450 2C190101
Serine hydroxymethyltransferase, mitochondrial0101
Vascular endothelial growth factor receptor 30101
Vascular endothelial growth factor receptor 20101
Potassium voltage-gated channel subfamily H member 20202
CREB-binding protein1001
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 0202
endonuclease IV1001
dopamine D1 receptor1001
arylsulfatase A1001
vasopressin V1b receptor1001
Tumor necrosis factor0101
Cholinesterase0101
Adenosine receptor A2b0101
Chitotriosidase-10213
Endochitinase B10213
Gag-Pol polyprotein0101
Cytochrome P450 2D60101
Gag-Pol polyprotein0101
Protease 0303
pregnane X receptor1001
Estrogen receptor 10101
Parkin1001
fMet-Leu-Phe receptor0101
M-phase phosphoprotein 81001
Prostaglandin G/H synthase 10101
Cytochrome P450 2C9 0303
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 2 0101
Prostaglandin G/H synthase 1 0101
Nicotinate phosphoribosyltransferase0101
Cyclooxygenase-2 0101
Solute carrier family 22 member 80101
Chain A, Activated Factor Xa Heavy Chain0101
Suppressor of tumorigenicity 14 protein0101
Polyphenol oxidase 20101
L-lactate dehydrogenase A chain0101
Chymotrypsinogen A0101
Albumin0101
Neuraminidase0101
Beta-lactamase0101
Aldo-keto reductase family 1 member B10101
Cytochrome P450 3A40202
Alpha-2A adrenergic receptor0303
Sialidase0101
Cystic fibrosis transmembrane conductance regulator0011
Alpha-2C adrenergic receptor0101
Dipeptidyl peptidase 40101
Bifunctional epoxide hydrolase 20101
Xanthine dehydrogenase/oxidase0101
Prolyl endopeptidase0101
Mitogen-activated protein kinase 100101
Mitogen-activated protein kinase 140101
Neuromedin-U receptor 20011
glucocerebrosidase1001
huntingtin isoform 21001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Bile salt export pump0101
5-hydroxytryptamine receptor 40202
Albumin0022
Glycoprotein0101
Muscarinic acetylcholine receptor M20011
ATP-dependent translocase ABCB10101
Cytochrome P450 2C80101
5-hydroxytryptamine receptor 1A0202
ATP-dependent translocase ABCB10102
Catechol O-methyltransferase0101
Potassium voltage-gated channel subfamily A member 30101
Histamine H2 receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
Sodium-dependent serotonin transporter0202
Delta-type opioid receptor0101
Multidrug resistance-associated protein 1 0214
Mu-type opioid receptor0101
D(3) dopamine receptor0202
Kappa-type opioid receptor0101
5-hydroxytryptamine receptor 2B0202
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20101
D(2) dopamine receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Chloroquine resistance transporter0101
Solute carrier organic anion transporter family member 1B10202
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]