Page last updated: 2024-09-27

Post-Traumatic Subarachnoid Hemorrhage

Bleeding into the SUBARACHNOID SPACE due to CRANIOCEREBRAL TRAUMA. Minor hemorrhages may be asymptomatic; moderate to severe hemorrhages may be associated with INTRACRANIAL HYPERTENSION and VASOSPASM, INTRACRANIAL.

Synonyms(3)

Synonym
Post-Traumatic Subarachnoid Hemorrhage
Subarachnoid Hemorrhage, Traumatic
Traumatic Subarachnoid Hemorrhage

Research Excerpts

Research

Studies (40)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's13 (32.50)18.1394
2010's22 (55.00)28.8240
2020's5 (12.50)9.53
DrugIndicatedRelationship StrengthStudiesTrials
carbon monoxide0low10
salicylic acid0low20
lactic acid0medium21
glycerol0medium11
dalteparin0low10
pyruvic acid0medium21
acetaminophen0low10
aspirin0low20
valproic acid0low10
iohexol0low10
nimodipine0low20
papaverine0low10
temozolomide0low10
ticlopidine0low10
tranexamic acid0low10
mannitol0low10
lithium carbonate0low10
dronabinol0low10
magnesium sulfate0low10
propiconazole0low20
simvastatin0medium11
clopidogrel0low20
atorvastatin0low10
simendan0low10
ursolic acid0low10
1,1-dimethylheptyl-11-hydroxytetrahydrocannabinol0low10
dabigatran0low10
rocuronium0low10
arginine vasopressin0low10
bilirubin0low10
vitamin k semiquinone radical0low10
deamino arginine vasopressin0low10
rivaroxaban0low20
apixaban0low20
heme0low10
warfarin0low30
exudates0low20
acyclovir0low10
dacarbazine0low10
eye0low10

Protein Targets (498)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Cannabinoid receptor 10314
Cannabinoid receptor 10528
Cannabinoid receptor 2 0326
Cannabinoid receptor 20303
RAR-related orphan receptor gamma8008
ATAD5 protein, partial5005
GLS protein7007
Microtubule-associated protein tau2002
Smad33003
aldehyde dehydrogenase 1 family, member A19009
thyroid stimulating hormone receptor5005
nuclear receptor subfamily 1, group I, member 39009
progesterone receptor7007
EWS/FLI fusion protein110011
retinoic acid nuclear receptor alpha variant 1130013
retinoid X nuclear receptor alpha8008
estrogen-related nuclear receptor alpha120012
estrogen nuclear receptor alpha170017
peroxisome proliferator activated receptor gamma9009
aryl hydrocarbon receptor4004
chromobox protein homolog 19009
thyroid hormone receptor beta isoform 2110011
peripheral myelin protein 227007
cytochrome P450 3A4 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3003
ATP-binding cassette sub-family C member 3012012
Multidrug resistance-associated protein 4012012
Solute carrier family 22 member 60304
Carbonic anhydrase 120303
UDP-glucuronosyltransferase 1A90002
Bile salt export pump0505
Voltage-dependent calcium channel gamma-2 subunit4004
Bile salt export pump017017
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10606
Carbonic anhydrase 20606
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20001
Prostaglandin G/H synthase 10303
Carbonic anhydrase 30202
Cytochrome P450 3A40303
Cytochrome P450 2D60202
Cytochrome P450 2C9 0707
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-13003
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
UDP-glucuronosyltransferase 1-60002
Glutamate receptor 24015
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 40202
Prostaglandin G/H synthase 10505
Carbonic anhydrase 60202
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Carbonic anhydrase 5A, mitochondrial0202
Prostaglandin G/H synthase 20607
Carbonic anhydrase 70202
Nuclear receptor ROR-gamma3104
Cytochrome P450 2J20505
Gamma-aminobutyric acid receptor subunit alpha-13104
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Carbonic anhydrase 90303
GABA theta subunit3003
Canalicular multispecific organic anion transporter 1012012
Carbonic anhydrase 150202
Carbonic anhydrase 130202
Gamma-aminobutyric acid receptor subunit epsilon3003
Carbonic anhydrase 140202
Carbonic anhydrase 5B, mitochondrial0202
toxin B0001
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Ferritin light chain6006
Thymidine kinase 0101
thioredoxin reductase6006
phosphopantetheinyl transferase4004
TDP1 protein9009
arylsulfatase A2002
euchromatic histone-lysine N-methyltransferase 27007
activating transcription factor 64004
Histone H2A.x2002
Bloom syndrome protein isoform 13003
hemoglobin subunit beta1001
atrial natriuretic peptide receptor 1 precursor3003
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
lamin isoform A-delta10100010
Solute carrier family 22 member 1 0001
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20001
Disintegrin and metalloproteinase domain-containing protein 173003
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60102
Thymidine kinase 0101
Solute carrier family 22 member 80102
Thymidine kinase0101
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)0101
Coagulation factor X0101
Prothrombin0404
Coagulation factor X0505
Trypsin-10202
Trypsin-20202
Trypsin-30202
Spike glycoprotein5005
vitamin D3 receptor isoform VDRA8008
Translocator protein0011
Vasopressin V2 receptor0326
Oxytocin receptor0123
Vasopressin V1a receptor0022
Vasopressin V1a receptor0224
Vasopressin V1b receptor0224
Vasopressin V2 receptor0011
Vasopressin V1b receptor0113
Translocator protein0203
Oxytocin receptor0101
Vasopressin V2 receptor 0224
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Phospholipase A2 isoform 30011
Chain A, 2-oxoglutarate Oxygenase5005
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 82002
AR protein120012
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 47007
glucocorticoid receptor [Homo sapiens]120012
cytochrome P450 2D68008
glucocerebrosidase2002
peroxisome proliferator-activated receptor delta6006
Rac1 protein0011
IDH13003
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
DNA polymerase iota isoform a (long)5005
DNA polymerase kappa isoform 16006
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)1001
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0101
Fatty acid-binding protein, liver0101
Integrin beta-31102
Myeloperoxidase0101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb1102
Glutathione hydrolase 1 proenzyme0101
Adenosine receptor A10101
Adenosine receptor A2a0303
Substance-P receptor0101
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
Sigma non-opioid intracellular receptor 10213
Sigma non-opioid intracellular receptor 10011
Chain A, Cruzipain3003
SMAD family member 23003
SMAD family member 33003
GLI family zinc finger 37007
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)6006
pregnane X nuclear receptor7007
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
caspase-31001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
Caspase-71001
thyroid hormone receptor beta isoform a5005
caspase-31001
nuclear factor erythroid 2-related factor 2 isoform 19009
geminin100010
Solute carrier organic anion transporter family member 2B1 0001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0404
Cellular tumor antigen p53100010
ATP-dependent translocase ABCB10303
Insulin receptor 0202
Dipeptidyl peptidase 40101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0202
Histone deacetylase 10303
Histone deacetylase 20303
Solute carrier organic anion transporter family member 1B30305
Histone deacetylase 60303
Broad substrate specificity ATP-binding cassette transporter ABCG20303
Solute carrier organic anion transporter family member 1B10507
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
USP1 protein, partial5005
caspase-1 isoform alpha precursor1001
Caspase-71001
Inositol monophosphatase 14004
nonstructural protein 13003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
Cytochrome P450 2C80202
Cytochrome P450 2B60303
Liver carboxylesterase 10203
Sodium-dependent serotonin transporter0202
Cytochrome P450 2C190505
Rap guanine nucleotide exchange factor 43003
P2Y purinoceptor 120101
G5005
Solute carrier family 22 member 20101
Plasminogen0314
Coagulation factor XII0202
Tissue-type plasminogen activator0101
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 5005
Vitamin K-dependent protein C0101
Serine protease hepsin0101
Muscarinic acetylcholine receptor M10101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Multidrug and toxin extrusion protein 20101
Inositol hexakisphosphate kinase 15005
Multidrug and toxin extrusion protein 10101
cytochrome P450 2C9, partial5005
hypoxia-inducible factor 1 alpha subunit3003
thyroid stimulating hormone receptor4004
survival motor neuron protein isoform d4004
Matrix metalloproteinase-90101
Isocitrate lyase0101
potassium voltage-gated channel subfamily H member 2 isoform d6006
Fatty-acid amide hydrolase 10101
Nuclear receptor subfamily 1 group I member 20022
Transient receptor potential cation channel subfamily A member 10001
L-lactate dehydrogenase A chain0101
Fatty acid-binding protein, liver0101
Glutamate receptor 10011
Glutamate receptor 30011
Glutamate receptor 40011
Glycine receptor subunit alpha-10011
D(3) dopamine receptor0011
Cannabinoid receptor 10101
Cannabinoid receptor 20112
N-arachidonyl glycine receptor0011
Transient receptor potential cation channel subfamily A member 10011
Lysophosphatidylserine lipase ABHD120101
ATPase family AAA domain-containing protein 55005
Monoglyceride lipase0101
Ataxin-25005
Monoacylglycerol lipase ABHD60101
G-protein coupled receptor 550112
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E0011
acetylcholinesterase3003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
cellular tumor antigen p53 isoform a1001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
TAR DNA-binding protein 434004
Fumarate hydratase2002
farnesoid X nuclear receptor5005
polyprotein2002
Parkin3003
NPC intracellular cholesterol transporter 1 precursor1001
D(1A) dopamine receptor1001
heat shock protein beta-13003
atrial natriuretic peptide receptor 2 precursor2002
flap endonuclease 11001
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
M-phase phosphoprotein 82002
histone acetyltransferase KAT2A isoform 14004
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Equilibrative nucleoside transporter 10101
B2 bradykinin receptor0101
Chymotrypsinogen A0101
Beta-lactamase0101
ATP-dependent translocase ABCB10101
Quinolone resistance protein NorA0101
Adenosine receptor A30202
5-hydroxytryptamine receptor 1A0101
ATP-dependent translocase ABCB10101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Adenosine receptor A30101
Malate dehydrogenase, cytoplasmic0101
D(1A) dopamine receptor1001
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Transient receptor potential cation channel subfamily A member 10022
Chain A, Beta-lactamase5005
endonuclease IV1001
glp-1 receptor, partial4004
regulator of G-protein signaling 42002
bromodomain adjacent to zinc finger domain 2B2002
peripheral myelin protein 22 isoform 11001
nuclear receptor ROR-gamma isoform 14004
neuropeptide S receptor isoform A1001
Voltage-dependent L-type calcium channel subunit beta-40101
Voltage-dependent P/Q-type calcium channel subunit alpha-1A0101
Voltage-dependent T-type calcium channel subunit alpha-1G0101
Voltage-dependent calcium channel gamma-3 subunit0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Voltage-dependent T-type calcium channel subunit alpha-1H0101
Voltage-dependent L-type calcium channel subunit beta-30101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Voltage-dependent calcium channel gamma-7 subunit0101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit beta-10101
Voltage-dependent calcium channel gamma-1 subunit0101
Voltage-dependent L-type calcium channel subunit beta-20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0202
Voltage-dependent R-type calcium channel subunit alpha-1E0101
Voltage-dependent calcium channel subunit alpha-2/delta-40101
Voltage-dependent calcium channel subunit alpha-2/delta-30101
Voltage-dependent calcium channel gamma-8 subunit0101
Bile acid receptor0101
Voltage-dependent calcium channel gamma-6 subunit0101
Voltage-dependent calcium channel subunit alpha-2/delta-20101
Voltage-dependent T-type calcium channel subunit alpha-1I0101
Voltage-dependent calcium channel gamma-4 subunit0101
Voltage-dependent calcium channel gamma-5 subunit0101
Voltage-dependent calcium channel gamma-2 subunit0101
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0101
15-lipoxygenase, partial1001
NFKB1 protein, partial1001
PPM1D protein2002
Thrombopoietin1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
cytochrome P450 2D6 isoform 12002
hexokinase-4 isoform 11001
polyunsaturated fatty acid lipoxygenase ALOX121001
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor1001
glucokinase regulatory protein1001
mitogen-activated protein kinase 11001
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
3',5'-cyclic-AMP phosphodiesterase 0101
Vascular endothelial growth factor receptor 1 0101
Acetylcholinesterase0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Serine hydroxymethyltransferase, mitochondrial0101
Vascular endothelial growth factor receptor 30101
Vascular endothelial growth factor receptor 20101
Histamine H2 receptor2002
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Potassium voltage-gated channel subfamily H member 20101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0202
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0202
CREB-binding protein1001
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 0202
Phosphodiesterase 0101
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0102
pregnane X receptor2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
Polyunsaturated fatty acid lipoxygenase ALOX15B1102
Guanine nucleotide-binding protein G1001
heat shock protein 90, putative0001
Monocarboxylate transporter 40001
Monocarboxylate transporter 20001
Monocarboxylate transporter 10001
C-terminal-binding protein 20101
Monocarboxylate transporter 20101
Prolyl 4-hydroxylase0101
Solute carrier organic anion transporter family member 2A10101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Activated Factor Xa Heavy Chain0101
Suppressor of tumorigenicity 14 protein0101
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Albumin0112
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10202
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10305
Estrogen receptor0001
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
Chain A, JmjC domain-containing histone demethylation protein 3A2002
PINK11001
photoreceptor-specific nuclear receptor0101
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
nuclear receptor subfamily 1, group I, member 21001
nuclear factor erythroid 2-related factor 2 isoform 21001
serine/threonine-protein kinase PLK11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Nuclear receptor subfamily 4 group A member 20011
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Sigma non-opioid intracellular receptor 10202
polyadenylate-binding protein 10101
muscleblind-like protein 1 isoform 11001
Tyrosine-protein kinase ABL10101
Tyrosine-protein kinase ABL20101
Luciferase2002
Alpha-2A adrenergic receptor0202
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
Chain A, PLASMINOGEN0011
Chain A, PLASMINOGEN0011
Urokinase-type plasminogen activator0101
Vpr1001
streptokinase A precursor0011
Aldo-keto reductase family 1 member B100202
Glycogen phosphorylase, muscle form0101
Basic phospholipase A2 10101
Pancreatic alpha-amylase0101
Hemagglutinin0011
Histidine-rich protein PFHRP-II0101
DNA polymerase beta0101
DNA polymerase beta0101
Neutrophil elastase0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Receptor-type tyrosine-protein phosphatase F0101
Aromatase0101
Cholesteryl ester transfer protein0101
Fatty acid synthase0101
Tyrosine-protein phosphatase non-receptor type 20101
Receptor-type tyrosine-protein phosphatase alpha0101
Receptor-type tyrosine-protein phosphatase epsilon0101
Sucrase-isomaltase, intestinal0101
Low molecular weight phosphotyrosine protein phosphatase0101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Tyrosine-protein phosphatase non-receptor type 60101
Delta-type opioid receptor0101
Basic phospholipase A2 PLA-A0101
Transcription factor p650101
Peroxisome proliferator-activated receptor alpha0011
Hypoxia-inducible factor 1-alpha0101
Env polyprotein 0011
Acidic phospholipase A2 EC-I0101
G-protein coupled bile acid receptor 10011
Ubiquitin carboxyl-terminal hydrolase 70101
Ubiquitin carboxyl-terminal hydrolase 470101
Prolyl hydroxylase EGLN20011
Ghrelin O-acyltransferase0101
Egl nine homolog 10011
Prolyl hydroxylase EGLN30011
Transmembrane prolyl 4-hydroxylase0011
Sentrin-specific protease 10101
Protease 0101
Cocaine esterase0101
Histone deacetylase 30202
Aldo-keto reductase family 1 member B10101
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 2B70102
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Histone deacetylase 70202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 90202
Histone deacetylase 50202
thioredoxin glutathione reductase1001
Rap guanine nucleotide exchange factor 31001
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]