Post-Cholecystectomy Syndrome

Abdominal symptoms after removal of the GALLBLADDER. The common postoperative symptoms are often the same as those present before the operation, such as COLIC, bloating, NAUSEA, and VOMITING. There is pain on palpation of the right upper quadrant and sometimes JAUNDICE. The term is often used, inaccurately, to describe such postoperative symptoms not due to gallbladder removal.

Synonym
Post-Choledochoduodenostomy Syndrome
Post-Choledochostomy Syndrome
Post-Choledochojejunostomy Syndrome
Postcholedochojejunostomy Syndrome
Postcholecystectomy Syndrome
Postcholedochoduodenostomy Syndrome
Postcholedochostomy Syndrome
Sump Syndrome
Post-Cholecystectomy Syndrome

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	8 (21.62)	23.3326
1990's	9 (24.32)	12.5806
2000's	11 (29.73)	18.1394
2010's	9 (24.32)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies	Trials
hydrochloric acid	low	1	0
albendazole	low	1	0
caffeine	low	1	0
fenipentol	low	1	0
iopanoic acid	low	1	0
iodipamide	low	3	0
mebeverine	medium	4	2
midazolam	medium	1	1
neostigmine	low	2	0
procaine	low	1	0
propofol	medium	1	1
n-pentyl nitrite	low	1	0
malondialdehyde	medium	1	1
barium sulfate	low	2	0
ursodeoxycholic acid	low	3	0
lovastatin	medium	1	1
bilirubin	low	2	0
morphine	low	4	0
sincalide	low	1	0
indocyanine green	low	1	0
rifamycins	medium	1	1
cholecystokinin	low	5	0
ceruletide	low	1	0
phosphatidylcholines	medium	1	1
vardenafil dihydrochloride	medium	1	1

Protein Targets (334)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Beta-lactamase	3	0	0	3
Luciferase	2	0	0	2
glp-1 receptor, partial	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
RAR-related orphan receptor gamma	5	0	0	5
ATAD5 protein, partial	2	0	0	2
Fumarate hydratase	1	0	0	1
TDP1 protein	5	0	0	5
GLI family zinc finger 3	6	0	0	6
AR protein	6	0	0	6
caspase 7, apoptosis-related cysteine protease	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
progesterone receptor	4	0	0	4
glucocorticoid receptor [Homo sapiens]	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
retinoid X nuclear receptor alpha	5	0	0	5
estrogen-related nuclear receptor alpha	8	0	0	8
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	5	0	0	5
estrogen nuclear receptor alpha	9	0	0	9
polyprotein	1	0	0	1
67.9K protein	1	0	0	1
peroxisome proliferator activated receptor gamma	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
caspase-3	4	0	0	4
IDH1	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	8	0	0	8
aryl hydrocarbon receptor	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Histone H2A.x	3	0	0	3
cellular tumor antigen p53 isoform a	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
chromobox protein homolog 1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
thyroid hormone receptor beta isoform 2	6	0	0	6
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	3	0	0	3
mitogen-activated protein kinase 1	2	0	0	2
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
geminin	6	0	0	6
Vif	0	0	0	1
peripheral myelin protein 22	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
muscleblind-like protein 1 isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
lamin isoform A-delta10	5	0	0	5
neuropeptide S receptor isoform A	1	0	0	1
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Bile salt export pump	0	9	0	9
Interferon beta	4	0	0	4
Cellular tumor antigen p53	7	0	0	7
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Methionine aminopeptidase	0	1	0	1
Glutamate receptor 2	3	0	0	3
Fatty-acid amide hydrolase 1	0	2	0	2
Inositol monophosphatase 1	2	0	0	2
Canalicular multispecific organic anion transporter 1	0	4	0	4
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Chain A, Cruzipain	2	0	0	2
phosphopantetheinyl transferase	3	0	0	3
USP1 protein, partial	3	0	0	3
Microtubule-associated protein tau	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	1	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
DNA polymerase kappa isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	4
Solute carrier organic anion transporter family member 1B1	0	3	0	4
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
GLS protein	3	0	0	3
thyroid stimulating hormone receptor	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
DNA polymerase beta	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	4	0	0	4
lethal factor (plasmid)	1	0	0	1
Potassium channel subfamily K member 2	0	0	1	1
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Cholinesterase	0	3	0	3
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Adenosine receptor A3	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	3	0	3
Adenosine receptor A1	0	2	0	3
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	3	1	6
Adenosine receptor A2a	0	2	0	4
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Guanine deaminase	0	1	0	1
ATP-dependent phosphofructokinase	1	0	0	1
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
peroxisome proliferator-activated receptor delta	2	0	0	2
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Alpha-2A adrenergic receptor	0	0	2	2
Vitamin D3 receptor	0	2	2	4
Alpha-2B adrenergic receptor	0	0	1	1
Alpha-2C adrenergic receptor	0	0	1	1
Retinoic acid receptor RXR-alpha	0	0	1	1
Guanine nucleotide-binding protein G	2	0	0	2
Ileal sodium/bile acid cotransporter	0	2	0	2
TAR DNA-binding protein 43	3	0	0	3
Bile acid receptor	0	0	1	1
G-protein coupled bile acid receptor 1	0	0	2	2
Bile acid receptor	0	0	2	2
G	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Spike glycoprotein	2	0	0	2
Inositol hexakisphosphate kinase 1	3	0	0	3
cytochrome P450 2C9, partial	3	0	0	3
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
thyroid stimulating hormone receptor	4	0	0	4
estrogen receptor 2 (ER beta)	2	0	0	2
cytochrome P450 2D6	2	0	0	2
Rap guanine nucleotide exchange factor 4	2	0	0	2
Chain A, Antigen Cd11a (p180)	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, Ferritin light chain	3	0	0	3
15-lipoxygenase, partial	1	0	0	1
pregnane X receptor	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
Smad3	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
PINK1	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
EWS/FLI fusion protein	1	0	0	1
Parkin	1	0	0	1
activating transcription factor 6	2	0	0	2
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
bcl-2-related protein A1	0	1	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	2	1	5
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Integrin beta-2	0	1	0	1
Intercellular adhesion molecule 1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
ATP-dependent translocase ABCB1	0	3	0	3
Neutrophil elastase	0	1	0	1
Insulin receptor	0	1	0	1
Androgen receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	2	2	1	5
Gamma-aminobutyric acid receptor subunit delta	2	2	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	2	2	1	5
Gamma-aminobutyric acid receptor subunit alpha-5	2	2	1	5
Gamma-aminobutyric acid receptor subunit alpha-3	2	2	1	5
Integrin alpha-L	0	1	1	2
Substance-K receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	2	1	5
Gamma-aminobutyric acid receptor subunit alpha-2	2	2	1	5
Sodium-dependent noradrenaline transporter	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	2	2	1	5
Gamma-aminobutyric acid receptor subunit gamma-3	2	2	1	5
Gamma-aminobutyric acid receptor subunit alpha-6	2	2	1	5
Prostaglandin G/H synthase 2	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	2	1	5
Gamma-aminobutyric acid receptor subunit beta-3	2	2	1	5
Gamma-aminobutyric acid receptor subunit beta-2	2	2	1	5
Sodium-dependent dopamine transporter	0	2	0	2
Histone deacetylase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
GABA theta subunit	2	2	1	5
Histone deacetylase 2	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	2	1	5
Histone deacetylase 6	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Cytochrome P450 3A4	0	2	1	3
Translocator protein	0	1	1	2
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	2	0	2
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	1	0	2
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	2	7
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Delta-type opioid receptor	0	2	2	5
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
regulator of G-protein signaling 4	1	0	0	1
arylsulfatase A	1	0	0	1
Cholinesterase	0	1	0	1
thioredoxin reductase	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Bloom syndrome protein isoform 1	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Cholecystokinin receptor type A	0	1	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	1	1	2
Cholecystokinin receptor type A	0	2	2	4
Gastrin/cholecystokinin type B receptor	0	2	2	4
Gastrin/cholecystokinin type B receptor	0	2	0	2
Cholecystokinin receptor type A	0	2	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Glucocorticoid receptor	0	0	1	1
Alpha-synuclein	1	0	0	1
Sodium/bile acid cotransporter	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
M1-family alanyl aminopeptidase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Post-Cholecystectomy Syndrome

Synonyms(9)

Research

Studies (37)

Protein Targets (334)

Post-Cholecystectomy Syndrome

Synonyms(9)

Research

Studies (37)

Drugs Studied (29)

Protein Targets (334)