Page last updated: 2024-09-27

Polydipsia, Primary

A clinical disorder characterized by excessive fluid intake (polydipsia); HYPONATREMIA; and POLYURIA in SCHIZOPHRENIA and other psychiatric disorders. Impaired water metabolism in psychogenic polydipsia can result in WATER INTOXICATION.

Synonyms(2)

Synonym
Polydipsia, Primary
Polydipsia, Psychogenic

Research Excerpts

Overview

ExcerptReference
"Primary polydipsia is characterized by excessive fluid intake which may suppress vasopressin levels."( Christ-Crain, M; da Conceição, I; Kuehne, JM; Refardt, J; Sailer, CO; Winzeler, B, 2023)

Research

Studies (36)

TimeframeStudies, This Condition (%)All Conditions %
pre-19908 (22.22)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's23 (63.89)28.8240
2020's5 (13.89)9.53
DrugIndicatedRelationship StrengthStudiesTrials
chlorine0low10
bupropion0low10
uric acid0low10
urea0low10
n-methyl-3,4-methylenedioxyamphetamine0low10
chlorothiazide0low20
clomipramine0low10
amphetamine0low10
valproic acid0low10
furosemide0low10
propranolol0low10
risperidone0low20
levodopa0low10
chloroform0low10
arginine0medium21
lithium carbonate0low10
quinpirole0low20
aripiprazole0low10
arginine vasopressin0low30
lithium0low10
deamino arginine vasopressin0low10
pituitrin0low60
glucagon0medium11
oxyntomodulin0medium11
olanzapine0low20

Protein Targets (466)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Solute carrier family 22 member 30101
5-hydroxytryptamine receptor 2C011112
Phenylethanolamine N-methyltransferase0202
Cytochrome P450 2A60202
Substance-P receptor0101
5-hydroxytryptamine receptor 2A011112
5-hydroxytryptamine receptor 1A012215
Cytochrome P450 2A50101
Sodium-dependent dopamine transporter0628
5-hydroxytryptamine receptor 1B010111
5-hydroxytryptamine receptor 1D0617
5-hydroxytryptamine receptor 1F0617
5-hydroxytryptamine receptor 2B010212
5-hydroxytryptamine receptor 60213
5-hydroxytryptamine receptor 7 0516
5-hydroxytryptamine receptor 5A0213
5-hydroxytryptamine receptor 5B0213
5-hydroxytryptamine receptor 3A0314
Sigma non-opioid intracellular receptor 10303
5-hydroxytryptamine receptor 4 0213
Beta-2 adrenergic receptor0214
5-hydroxytryptamine receptor 3B0314
Sigma non-opioid intracellular receptor 10202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase7007
phosphopantetheinyl transferase2002
NFKB1 protein, partial3003
GLS protein6006
thyroid stimulating hormone receptor6006
alpha-galactosidase1001
euchromatic histone-lysine N-methyltransferase 27007
cytochrome P450 2C19 precursor4004
chromobox protein homolog 16006
flap endonuclease 13003
DNA polymerase iota isoform a (long)4004
muscarinic acetylcholine receptor M17007
lethal factor (plasmid)4004
Cytochrome P450 3A40507
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase6006
vitamin D3 receptor isoform VDRA2002
peripheral myelin protein 226006
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
Bile salt export pump011011
Translocator protein0011
Vasopressin V2 receptor0326
Oxytocin receptor0123
Vasopressin V1a receptor0022
Vasopressin V1a receptor0336
Vasopressin V1b receptor0224
Vasopressin V2 receptor0011
Vasopressin V1b receptor0113
Translocator protein0203
Oxytocin receptor0101
Vasopressin V2 receptor 0224
Canalicular multispecific organic anion transporter 10909
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, JmjC domain-containing histone demethylation protein 3A4004
5-hydroxytryptamine receptor 3E0303
acetylcholinesterase4004
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma6006
SMAD family member 21001
Fumarate hydratase3003
USP1 protein, partial4004
PPM1D protein2002
SMAD family member 31001
TDP1 protein6006
GLI family zinc finger 36006
Microtubule-associated protein tau2002
AR protein7007
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 37007
progesterone receptor4004
EWS/FLI fusion protein7007
glucocorticoid receptor [Homo sapiens]4004
retinoic acid nuclear receptor alpha variant 18008
retinoid X nuclear receptor alpha3003
estrogen-related nuclear receptor alpha8008
farnesoid X nuclear receptor4004
pregnane X nuclear receptor2002
estrogen nuclear receptor alpha9009
G2002
cytochrome P450 2D64004
polyprotein3003
67.9K protein1001
peroxisome proliferator-activated receptor delta6006
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
thyroid stimulating hormone receptor3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)5005
lysosomal alpha-glucosidase preproprotein2002
mu-type opioid receptor isoform MOR-10011
nuclear factor erythroid 2-related factor 2 isoform 21001
potassium voltage-gated channel subfamily H member 2 isoform d5005
transcriptional regulator ERG isoform 33003
thyroid hormone receptor beta isoform 25005
heat shock protein beta-11001
nuclear factor erythroid 2-related factor 2 isoform 17007
nuclear receptor ROR-gamma isoform 13003
geminin7007
histone acetyltransferase KAT2A isoform 13003
5-hydroxytryptamine receptor 2A0011
neuropeptide S receptor isoform A1001
Solute carrier family 22 member 20202
5-hydroxytryptamine receptor 3A0202
Voltage-dependent calcium channel gamma-2 subunit4004
5-hydroxytryptamine receptor 3B0303
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 2002
Cellular tumor antigen p535005
ATP-dependent translocase ABCB10306
5-hydroxytryptamine receptor 1A06511
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
D(2) dopamine receptor012318
Alpha-1B adrenergic receptor0729
Alpha-2C adrenergic receptor010213
D0607
Glutamate receptor 24004
Muscarinic acetylcholine receptor M3010212
D(1A) dopamine receptor011113
D(4) dopamine receptor07111
D(1B) dopamine receptor0203
Alpha-1D adrenergic receptor0729
Alpha-1D adrenergic receptor09111
5-hydroxytryptamine receptor 2A013116
5-hydroxytryptamine receptor 2C012214
D(4) dopamine receptor0404
Histamine H1 receptor0404
Sodium-dependent serotonin transporter014115
5-hydroxytryptamine receptor 70516
Alpha-1A adrenergic receptor07210
Histamine H1 receptor010315
Alpha-1B adrenergic receptor0416
D(3) dopamine receptor010214
5-hydroxytryptamine receptor 2B011213
Alpha-1A adrenergic receptor08210
5-hydroxytryptamine receptor 3A0303
5-hydroxytryptamine receptor 6010112
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0404
Spike glycoprotein6017
D(2) dopamine receptor010214
Inositol monophosphatase 14004
Potassium voltage-gated channel subfamily H member 20909
5-hydroxytryptamine receptor 3D0303
Multidrug and toxin extrusion protein 20202
5-hydroxytryptamine receptor 3C0303
Inositol hexakisphosphate kinase 12002
Multidrug and toxin extrusion protein 10303
Histamine H3 receptor0303
cytochrome P450 2C9, partial2002
D(1A) dopamine receptor4004
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Integrin alpha-50101
Acetylcholine receptor subunit beta0101
UDP-glucuronosyltransferase 2B70203
Neuronal acetylcholine receptor subunit beta-20102
UDP-glucuronosyltransferase 1-60102
Cytochrome P450 2B60002
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40103
Sodium-dependent noradrenaline transporter 09110
Neuronal acetylcholine receptor subunit beta-40102
Neuronal acetylcholine receptor subunit alpha-30101
Cytochrome P450 2C190203
UDP-glucuronosyltransferase 2B10 0101
Neuronal acetylcholine receptor subunit alpha-70101
Neuronal acetylcholine receptor subunit alpha-40102
Sodium-dependent dopamine transporter 0718
Acetylcholine receptor subunit delta0101
Carbonic anhydrase 10204
Carbonic anhydrase 20204
Carbonic anhydrase 40204
Carbonic anhydrase0102
Carbonic anhydrase 150102
Luciferase4004
interleukin 81001
Histone H2A.x4004
lamin isoform A-delta106006
Nuclear receptor ROR-gamma2002
Chain A, Beta-lactamase1001
regulator of G-protein signaling 41001
nonstructural protein 11001
arylsulfatase A5005
Bloom syndrome protein isoform 13003
cytochrome P450 3A4 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3216
Gamma-aminobutyric acid receptor subunit beta-13216
Gamma-aminobutyric acid receptor subunit delta3216
Gamma-aminobutyric acid receptor subunit gamma-23216
Gamma-aminobutyric acid receptor subunit alpha-53216
Gamma-aminobutyric acid receptor subunit alpha-33216
Gamma-aminobutyric acid receptor subunit gamma-13216
Gamma-aminobutyric acid receptor subunit alpha-23216
Gamma-aminobutyric acid receptor subunit alpha-43216
Gamma-aminobutyric acid receptor subunit gamma-33216
Gamma-aminobutyric acid receptor subunit alpha-63216
Gamma-aminobutyric acid receptor subunit alpha-13216
Gamma-aminobutyric acid receptor subunit beta-33216
Gamma-aminobutyric acid receptor subunit beta-23216
GABA theta subunit3216
Gamma-aminobutyric acid receptor subunit epsilon3216
ORF730011
ATAD5 protein, partial2002
Thrombopoietin1001
caspase 7, apoptosis-related cysteine protease3003
cytochrome P450 family 3 subfamily A polypeptide 43003
caspase-33003
Spike glycoprotein0011
Replicase polyprotein 1ab0011
cytochrome P450 2D6 isoform 13003
cellular tumor antigen p53 isoform a1001
atrial natriuretic peptide receptor 1 precursor2002
mitogen-activated protein kinase 13003
atrial natriuretic peptide receptor 2 precursor2002
serine/threonine-protein kinase mTOR isoform 11001
Solute carrier family 22 member 1 0202
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Transmembrane protease serine 20011
5-hydroxytryptamine receptor 4010010
Procathepsin L0011
Aldo-keto reductase family 1 member B10505
Muscarinic acetylcholine receptor M20729
Muscarinic acetylcholine receptor M40718
Muscarinic acetylcholine receptor M50707
Alpha-2A adrenergic receptor09212
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Cytochrome P450 2D60406
Muscarinic acetylcholine receptor M107310
Alpha-2B adrenergic receptor08110
Alpha-2B adrenergic receptor0527
Alpha-2C adrenergic receptor0527
Alpha-2A adrenergic receptor0527
Histamine H2 receptor0606
Trypanothione reductase0202
Histamine H1 receptor0303
Trypanothione reductase0101
Histamine H2 receptor2103
D(1A) dopamine receptor1102
5-hydroxytryptamine receptor 70202
Proteasome subunit alpha type-60011
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Envelope glycoprotein0011
Ataxin-24004
Sigma non-opioid intracellular receptor 10505
Angiotensin-converting enzyme 2 0011
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Beta-1 adrenergic receptor 0214
glucocerebrosidase1001
bromodomain adjacent to zinc finger domain 2B1001
IDH11001
Adenylate cyclase type 1 0101
peripheral myelin protein 22 isoform 12002
cytochrome P450 2C9 precursor1001
DNA polymerase beta1001
short transient receptor potential channel 6 isoform 10011
survival motor neuron protein isoform d2002
M-phase phosphoprotein 82002
transient receptor potential cation channel subfamily V member 11001
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Bile salt export pump0404
Albumin0022
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Calmodulin-10101
Beta-2 adrenergic receptor0405
Muscarinic acetylcholine receptor M20202
Cytochrome P450 2C9 0304
Angiotensin-converting enzyme0505
Beta-1 adrenergic receptor0416
D(3) dopamine receptor0619
D(2) dopamine receptor0303
Endothelin receptor type B0101
Adenylate cyclase type 30101
5-hydroxytryptamine receptor 3A0101
Endothelin receptor type B0101
Adenosine receptor A10203
D(1B) dopamine receptor0202
Beta-3 adrenergic receptor0303
Adenylate cyclase type 20101
Adenylate cyclase type 40101
Sodium-dependent serotonin transporter0213
5-hydroxytryptamine receptor 2C 0202
5-hydroxytryptamine receptor 2A0202
Adenylate cyclase type 80101
5-hydroxytryptamine receptor 5A0101
Cytochrome P450 2J20304
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
D(2) dopamine receptor0202
Calmodulin 0011
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
5-hydroxytryptamine receptor 2B0202
Adenylate cyclase type 60101
Adenylate cyclase type 50101
5-hydroxytryptamine receptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Transporter0303
Cholecystokinin receptor type A0101
5-hydroxytryptamine receptor 1A0202
Nuclear receptor subfamily 3 group C member 3 0505
Adenylyl cyclase 7 0101
D0303
ATPase family AAA domain-containing protein 52002
Histamine H4 receptor0112
Transporter0303
aldehyde dehydrogenase 1 family, member A12002
aryl hydrocarbon receptor2002
thyrotropin-releasing hormone receptor1001
Solute carrier family 22 member 60101
Carbonic anhydrase 120103
Albumin0112
Carbonic anhydrase 30102
Glucose-6-phosphate 1-dehydrogenase0202
Carbonic anhydrase 60103
Serum paraoxonase/arylesterase 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase 5A, mitochondrial0103
Carbonic anhydrase 70103
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
6-phosphogluconate dehydrogenase, decarboxylating0101
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0202
Carbonic anhydrase 90103
Carbonic anhydrase 130103
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 140103
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Carbonic anhydrase 5B, mitochondrial0103
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
dopamine D1 receptor2002
15-lipoxygenase, partial2002
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
apical membrane antigen 1, AMA11001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
pyruvate kinase1001
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
importin subunit beta-1 isoform 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase kappa isoform 11001
Polyphenol oxidase 20001
Epidermal growth factor receptor0101
Plasma kallikrein0001
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Polyunsaturated fatty acid lipoxygenase ALOX150202
Tyrosinase0101
Adenosine receptor A2a0102
Glutamate receptor ionotropic, NMDA 1 0001
Solute carrier family 15 member 10101
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Glutamate receptor ionotropic, NMDA 3B0001
Monocarboxylate transporter 100001
Glutamate receptor ionotropic, NMDA 3A0001
phosphoglycerate kinase1001
Aldo-keto reductase family 1 member B10101
Trace amine-associated receptor 10011
FAD-linked sulfhydryl oxidase ALR0001
Disintegrin and metalloproteinase domain-containing protein 171001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Cytochrome P450 1A20101
Beta-2 adrenergic receptor0314
Beta-1 adrenergic receptor0213
Adenosine receptor A30112
Cytochrome P450 2C80101
Beta-3 adrenergic receptor0213
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Endothelin-1 receptor0112
5-hydroxytryptamine receptor 1B0213
Adenosine receptor A2a0123
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
Beta-1 adrenergic receptor0101
Mu-type opioid receptor0112
Delta-type opioid receptor0112
Kappa-type opioid receptor0112
Beta-2 adrenergic receptor0101
Sodium channel protein type 5 subunit alpha0202
Nuclear receptor subfamily 2 group E member 10022
interferon gamma precursor0001
Dipeptidyl peptidase 40011
Dipeptidyl peptidase 40011
Metabotropic glutamate receptor 50011
5-hydroxytryptamine receptor 2A0112
Mu-type opioid receptor0011
Smad31001
Glycine receptor subunit alpha-10011
Rap guanine nucleotide exchange factor 31001
Urease subunit alpha0101
Urease subunit beta0101
Olfactory receptor 51E20011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 22 member 60001
Solute carrier family 22 member 80101
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
pregnane X receptor1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
thyroid hormone receptor beta isoform a1001
Cocaine esterase0101
Histone deacetylase 30202
UDP-glucuronosyltransferase 1A90001
Tissue factor0101
Aldo-keto reductase family 1 member A10101
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]