Page last updated: 2024-09-28

Bulbar Polio

A form of paralytic poliomyelitis affecting neurons of the MEDULLA OBLONGATA of the brain stem. Clinical features include impaired respiration, HYPERTENSION, alterations of vasomotor control, and dysphagia. Weakness and atrophy of the limbs and trunk due to spinal cord involvement is usually associated. (From Adams et al., Principles of Neurology, 6th ed, p765)

Synonyms(4)

Synonym
Bulbar Poliomyelitis
Poliomyelitis, Medullary Involvement
Poliomyelitis, Bulbar
Bulbar Polio

Research

Studies (58)

TimeframeStudies, This Condition (%)All Conditions %
pre-199057 (98.28)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's1 (1.72)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
betaine0low20
glycine0low20
glycocyamine0low20
hydrogen carbonate0low10
pyridoxine0low10
thiamine0low10
cetyltrimethylammonium ion0low10
chlorpromazine0low20
meperidine0low10
apnea0low10
procaine0low40
promethazine0low10
tubocurarine0low10
oxophenarsine0low10
chlorine0low20
propiconazole0low10
fomesafen0low20
glucose, (beta-d)-isomer0low10
triazoles0low10
cortisone0low20
oxytocin0low10
retinol0low10
glycosides0low10
vitamin k semiquinone radical0low10
arsenic0low10
chlortetracycline0low30
brine0low10
hyaluronoglucosaminidase0low10
folic acid0low10

Protein Targets (408)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
thioredoxin reductase8008
ATAD5 protein, partial2002
TDP1 protein7007
Microtubule-associated protein tau3003
estrogen-related nuclear receptor alpha8008
arylsulfatase A1001
euchromatic histone-lysine N-methyltransferase 27007
Bloom syndrome protein isoform 12002
D(1A) dopamine receptor3003
lamin isoform A-delta104004
neuropeptide S receptor isoform A1001
Chain A, Betaine ABC transporter permease and substrate binding protein0011
Chain A, Osmoprotection protein (ProX)0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
GLI family zinc finger 38008
Bile salt export pump0303
Bile salt export pump0909
Proton-coupled amino acid transporter 10303
interferon gamma precursor0001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Proteasome subunit beta type-110001
acetylcholinesterase3003
phosphopantetheinyl transferase4004
RAR-related orphan receptor gamma6006
Fumarate hydratase1001
USP1 protein, partial4004
NFKB1 protein, partial1001
Thrombopoietin1001
AR protein9009
Smad31001
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor5005
NADPH oxidase 10101
cytochrome P450 family 3 subfamily A polypeptide 43003
glucocorticoid receptor [Homo sapiens]6006
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha5005
farnesoid X nuclear receptor2002
pregnane X nuclear receptor5005
estrogen nuclear receptor alpha8008
G1001
cytochrome P450 2D62002
polyprotein1001
67.9K protein1001
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma6006
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
Snq2p0002
caspase-31001
IDH12002
Adenylate cyclase type 1 0202
thyroid stimulating hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x2002
Caspase-71001
Spike glycoprotein0224
Replicase polyprotein 1ab0224
cytochrome P450 2D6 isoform 12002
cellular tumor antigen p53 isoform a1001
vitamin D3 receptor isoform VDRA5005
chromobox protein homolog 16006
potassium voltage-gated channel subfamily H member 2 isoform d3003
caspase-31001
thyroid hormone receptor beta isoform 24004
histone deacetylase 9 isoform 31001
heat shock protein beta-13003
mitogen-activated protein kinase 12002
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 17007
geminin5005
DNA polymerase kappa isoform 11001
peripheral myelin protein 225005
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 83003
histone acetyltransferase KAT2A isoform 13003
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)1001
Gamma-aminobutyric acid receptor subunit pi3104
Proteasome subunit alpha type-70001
Solute carrier family 22 member 1 0405
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Transmembrane protease serine 20224
Glutamate receptor ionotropic, NMDA 2D0101
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40304
Transient receptor potential cation channel subfamily V member 10101
Glutamate receptor ionotropic, NMDA 3B0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40404
Potassium channel subfamily K member 20101
Epidermal growth factor receptor0101
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Albumin0011
Albumin0011
Major prion protein0022
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20101
Cellular tumor antigen p536006
Major prion protein0011
Integrin beta-31001
Cytochrome P450 1A20011
Tyrosine-protein kinase Fyn0101
Procathepsin L0224
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40404
ATP-dependent translocase ABCB10102
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 1A0101
5-hydroxytryptamine receptor 2C0101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor0404
Replicase polyprotein 1a0224
Replicase polyprotein 1ab0224
Replicase polyprotein 1ab0224
Cys-loop ligand-gated ion channel0101
Calmodulin-10314
Replicase polyprotein 1ab0224
Cytochrome P450 2D60112
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10404
Cytochrome P450 2C9 0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0405
5-hydroxytryptamine receptor 2A0101
Gamma-aminobutyric acid receptor subunit beta-13104
Alpha-1B adrenergic receptor0202
Sphingomyelin phosphodiesterase0101
Alpha-2B adrenergic receptor0404
Gamma-aminobutyric acid receptor subunit delta3104
Gamma-aminobutyric acid receptor subunit gamma-23104
Alpha-2C adrenergic receptor0404
D0202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 1A0404
Alpha-2B adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit alpha-53104
Gamma-aminobutyric acid receptor subunit alpha-33104
D(2) dopamine receptor0101
Muscarinic acetylcholine receptor M30404
Proteasome subunit beta type-10001
Substance-K receptor0202
D(1A) dopamine receptor0405
D(4) dopamine receptor0203
D(1B) dopamine receptor0102
Adenylate cyclase type 30202
Alpha-2C adrenergic receptor0202
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit gamma-13104
Gamma-aminobutyric acid receptor subunit alpha-23104
Alpha-1D adrenergic receptor0202
Sodium-dependent noradrenaline transporter 0404
Sodium-dependent dopamine transporter0303
Histamine H2 receptor0404
Alpha-1D adrenergic receptor0404
D(1B) dopamine receptor0202
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20202
Adenylate cyclase type 40202
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 2C0404
Gamma-aminobutyric acid receptor subunit alpha-43104
Gamma-aminobutyric acid receptor subunit gamma-33104
5-hydroxytryptamine receptor 1B0404
Trypanothione reductase0404
Gamma-aminobutyric acid receptor subunit alpha-63104
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 2B0101
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0404
Melanocortin receptor 40202
5-hydroxytryptamine receptor 7 0101
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0204
5-hydroxytryptamine receptor 70101
Histamine H1 receptor0404
Mu-type opioid receptor0314
Glutamate receptor ionotropic, NMDA 1 0314
D(3) dopamine receptor0405
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Adenylate cyclase type 80202
Proteasome subunit beta type-100001
Delta-type opioid receptor0303
Kappa-type opioid receptor0303
5-hydroxytryptamine receptor 2B0404
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0202
Histamine H2 receptor2002
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 60404
5-hydroxytryptamine receptor 70202
Cytochrome P450 2J20101
Gastrin/cholecystokinin type B receptor0101
Spike glycoprotein3227
Proteasome subunit alpha type-60012
D(2) dopamine receptor0203
Calmodulin 0123
Gamma-aminobutyric acid receptor subunit alpha-13104
Gamma-aminobutyric acid receptor subunit beta-33104
Gamma-aminobutyric acid receptor subunit beta-23104
Aldehyde oxidase 10101
Glutamate receptor ionotropic, NMDA 2A 0314
Glutamate receptor ionotropic, NMDA 2B0314
Glutamate receptor ionotropic, NMDA 2C0314
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Sodium-dependent dopamine transporter 0202
Adenylate cyclase type 60202
Adenylate cyclase type 50202
Glutamate receptor ionotropic, NMDA 10101
Aldehyde oxidase0202
Potassium voltage-gated channel subfamily H member 20404
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, NMDA 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium channel protein type 9 subunit alpha0101
Glutamate receptor ionotropic, NMDA 2D0314
Nuclear receptor subfamily 3 group C member 3 0202
Adenylyl cyclase 7 0202
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0314
GABA theta subunit3104
Inositol hexakisphosphate kinase 11001
Canalicular multispecific organic anion transporter 10303
D0101
Sodium channel protein type 2 subunit alpha0101
Proteasome subunit beta type-70001
Ataxin-23003
Sigma non-opioid intracellular receptor 10404
Angiotensin-converting enzyme 2 0224
Gamma-aminobutyric acid receptor subunit epsilon3104
Sodium channel protein type 3 subunit alpha0101
Glutamate receptor ionotropic, NMDA 3A0314
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial1001
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
P2Y purinoceptor 120101
Protein-arginine deiminase type-40202
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
endonuclease IV1001
dopamine D1 receptor1001
pregnane X receptor3003
GLS protein3003
aldehyde dehydrogenase 1 family, member A15005
regulator of G-protein signaling 43003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
peripheral myelin protein 22 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
flap endonuclease 11001
Glucocorticoid receptor0202
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 432002
Multidrug and toxin extrusion protein 10202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, Ferritin light chain3003
acid sphingomyelinase1001
glp-1 receptor, partial3003
thyroid stimulating hormone receptor3003
glucocerebrosidase2002
alpha-galactosidase1001
activating transcription factor 62002
lysosomal alpha-glucosidase preproprotein2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 21001
DNA polymerase beta1001
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Alpha-synuclein1102
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Luciferase1001
hypoxia-inducible factor 1 alpha subunit1001
Glycogen phosphorylase, muscle form0101
Asialoglycoprotein receptor 10112
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10101
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Carbonic anhydrase 40101
Carbonic anhydrase0101
Carbonic anhydrase 150101
Liver carboxylesterase 10001
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0101
Kappa-type opioid receptor0101
Mu-type opioid receptor0101
Mu-type opioid receptor0101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Vasopressin V2 receptor0112
Oxytocin receptor0224
Vasopressin V1a receptor0101
Vasopressin V1a receptor0213
Vasopressin V1b receptor0112
Vasopressin V1b receptor0101
Oxytocin receptor0101
Oxytocin receptor0011
Vasopressin V2 receptor 0101
GALC protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
beta-2 adrenergic receptor1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
huntingtin isoform 21001
Inositol monophosphatase 11001
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Chloroquine resistance transporter0101
ATP-dependent phosphofructokinase1001
Chain A, Beta-lactamase2002
SMAD family member 22002
SMAD family member 32002
nonstructural protein 11001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
aryl hydrocarbon receptor1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
thyroid hormone receptor beta isoform a1001
heat shock protein HSP 90-alpha isoform 20001
DNA polymerase iota isoform a (long)3003
nuclear receptor ROR-gamma isoform 12002
Voltage-dependent calcium channel gamma-2 subunit1001
Cytochrome P450 3A40101
Glutamate receptor 21001
Guanine nucleotide-binding protein G1001
ATPase family AAA domain-containing protein 51001
heat shock protein 90, putative0001
Pyridoxal kinase0001
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Chain A, Cruzipain1001
interleukin 81001
15-lipoxygenase, partial1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Retinol-binding protein 40011
Beta-lactoglobulin0011
Amyloid-beta precursor protein0101
Nuclear receptor ROR-gamma1001
Disintegrin and metalloproteinase domain-containing protein 171001
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Carbonic anhydrase 60101
Transketolase0011
Thiamine-binding periplasmic protein0011
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
Solute carrier family 22 member 20101
Multidrug and toxin extrusion protein 20101
thioredoxin glutathione reductase1001
Rap guanine nucleotide exchange factor 31001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]