Enzootic Calf Pneumonia

Chronic endemic respiratory disease of dairy calves and an important component of bovine respiratory disease complex. It primarily affects calves up to six months of age and the etiology is multifactorial. Stress plus a primary viral infection is followed by a secondary bacterial infection. The latter is most commonly associated with PASTEURELLA MULTOCIDA producing a purulent BRONCHOPNEUMONIA. Sometimes present are MANNHEIMIA HAEMOLYTICA; HAEMOPHILUS SOMNUS and mycoplasma species.

Synonym
Enzootic Calf Pneumonia
Enzootic Pneumonia of Calves
Pneumonia of Calves, Enzootic

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	5 (23.81)	18.1394
2010's	16 (76.19)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies	Trials
lactic acid	low	1	0
carprofen	low	2	0
sulfamethazine	medium	1	1
ticlopidine	low	1	0
thiamphenicol	low	2	0
amoxicillin	low	1	0
clopidogrel	low	1	0
marbofloxacin	low	1	0
enrofloxacin	low	1	0
fibrinogen	low	1	0
florfenicol	low	2	0
melengestrol acetate	low	1	0
tulathromycin	low	2	0
interleukin-8	low	1	0
tilmicosin	low	2	0
tylosin	medium	3	1
heme	low	1	0
leukotoxin	low	3	0
chlortetracycline	medium	1	1
oxytetracycline, anhydrous	low	2	0
gamithromycin	medium	2	2

Protein Targets (238)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, Beta-lactamase	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
AR protein	6	0	0	6
apical membrane antigen 1, AMA1	2	0	0	2
estrogen nuclear receptor alpha	10	0	0	10
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	4	0	0	4
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
DNA polymerase kappa isoform 1	3	0	0	3
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	3
Bile salt export pump	0	2	0	2
Bile salt export pump	0	6	0	6
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Cytochrome P450 2C9	0	2	0	2
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	3	0	3
Luciferase	2	0	0	2
RAR-related orphan receptor gamma	6	0	0	6
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
Microtubule-associated protein tau	3	0	0	3
progesterone receptor	3	0	0	3
nonstructural protein 1	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	3	0	0	3
retinoid X nuclear receptor alpha	4	0	0	4
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
activating transcription factor 6	1	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
histone deacetylase 9 isoform 3	1	0	0	1
geminin	5	0	0	5
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Complement C5	0	0	1	1
Cellular tumor antigen p53	2	0	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
Protein-arginine deiminase type-4	0	2	0	2
EWS/FLI fusion protein	3	0	0	3
chromobox protein homolog 1	4	0	0	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2B6	0	3	0	3
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Cytochrome P450 2C19	0	3	0	3
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
USP1 protein, partial	3	0	0	3
TDP1 protein	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
IDH1	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
streptokinase A precursor	0	0	2	2
lamin isoform A-delta10	2	0	0	2
GLI family zinc finger 3	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
estrogen-related nuclear receptor alpha	4	0	0	4
transcriptional regulator ERG isoform 3	2	0	0	2
twin arginine protein translocation system - TatA protein	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
acetylcholinesterase	3	0	0	3
estrogen receptor 2 (ER beta)	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
cytochrome P450 2D6	4	0	0	4
thyroid stimulating hormone receptor	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
cellular tumor antigen p53 isoform a	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
phosphopantetheinyl transferase	2	0	0	2
ATAD5 protein, partial	2	0	0	2
thioredoxin glutathione reductase	3	0	0	3
glucocorticoid receptor [Homo sapiens]	2	0	0	2
farnesoid X nuclear receptor	1	0	0	1
pregnane X nuclear receptor	4	0	0	4
G	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
thyroid hormone receptor beta isoform 2	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	3	0	0	3
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Spike glycoprotein	2	0	0	2
Inositol hexakisphosphate kinase 1	2	0	0	2
cytochrome P450 2C9, partial	2	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
thioredoxin reductase	1	0	0	1
WRN	1	0	0	1
GLS protein	1	0	0	1
Valosin-containing protein	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
aryl hydrocarbon receptor	1	0	0	1
Histone H2A.x	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
DNA polymerase beta	1	0	0	1
flap endonuclease 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
snurportin-1	1	0	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
interleukin 8	1	0	0	1
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
GABA theta subunit	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Estrogen receptor	0	0	1	1
Estrogen receptor beta	0	0	1	1
Chain A, Ferritin light chain	1	0	0	1
glp-1 receptor, partial	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
heat shock protein beta-1	1	0	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Cytochrome P450 2D6	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research

Studies (21)

Protein Targets (238)

Enzootic Calf Pneumonia

Synonyms(3)

Research

Studies (21)

Drugs Studied (25)

Protein Targets (238)