Page last updated: 2024-09-27

Plagiocephaly

The condition characterized by uneven or irregular shape of the head often in parallelogram shape with a flat spot on the back or one side of the head. It can either result from the premature CRANIAL SUTURE closure (CRANIOSYNOSTOSIS) or from external forces (NONSYNOSTOTIC PLAGIOCEPHALY).

Synonyms(1)

Synonym
Plagiocephaly

Research Excerpts

Overview

ExcerptReference
"Anterior plagiocephaly is a premature closing of unilateral coronal suture."( Consorti, G; Luzi, M; Messi, M, 2018)

Research

Studies (14)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's12 (85.71)28.8240
2020's2 (14.29)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
pamidronate0low10
propiconazole0low100

Protein Targets (107)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
glucocorticoid receptor [Homo sapiens]2002
geminin2002
histone acetyltransferase KAT2A isoform 12002
lamin isoform A-delta101001
Geranylgeranyl pyrophosphate synthase0101
Farnesyl pyrophosphate synthase0202
Hypoxanthine-guanine phosphoribosyltransferase0101
Farnesyl pyrophosphate synthase 0101
Chain A, Beta-lactamase1001
Chain A, Ferritin light chain1001
glp-1 receptor, partial1001
pregnane X receptor1001
phosphopantetheinyl transferase1001
RAR-related orphan receptor gamma1001
SMAD family member 21001
SMAD family member 31001
TDP1 protein1001
GLI family zinc finger 31001
AR protein1001
estrogen receptor 2 (ER beta)1001
nuclear receptor subfamily 1, group I, member 31001
progesterone receptor1001
nonstructural protein 11001
retinoic acid nuclear receptor alpha variant 11001
retinoid X nuclear receptor alpha2002
estrogen-related nuclear receptor alpha1001
farnesoid X nuclear receptor1001
pregnane X nuclear receptor1001
estrogen nuclear receptor alpha2002
peroxisome proliferator-activated receptor delta1001
peroxisome proliferator activated receptor gamma1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
aryl hydrocarbon receptor1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
vitamin D3 receptor isoform VDRA1001
chromobox protein homolog 11001
thyroid hormone receptor beta isoform a1001
thyroid hormone receptor beta isoform 21001
heat shock protein HSP 90-alpha isoform 20001
nuclear factor erythroid 2-related factor 2 isoform 11001
DNA polymerase iota isoform a (long)1001
nuclear receptor ROR-gamma isoform 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent calcium channel gamma-2 subunit1001
Cellular tumor antigen p531001
Cytochrome P450 3A40101
Glutamate receptor 21001
Histamine H2 receptor1001
Guanine nucleotide-binding protein G1001
TAR DNA-binding protein 431001
ATPase family AAA domain-containing protein 51001
Ataxin-21001
heat shock protein 90, putative0001
Chain A, 2-oxoglutarate Oxygenase1001
thioredoxin reductase1001
chaperonin-containing TCP-1 beta subunit homolog1001
aldehyde dehydrogenase 1 family, member A11001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
survival motor neuron protein isoform d1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Bile salt export pump0101
Bile salt export pump0101
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Albumin0101
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]