Phlebitis, Sagittal Sinus, Septic

Formation or presence of a blood clot (THROMBUS) in the SUPERIOR SAGITTAL SINUS or the inferior sagittal sinus. Sagittal sinus thrombosis can result from infections, hematological disorders, CRANIOCEREBRAL TRAUMA; and NEUROSURGICAL PROCEDURES. Clinical features are primarily related to the increased intracranial pressure causing HEADACHE; NAUSEA; and VOMITING. Severe cases can evolve to SEIZURES or COMA.

Synonym
Septic Phlebitis, Sagittal Sinus
Sagittal Sinus Thrombophlebitis
Sagittal Sinus Thrombosis
Thrombosis, Sagittal Sinus
Sagittal Sinus Septic Phlebitis
Phlebitis, Sagittal Sinus, Septic

Excerpt	Reference
"Superior sagittal sinus thrombosis (SSST) has been reported to be caused by coagulopathy following oral contraceptive therapy, DIC, infection around the sinus, compression from a tumor, infiltration of tumor, and an inherited deficiency of proteins C and S, but SSST associated with hematological malignancies and L-asparaginase (L-Asp) therapy is rare."	( Iijima, K; Iki, S; Kida, M; Nakasone, H; Taoka, K; Urabe, A; Usuki, K; Yoshimi, A, 2006)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	23 (56.10)	18.1394
2010's	16 (39.02)	28.8240
2020's	2 (4.88)	9.53

Drug	Relationship Strength	Studies
adenine	low	1
betaine	low	1
chlorine	low	2
salicylic acid	low	1
lactic acid	low	1
dalteparin	low	5
pyridoxine	low	1
acetazolamide	low	1
aspirin	low	1
azathioprine	low	2
carbamazepine	low	1
valproic acid	low	1
mitoxantrone	low	1
piracetam	low	1
sulfasalazine	low	1
ticlopidine	low	1
prednisolone	low	1
prednisone	low	3
cytarabine	low	3
testosterone enanthate	low	1
nandrolone decanoate	low	2
nandrolone	low	2
dimenhydrinate	low	1
gadolinium	low	1
ferric chloride	low	2
iodine	low	1
daunorubicin	low	1
fluorodeoxyglucose f18	low	1
homocysteine	low	1
methotrexate	low	3
mercaptopurine	low	1
tamoxifen	low	3
lithium	low	1
levetiracetam	low	1
rivaroxaban	low	1
apixaban	low	1
losartan potassium	low	1
warfarin	low	7
thromboplastin	low	1
guanine	low	1

Protein Targets (716)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	10	0	0	10
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	6	0	0	6
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	9	0	0	9
GALC protein	1	0	0	1
GLI family zinc finger 3	12	0	0	12
nuclear receptor subfamily 1, group I, member 3	14	0	0	14
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
glucocorticoid receptor [Homo sapiens]	17	0	0	17
retinoic acid nuclear receptor alpha variant 1	18	0	0	18
retinoid X nuclear receptor alpha	10	0	0	10
estrogen-related nuclear receptor alpha	18	0	0	18
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	5	0	0	5
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
Bloom syndrome protein isoform 1	8	0	0	8
thyroid hormone receptor beta isoform a	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	12	0	0	12
geminin	11	0	0	11
peripheral myelin protein 22	6	0	0	6
survival motor neuron protein isoform d	6	0	0	6
muscleblind-like protein 1 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	6	1	0	7
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	15
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	3	1	6
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	22	0	22
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	10	1	15
Carbonic anhydrase 2	0	10	2	15
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Carbonic anhydrase 3	0	3	1	6
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	3	0	3
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2D6	0	4	0	4
Cytochrome P450 2A6	0	2	0	2
Cytochrome P450 2C9	0	6	0	6
5-hydroxytryptamine receptor 2A	0	2	0	2
Androgen receptor	0	8	0	8
Gamma-aminobutyric acid receptor subunit beta-1	6	1	0	7
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	6	1	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	6	1	0	7
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	4	1	5
Carbonic anhydrase 4	0	5	1	7
Carbonic anhydrase 6	0	3	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	6	1	0	7
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	6	1	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	6	1	0	7
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	6	1	0	7
Adenosine receptor A2a	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	3	0	3
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	3	1	6
Carbonic anhydrase	0	3	0	3
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	3	1	5
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	2	1	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	6	2	0	8
Gamma-aminobutyric acid receptor subunit beta-3	6	1	0	7
Gamma-aminobutyric acid receptor subunit beta-2	6	1	0	7
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	3	1	6
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	1
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	6	1	0	7
Canalicular multispecific organic anion transporter 1	0	13	0	13
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 15	0	4	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	3	0	4
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	6	1	0	7
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	3	1	6
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	3	1	6
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	13	0	0	13
TDP1 protein	15	0	0	15
AR protein	19	0	0	19
pregnane X nuclear receptor	13	0	0	13
estrogen nuclear receptor alpha	21	0	0	21
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
heat shock protein beta-1	6	0	0	6
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
lamin isoform A-delta10	10	0	0	10
Voltage-dependent calcium channel gamma-2 subunit	10	0	0	10
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	10	0	0	10
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	2	1	0	3
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	9	0	0	9
Ataxin-2	11	0	0	11
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)	0	1	0	1
EWS/FLI fusion protein	10	0	0	10
Coagulation factor X	0	1	0	1
Prothrombin	0	2	0	2
Coagulation factor X	0	4	0	4
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Trypsin-3	0	1	0	1
Spike glycoprotein	6	0	1	7
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	2	0	0	2
GLS protein	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	13	0	0	13
thyroid stimulating hormone receptor	4	0	0	4
hypothetical protein, conserved	2	0	0	2
cytochrome P450 2D6	7	0	0	7
glucocerebrosidase	4	0	0	4
peroxisome proliferator-activated receptor delta	7	0	0	7
Rac1 protein	0	0	1	1
IDH1	8	0	0	8
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
DNA polymerase iota isoform a (long)	7	0	0	7
DNA polymerase kappa isoform 1	5	0	0	5
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	4	0	0	4
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	3	0	3
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	7	1	0	8
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	7	1	0	8
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	4	0	4
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	5	0	0	5
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	6	1	7
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, Ferritin light chain	8	0	0	8
acetylcholinesterase	8	0	0	8
phosphopantetheinyl transferase	7	0	0	7
SMAD family member 2	4	0	0	4
ATAD5 protein, partial	6	0	0	6
Fumarate hydratase	5	0	0	5
SMAD family member 3	4	0	0	4
Microtubule-associated protein tau	7	0	0	7
thioredoxin glutathione reductase	3	0	0	3
farnesoid X nuclear receptor	9	0	0	9
G	7	0	0	7
polyprotein	5	0	0	5
P53	1	0	0	1
peroxisome proliferator activated receptor gamma	9	0	0	9
aryl hydrocarbon receptor	4	0	0	4
thyroid stimulating hormone receptor	8	0	0	8
activating transcription factor 6	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Histone H2A.x	9	0	0	9
peripheral myelin protein 22 isoform 1	2	0	0	2
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	8	0	0	8
thyroid hormone receptor beta isoform 2	11	0	0	11
cytochrome P450 3A4 isoform 1	6	0	0	6
M-phase phosphoprotein 8	6	0	0	6
Bile salt export pump	0	8	0	8
Interferon beta	13	0	0	13
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Cellular tumor antigen p53	14	0	0	14
Inositol hexakisphosphate kinase 1	7	0	0	7
Protein-arginine deiminase type-4	0	2	0	2
cytochrome P450 2C9, partial	7	0	0	7
Chain A, Betaine ABC transporter permease and substrate binding protein	0	0	1	1
Chain A, Osmoprotection protein (ProX)	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
USP1 protein, partial	8	0	0	8
mitogen-activated protein kinase 1	3	0	0	3
Vpr	2	0	0	2
Albumin	0	0	2	2
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	3
Sodium channel protein type 4 subunit alpha	0	1	0	2
Cytochrome P450 2J2	0	4	0	4
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Sodium channel protein type 9 subunit alpha	0	2	0	2
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
endonuclease IV	2	0	0	2
glp-1 receptor, partial	4	0	0	4
67.9K protein	4	0	0	4
LMP1 [Human herpesvirus 4]	0	0	0	2
chromobox protein homolog 1	8	0	0	8
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	2	0	3
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Luciferase	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
PPM1D protein	4	0	0	4
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	7	0	0	7
progesterone receptor	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
caspase-3	3	0	0	3
Caspase-7	3	0	0	3
runt-related transcription factor 1 isoform AML1b	1	0	0	1
vitamin D3 receptor isoform VDRA	5	0	0	5
caspase-3	3	0	0	3
core-binding factor subunit beta isoform 2	1	0	0	1
huntingtin isoform 2	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
nuclear receptor ROR-gamma isoform 1	4	0	0	4
histone acetyltransferase KAT2A isoform 1	6	0	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Transthyretin	0	1	0	1
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
ATP-dependent translocase ABCB1	0	4	2	7
72 kDa type IV collagenase	0	1	0	1
DNA topoisomerase 2-alpha	0	1	0	3
Carbonyl reductase [NADPH] 1	0	0	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Platelet-activating factor receptor	1	0	0	1
Multidrug resistance-associated protein 1	0	3	0	5
Histamine H2 receptor	5	0	0	5
Inositol monophosphatase 1	3	0	0	3
Histone deacetylase 1	0	3	0	3
Reverse transcriptase/RNaseH	0	1	0	1
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
5-hydroxytryptamine receptor 4	0	6	0	6
Aldo-keto reductase family 1 member B1	0	7	0	7
Muscarinic acetylcholine receptor M2	0	6	0	6
Muscarinic acetylcholine receptor M4	0	6	0	6
Muscarinic acetylcholine receptor M5	0	4	0	4
Alpha-2A adrenergic receptor	0	6	0	6
Muscarinic acetylcholine receptor M1	0	6	0	6
Alpha-2B adrenergic receptor	0	6	0	6
Muscarinic acetylcholine receptor M3	0	4	0	4
Sodium-dependent noradrenaline transporter	0	6	0	6
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	6	0	6
Histamine H1 receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	4	0	4
Sodium-dependent dopamine transporter	0	4	0	4
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	2
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
flap endonuclease 1	3	0	0	3
Synaptic vesicle glycoprotein 2A	0	2	0	2
Smad3	3	0	0	3
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
apical membrane antigen 1, AMA1	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
transcriptional regulator ERG isoform 3	3	0	0	3
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	2	0	0	2
ClpP	1	0	0	1
15-lipoxygenase, partial	3	0	0	3
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
DNA polymerase beta	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Solute carrier family 22 member 11	0	0	0	1
Chain A, Probable serine/threonine-protein kinase pknB	0	1	0	1
WRN	1	0	0	1
NFKB1 protein, partial	1	0	0	1
Thrombopoietin	1	0	0	1
DNA polymerase III, partial	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
regulator of G-protein signaling 4	2	0	0	2
nonstructural protein 1	0	1	0	1
LANA	0	0	0	1
Parkin	1	0	0	1
pyruvate kinase	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
phospholipase A2, group III	0	1	0	1
cytochrome P450 2D6 isoform 1	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
interferon gamma precursor	0	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
ras-related protein Rab-9A	2	0	0	2
protein AF-9 isoform a	0	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Amyloid-beta precursor protein	1	0	0	1
Tyrosine-protein kinase Fyn	0	2	0	2
Proto-oncogene tyrosine-protein kinase ROS	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Angiotensin-converting enzyme	0	4	0	4
DNA topoisomerase 2	0	0	0	1
Casein kinase II subunit alpha'	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
DNA topoisomerase 2-beta	0	0	0	1
Tyrosine-protein kinase BTK	0	1	0	1
NEDD8-activating enzyme E1 regulatory subunit	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Integrase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Casein kinase II subunit alpha 3	0	1	0	1
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
P2Y purinoceptor 12	0	1	0	1
phosphoglycerate kinase	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
Hsf1 protein	0	0	1	2
luciferase	0	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Estrogen receptor	0	5	1	7
Glucocorticoid receptor	0	4	2	11
Progesterone receptor	0	3	0	4
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	4	0	4
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	5	1	6
pregnane X receptor	3	0	0	3
Pyridoxal kinase	0	0	0	1
Prolyl 4-hydroxylase, beta polypeptide	0	0	0	1
nonstructural protein 1	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Estrogen receptor	0	1	1	3
Gastric inhibitory polypeptide receptor	0	1	0	1
Estrogen receptor beta	0	1	1	3
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Coagulation factor XII	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Albumin	0	1	1	2
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, Glutathione S-transferase	0	1	0	1
Replicase polyprotein 1ab	0	0	2	2
cytochrome P450 2C9 precursor	1	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Tumor necrosis factor	0	0	1	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Thromboxane-A synthase	0	2	0	2
Mitogen-activated protein kinase 1	0	1	0	1
Caspase-1	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Sodium/bile acid cotransporter	0	1	0	1
Cystine/glutamate transporter	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Chain A, CES1 protein	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Spike glycoprotein	0	0	1	1
D(1A) dopamine receptor	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
streptokinase A precursor	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Procathepsin L	0	0	1	1
Beta-1 adrenergic receptor	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosine receptor A3	0	2	0	2
Replicase polyprotein 1ab	0	0	1	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Protein kinase C eta type	0	1	0	1
Histamine H2 receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Adenosine receptor A2a	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Alpha-synuclein	1	0	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Protein kinase C eta type	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
cytochrome P450 2C19 precursor	1	0	0	1
Alpha-2C adrenergic receptor	0	2	0	2
Cocaine esterase	0	1	0	1
Histone deacetylase 3	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Histone deacetylase 4	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Phlebitis, Sagittal Sinus, Septic

Synonyms(6)

Research Excerpts

Treatment

Research

Studies (41)

Protein Targets (716)

Phlebitis, Sagittal Sinus, Septic

Synonyms(6)

Research Excerpts

Treatment

Research

Studies (41)

Drugs Studied (50)

Protein Targets (716)