Page last updated: 2024-09-27

Pelvic Floor Diseases

Injury, weakening, or PROLAPSE of the pelvic muscles, surrounding connective tissues or ligaments (PELVIC FLOOR).

Synonyms(2)

Synonym
Pelvic Floor Disorders
Pelvic Floor Diseases

Research Excerpts

Overview

ExcerptReference
"Pelvic floor disorders are common and bothersome problems that include a variety of conditions."( Tzur, T; Weintraub, AY; Yohai, D, 2016)
"Pelvic floor disorders are common and of concern, as the majority of maternity healthcare providers seldom discuss this issue with patients compared to other antenatal issues."( Lim, PS; Ng, BK; Nor Azlin, MI; Nur Azurah, AG; Nur Farihan, M; Phon, SE, 2022)

Research

Studies (45)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's32 (71.11)28.8240
2020's13 (28.89)9.53
DrugIndicatedRelationship StrengthStudiesTrials
lactic acid0low10
bupivacaine0medium22
caffeine0low10
diazepam0medium21
fentanyl0medium11
isoflurane0medium11
loperamide0low10
oxybutynin0low10
propofol0medium11
thiazoles0low20
hematoxylin0low10
dehydroepiandrosterone sulfate0low10
hexafluoroisopropanol0low10
barium sulfate0low10
triamcinolone0medium11
fomesafen0low20
raloxifene hydrochloride0low10
benzofurans0low10
glycogen0low10
elastin0low30
oxytocin0low20
tibolone0low10
tamoxifen0low20
dermatan sulfate0low10
ospemifene0low10
prucalopride0low10
deamino arginine vasopressin0low10
barium0medium21
mirabegron0low20
td-51080low10
heparitin sulfate0low10
rome0low10
exudates0low10

Protein Targets (492)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20022
Potassium channel subfamily K member 90101
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
phosphopantetheinyl transferase4004
RAR-related orphan receptor gamma8008
GLS protein3003
GLI family zinc finger 39009
AR protein9009
nuclear receptor subfamily 1, group I, member 35005
glucocorticoid receptor [Homo sapiens]7007
retinoic acid nuclear receptor alpha variant 18008
retinoid X nuclear receptor alpha5005
estrogen-related nuclear receptor alpha100010
farnesoid X nuclear receptor6006
pregnane X nuclear receptor100010
estrogen nuclear receptor alpha110011
euchromatic histone-lysine N-methyltransferase 28008
thyroid stimulating hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)5005
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 14004
thyroid hormone receptor beta isoform a2002
thyroid hormone receptor beta isoform 27007
DNA polymerase beta2002
nuclear factor erythroid 2-related factor 2 isoform 16006
nuclear receptor ROR-gamma isoform 15005
geminin6006
DNA polymerase kappa isoform 12002
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)3003
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40506
Voltage-dependent calcium channel gamma-2 subunit5005
Bile salt export pump0505
Glycogen phosphorylase, muscle form0101
Renin0101
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Cholinesterase0101
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0123
Adenosine receptor A30303
Replicase polyprotein 1ab0224
Glutamate receptor 25005
Amine oxidase [flavin-containing] A0202
Acetylcholinesterase0101
Adenosine receptor A10203
Amine oxidase [flavin-containing] B0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Adenosine receptor A30101
Adenosine receptor A2a0416
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Adenosine receptor A10316
Adenosine receptor A2a0204
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0123
Endochitinase B10101
Muscarinic acetylcholine receptor0012
Canalicular multispecific organic anion transporter 10303
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Guanine deaminase0101
ATP-dependent phosphofructokinase2002
Vasopressin V2 receptor0224
Oxytocin receptor0235
Vasopressin V1a receptor0325
Vasopressin V1b receptor0224
Translocator protein0101
Vasopressin V2 receptor 0213
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Steryl-sulfatase0001
Multidrug resistance-associated protein 1 0001
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
G-protein coupled bile acid receptor 10011
ATP-binding cassette sub-family C member 110001
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1B20001
Solute carrier organic anion transporter family member 1B10001
Gamma-aminobutyric acid 0101
glp-1 receptor, partial3003
TDP1 protein7007
estrogen receptor 2 (ER beta)5005
progesterone receptor7007
cytochrome P450 family 3 subfamily A polypeptide 49009
G8008
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit pi63211
Gamma-aminobutyric acid receptor subunit delta0202
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Interferon beta100010
HLA class I histocompatibility antigen, B alpha chain 8008
Fatty acid-binding protein, liver0101
Alpha-1-acid glycoprotein 10001
Albumin0012
Albumin0011
Cellular tumor antigen p537007
ATP-dependent translocase ABCB10417
Gamma-aminobutyric acid receptor subunit alpha-10203
Gamma-aminobutyric acid receptor subunit beta-10203
Neuronal acetylcholine receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit alpha-20203
Gamma-aminobutyric acid receptor subunit alpha-30203
Neuronal acetylcholine receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-10336
Gamma-aminobutyric acid receptor subunit beta-163211
Translocator protein0113
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit beta-10213
Gamma-aminobutyric acid receptor subunit delta63211
Gamma-aminobutyric acid receptor subunit gamma-20325
Gamma-aminobutyric acid receptor subunit gamma-263211
5-hydroxytryptamine receptor 1A0415
Gamma-aminobutyric acid receptor subunit alpha-563211
Gamma-aminobutyric acid receptor subunit alpha-363211
Gamma-aminobutyric acid receptor subunit alpha-40203
Gamma-aminobutyric acid receptor subunit gamma-20203
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit gamma-163211
Gamma-aminobutyric acid receptor subunit alpha-263211
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-463211
Gamma-aminobutyric acid receptor subunit beta-30325
Gamma-aminobutyric acid receptor subunit gamma-363211
Gamma-aminobutyric acid receptor subunit alpha-663211
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50235
Gamma-aminobutyric acid receptor subunit alpha-30224
Gamma-aminobutyric acid receptor subunit alpha-20224
Gamma-aminobutyric acid receptor subunit beta-20224
Gamma-aminobutyric acid receptor subunit alpha-40213
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit alpha-163211
Gamma-aminobutyric acid receptor subunit beta-363211
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit beta-263211
Gamma-aminobutyric acid receptor subunit epsilon0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Neuronal acetylcholine receptor subunit alpha-70101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Gamma-aminobutyric acid receptor subunit alpha-60213
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit pi0101
Sphingosine-1-phosphate lyase 10101
GABA theta subunit63211
Inositol hexakisphosphate kinase 18008
ATPase family AAA domain-containing protein 55005
Ataxin-25005
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit epsilon63211
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit theta0202
cytochrome P450 2C9, partial8008
Luciferase3003
potassium voltage-gated channel subfamily H member 2 isoform d3003
Solute carrier family 22 member 1 0202
Nuclear receptor subfamily 1 group I member 20011
D(2) dopamine receptor0404
D(4) dopamine receptor0404
Delta-type opioid receptor0202
Delta-type opioid receptor0303
Mu-type opioid receptor0415
Kappa-type opioid receptor0101
Histamine H1 receptor0101
Mu-type opioid receptor0617
D(3) dopamine receptor0707
Delta-type opioid receptor0617
Kappa-type opioid receptor0202
Kappa-type opioid receptor0606
Mu-type opioid receptor0101
Mu-type opioid receptor0213
Potassium voltage-gated channel subfamily H member 20505
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10808
Sigma non-opioid intracellular receptor 10101
hypoxia-inducible factor 1 alpha subunit3003
Histone H2A.x3003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain E, Fibrin beta chain0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, RNA-directed RNA polymerase NS50101
thioredoxin reductase3003
15-lipoxygenase, partial3003
WRN1001
Mcl-10101
MPI protein0101
USP1 protein, partial3003
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)0001
PPM1D protein3003
Microtubule-associated protein tau3003
alkaline phosphatase, intestinal0011
thioredoxin glutathione reductase2002
apical membrane antigen 1, AMA12002
aldehyde dehydrogenase 1 family, member A12002
hypothetical protein, conserved1001
regulator of G-protein signaling 42002
67.9K protein2002
glucocerebrosidase3003
luciferase1001
bromodomain adjacent to zinc finger domain 2B2002
pyruvate kinase1001
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
CDK50001
serine-protein kinase ATM isoform a1001
lysosomal alpha-glucosidase preproprotein1001
major prion protein preproprotein Prp precursor0101
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0011
cellular tumor antigen p53 isoform a5005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
vitamin D3 receptor isoform VDRA2002
glucose-6-phosphate 1-dehydrogenase isoform b0101
intestinal alkaline phosphatase precursor0011
nuclear factor erythroid 2-related factor 2 isoform 23003
mitogen-activated protein kinase 11001
flap endonuclease 12002
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)3003
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Vif0101
Tat0101
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 16006
histone acetyltransferase KAT2A isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11102
alkaline phosphatase, germ cell type preproprotein0011
endoribonuclease toxin MazF0011
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Polyunsaturated fatty acid lipoxygenase ALOX15B4004
Rap guanine nucleotide exchange factor 31001
Integrin beta-34004
Integrin alpha-IIb4004
Pyruvate kinase PKM0101
Endothelin receptor type B1001
Endothelin-1 receptor1001
Histamine H2 receptor4005
Inositol monophosphatase 12002
phosphoglycerate kinase1001
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
large T antigen0101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit alpha-70101
acetylcholinesterase4004
cytochrome P450 2D66006
SMAD family member 24004
ATAD5 protein, partial2002
SMAD family member 34004
Thrombopoietin1001
caspase 7, apoptosis-related cysteine protease4004
thyroid stimulating hormone receptor2002
EWS/FLI fusion protein2002
peroxisome proliferator-activated receptor delta3003
arylsulfatase A3003
caspase-34004
Spike glycoprotein0022
Replicase polyprotein 1ab0022
cytochrome P450 2D6 isoform 12002
polyunsaturated fatty acid lipoxygenase ALOX121001
huntingtin isoform 22002
atrial natriuretic peptide receptor 2 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 12002
peripheral myelin protein 221001
lamin isoform A-delta104004
Menin0101
Cocaine esterase0202
Transmembrane protease serine 20022
Beta-2 adrenergic receptor0202
Procathepsin L0022
Replicase polyprotein 1a0022
Replicase polyprotein 1ab0022
Cytochrome P450 2D60101
Histamine H2 receptor0404
Sodium-dependent serotonin transporter0606
Nociceptin receptor0101
5-hydroxytryptamine receptor 2B0909
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 70101
Spike glycoprotein4026
Calmodulin 0112
Disintegrin and metalloproteinase domain-containing protein 171001
Angiopoietin-1 receptor0011
Sodium channel protein type 5 subunit alpha0101
Angiotensin-converting enzyme 2 0022
Fumarate hydratase4004
polyprotein4004
D(1A) dopamine receptor3003
Amyloid-beta precursor protein0101
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M20416
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M50404
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10405
Muscarinic acetylcholine receptor M30404
Sodium-dependent noradrenaline transporter 0606
Cytochrome P450 2C190202
Sodium-dependent dopamine transporter 0404
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Vasopressin V1a receptor0101
Vasopressin V1b receptor0101
Oxytocin receptor0101
Oxytocin receptor0011
Chain A, Ferritin light chain3003
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
activating transcription factor 63003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
Bloom syndrome protein isoform 13003
heat shock protein beta-15005
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
5-hydroxytryptamine receptor 40516
Polyunsaturated fatty acid lipoxygenase ALOX150101
Prostaglandin G/H synthase 10202
Sodium- and chloride-dependent GABA transporter 10101
5-hydroxytryptamine receptor 2C0505
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A80001
Cytochrome P450 3A40112
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 40224
5-hydroxytryptamine receptor 4 0011
endonuclease IV1001
pregnane X receptor1001
Prolyl 4-hydroxylase, beta polypeptide0001
Smad32002
nonstructural protein 11001
IDH12002
Caspase-72002
peripheral myelin protein 22 isoform 12002
caspase-32002
nuclear factor NF-kappa-B p105 subunit isoform 11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
M-phase phosphoprotein 82002
neuropeptide S receptor isoform A1001
Estrogen receptor0517
HLA class I histocompatibility antigen, A alpha chain 0011
Estrogen receptor0113
Gastric inhibitory polypeptide receptor0101
Estrogen receptor beta0113
Estrogen receptor beta0314
Sphingosine kinase 20202
Sphingosine kinase 10101
Chain A, CES1 protein0101
Chain A, Beta-lactamase1001
DNA polymerase III, partial1001
thyrotropin-releasing hormone receptor1001
NPC intracellular cholesterol transporter 1 precursor1001
interferon gamma precursor0001
transcriptional regulator ERG isoform 31001
ubiquitin-conjugating enzyme E2 N0101
streptokinase A precursor0011
Serine/threonine-protein kinase D30101
Epidermal growth factor receptor0101
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Progesterone receptor0101
Beta-1 adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Beta-3 adrenergic receptor0202
Androgen receptor0404
Alpha-1B adrenergic receptor0202
Protein kinase C alpha type0101
Alpha-2B adrenergic receptor0202
Cytochrome P450 2B60101
Substance-K receptor0202
D(1A) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Thromboxane-A synthase 0101
Protein kinase C eta type0101
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0303
5-hydroxytryptamine receptor 1B0202
B2 bradykinin receptor0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Alpha-synuclein1001
Protein kinase C iota type0101
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0202
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Emopamil-binding protein-like0101
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 70101
nuclear receptor subfamily 1, group I, member 21001
NFKB1 protein, partial1001
procathepsin L isoform 1 preproprotein0101
muscleblind-like protein 1 isoform 11001
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Cytochrome P450 2C9 0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Cytochrome P450 2J20101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]