Page last updated: 2024-09-28

Paranoid Personality

A personality disorder characterized by the avoidance of accepting deserved blame and an unwarranted view of others as malevolent. The latter is expressed as suspiciousness, hypersensitivity, and mistrust.

Synonyms(3)

Synonym
Paranoid Personality Disorder
Personality Disorder, Paranoid
Paranoid Personality

Research Excerpts

Research

Studies (21)

TimeframeStudies, This Condition (%)All Conditions %
pre-19908 (38.10)23.3326
1990's5 (23.81)12.5806
2000's3 (14.29)18.1394
2010's5 (23.81)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
3,4-methylenedioxyamphetamine0low10
fluphenazine0low20
haloperidol0low20
risperidone0low20
dextroamphetamine0medium11
levodopa0medium11
quinoxalines0low10
bufotenin0low20
pimozide0low20
flupenthixol0low10
paroxetine0low10
clorazepate dipotassium0low10
varenicline0low10
ego0low50

Protein Targets (456)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C0628
5-hydroxytryptamine receptor 2A0628
5-hydroxytryptamine receptor 1A0729
Sodium-dependent noradrenaline transporter 010212
Sodium-dependent dopamine transporter0527
5-hydroxytryptamine receptor 1B0628
5-hydroxytryptamine receptor 1D0123
5-hydroxytryptamine receptor 1F0123
5-hydroxytryptamine receptor 2B0628
5-hydroxytryptamine receptor 60022
Sodium-dependent serotonin transporter012315
Sodium-dependent serotonin transporter0437
5-hydroxytryptamine receptor 7 0426
5-hydroxytryptamine receptor 5A0022
5-hydroxytryptamine receptor 5B0022
5-hydroxytryptamine receptor 3A0022
Sodium-dependent dopamine transporter 08210
5-hydroxytryptamine receptor 4 0022
5-hydroxytryptamine receptor 3B0022
hypoxia-inducible factor 1 alpha subunit3003
Fumarate hydratase4004
GLS protein4004
GLI family zinc finger 37007
estrogen receptor 2 (ER beta)4004
progesterone receptor7007
cytochrome P450 family 3 subfamily A polypeptide 45005
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha4004
farnesoid X nuclear receptor3003
cytochrome P450 2D66006
polyprotein4004
thyroid stimulating hormone receptor6006
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
Histone H2A.x1001
heat shock protein beta-13003
Gamma-aminobutyric acid receptor subunit pi4105
Acetylcholinesterase0101
5-hydroxytryptamine receptor 1A0347
Gamma-aminobutyric acid receptor subunit beta-14105
Gamma-aminobutyric acid receptor subunit delta4105
Gamma-aminobutyric acid receptor subunit gamma-24105
Gamma-aminobutyric acid receptor subunit alpha-54105
Gamma-aminobutyric acid receptor subunit alpha-34105
Gamma-aminobutyric acid receptor subunit gamma-14105
Gamma-aminobutyric acid receptor subunit alpha-24105
5-hydroxytryptamine receptor 2C0707
Gamma-aminobutyric acid receptor subunit alpha-44105
Gamma-aminobutyric acid receptor subunit gamma-34105
Gamma-aminobutyric acid receptor subunit alpha-64105
Gamma-aminobutyric acid receptor subunit alpha-14105
Gamma-aminobutyric acid receptor subunit beta-34105
Gamma-aminobutyric acid receptor subunit beta-24105
GABA theta subunit4105
Gamma-aminobutyric acid receptor subunit epsilon4105
peripheral myelin protein 226006
Phenylethanolamine N-methyltransferase0101
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A0101
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] B0101
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Sigma non-opioid intracellular receptor 10213
acetylcholinesterase4004
phosphopantetheinyl transferase3003
RAR-related orphan receptor gamma5005
USP1 protein, partial2002
NFKB1 protein, partial4004
PPM1D protein2002
TDP1 protein6006
Microtubule-associated protein tau2002
Thrombopoietin3003
AR protein9009
caspase 7, apoptosis-related cysteine protease3003
nuclear receptor subfamily 1, group I, member 35005
NADPH oxidase 10101
regulator of G-protein signaling 42002
EWS/FLI fusion protein4004
glucocorticoid receptor [Homo sapiens]7007
estrogen-related nuclear receptor alpha7007
glucocerebrosidase2002
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
arylsulfatase A5005
Snq2p0001
caspase-33003
euchromatic histone-lysine N-methyltransferase 26006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
v-jun sarcoma virus 17 oncogene homolog (avian)4004
Caspase-72002
Spike glycoprotein0112
Replicase polyprotein 1ab0112
cytochrome P450 2D6 isoform 14004
cellular tumor antigen p53 isoform a2002
D(1A) dopamine receptor4004
chromobox protein homolog 15005
potassium voltage-gated channel subfamily H member 2 isoform d4004
caspase-32002
thyroid hormone receptor beta isoform 24004
mitogen-activated protein kinase 12002
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
serine/threonine-protein kinase mTOR isoform 14004
nuclear factor erythroid 2-related factor 2 isoform 16006
geminin6006
cytochrome P450 3A4 isoform 14004
M-phase phosphoprotein 84004
muscarinic acetylcholine receptor M15005
lethal factor (plasmid)3003
lamin isoform A-delta103003
Solute carrier family 22 member 1 0202
Transmembrane protease serine 20112
5-hydroxytryptamine receptor 40606
Potassium channel subfamily K member 20325
Bile salt export pump0606
Epidermal growth factor receptor0202
Interferon beta5005
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20101
Cellular tumor antigen p533003
Integrin beta-32002
Tyrosine-protein kinase Fyn0202
Procathepsin L0112
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M20606
Muscarinic acetylcholine receptor M40606
ATP-dependent translocase ABCB10507
Integrin alpha-IIb2002
Alpha-2A adrenergic receptor0606
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Adenosine receptor A30202
Replicase polyprotein 1ab0112
Muscarinic acetylcholine receptor M10707
Angiotensin-converting enzyme0707
Beta-3 adrenergic receptor0202
D(2) dopamine receptor07211
Androgen receptor0303
Alpha-1B adrenergic receptor0505
Alpha-2B adrenergic receptor0606
Alpha-2C adrenergic receptor0606
Muscarinic acetylcholine receptor M30707
Substance-K receptor0202
D(1A) dopamine receptor0607
D(4) dopamine receptor0518
D(1B) dopamine receptor0304
Histamine H2 receptor0606
Alpha-1D adrenergic receptor0606
5-hydroxytryptamine receptor 2A0606
Trypanothione reductase0202
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0102
Histamine H1 receptor0606
Mu-type opioid receptor0516
D(3) dopamine receptor0619
Delta-type opioid receptor0303
Kappa-type opioid receptor0303
5-hydroxytryptamine receptor 2B0606
Alpha-1A adrenergic receptor0505
D(1A) dopamine receptor4105
5-hydroxytryptamine receptor 60505
5-hydroxytryptamine receptor 70202
Spike glycoprotein5117
Disintegrin and metalloproteinase domain-containing protein 172002
Inositol monophosphatase 12002
Potassium voltage-gated channel subfamily H member 2010010
Nuclear receptor subfamily 3 group C member 3 0606
Ataxin-26006
Sigma non-opioid intracellular receptor 10606
Angiotensin-converting enzyme 2 0112
Histamine H3 receptor0202
ATP-dependent phosphofructokinase5005
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
glp-1 receptor, partial3003
thioredoxin reductase5005
15-lipoxygenase, partial3003
ATAD5 protein, partial4004
thyroid stimulating hormone receptor3003
nonstructural protein 12002
pregnane X nuclear receptor4004
estrogen nuclear receptor alpha8008
Adenylate cyclase type 1 0101
peripheral myelin protein 22 isoform 14004
cytochrome P450 2C9 precursor1001
nuclear receptor ROR-gamma isoform 12002
transient receptor potential cation channel subfamily V member 11001
Cocaine esterase0101
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Transient receptor potential cation channel subfamily V member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
UDP-glucuronosyltransferase 1A90102
Voltage-dependent L-type calcium channel subunit alpha-1F0404
Voltage-dependent calcium channel gamma-2 subunit4004
Albumin0022
Major prion protein0011
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40303
Cytochrome P450 3A40304
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M50505
Beta-2 adrenergic receptor0202
Muscarinic acetylcholine receptor M20202
Cytochrome P450 2C9 0202
Integrin alpha-40101
Carbonyl reductase [NADPH] 10001
UDP-glucuronosyltransferase 2B70102
Beta-1 adrenergic receptor0202
D0404
D(3) dopamine receptor0404
Alpha-2B adrenergic receptor0303
Glutamate receptor 24004
D(2) dopamine receptor0202
Adenylate cyclase type 30101
Alpha-2C adrenergic receptor0303
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0303
Alpha-1D adrenergic receptor0303
5-hydroxytryptamine receptor 3A0101
Adenosine receptor A10102
D(1B) dopamine receptor0303
Beta-3 adrenergic receptor0101
Adenylate cyclase type 20101
Adenylate cyclase type 40101
D(4) dopamine receptor0303
Histamine H1 receptor0202
C-8 sterol isomerase0101
Delta-type opioid receptor0202
Mu-type opioid receptor0202
5-hydroxytryptamine receptor 2C 0202
5-hydroxytryptamine receptor 70202
Kappa-type opioid receptor0101
Alpha-1A adrenergic receptor0303
5-hydroxytryptamine receptor 2A0202
Alpha-1B adrenergic receptor0202
Glutamate receptor ionotropic, NMDA 1 0102
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 4 subunit alpha0202
Adenylate cyclase type 80101
Kappa-type opioid receptor0101
Histamine H2 receptor2003
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 2J20202
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
D(2) dopamine receptor0606
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
Glutamate receptor ionotropic, NMDA 2A 0102
Glutamate receptor ionotropic, NMDA 2B0102
Glutamate receptor ionotropic, NMDA 2C0102
Sodium channel protein type 7 subunit alpha0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0404
5-hydroxytryptamine receptor 2B0202
Adenylate cyclase type 60101
Adenylate cyclase type 50101
TAR DNA-binding protein 432002
5-hydroxytryptamine receptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1S0404
Voltage-dependent L-type calcium channel subunit alpha-1C0404
Sodium channel protein type 5 subunit alpha0303
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0202
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20101
Sigma intracellular receptor 20101
Sigma non-opioid intracellular receptor 10101
Zinc finger protein 6640101
Glutamate receptor ionotropic, NMDA 2D0102
Vesicular acetylcholine transporter0101
Transporter0202
Cholecystokinin receptor type A0101
Protease 0202
Adenylyl cyclase 7 0101
Glutamate receptor ionotropic, NMDA 3B0102
Canalicular multispecific organic anion transporter 10404
D0101
ATPase family AAA domain-containing protein 55005
Sodium channel protein type 2 subunit alpha0202
Transient receptor potential cation channel subfamily V member 40101
Sodium channel protein type 3 subunit alpha0202
Glutamate receptor ionotropic, NMDA 3A0102
Sodium channel protein type 11 subunit alpha0202
Sodium channel protein type 8 subunit alpha0202
Transient receptor potential cation channel subfamily V member 20101
Sodium channel protein type 10 subunit alpha0202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Luciferase1001
dopamine D1 receptor1001
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
apical membrane antigen 1, AMA12002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
pyruvate kinase1001
Bloom syndrome protein isoform 13003
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor2002
glucokinase regulatory protein1001
importin subunit beta-1 isoform 11001
flap endonuclease 11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)2002
DNA polymerase kappa isoform 12002
Polyphenol oxidase 20001
Carbonic anhydrase 120001
Carbonic anhydrase 10001
Carbonic anhydrase 20001
Plasma kallikrein0001
Tyrosine-protein kinase Lck0101
Carbonic anhydrase 30001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Tyrosinase0101
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Solute carrier family 15 member 10101
Carbonic anhydrase0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Carbonic anhydrase 0001
Monocarboxylate transporter 100001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
phosphoglycerate kinase1001
G3003
bromodomain adjacent to zinc finger domain 2B2002
IDH12002
nuclear receptor subfamily 1, group I, member 21001
nuclear factor erythroid 2-related factor 2 isoform 23003
muscleblind-like protein 1 isoform 12002
Nuclear receptor subfamily 1 group I member 20011
HLA class I histocompatibility antigen, B alpha chain 3003
Glucocorticoid receptor0404
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Inositol hexakisphosphate kinase 13003
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial3003
activating transcription factor 62002
NPC intracellular cholesterol transporter 1 precursor1001
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A2002
Sodium-dependent noradrenaline transporter0101
Myeloperoxidase0101
Quinolone resistance protein NorA0101
Cytochrome P450 2D60303
Aldo-keto reductase family 1 member B10101
Beta-adrenergic receptor kinase 10101
Potassium voltage-gated channel subfamily A member 30101
Beta-adrenergic receptor kinase 10112
Substance-P receptor0101
Rhodopsin kinase GRK10101
G protein-coupled receptor kinase 50101
G protein-coupled receptor kinase 50101
P2X purinoceptor 40101
Envelope glycoprotein0011
Rhodopsin kinase GRK10101
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
P2X purinoceptor 40101
Beta-adrenergic receptor kinase 10001
Transporter0303
Chain A, Beta-lactamase1001
Chain A, Ferritin light chain1001
endonuclease IV1001
pregnane X receptor1001
SMAD family member 22002
GALC protein1001
SMAD family member 32002
DNA polymerase III, partial1001
aldehyde dehydrogenase 1 family, member A11001
67.9K protein2002
XBP10101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
cytochrome P450 2C19 precursor2002
vitamin D3 receptor isoform VDRA1001
thyroid hormone receptor beta isoform a1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
huntingtin isoform 21001
nuclear factor NF-kappa-B p105 subunit isoform 11001
DNA damage-inducible transcript 3 protein0101
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
survival motor neuron protein isoform d2002
neuropeptide S receptor isoform A1001
Solute carrier family 22 member 20202
Voltage-dependent T-type calcium channel subunit alpha-1G0011
Ubiquitin carboxyl-terminal hydrolase 10101
Sodium channel protein type 2 subunit alpha0101
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10101
Glycine receptor subunit alpha-10022
Multidrug and toxin extrusion protein 20202
WD repeat-containing protein 480101
Multidrug and toxin extrusion protein 10202
Histamine H4 receptor0101
Smad33003
transcriptional regulator ERG isoform 31001
Histamine H1 receptor0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
D(2) dopamine receptor0101
5-hydroxytryptamine receptor 1A0101
thioredoxin glutathione reductase1001
procathepsin L isoform 1 preproprotein0101
Acetylcholine receptor subunit alpha0213
Neuronal acetylcholine receptor subunit alpha-30213
Acetylcholine receptor subunit gamma0213
Neuronal acetylcholine receptor subunit alpha-40213
Acetylcholine receptor subunit beta0213
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit beta-30011
Neuronal acetylcholine receptor subunit beta-40213
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-50011
Neuronal acetylcholine receptor subunit beta-40213
Muscarinic acetylcholine receptor M40101
Neuronal acetylcholine receptor subunit alpha-30213
Delta-type opioid receptor0101
Neuronal acetylcholine receptor subunit alpha-70101
Neuronal acetylcholine receptor subunit alpha-60011
Neuronal acetylcholine receptor subunit alpha-40213
Mu-type opioid receptor0101
Neuronal acetylcholine receptor subunit alpha-70112
Acetylcholine receptor subunit delta0213
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]