Papilloma, Inverted

A mucosal tumor of the urinary bladder or nasal cavity in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded than in other papillomas. (Stedman, 25th ed)

Synonym
Papilloma, Inverted

Excerpt	Reference
"Inverted papilloma is a rare benign tumor of the nose and the paranasal sinuses."	( Grossenbacher, R; Peter, B, 1997)
"Inverted papilloma is a benign sinunasal tumor, characterized by aggressive nature and tendency to recur."	( Baumann, I; Plinkert, PK; Ruck, P; Scheffler, B, 1997)
"Nasal inverted papilloma is a rare benign tumor of epithelial origin with aggressive evolution, bone destruction, recurrence, and malignant transformation."	( Berdal, A; Depondt, J; Lezot, F; Pibouin, L; Shabana, el-H; Walker, F, 2008)
"Inverted papillomas are primarily benign neoplasms that occur in the nasal cavity and paranasal sinuses."	( Behringer, S; Kayser, G; Pfeiffer, J; Ridder, GJ, 2008)
"Sinonasal inverted papilloma is a rare benign tumor with a high recurrence rate and potential malignant transformation."	( Adjibabi, W; Afouda, SL; Alamou, S; Avakoudjo, F; Biaou, O; Hounkpatin, S; Hounkpe, Y; Stoll, D, 2011)
"Inverted papillomas are a unique group of locally aggressive benign epithelial neoplasms in the nasal cavity and paranasal sinuses arising from the Schneiderian mucosa."	( Bryś, M; Danilewicz, M; Forma, E; Krześlak, A; Lewy-Trenda, I; Olszewski, J; Pietkiewicz, P; Starska, K; Stasikowska-Kanicka, O, 2015)
"Inverted papilloma is a rare entity in the spectrum of urological diseases."	( Hupe, MC; Kramer, M; Matzen, M; Merseburger, AS; Offermann, A; Perner, S; Tharun, L, 2021)
"Inverted papilloma is an uncommon primary nasal tumor that presents three typical characteristics: a high rate of recurrence, local aggressive behaviour and association with malignancy."	( Ameen, AH; Gubari, MIM; Kareem, RHR; Maurizi, R; Omer, GL; Yazan, AS, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	11 (14.86)	12.5806
2000's	22 (29.73)	18.1394
2010's	31 (41.89)	28.8240
2020's	10 (13.51)	9.53

Drug	Relationship Strength	Studies
aminolevulinic acid	low	2
toluene	low	1
fluorouracil	low	2
guaifenesin	low	1
loratadine	low	1
oxonic acid	low	1
tegafur	low	1
mitomycin	low	1
deoxycytidine	low	1
fluorescein	low	1
dithiothreitol	low	1
cadmium	low	1
1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidinyl)-1-nitrosourea	low	1
etoposide	low	1
propiconazole	low	5
gemcitabine	low	1
fluorodeoxyglucose f18	low	7
nsc-172755	low	1
fibrinogen	low	1
desloratadine	low	1
inositol 3-phosphate	low	2
bromochloroacetic acid	low	7
phenylephrine hydrochloride	low	26
fluticasone	low	1
gadolinium dtpa	low	2
acid phosphatase	low	1
interleukin-8	low	1
s 1 (combination)	low	1
epidermal growth factor	low	1
cyclin d1	low	8
transforming growth factor alpha	low	1
concanavalin a	low	1
metallothionein	low	3

Protein Targets (296)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Beta-lactamase	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
geminin	7	0	0	7
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
RAR-related orphan receptor gamma	8	0	0	8
AR protein	9	0	0	9
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
thyroid stimulating hormone receptor	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
Cellular tumor antigen p53	9	0	0	9
Nuclear receptor ROR-gamma	1	0	0	1
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	0	0	2
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	2
AAA family ATPase	0	0	0	2
Reverse transcriptase/RNaseH	0	0	1	1
acetylcholinesterase	5	0	0	5
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
TDP1 protein	7	0	0	7
GLI family zinc finger 3	7	0	0	7
thioredoxin glutathione reductase	1	0	0	1
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	6	0	0	6
progesterone receptor	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
estrogen-related nuclear receptor alpha	10	0	0	10
farnesoid X nuclear receptor	7	0	0	7
pregnane X nuclear receptor	7	0	0	7
estrogen nuclear receptor alpha	9	0	0	9
G	2	0	0	2
cytochrome P450 2D6	3	0	0	3
peroxisome proliferator-activated receptor delta	7	0	0	7
caspase-3	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
Histone H2A.x	5	0	0	5
vitamin D3 receptor isoform VDRA	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
thyroid hormone receptor beta isoform 2	7	0	0	7
peripheral myelin protein 22	5	0	0	5
lamin isoform A-delta10	6	0	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
5-hydroxytryptamine receptor 4	0	2	0	2
Bile salt export pump	0	5	0	5
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
ATP-dependent translocase ABCB1	0	4	0	5
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Histamine H1 receptor	0	4	2	6
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	4	0	4
Histamine H2 receptor	3	0	0	3
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	0	1	0	1
Protein farnesyltransferase subunit beta	0	1	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Spike glycoprotein	3	0	1	4
Inositol monophosphatase 1	2	0	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Inositol hexakisphosphate kinase 1	2	0	0	2
Canalicular multispecific organic anion transporter 1	0	5	0	6
Sodium-dependent neutral amino acid transporter B(0)AT2	0	2	0	2
cytochrome P450 2C9, partial	2	0	0	2
glp-1 receptor, partial	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
glucocorticoid receptor [Homo sapiens]	7	0	0	7
retinoid X nuclear receptor alpha	7	0	0	7
67.9K protein	3	0	0	3
peroxisome proliferator activated receptor gamma	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
LMP1 [Human herpesvirus 4]	0	0	0	1
activating transcription factor 6	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
chromobox protein homolog 1	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
heat shock protein beta-1	3	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
DNA polymerase iota isoform a (long)	3	0	0	3
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Cytochrome P450 3A4	0	2	0	2
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
Cytochrome P450 2C9	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
DNA topoisomerase 2	0	0	0	1
Glutamate receptor 2	6	0	0	6
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	3
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	3
Glutamate receptor ionotropic, NMDA 2B	0	2	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	4
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	2	0	3
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	3
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	4	0	0	4
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	2	0	0	2
Microtubule-associated protein tau	4	0	0	4
aryl hydrocarbon receptor	4	0	0	4
thyrotropin-releasing hormone receptor	1	0	0	1
Bloom syndrome protein isoform 1	3	0	0	3
DNA polymerase kappa isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	2	0	0	2
interleukin 8	1	0	0	1
endonuclease IV	1	0	0	1
Skn7p	0	0	0	1
thioredoxin reductase	4	0	0	4
pregnane X receptor	2	0	0	2
ATAD5 protein, partial	2	0	0	2
Thrombopoietin	2	0	0	2
thyroid stimulating hormone receptor	3	0	0	3
EWS/FLI fusion protein	3	0	0	3
nonstructural protein 1	3	0	0	3
arylsulfatase A	2	0	0	2
IDH1	3	0	0	3
peripheral myelin protein 22 isoform 1	2	0	0	2
hemoglobin subunit beta	1	0	0	1
huntingtin isoform 2	1	0	0	1
flap endonuclease 1	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Vpr	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
muscleblind-like protein 1 isoform 1	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	1	0	1
Amyloid-beta precursor protein	1	0	0	1
Thymidylate synthase	0	1	0	1
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Equilibrative nucleoside transporter 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Chain A, Cruzipain	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
Fumarate hydratase	2	0	0	2
USP1 protein, partial	1	0	0	1
GLS protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
isocitrate dehydrogenase 1, partial	1	0	0	1
polyprotein	2	0	0	2
alpha-galactosidase	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
cytochrome P450 3A4 isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Angiotensin-converting enzyme	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Platelet-activating factor receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Cytochrome P450 2C19	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
GABA theta subunit	1	0	0	1
Bile acid receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
Histamine H4 receptor	0	1	0	1
Potassium channel subfamily K member 9	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Cytochrome P450 2B6	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Muscarinic acetylcholine receptor M4	0	0	1	2
Delta-type opioid receptor	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Mu-type opioid receptor	0	0	0	1
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
GALC protein	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
TAR DNA-binding protein 43	1	0	0	1
heat shock protein 90, putative	0	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Endolysin	0	0	1	1
Acetylcholinesterase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (74)

Protein Targets (296)

Papilloma, Inverted

Synonyms(1)

Research Excerpts

Overview

Research

Studies (74)

Drugs Studied (36)

Protein Targets (296)