Orthostatic Intolerance

Symptoms of cerebral hypoperfusion or autonomic overaction which develop while the subject is standing, but are relieved on recumbency. Types of this include NEUROCARDIOGENIC SYNCOPE; POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME; and neurogenic ORTHOSTATIC HYPOTENSION. (From Noseworthy, JH., Neurological Therapeutics Principles and Practice, 2007, p2575-2576)

Synonym
Orthostatic Intolerance

Excerpt	Reference
"Spaceflight-induced orthostatic intolerance has been studied for decades."	( Arzeno, NM; Lee, SM; Platts, SH; Ploutz-Snyder, R; Stenger, MB, 2013)

Excerpt	Reference
"Orthostatic intolerance affects a significant number of arthroplasty patients."	( Dennis, DA; Jennings, JM; Johnson, RM; Kurkis, GM; Mejia, M; Yazdani-Farsad, Y, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	7 (8.05)	18.1394
2010's	66 (75.86)	28.8240
2020's	14 (16.09)	9.53

Drug	Relationship Strength	Studies	Trials
choline	low	1	0
bupropion	low	1	0
glycerol	low	2	0
inositol	low	1	0
melatonin	medium	2	1
bupivacaine	low	1	0
clonazepam	low	2	0
fentanyl	low	1	0
losartan	medium	1	1
metoprolol	medium	3	1
midodrine	medium	4	2
modafinil	low	1	0
activins	low	1	0
nitroglycerin	medium	4	1
aldosterone	medium	4	2
norethindrone	medium	1	1
pyridostigmine bromide	medium	2	1
d-alpha tocopherol	medium	1	1
fludrocortisone	medium	2	1
desogestrel	medium	1	1
captopril	medium	1	1
fomesafen	low	6	0
drospirenone	medium	1	1
droxidopa	low	1	0
reboxetine	medium	1	1
ivabradine	medium	3	1
angiotensin ii	medium	4	2
anandamide	low	1	0
glyceryl 2-arachidonate	low	1	0
morphine	low	2	0
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane	low	1	0
pituitrin	low	2	0
natriuretic peptide, brain	low	1	0
minocycline	low	1	0
angiotensin i	low	1	0
sapropterin	low	1	0

Protein Targets (440)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Sodium-dependent dopamine transporter	0	5	0	5
AR protein	13	0	0	13
glucocorticoid receptor [Homo sapiens]	7	0	0	7
thyroid hormone receptor beta isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
geminin	7	0	0	7
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	1	2	3
Androgen receptor	0	3	0	3
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Chain A, Ferritin light chain	2	0	0	2
phosphopantetheinyl transferase	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
Bloom syndrome protein isoform 1	2	0	0	2
vitamin D3 receptor isoform VDRA	2	0	0	2
DNA polymerase kappa isoform 1	3	0	0	3
Fatty-acid amide hydrolase 1	0	3	0	3
Fatty-acid amide hydrolase 1	0	0	0	1
Potassium channel subfamily K member 3	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Fatty acid-binding protein, liver	0	2	0	2
Glutamate receptor 1	0	0	1	1
Glutamate receptor 2	1	0	1	2
Glutamate receptor 3	0	0	1	1
Glutamate receptor 4	0	0	1	1
Cannabinoid receptor 1	0	2	1	3
Cannabinoid receptor 1	0	2	1	4
Cannabinoid receptor 2	0	2	1	4
Alpha-1A adrenergic receptor	0	4	1	5
Cannabinoid receptor 1	0	1	0	1
Histamine H2 receptor	2	0	0	2
Cannabinoid receptor 2	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	3
Fatty acid-binding protein 5	0	0	1	1
Corticotropin-releasing factor receptor 2	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	0	1	2
Cannabinoid receptor 2	0	2	0	2
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
glucocerebrosidase	1	0	0	1
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Atrial natriuretic peptide receptor 3	0	2	0	2
Type-1A angiotensin II receptor	0	4	2	6
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	4	0	4
Type-1 angiotensin II receptor	0	4	3	9
Type-2 angiotensin II receptor	0	4	0	4
Type-2 angiotensin II receptor	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Potassium channel subfamily K member 9	0	1	0	1
thioredoxin reductase	3	0	0	3
USP1 protein, partial	3	0	0	3
GLS protein	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
Bile salt export pump	0	9	0	9
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	2
UDP-glucuronosyltransferase 1-6	0	1	0	1
Cytochrome P450 2B6	0	0	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
Sodium-dependent noradrenaline transporter	0	5	0	5
Sodium-dependent dopamine transporter	0	3	0	3
Neuronal acetylcholine receptor subunit beta-4	0	1	0	2
Sodium-dependent serotonin transporter	0	5	0	5
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Cytochrome P450 2C19	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	2
Acetylcholine receptor subunit delta	0	1	0	1
ATP-dependent phosphofructokinase	4	0	0	4
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
15-lipoxygenase, partial	1	0	0	1
Microtubule-associated protein tau	3	0	0	3
Thrombopoietin	1	0	0	1
thioredoxin glutathione reductase	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
Metallo-beta-lactamase type 2	0	1	1	2
euchromatic histone-lysine N-methyltransferase 2	6	0	0	6
peripheral myelin protein 22 isoform 1	2	0	0	2
chromobox protein homolog 1	2	0	0	2
M-phase phosphoprotein 8	3	0	0	3
transient receptor potential cation channel subfamily V member 1	1	0	0	1
lamin isoform A-delta10	8	0	0	8
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Prothrombin	0	1	0	1
Renin	0	1	0	1
Neprilysin	0	1	0	1
Neprilysin	0	2	0	2
Leukotriene A-4 hydrolase	0	2	1	3
EEF1AKMT4-ECE2 readthrough transcript protein	0	1	0	1
Angiotensin-converting enzyme	0	3	1	4
Angiotensin-converting enzyme	0	2	0	3
Leukotriene A-4 hydrolase	0	1	0	1
Thymidine phosphorylase	0	0	1	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Endothelin-converting enzyme 1	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	1
Mu-type opioid receptor	0	5	1	6
TAR DNA-binding protein 43	2	0	0	2
Beta-lactamase	0	2	0	3
Canalicular multispecific organic anion transporter 1	0	3	0	3
Beta-lactamase	0	2	0	2
Angiotensin-converting enzyme 2	0	1	0	1
Beta-lactamase class B VIM-2	0	1	1	2
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
muscarinic acetylcholine receptor M1	3	0	0	3
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	4	0	6
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	3	0	3
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	2	1	1	4
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	2	1	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	2	1	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-3	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-2	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	2	1	1	4
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-6	2	1	1	4
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	2	1	1	4
Gamma-aminobutyric acid receptor subunit beta-3	2	1	1	4
Gamma-aminobutyric acid receptor subunit beta-2	2	1	1	4
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
GABA theta subunit	2	1	1	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	2	1	1	4
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Chain A, Cruzipain	3	0	0	3
acetylcholinesterase	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
regulator of G-protein signaling 4	2	0	0	2
cytochrome P450 2D6	4	0	0	4
Beta-1 adrenergic receptor	0	0	2	2
arylsulfatase A	1	0	0	1
Alpha-1B adrenergic receptor	0	0	2	2
cytochrome P450 2D6 isoform 1	2	0	0	2
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2A adrenergic receptor	0	3	3	6
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	3	1	4
Alpha-1A adrenergic receptor	0	1	2	3
Alpha-2C adrenergic receptor	0	3	2	5
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	4	1	5
Alpha-2B adrenergic receptor	0	3	0	3
Amine oxidase [flavin-containing] A	0	2	0	2
Alpha-2C adrenergic receptor	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	1	3
D(1B) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Adenosine receptor A2b	0	0	1	1
Adenosine receptor A2a	0	1	1	2
Alpha-2B adrenergic receptor	0	0	0	2
D(4) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	4	0	5
Alpha-1A adrenergic receptor	0	2	2	4
Alpha-1B adrenergic receptor	0	2	2	4
5-hydroxytryptamine receptor 7	0	2	0	2
Spike glycoprotein	5	0	0	5
D(2) dopamine receptor	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Alpha-2C adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Multidrug and toxin extrusion protein 1	0	2	0	2
Nischarin	0	1	0	1
retinoic acid nuclear receptor alpha variant 1	5	0	0	5
estrogen-related nuclear receptor alpha	6	0	0	6
estrogen nuclear receptor alpha	12	0	0	12
activating transcription factor 6	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
heat shock protein beta-1	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Cellular tumor antigen p53	5	0	0	5
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
pregnane X nuclear receptor	6	0	0	6
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
thyroid hormone receptor beta isoform 2	4	0	0	4
RAR-related orphan receptor gamma	4	0	0	4
SMAD family member 2	2	0	0	2
PPM1D protein	1	0	0	1
SMAD family member 3	2	0	0	2
TDP1 protein	7	0	0	7
GLI family zinc finger 3	5	0	0	5
progesterone receptor	4	0	0	4
retinoid X nuclear receptor alpha	3	0	0	3
G	3	0	0	3
peroxisome proliferator-activated receptor delta	3	0	0	3
peroxisome proliferator activated receptor gamma	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	4	0	0	4
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Inositol hexakisphosphate kinase 1	3	0	0	3
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
cytochrome P450 2C9, partial	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Luciferase	2	0	0	2
ATP-dependent translocase ABCB1	0	4	0	7
D(2) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	5	2	10
Kappa-type opioid receptor	0	3	1	5
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	4	2	7
D(3) dopamine receptor	0	2	0	2
Delta-type opioid receptor	0	4	1	6
Kappa-type opioid receptor	0	4	0	4
Kappa-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	3	1	6
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	1	0	1
GALC protein	1	0	0	1
aryl hydrocarbon receptor	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
Histone H2A.x	2	0	0	2
Gonadotropin-releasing hormone receptor	0	1	1	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
alpha-galactosidase	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
Amyloid-beta precursor protein	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	0	0	1	1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	0	0	1	1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	0	0	1	1
cytochrome P450 3A4 isoform 1	2	0	0	2
Cytochrome P450 2C9	0	3	0	3
Thromboxane A2 receptor	0	1	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Type-1 angiotensin II receptor	0	1	1	2
Squalene synthase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Platelet glycoprotein VI	0	1	1	3
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Type-1 angiotensin II receptor	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
interleukin 8	1	0	0	1
ClpP	1	0	0	1
ATAD5 protein, partial	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
EWS/FLI fusion protein	3	0	0	3
caspase-3	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear receptor ROR-gamma	1	0	0	1
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	1	0	1
estrogen receptor 2 (ER beta)	2	0	0	2
Beta-2 adrenergic receptor	0	2	2	4
Beta-1 adrenergic receptor	0	2	2	4
Beta-3 adrenergic receptor	0	0	2	2
Beta-1 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
Beta-2 adrenergic receptor	0	1	1	2
Albumin	0	0	1	1
Stromelysin-1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein-arginine deiminase type-4	0	2	0	2
mitogen-activated protein kinase 1	1	0	0	1
Sodium-dependent serotonin transporter	0	3	0	3
Transporter	0	1	0	1
Transporter	0	2	0	2
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Cytochrome P450 3A4	0	1	1	2
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Atrial natriuretic peptide receptor 1	0	1	0	1
farnesoid X nuclear receptor	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	2	0	2
Estrogen receptor	0	0	1	1
Progesterone receptor	0	2	2	4
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Estrogen receptor beta	0	0	1	1
dopamine D1 receptor	1	0	0	1
glp-1 receptor, partial	1	0	0	1
NFKB1 protein, partial	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
POU domain, class 2, transcription factor 1	0	0	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Chain A, Beta-lactamase	1	0	0	1
endonuclease IV	1	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Nitric oxide synthase, brain	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Studies (87)

Protein Targets (440)

Orthostatic Intolerance

Synonyms(1)

Research Excerpts

Context

Actions

Research

Studies (87)

Drugs Studied (57)

Protein Targets (440)