Page last updated: 2024-09-27

Ophthalmoplegic Migraine

Childhood-onset of recurrent headaches with an oculomotor cranial nerve palsy. Typically, ABDUCENS NERVE; OCULOMOTOR NERVE; and TROCHLEAR NERVE are involved with DIPLOPIA and BLEPHAROPTOSIS.

Synonyms(2)

Synonym
Ophthalmoplegic Migraine Syndrome
Ophthalmoplegic Migraine

Research

Studies (7)

TimeframeStudies, This Condition (%)All Conditions %
pre-19904 (57.14)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's2 (28.57)28.8240
2020's1 (14.29)9.53
DrugIndicatedRelationship StrengthStudiesTrials
valproic acid0low20
propranolol0low10
prednisolone0low10
ergotamine0low10
dimenhydrinate0low10
eye0low30

Protein Targets (298)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma3003
GLI family zinc finger 32002
AR protein3003
aldehyde dehydrogenase 1 family, member A11001
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor3003
retinoic acid nuclear receptor alpha variant 13003
estrogen-related nuclear receptor alpha4004
pregnane X nuclear receptor2002
estrogen nuclear receptor alpha4004
thyroid stimulating hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x1001
potassium voltage-gated channel subfamily H member 2 isoform d2002
thyroid hormone receptor beta isoform 22002
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 13003
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
5-hydroxytryptamine receptor 40606
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump0505
Cellular tumor antigen p534004
Aldo-keto reductase family 1 member B10303
Muscarinic acetylcholine receptor M20314
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0528
Cytochrome P450 2D60202
Muscarinic acetylcholine receptor M10314
Alpha-2B adrenergic receptor0416
Glutamate receptor 23003
Muscarinic acetylcholine receptor M30314
Sodium-dependent noradrenaline transporter 0202
Alpha-1D adrenergic receptor0416
5-hydroxytryptamine receptor 2A0617
5-hydroxytryptamine receptor 2C0617
Histamine H1 receptor0202
5-hydroxytryptamine receptor 2B0617
Nuclear receptor ROR-gamma3003
Inositol monophosphatase 11001
Sodium-dependent dopamine transporter 0202
Canalicular multispecific organic anion transporter 10404
Sigma non-opioid intracellular receptor 10404
Adenylate cyclase 0101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
ATP-dependent translocase ABCB10101
Beta-2 adrenergic receptor0415
ATP-dependent translocase ABCB10404
Beta-1 adrenergic receptor0415
Cytochrome P450 3A40202
D(2) dopamine receptor0314
Alpha-2C adrenergic receptor0326
5-hydroxytryptamine receptor 1A0416
ATP-dependent translocase ABCB10101
D(1A) dopamine receptor0314
Sodium-dependent dopamine transporter0202
Thromboxane-A synthase 0202
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1B0314
5-hydroxytryptamine receptor 1B0404
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 60415
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Cruzipain1001
Luciferase2002
interleukin 81001
SMAD family member 21001
SMAD family member 31001
TDP1 protein3003
Microtubule-associated protein tau1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
estrogen receptor 2 (ER beta)1001
cytochrome P450 family 3 subfamily A polypeptide 42002
EWS/FLI fusion protein1001
glucocorticoid receptor [Homo sapiens]3003
retinoid X nuclear receptor alpha1001
farnesoid X nuclear receptor2002
G1001
67.9K protein1001
glucocerebrosidase1001
Parkin1001
bromodomain adjacent to zinc finger domain 2B1001
peroxisome proliferator-activated receptor delta1001
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
euchromatic histone-lysine N-methyltransferase 22002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
aryl hydrocarbon receptor2002
cytochrome P450 2D6 isoform 11001
peripheral myelin protein 22 isoform 11001
cytochrome P450 2C9 precursor1001
vitamin D3 receptor isoform VDRA1001
thyroid hormone receptor beta isoform a2002
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
DNA polymerase iota isoform a (long)1001
nuclear receptor ROR-gamma isoform 11001
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 81001
lamin isoform A-delta101001
neuropeptide S receptor isoform A1001
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0102
Prostaglandin G/H synthase 2 0102
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Epidermal growth factor receptor0101
Phospholipase A2, major isoenzyme0101
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 1001
Albumin0123
Prostaglandin G/H synthase 10203
Procathepsin L0101
Neuronal acetylcholine receptor subunit alpha-40101
Interleukin-80101
Androgen receptor0213
Neuronal acetylcholine receptor subunit beta-20101
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 10101
Sodium- and chloride-dependent GABA transporter 10101
Adenosine receptor A10101
Serum paraoxonase/arylesterase 10101
Indoleamine 2,3-dioxygenase 10101
Caspase-10001
Nitric oxide synthase, inducible0101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 20314
Prostaglandin G/H synthase 2 0101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0011
Aldo-keto reductase family 1 member C30202
Histamine H2 receptor1001
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Spike glycoprotein1001
Guanine nucleotide-binding protein G1001
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30101
Prostaglandin G/H synthase 20202
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20102
Potassium voltage-gated channel subfamily H member 20202
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Prostaglandin G/H synthase 1 0101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80101
Inositol hexakisphosphate kinase 11001
Multidrug and toxin extrusion protein 10101
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Solute carrier organic anion transporter family member 1B30202
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10202
cytochrome P450 2C9, partial1001
luciferase0001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
nuclear receptor subfamily 1, group I, member 21001
nuclear factor erythroid 2-related factor 2 isoform 21001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Cytochrome P450 2C9 0202
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Nociceptin receptor0011
Cytochrome P450 2J20202
Estrogen receptor beta0202
ATPase family AAA domain-containing protein 52002
Ataxin-23003
thioredoxin reductase1001
Beta-1 adrenergic receptor 0113
arylsulfatase A1001
D(1A) dopamine receptor1001
Gamma-aminobutyric acid receptor subunit pi0112
Solute carrier family 22 member 1 0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Bile salt export pump0202
Cytochrome P450 1A20101
5-hydroxytryptamine receptor 1A0101
Adenosine receptor A30112
Beta-2 adrenergic receptor0203
Cytochrome P450 2C80101
Beta-3 adrenergic receptor0213
Gamma-aminobutyric acid receptor subunit beta-10112
Alpha-1B adrenergic receptor0112
Beta-1 adrenergic receptor0214
Gamma-aminobutyric acid receptor subunit delta0112
Gamma-aminobutyric acid receptor subunit gamma-20112
D(3) dopamine receptor0101
Alpha-2B adrenergic receptor0011
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit alpha-30112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
Gamma-aminobutyric acid receptor subunit gamma-10112
Gamma-aminobutyric acid receptor subunit alpha-20112
Alpha-1D adrenergic receptor0112
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit gamma-30112
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Gamma-aminobutyric acid receptor subunit alpha-60112
Type-1 angiotensin II receptor0112
Sodium-dependent serotonin transporter0202
Cholecystokinin receptor type A0112
Cytochrome P450 2C190101
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
Mu-type opioid receptor0112
Vasopressin V1a receptor0112
Delta-type opioid receptor0112
Kappa-type opioid receptor0112
Alpha-1A adrenergic receptor0112
5-hydroxytryptamine receptor 70101
Beta-2 adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit beta-20112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium/bile acid cotransporter0101
Beta-2 adrenergic receptor0113
GABA theta subunit0112
Gamma-aminobutyric acid receptor subunit epsilon0112
Nuclear receptor subfamily 2 group E member 10022
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
pregnane X receptor1001
Cocaine esterase0101
Histone deacetylase 30202
UDP-glucuronosyltransferase 1A90001
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 2B70102
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Sigma non-opioid intracellular receptor 10101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]