Page last updated: 2024-09-27

Nonsynostotic Plagiocephaly

A deformity of the SKULL that is not due to bone fusion (SYNOSTOSIS), such as craniosynostoses, and is characterized by an asymmetric skull and face. It is observed with an increased frequency in INFANTS after the adoption of supine sleeping recommendations to prevent SUDDEN INFANT DEATH SYNDROME.

Synonyms(4)

Synonym
Plagiocephaly, Deformational
Plagiocephaly, Nonsynostotic
Plagiocephaly, Positional
Nonsynostotic Plagiocephaly

Research Excerpts

Research

Studies (7)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's4 (57.14)18.1394
2010's3 (42.86)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
apnea0low10
arginine0low10
trolamine salicylate0low10
proline0low10
folic acid0low20

Protein Targets (126)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
thioredoxin reductase3003
ATAD5 protein, partial1001
TDP1 protein1001
Microtubule-associated protein tau1001
estrogen-related nuclear receptor alpha2002
arylsulfatase A1001
euchromatic histone-lysine N-methyltransferase 22002
Bloom syndrome protein isoform 11001
D(1A) dopamine receptor1001
lamin isoform A-delta102002
neuropeptide S receptor isoform A1001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
phosphopantetheinyl transferase1001
NFKB1 protein, partial1001
GLS protein1001
thyroid stimulating hormone receptor2002
alpha-galactosidase2002
cytochrome P450 2C19 precursor1001
chromobox protein homolog 11001
flap endonuclease 11001
DNA polymerase iota isoform a (long)1001
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)2002
Cytochrome P450 3A40001
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase1001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, Ferritin light chain1001
acid sphingomyelinase1001
glp-1 receptor, partial1001
USP1 protein, partial1001
GLI family zinc finger 31001
AR protein1001
aldehyde dehydrogenase 1 family, member A12002
retinoid X nuclear receptor alpha3003
estrogen nuclear receptor alpha2002
glucocerebrosidase1001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
activating transcription factor 61001
lysosomal alpha-glucosidase preproprotein1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 21001
DNA polymerase beta1001
Multidrug resistance-associated protein 40001
Bile salt export pump0202
Cellular tumor antigen p531001
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10202
Alpha-synuclein1001
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Glutamate receptor ionotropic, NMDA 1 0101
Neutral amino acid transporter A0101
Neutral amino acid transporter B(0)0101
Proton-coupled amino acid transporter 10101
Amino acid transporter0101
chaperonin-containing TCP-1 beta subunit homolog1001
geminin1001
survival motor neuron protein isoform d1001
histone acetyltransferase KAT2A isoform 11001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Bile salt export pump0101
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Albumin0101
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
RAR-related orphan receptor gamma1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]