A form of frontotemporal lobar degeneration and a progressive form of dementia characterized by motor speech impairment and AGRAMMATISM, with relative sparing of single word comprehension and semantic memory.
| Synonym |
|---|
| Progressive Nonfluent Aphasia |
| Non-fluent Primary Progressive Aphasia |
| PPA Syndrome |
| Primary Progressive Nonfluent Aphasia |
| Timeframe | Studies, This Condition (%) | All Conditions % |
|---|---|---|
| pre-1990 | 0 (0.00) | 23.3326 |
| 1990's | 0 (0.00) | 12.5806 |
| 2000's | 1 (11.11) | 18.1394 |
| 2010's | 7 (77.78) | 28.8240 |
| 2020's | 1 (11.11) | 9.53 |
| Drug | Indicated | Relationship Strength | Studies | Trials |
|---|---|---|---|---|
| leucine | 0 | low | 1 | 0 |
| thiazoles | 0 | low | 2 | 0 |
| fluorodeoxyglucose f18 | 0 | low | 5 | 0 |
| proline | 0 | low | 1 | 0 |
| 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole | 0 | low | 2 | 0 |
| myelin basic protein | 0 | low | 1 | 0 |
| cysteine | 0 | low | 1 | 0 |
| 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane | 0 | low | 1 | 0 |
| technetium tc 99m bicisate | 0 | low | 1 | 0 |
| Protein | Potency Measurements | Inhibition Measurements | Activation Measurements | Drugs |
|---|---|---|---|---|
| Amyloid-beta precursor protein | 0 | 2 | 0 | 2 |
| Sodium-dependent dopamine transporter | 0 | 1 | 0 | 1 |
| Chain A, AMINOPEPTIDASE | 0 | 1 | 0 | 1 |
| Chain A, AMINOPEPTIDASE | 0 | 1 | 0 | 1 |
| Chain A, Leucine Aminopeptidase | 0 | 1 | 0 | 1 |
| Alkaline phosphatase, tissue-nonspecific isozyme | 0 | 1 | 0 | 1 |
| Intestinal-type alkaline phosphatase | 0 | 1 | 0 | 1 |
| Large neutral amino acids transporter small subunit 1 | 0 | 1 | 0 | 1 |
| Proton-coupled amino acid transporter 1 | 0 | 2 | 0 | 3 |
| Phospholipase A-2-activating protein | 0 | 1 | 0 | 1 |
| lethal factor (plasmid) | 1 | 0 | 0 | 1 |
| lamin isoform A-delta10 | 1 | 0 | 0 | 1 |
| Glutamate 5-kinase | 0 | 0 | 0 | 1 |
| Angiotensin-converting enzyme | 0 | 1 | 0 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | 0 | 1 | 0 | 1 |
| Neutral amino acid transporter A | 0 | 1 | 0 | 1 |
| Neutral amino acid transporter B(0) | 0 | 1 | 0 | 1 |
| Amino acid transporter | 0 | 1 | 0 | 1 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | ||||