Page last updated: 2024-09-27

Neurolymphomatosis

Infiltration of the nervous system by malignant lymphoma cells.

Synonyms(2)

Synonym
Primary Neurolymphomatosis
Neurolymphomatosis

Research Excerpts

Overview

ExcerptReference
"Neurolymphomatosis is an uncommon finding on FDG PET/CT and can be the only site of relapse."( Ganeshalingam, R; Roach, P; Schembri, GP, 2019)
"As neurolymphomatosis is a rare neurologic manifestation in recurrence of NK/T cell lymphoma, recognition of its presentation is important for prompt diagnosis and initiating treatment approach."( Luo, Y; Pan, Q, 2020)
"Neurolymphomatosis is rare."( Abdelhamid, MT; Aboudi, K; Al Battah, A; Alazawi, S; Bakr, M; Ellahie, A; Elomri, H; Fadul, A; Fernyhough, LJ; Gameil, A; Sabah, HE; Szabados, L; Taha, R; Yassin, M, 2021)
"Neurolymphomatosis is rare and can be difficult to diagnose by biopsy but reliably confirmed by a combined imaging approach."( Abdelhamid, MT; Aboudi, K; Al Battah, A; Alazawi, S; Bakr, M; Ellahie, A; Elomri, H; Fadul, A; Fernyhough, LJ; Gameil, A; Sabah, HE; Szabados, L; Taha, R; Yassin, M, 2021)
"Neurolymphomatosis is a rare condition of neoplastic endoneurial invasion, which is primary or secondary to non-Hodgkin's lymphoma and leukemia."( Chen, B; He, J; Peng, L; Stebbing, J; Yang, H; Zhao, Y, 2022)
"Neurolymphomatosis is a neurological manifestation of lymphoma that involves the cranial or spinal peripheral nerves, nerve roots, and plexus with direct invasion of neoplastic cells."( Akagi, A; Ando, T; Fujino, M; Goto, Y; Ito, A; Ito, M; Iwasaki, Y; Kamoshita, S; Katsuno, M; Mano, K; Miyahara, H; Miyamura, K; Ozawa, Y; Riku, Y; Yoshida, M, 2022)

Context

ExcerptReference
"Neurolymphomatosis has most commonly been described in association with B-cell non-Hodgkin lymphoma."( Abdelhamid, MT; Aboudi, K; Al Battah, A; Alazawi, S; Bakr, M; Ellahie, A; Elomri, H; Fadul, A; Fernyhough, LJ; Gameil, A; Sabah, HE; Szabados, L; Taha, R; Yassin, M, 2021)

Research

Studies (29)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's11 (37.93)28.8240
2020's18 (62.07)9.53
DrugIndicatedRelationship StrengthStudiesTrials
thiotepa0low10
cytarabine0low10
gadolinium0low10
propiconazole0low10
fluorodeoxyglucose f180medium240
bendamustine hydrochloride0low30
methotrexate0medium31
cyclosporine0low10

Protein Targets (217)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
estrogen-related nuclear receptor alpha4004
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
endonuclease IV1001
glp-1 receptor, partial2002
thioredoxin reductase3003
phosphopantetheinyl transferase3003
RAR-related orphan receptor gamma3003
USP1 protein, partial2002
TDP1 protein4004
AR protein4004
nuclear receptor subfamily 1, group I, member 34004
cytochrome P450 family 3 subfamily A polypeptide 42002
EWS/FLI fusion protein3003
glucocorticoid receptor [Homo sapiens]3003
retinoic acid nuclear receptor alpha variant 13003
estrogen nuclear receptor alpha3003
G2002
67.9K protein2002
LMP1 [Human herpesvirus 4]0002
euchromatic histone-lysine N-methyltransferase 23003
Histone H2A.x3003
chromobox protein homolog 14004
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 22002
thyroid hormone receptor beta isoform 24004
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0202
serine/threonine-protein kinase mTOR isoform 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase iota isoform a (long)4004
transactivating tegument protein VP16 [Human herpesvirus 1]0202
geminin3003
peripheral myelin protein 222002
lamin isoform A-delta103003
nuclear receptor coactivator 3 isoform a0202
Thymidine kinase 2, mitochondrial0101
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40304
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump0303
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Thymidine kinase, cytosolic0101
Cellular tumor antigen p534004
Thymidine kinase0101
Thymidylate synthase0203
Cytochrome P450 3A40202
Thymidine kinase0101
Glutamate receptor 23003
Deoxycytidine kinase0001
Probable deoxycytidylate deaminase0001
Cytidine deaminase0102
D(1A) dopamine receptor1001
E3 ubiquitin-protein ligase Mdm20101
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Inositol hexakisphosphate kinase 12002
Canalicular multispecific organic anion transporter 10303
Ataxin-23003
Thymidine kinase0101
Deoxynucleoside kinase0101
cytochrome P450 2C9, partial2002
ATP-dependent phosphofructokinase2002
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Ferritin light chain2002
acid sphingomyelinase1001
dopamine D1 receptor1001
ClpP1001
15-lipoxygenase, partial1001
ATAD5 protein, partial1001
Microtubule-associated protein tau1001
aldehyde dehydrogenase 1 family, member A11001
estrogen receptor 2 (ER beta)2002
progesterone receptor3003
retinoid X nuclear receptor alpha3003
farnesoid X nuclear receptor3003
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
Thymidylate synthase 0101
alpha-galactosidase1001
IDH11001
Thymidylate synthase 0101
Bloom syndrome protein isoform 11001
cellular tumor antigen p53 isoform a1001
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
vitamin D3 receptor isoform VDRA3003
transcriptional regulator ERG isoform 31001
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
flap endonuclease 11001
snurportin-11001
nuclear factor erythroid 2-related factor 2 isoform 13003
DNA polymerase eta isoform 11001
DNA polymerase kappa isoform 11001
survival motor neuron protein isoform d2002
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 11001
histone acetyltransferase KAT2A isoform 11001
caspase-1 isoform alpha precursor1001
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20011
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Spike glycoprotein1001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 432002
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80001
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
ATPase family AAA domain-containing protein 52002
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
Chain A, Beta-lactamase1001
pregnane X receptor1001
SMAD family member 21001
SMAD family member 31001
GLI family zinc finger 32002
nonstructural protein 11001
pregnane X nuclear receptor2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
aryl hydrocarbon receptor1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
heat shock protein HSP 90-alpha isoform 20001
nuclear receptor ROR-gamma isoform 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Histamine H2 receptor1001
Guanine nucleotide-binding protein G1001
heat shock protein 90, putative0001
Luciferase1001
acetylcholinesterase1001
hypoxia-inducible factor 1 alpha subunit1001
GALC protein1001
regulator of G-protein signaling 41001
cytochrome P450 2D61001
thyroid stimulating hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
hemoglobin subunit beta1001
heat shock protein beta-11001
serine/threonine-protein kinase PLK11001
cytochrome P450 3A4 isoform 11001
Gamma-aminobutyric acid receptor subunit pi1001
Cytochrome P450 2B10101
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Cytochrome P450 2B60101
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
GABA theta subunit1001
Gamma-aminobutyric acid receptor subunit epsilon1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]