Page last updated: 2024-09-27

Neurobehavioral Manifestations

Signs and symptoms of higher cortical dysfunction caused by organic conditions. These include certain behavioral alterations and impairments of skills involved in the acquisition, processing, and utilization of knowledge or information.

Synonyms(1)

Synonym
Neurobehavioral Manifestations

Research

Studies (31)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's22 (70.97)12.5806
2000's9 (29.03)18.1394
2010's0 (0.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
ammonium hydroxide0low20
formic acid0low10
glycine0low10
methanol0low10
toluene0low10
urea0low20
3-nitropropionic acid0low10
theophylline0low10
ifosfamide0low10
2-propanol0low10
methylphenidate0medium11
phenobarbital0medium11
pirenzepine0low10
risperidone0low10
corticosterone0low10
dehydroepiandrosterone0low10
physostigmine0low10
methylene blue0low10
medroxyprogesterone acetate0medium11
methyl formate0low10
methyl tert-butyl ether0low10
xanomeline0medium11
physostigmine heptyl0low10
lysophosphatidylcholines0low10
aluminum0low10
naltrexone0low10
scopolamine hydrobromide0medium11
phosphatidylcholines0low10
quetiapine fumarate0low10
clozapine0low10
olanzapine0low10

Protein Targets (471)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Cruzipain2002
regulator of G-protein signaling 42002
Platelet-activating factor receptor0202
Inositol monophosphatase 16006
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma130013
GLI family zinc finger 3110011
AR protein140014
aldehyde dehydrogenase 1 family, member A16006
retinoic acid nuclear receptor alpha variant 1120012
retinoid X nuclear receptor alpha100010
estrogen nuclear receptor alpha120012
peroxisome proliferator-activated receptor delta7007
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
activating transcription factor 62002
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x5005
thyroid hormone receptor beta isoform a4004
heat shock protein beta-16006
nuclear factor erythroid 2-related factor 2 isoform 1120012
lamin isoform A-delta10100010
Voltage-dependent calcium channel gamma-2 subunit6006
Glutamate receptor 26006
acetylcholinesterase5005
thioredoxin reductase6006
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
progesterone receptor7007
glucocorticoid receptor [Homo sapiens]100010
estrogen-related nuclear receptor alpha100010
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
euchromatic histone-lysine N-methyltransferase 27007
aryl hydrocarbon receptor5005
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
Bloom syndrome protein isoform 14004
hemoglobin subunit beta1001
chromobox protein homolog 17007
DNA polymerase iota isoform a (long)5005
geminin8008
muscarinic acetylcholine receptor M14004
Cellular tumor antigen p534004
Delta-aminolevulinic acid dehydratase0101
Isocitrate lyase 10101
Isocitrate lyase0101
TAR DNA-binding protein 434004
Isocitrate lyase0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, JmjC domain-containing histone demethylation protein 3A3003
5-hydroxytryptamine receptor 3E0303
Luciferase2002
ATAD5 protein, partial4004
Fumarate hydratase2002
NFKB1 protein, partial2002
GLS protein4004
TDP1 protein9009
Microtubule-associated protein tau2002
caspase 7, apoptosis-related cysteine protease3003
thyroid stimulating hormone receptor4004
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 35005
cytochrome P450 family 3 subfamily A polypeptide 44004
EWS/FLI fusion protein4004
G4004
cytochrome P450 2D66006
polyprotein2002
Beta-1 adrenergic receptor 0101
glucocerebrosidase1001
bromodomain adjacent to zinc finger domain 2B3003
caspase-33003
IDH16006
Adenylate cyclase type 1 0101
cytochrome P450 2D6 isoform 13003
peripheral myelin protein 22 isoform 12002
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor1001
D(1A) dopamine receptor2002
potassium voltage-gated channel subfamily H member 2 isoform d3003
thyroid hormone receptor beta isoform 29009
DNA polymerase beta2002
mitogen-activated protein kinase 14004
atrial natriuretic peptide receptor 2 precursor1001
nuclear receptor ROR-gamma isoform 11001
short transient receptor potential channel 6 isoform 10011
peripheral myelin protein 225005
survival motor neuron protein isoform d5005
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 82002
transient receptor potential cation channel subfamily V member 11001
lethal factor (plasmid)4004
Gamma-aminobutyric acid receptor subunit pi3104
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Bile salt export pump0202
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 40606
5-hydroxytryptamine receptor 3B0303
Bile salt export pump011011
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 4004
Albumin0022
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M209211
Muscarinic acetylcholine receptor M4011213
ATP-dependent translocase ABCB10003
Muscarinic acetylcholine receptor M10606
Muscarinic acetylcholine receptor M30505
Muscarinic acetylcholine receptor M40505
Cytochrome P450 3A40405
5-hydroxytryptamine receptor 1A0538
5-hydroxytryptamine receptor 2C0606
Muscarinic acetylcholine receptor M50505
Muscarinic acetylcholine receptor M509110
Alpha-2A adrenergic receptor0606
Calmodulin-10101
Beta-2 adrenergic receptor0202
Cytochrome P450 2D60305
Muscarinic acetylcholine receptor M20718
Muscarinic acetylcholine receptor M1010415
Cytochrome P450 2C9 0102
Angiotensin-converting enzyme0505
D(2) dopamine receptor0609
5-hydroxytryptamine receptor 2A0606
Gamma-aminobutyric acid receptor subunit beta-13104
Alpha-1B adrenergic receptor0617
Alpha-2B adrenergic receptor0606
Beta-1 adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit delta3104
Gamma-aminobutyric acid receptor subunit gamma-23104
Alpha-2C adrenergic receptor0606
D0404
D(3) dopamine receptor0505
5-hydroxytryptamine receptor 1A0606
Alpha-2B adrenergic receptor0415
Gamma-aminobutyric acid receptor subunit alpha-53104
Gamma-aminobutyric acid receptor subunit alpha-33104
D(2) dopamine receptor0202
Muscarinic acetylcholine receptor M3010212
Endothelin receptor type B0101
D(1A) dopamine receptor0607
D(4) dopamine receptor0507
D(1B) dopamine receptor0102
Adenylate cyclase type 30101
Alpha-2C adrenergic receptor0415
UDP-glucuronosyltransferase 1A40002
Alpha-2A adrenergic receptor0415
Gamma-aminobutyric acid receptor subunit gamma-13104
Gamma-aminobutyric acid receptor subunit alpha-23104
Alpha-1D adrenergic receptor0617
Sodium-dependent noradrenaline transporter 0516
Sodium-dependent dopamine transporter0404
5-hydroxytryptamine receptor 3A0101
Endothelin receptor type B0101
Histamine H2 receptor0606
Adenosine receptor A10405
Alpha-1D adrenergic receptor0606
D(1B) dopamine receptor0202
Beta-3 adrenergic receptor0101
Adenylate cyclase type 20101
Adenylate cyclase type 40101
5-hydroxytryptamine receptor 2A0608
5-hydroxytryptamine receptor 2C0617
Gamma-aminobutyric acid receptor subunit alpha-43104
Gamma-aminobutyric acid receptor subunit gamma-33104
5-hydroxytryptamine receptor 1B0505
5-hydroxytryptamine receptor 1D0202
Gamma-aminobutyric acid receptor subunit alpha-63104
D(4) dopamine receptor0303
5-hydroxytryptamine receptor 1F0202
5-hydroxytryptamine receptor 2B0617
Histamine H1 receptor0303
Histamine H1 receptor0202
Sodium-dependent serotonin transporter0707
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0202
Cytochrome P450 2C190001
5-hydroxytryptamine receptor 2C 0202
5-hydroxytryptamine receptor 70303
Alpha-1A adrenergic receptor0404
5-hydroxytryptamine receptor 2A0202
Histamine H1 receptor06311
Alpha-1B adrenergic receptor0303
D(3) dopamine receptor0608
5-hydroxytryptamine receptor 3A0101
Adenylate cyclase type 80101
5-hydroxytryptamine receptor 2B0617
Alpha-1A adrenergic receptor0617
5-hydroxytryptamine receptor 3A0303
Histamine H2 receptor1001
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 60506
Cytochrome P450 2J20102
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0303
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
Spike glycoprotein5005
D(2) dopamine receptor0202
D(2) dopamine receptor0606
Calmodulin 0011
Gamma-aminobutyric acid receptor subunit alpha-13104
Gamma-aminobutyric acid receptor subunit beta-33104
Gamma-aminobutyric acid receptor subunit beta-23104
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Sodium-dependent dopamine transporter 0303
5-hydroxytryptamine receptor 2B0202
Adenylate cyclase type 60101
Adenylate cyclase type 50101
Potassium voltage-gated channel subfamily H member 20707
5-hydroxytryptamine receptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Transporter0303
Cholecystokinin receptor type A0101
5-hydroxytryptamine receptor 1A0202
Nuclear receptor subfamily 3 group C member 3 0505
5-hydroxytryptamine receptor 3D0303
Adenylyl cyclase 7 0101
5-hydroxytryptamine receptor 3C0303
GABA theta subunit3104
Inositol hexakisphosphate kinase 14004
Canalicular multispecific organic anion transporter 10606
D0202
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Sigma non-opioid intracellular receptor 10202
Gamma-aminobutyric acid receptor subunit epsilon3104
Histamine H4 receptor0112
5-hydroxytryptamine receptor 3B0101
Sigma non-opioid intracellular receptor 10101
Transporter0303
Histamine H3 receptor0202
cytochrome P450 2C9, partial4004
pregnane X receptor2002
GALC protein3003
Thrombopoietin1001
nonstructural protein 13003
farnesoid X nuclear receptor5005
pregnane X nuclear receptor8008
thyroid stimulating hormone receptor5005
nuclear factor erythroid 2-related factor 2 isoform 23003
serine/threonine-protein kinase mTOR isoform 11001
Solute carrier family 22 member 20202
Solute carrier family 22 member 1 0303
Solute carrier family 22 member 30101
Solute carrier family 22 member 30101
Sex hormone-binding globulin0033
Corticosteroid-binding globulin0202
Mineralocorticoid receptor 0112
Androgen receptor0303
C-8 sterol isomerase0101
Solute carrier organic anion transporter family member 1A10101
Nuclear receptor ROR-gamma3003
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Solute carrier family 22 member 10202
Solute carrier family 22 member 20202
SMAD family member 23003
SMAD family member 33003
peroxisome proliferator activated receptor gamma3003
Beta-glucuronidase0101
Beta-glucuronidase0101
Glucose-6-phosphate 1-dehydrogenase0303
Alpha-synuclein3003
G-protein coupled bile acid receptor 10011
Glucose-6-phosphate 1-dehydrogenase 0101
NPC1-like intracellular cholesterol transporter 10011
Glycine receptor subunit alpha-10022
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor ionotropic, NMDA 1 0213
Sodium- and chloride-dependent glycine transporter 10101
Glutamate receptor ionotropic, NMDA 2A 0213
Glutamate receptor ionotropic, NMDA 2B0213
Glutamate receptor ionotropic, NMDA 2C0213
Large neutral amino acids transporter small subunit 10101
Glutamate receptor ionotropic, NMDA 2D0213
Proton-coupled amino acid transporter 10101
Glutamate receptor ionotropic, NMDA 3B0213
Serine racemase0101
Olfactory receptor 51E20022
Glutamate receptor ionotropic, NMDA 3A0213
Sodium- and chloride-dependent glycine transporter 20101
Chain A, Beta-lactamase2002
Serum paraoxonase/arylesterase 10101
interleukin 81001
PINK11001
Parkin1001
nuclear receptor subfamily 1, group I, member 21001
transcriptional regulator ERG isoform 33003
neuropeptide S receptor isoform A2002
Estrogen receptor0112
Glucocorticoid receptor0213
Progesterone receptor0213
Glycine receptor subunit alpha-10202
Androgen receptor0224
Androgen receptor0011
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Aldo-keto reductase family 1 member C30101
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G3003
Aldo-keto reductase family 1 member C10101
Estrogen receptor beta0112
Chain E, Fibrin beta chain0101
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain1001
T cell receptor, partial1001
luteinizing hormone receptor1001
glp-1 receptor, partial1001
integrase, partial0101
chaperonin-containing TCP-1 beta subunit homolog1001
lens epithelium-derived growth factor p750101
phosphopantetheinyl transferase2002
Caspase 6, apoptosis-related cysteine peptidase0001
PPM1D protein1001
TSHR protein1001
Apoptotic peptidase activating factor 10101
thioredoxin glutathione reductase1001
Smad32002
hypothetical protein, conserved1001
isocitrate dehydrogenase 1, partial1001
luciferase1001
serine-protein kinase ATM isoform a1001
neutrophil cytosol factor 10101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
caspase-9 isoform alpha precursor0101
histone deacetylase 9 isoform 31001
huntingtin isoform 21001
pyruvate kinase PKM isoform a1001
flap endonuclease 11001
caspase-3 isoform a preproprotein0101
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Vpr1001
muscleblind-like protein 1 isoform 11001
replicative DNA helicase0001
recombinase A0011
POsterior Segregation0011
DNA repair protein RAD52 homolog isoform a0001
Glutathione reductase0101
Glutathione reductase, mitochondrial0102
Glycoprotein hormones alpha chain1001
Albumin0001
Amyloid-beta precursor protein0202
Dihydrolipoyl dehydrogenase, mitochondrial0102
Microtubule-associated protein tau0112
Amine oxidase [flavin-containing] A0101
Cruzipain0101
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
Zinc finger protein mex-50011
phosphoglycerate kinase1001
ATP-dependent phosphofructokinase3003
Histidine decarboxylase0011
UDP-glucuronosyltransferase 1A1 0001
Delta-type opioid receptor0315
Delta-type opioid receptor0213
Kappa-type opioid receptor0213
Mu-type opioid receptor0213
Kappa-type opioid receptor0213
Mu-type opioid receptor0226
Delta-type opioid receptor0226
Kappa-type opioid receptor0203
Kappa-type opioid receptor0216
Nociceptin receptor0101
Mu-type opioid receptor0214
Mu-type opioid receptor0214
UDP-glucuronosyltransferase 1A80001
lysosomal alpha-glucosidase preproprotein1001
vitamin D3 receptor isoform VDRA1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
FAD-linked sulfhydryl oxidase ALR0001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Disintegrin and metalloproteinase domain-containing protein 172002
Sigma non-opioid intracellular receptor 10202
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
arylsulfatase A2002
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
glucokinase regulatory protein1001
histone acetyltransferase KAT2A isoform 12002
Acetylcholinesterase0203
Acetylcholinesterase0101
Cholinesterase0404
Acetylcholinesterase0202
Acetylcholinesterase0405
Acetylcholinesterase 0101
Acetylcholinesterase0101
Acetylcholinesterase0101
Cholinesterase0203
Cholinesterase0101
Acyl-CoA:cholesterol acyltransferase 0101
Carboxylic ester hydrolase 0101
Carboxylic ester hydrolase 0101
dopamine D1 receptor1001
Muscarinic acetylcholine receptor M10213
Muscarinic acetylcholine receptor DM10101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor0202
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M30112
Muscarinic acetylcholine receptor M20101
Sodium channel protein type 5 subunit alpha0101
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Chain A, Pyridoxal kinase0101
Chain A, Pyridoxal Kinase0101
USP1 protein, partial1001
Phosphodiesterase 0202
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Potassium channel subfamily K member 20011
Renin0101
Alkaline phosphatase, tissue-nonspecific isozyme0202
Intestinal-type alkaline phosphatase0101
Replicase polyprotein 1ab0101
Adenosine receptor A30101
Replicase polyprotein 1ab0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Thyroid hormone receptor beta0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Adenosine receptor A10202
Adenosine receptor A30101
Adenosine receptor A2a0225
Adenosine receptor A2b0102
Adenosine receptor A2b0102
Adenosine receptor A10215
Adenosine receptor A2a0103
Vasopressin V2 receptor0001
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
Adenosine receptor A10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Adenylate cyclase type 10001
Chitotriosidase-10101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Adenosine receptor A2b0001
Palmitoleoyl-protein carboxylesterase NOTUM0011
Endochitinase B10101
Phospholipase A-2-activating protein0101
polyunsaturated fatty acid lipoxygenase ALOX121001
Endolysin0011
Rap guanine nucleotide exchange factor 31001
Urease subunit alpha0101
Urease subunit beta0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]