Conditions > Neuralgia, Pudendal
Page last updated: 2024-09-27

Neuralgia, Pudendal

Pain associated with a damaged PUDENDAL NERVE. Clinical features may include positional pain with sitting in the perineal and genital areas, sexual dysfunction and FECAL INCONTINENCE and URINARY INCONTINENCE.

Synonyms(6)

Synonym
Neuralgia, Pudendal
Pudendal Nerve Entrapment Syndrome
Pudendal Nerve Entrapment
Pudendal Neuralgia
Pudendal Neuropathy
Pudendal Canal Entrapment Syndrome

Research Excerpts

Overview

ExcerptReference
"Pudendal neuropathy is a tunnel syndrome characterized by pelvic pain and may include bowel, bladder, or sexual dysfunction or a combination of these."( Antolak, C; Antolak, S; Lendway, L, 2016)

Treatment

ExcerptReference
"Patients with a diagnosis of pudendal neuropathy are treated with PNPIs."( Antolak, C; Antolak, S; Lendway, L, 2016)
"When treating patients with cancerous pudendal neuralgia with OxyContin and Pregabalin, the addition of celecoxib has a significant effect, which can effectively improve the patient's pain, improve their quality of life to a certain extent, and reduce the consumption of OxyContin."( Fang, Y; Hou, J; Jiang, X; Jin, NY; Li, X; Li, XN; Lin, Y; Liu, N; Lu, X; Mi, X; Ni, Z; Yang, Y; Yu, Y; Zhou, Y, 2021)

Research

Studies (11)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's6 (54.55)28.8240
2020's5 (45.45)9.53
DrugIndicatedRelationship StrengthStudiesTrials
amitriptyline0low10
bupivacaine0low30
lidocaine0medium11
midazolam0low10
estriol0low10
pregnenolone0low10
triamcinolone0low10
finasteride0low10
tadalafil0low10
pregabalin0medium11

Protein Targets (323)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
thioredoxin reductase3003
USP1 protein, partial2002
NFKB1 protein, partial2002
GLS protein2002
cytochrome P450 family 3 subfamily A polypeptide 44004
cytochrome P450 2D63003
arylsulfatase A2002
cytochrome P450 2D6 isoform 11001
D(1A) dopamine receptor1001
chromobox protein homolog 13003
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 15005
muscarinic acetylcholine receptor M12002
Solute carrier family 22 member 1 0303
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40202
Bile salt export pump0909
Albumin0011
High affinity nerve growth factor receptor0123
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
5-hydroxytryptamine receptor 2C0101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10202
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
5-hydroxytryptamine receptor 2A0101
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
5-hydroxytryptamine receptor 1A0202
Muscarinic acetylcholine receptor M30202
D(1A) dopamine receptor0202
D(1B) dopamine receptor0101
UDP-glucuronosyltransferase 1A40203
Sodium-dependent noradrenaline transporter 0404
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 60101
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0404
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Histamine H1 receptor0202
D(3) dopamine receptor0202
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0202
UDP-glucuronosyltransferase 1A30002
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0101
Histamine H2 receptor1103
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
5-hydroxytryptamine receptor 70101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Sodium-dependent dopamine transporter 0202
Potassium voltage-gated channel subfamily H member 20404
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0303
Sodium channel protein type 9 subunit alpha0202
Sigma non-opioid intracellular receptor 10011
5-hydroxytryptamine receptor 4 0101
Nuclear receptor subfamily 3 group C member 3 0202
Canalicular multispecific organic anion transporter 10606
Sodium channel protein type 2 subunit alpha0101
Ataxin-23003
Sigma non-opioid intracellular receptor 10202
5-hydroxytryptamine receptor 3B0101
Sodium channel protein type 3 subunit alpha0202
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0101
Sodium channel protein type 10 subunit alpha0101
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20112
Potassium channel subfamily K member 90101
Aldo-keto reductase family 1 member B100101
UDP-glucuronosyltransferase 1A90102
Prostaglandin G/H synthase 1 0101
Transient receptor potential cation channel subfamily A member 10011
Dihydrofolate reductase0101
Cytochrome c oxidase subunit 20101
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Fatty acid-binding protein, liver0101
Transthyretin0013
Albumin0112
Prostaglandin G/H synthase 10101
Cytochrome P450 3A40202
Interleukin-80101
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
Cytochrome P450 2C9 0304
Fatty acid-binding protein, intestinal0101
Aldo-keto reductase family 1 member B10101
UDP-glucuronosyltransferase 2B70204
UDP-glucuronosyltransferase 1-60303
UDP-glucuronosyltransferase 1A1 0303
Prostaglandin G/H synthase 10101
Sodium- and chloride-dependent GABA transporter 10101
C-X-C chemokine receptor type 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 2 0101
UDP-glucuronosyltransferase 2B10 0202
Sodium- and chloride-dependent betaine transporter0101
Cytochrome P450 2J20202
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 90101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0101
Carbonic anhydrase 40101
Multidrug and toxin extrusion protein 10202
P2Y purinoceptor 120101
UDP-glucuronosyltransferase 1A70101
UDP-glucuronosyltransferase 1A100102
glp-1 receptor, partial3003
RAR-related orphan receptor gamma5005
Fumarate hydratase1001
TDP1 protein5005
GLI family zinc finger 35005
AR protein7007
Smad32002
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor5005
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha3003
estrogen-related nuclear receptor alpha4004
farnesoid X nuclear receptor2002
pregnane X nuclear receptor5005
estrogen nuclear receptor alpha8008
polyprotein1001
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
caspase-31001
IDH12002
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
thyroid hormone receptor beta isoform 24004
heat shock protein beta-12002
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 12002
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
geminin6006
Interferon beta4004
Cellular tumor antigen p532002
Alpha-synuclein1102
Spike glycoprotein2002
ATPase family AAA domain-containing protein 52002
Voltage-dependent calcium channel gamma-2 subunit2002
Estrogen receptor0202
Glucocorticoid receptor0404
Sex hormone-binding globulin0022
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0202
Polyunsaturated fatty acid lipoxygenase ALOX150101
Androgen receptor0202
Glutamate receptor 22002
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Solute carrier organic anion transporter family member 1A10101
Lanosterol 14-alpha demethylase0011
Olfactory receptor 51E20011
SMAD family member 22002
SMAD family member 32002
G2002
mitogen-activated protein kinase 13003
nuclear receptor ROR-gamma isoform 11001
HLA class I histocompatibility antigen, B alpha chain 2002
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 10101
3-oxo-5-alpha-steroid 4-dehydrogenase 10202
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0202
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
3-oxo-5-alpha-steroid 4-dehydrogenase 20202
Cytochrome P450 2C190101
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase0101
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, Beta-lactamase3003
Microtubule-associated protein tau1001
aldehyde dehydrogenase 1 family, member A11001
euchromatic histone-lysine N-methyltransferase 24004
flap endonuclease 11001
cytochrome P450 3A4 isoform 12002
lamin isoform A-delta102002
Gamma-aminobutyric acid receptor subunit pi2103
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Gamma-aminobutyric acid receptor subunit beta-12103
Gamma-aminobutyric acid receptor subunit delta2103
Gamma-aminobutyric acid receptor subunit gamma-22103
Gamma-aminobutyric acid receptor subunit alpha-52103
Gamma-aminobutyric acid receptor subunit alpha-32103
Potassium voltage-gated channel subfamily A member 50101
Gamma-aminobutyric acid receptor subunit gamma-12103
Gamma-aminobutyric acid receptor subunit alpha-22103
Gamma-aminobutyric acid receptor subunit alpha-42103
Gamma-aminobutyric acid receptor subunit gamma-32103
Gamma-aminobutyric acid receptor subunit alpha-62103
Gamma-aminobutyric acid receptor subunit alpha-12103
Gamma-aminobutyric acid receptor subunit beta-32103
Gamma-aminobutyric acid receptor subunit beta-22103
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
GABA theta subunit2103
Gamma-aminobutyric acid receptor subunit epsilon2103
peripheral myelin protein 221001
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10101
Translocator protein0101
ATP-dependent translocase ABCB10101
EWS/FLI fusion protein1001
Voltage-dependent calcium channel subunit alpha-2/delta-10102
Voltage-dependent calcium channel subunit alpha-2/delta-20101
hypoxia-inducible factor 1 alpha subunit1001
Glucose-6-phosphate 1-dehydrogenase0101
Guanine nucleotide-binding protein G1001
Lanosterol 14-alpha demethylase0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase0101
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase0101
acetylcholinesterase1001
Phosphodiesterase 0101
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta0101
cGMP-specific 3',5'-cyclic phosphodiesterase0112
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0213
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha0101
Cystic fibrosis transmembrane conductance regulator0011
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
Potassium voltage-gated channel subfamily E member 10101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha0101
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta0101
Acetylcholinesterase0101
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'0101
Potassium voltage-gated channel subfamily KQT member 10101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Synaptic vesicular amine transporter0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta0101
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 7B0101
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0101
Nuclear receptor subfamily 2 group E member 10011
Mu-type opioid receptor0112
Delta-type opioid receptor0101
Kappa-type opioid receptor0101
ATAD5 protein, partial1001
thioredoxin glutathione reductase1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
Bloom syndrome protein isoform 11001
peripheral myelin protein 22 isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 21001
procathepsin L isoform 1 preproprotein0101
muscleblind-like protein 1 isoform 11001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]