Neonatal Alloimmune Thrombocytopenia

A condition in newborns caused by immunity of the mother to PLATELET ALLOANTIGENS on the fetal platelets. The PLATELETS, coated with maternal ANTIBODIES, are destroyed and removed by the fetal MONONUCLEAR PHAGOCYTE SYSTEM. Affected infants may have INTRACRANIAL HEMORRHAGES.

Synonym
Neonatal Alloimmune Thrombocytopenia
Neonatal Thrombocytopenia
Thrombocytopenia, Neonatal Alloimmune

Excerpt	Reference
"Neonatal alloimmune thrombocytopenia is a rare (1/1000-5000 births) life-threatening disorder, caused by fetomaternal incompatibility for a fetal human platelet alloantigen inherited from the father, with production of maternal alloantibodies against fetal platelets, leading to severe thrombocytopenia and potential bleeding."	( Morais, S; Salvado, R; Sevivas, T; Silva, F; Taborda, A; Veiga, R, 2011)
"Fetal and neonatal alloimmune thrombocytopenia is an alloimmune disorder resulting from platelet opsonization by maternal antibodies that destroy fetal platelets."	( Gilman-Sachs, A; Kwak-Kim, J; Salazar Garcia, MD; Skariah, A; Sung, N; Tikoo, A; Wu, L, 2017)

Excerpt	Reference
"Fetal-neonatal alloimmune thrombocytopenia affects approximately 1 of 1000 live births, most of which are not severely thrombocytopenic."	( Berkowitz, RL; Bussel, JB; Ferd, P; Gabor, J; Jin, JC; Lakkaraja, M; Manotas, KC; McFarland, JG; Vinograd, CA; Wissert, M, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	3 (10.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	2 (6.67)	18.1394
2010's	22 (73.33)	28.8240
2020's	3 (10.00)	9.53

Drug	Relationship Strength	Studies	Trials
acetaminophen	low	1	0
chlorothiazide	low	3	0
hydrochlorothiazide	low	1	0
ibuprofen	low	1	0
methyclothiazide	low	1	0
prednisolone	low	1	0
prednisone	medium	7	2
galactose	low	1	0
edetic acid	low	2	0
leucine	low	1	0
methionine	low	1	0
asparagine	low	1	0
histidine	low	1	0
methylprednisolone	low	1	0
hydrazine	low	2	0
betamethasone	low	1	0
fucose	low	2	0
fibrinogen	low	3	0
arginyl-glycyl-aspartyl-serine	low	1	0
7-(4'-(2-nitroimidazole-1-yl)butyl)theophylline	low	1	0
amotosalen	low	1	0
n-acetylneuraminic acid	low	1	0
quinine	low	1	0
ganciclovir	low	1	0
amg531	low	2	0

Protein Targets (325)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	5	0	0	5
ATAD5 protein, partial	3	0	0	3
GLS protein	4	0	0	4
Microtubule-associated protein tau	1	0	0	1
Smad3	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
thyroid stimulating hormone receptor	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
progesterone receptor	7	0	0	7
EWS/FLI fusion protein	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
retinoid X nuclear receptor alpha	4	0	0	4
estrogen-related nuclear receptor alpha	9	0	0	9
estrogen nuclear receptor alpha	10	0	0	10
peroxisome proliferator activated receptor gamma	4	0	0	4
aryl hydrocarbon receptor	5	0	0	5
chromobox protein homolog 1	4	0	0	4
thyroid hormone receptor beta isoform 2	4	0	0	4
peripheral myelin protein 22	2	0	0	2
cytochrome P450 3A4 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	4	0	0	4
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	7
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	2	0	3
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Bile salt export pump	0	8	0	8
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	2	0	5
Carbonic anhydrase 2	0	3	0	6
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	0	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 3	0	2	0	3
Cytochrome P450 3A4	0	1	0	1
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2C9	0	5	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	4	0	0	4
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	4	0	0	4
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	4	0	0	4
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	2	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 6	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	4	0	0	4
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Prostaglandin G/H synthase 2	0	2	0	3
Carbonic anhydrase 7	0	2	0	3
Nuclear receptor ROR-gamma	2	0	0	2
Cytochrome P450 2J2	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-2	4	0	0	4
Carbonic anhydrase 9	0	2	0	3
GABA theta subunit	4	0	0	4
Canalicular multispecific organic anion transporter 1	0	7	0	7
Carbonic anhydrase 15	0	1	0	2
Carbonic anhydrase 13	0	2	0	3
Gamma-aminobutyric acid receptor subunit epsilon	4	0	0	4
Carbonic anhydrase 14	0	2	0	3
Carbonic anhydrase 5B, mitochondrial	0	2	0	3
toxin B	0	0	0	1
Luciferase	2	0	0	2
acetylcholinesterase	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
estrogen receptor 2 (ER beta)	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
farnesoid X nuclear receptor	3	0	0	3
G	3	0	0	3
cytochrome P450 2D6	2	0	0	2
peroxisome proliferator-activated receptor delta	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	2	0	0	2
heat shock protein beta-1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	8	0	0	8
Solute carrier family 22 member 1	0	3	0	4
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Thrombopoietin receptor	0	0	1	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Inositol hexakisphosphate kinase 1	3	0	0	3
Solute carrier organic anion transporter family member 1B3	0	1	0	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
cytochrome P450 2C9, partial	3	0	0	3
Integrin beta-3	0	1	0	1
Integrin beta-1	0	1	0	1
Integrin alpha-IIb	0	1	0	1
Integrin alpha-5	0	1	0	1
Integrin alpha-2	0	1	0	1
Integrin alpha-3	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	0	1	0	1
Integrin beta	0	1	0	1
Glycoprotein IIb	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Amino acid transporter	0	1	0	1
pregnane X receptor	2	0	0	2
GLI family zinc finger 3	6	0	0	6
AR protein	6	0	0	6
glucocorticoid receptor [Homo sapiens]	5	0	0	5
pregnane X nuclear receptor	4	0	0	4
IDH1	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
thyroid hormone receptor beta isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ORF73	0	0	2	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
Chain A, Beta-lactamase	1	0	0	1
USP1 protein, partial	3	0	0	3
NFKB1 protein, partial	3	0	0	3
regulator of G-protein signaling 4	1	0	0	1
nonstructural protein 1	3	0	0	3
arylsulfatase A	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	6	0	0	6
Bloom syndrome protein isoform 1	2	0	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
geminin	5	0	0	5
muscarinic acetylcholine receptor M1	1	0	0	1
lamin isoform A-delta10	4	0	0	4
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Cellular tumor antigen p53	4	0	0	4
Amyloid-beta precursor protein	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Histamine H2 receptor	2	0	0	2
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Fucose-binding lectin PA-IIL	0	1	0	1
CD209 antigen	0	2	0	2
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
DNA polymerase kappa isoform 1	2	0	0	2
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Thymidine kinase	0	1	0	1
endonuclease IV	1	0	0	1
thioredoxin reductase	1	0	0	1
ClpP	2	0	0	2
Fumarate hydratase	1	0	0	1
TDP1 protein	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
polyprotein	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
survival motor neuron protein isoform d	2	0	0	2
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	1	0	2
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
flap endonuclease 1	1	0	0	1
Plasma kallikrein	0	0	0	1
Histidine-binding periplasmic protein	0	0	1	1
Adenosine receptor A1	0	1	0	2
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Carbonic anhydrase 4	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Carbonic anhydrase	0	1	0	1
Hsf1 protein	0	0	1	1
Carbonic anhydrase	0	1	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
Albumin	0	2	2	4
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Spike glycoprotein	1	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
67.9K protein	1	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Albumin	0	1	0	1
Albumin	0	0	1	1
Cholinesterase	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Caspase-1	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	2
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
TAR DNA-binding protein 43	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	2
Phospholipase A-2-activating protein	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
GALC protein	1	0	0	1
PPM1D protein	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Androgen receptor	0	3	0	3
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	3
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Cytochrome P450 2D4	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Neonatal Alloimmune Thrombocytopenia

Synonyms(3)

Research Excerpts

Overview

Actions

Research

Studies (30)

Protein Targets (325)

Neonatal Alloimmune Thrombocytopenia

Synonyms(3)

Research Excerpts

Overview

Actions

Research

Studies (30)

Drugs Studied (30)

Protein Targets (325)