Margins of Excision

The edges of tissue removed in a surgery for assessment of the effectiveness of a surgical procedure in achieving the local control of a neoplasm and the adequacy of tumor removal. When the margin is negative or not involved by tumor (e.g., CANCER) it suggests all of the tumor has been removed by the surgery.

Synonym
Negative Surgical Margins
Surgical Margins
Margins of Excision
Resection Margin
Positive Surgical Margins
Tumor-Free Margins

Excerpt	Reference
"Positive resection margins are strongly associated with tumour rupture."	( Bjerkehagen, B; Boye, K; Hompland, I; Hølmebakk, T; Stoldt, S, 2019)
"Positive surgical margins are adverse prognostic factors for survival."	( Cheng, NC; Hsieh, JH; Huang, HF; Jyuhn-Hsiarn Lee, L; Kuan, CH; Lai, HS; Tai, HC; Tseng, TY; Yang, HW, 2021)
"Negative surgical margins are significant in improving patient outcomes."	( Cai, L; Deng, Z; Guo, L; He, S; Huang, H; Lei, J; Wang, Y; Wei, R; Xie, Y; Zhu, X, 2023)

Excerpt	Reference
"Positive surgical margins have been associated with worse outcomes in gastric cancer patients."	( Blaskowsky, LS; Enzinger, PZ; Hong, TS; Kwak, EL; Mamon, HJ; Mullen, JT; Ryan, DP; Schoenfeld, JD; Wo, JY, 2016)

Excerpt	Reference
"In case of close or positive resection margins after oncological resection in head and neck surgery, additional treatment is necessary."	( Karakullukçu, MB; Lopez-Yurda, M; Schreuder, WH; Tan, IB; van Doeveren, TEM; van Veen, RLP, 2018)
"The liver surface and resection margin were intraoperatively assessed by intraoperative ultrasonography and NIR fluorescence imaging, after intravenous administration of indocyanine green (0."	( Chi, C; Fang, C; He, K; He, P; Li, B; Su, S; Tian, J; Xia, X, 2019)
"Chemotherapy, nodal status and resection margin according to UICC R status are univariate factors for OS after PDAC."	( Obonyo, D; Stricker, I; Tannapfel, A; Uslar, VN; Weyhe, D, 2021)
"Positive resection margin frequently exists in breast-conserving treatment (BCT) of early-stage breast cancer, and insufficient therapeutic efficacy is common during radiotherapy (RT) in advanced breast cancer patients."	( Dang, YY; Gao, YY; Huang, WH; Li, Y; Liu, XL; Lou, KL; Tian, HN; Wang, PY; Yang, RQ; Zhang, GJ; Zhang, YQ, 2022)
"In this paper, we evaluated the role of surgical margins, radiotherapy, and chemotherapy in myoepithelial carcinoma of soft tissue and bone (MC-SB) treated at our Institute."	( Aiba, H; Ciani, G; Errani, C; Frega, G; Gambarotti, M; Ibrahim, T; Longhi, A; Maioli, M; Righi, A; Spinnato, P, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	158 (48.62)	28.8240
2020's	167 (51.38)	9.53

Drug	Relationship Strength	Studies	Trials
aminolevulinic acid	medium	19	1
acetic acid	low	1	0
carbamates	low	1	0
salicylic acid	low	14	0
formaldehyde	medium	10	1
glycerol	low	1	0
1-anilino-8-naphthalenesulfonate	low	1	0
albendazole	low	1	0
bupivacaine	medium	1	1
carmustine	low	2	0
chlorpyrifos	medium	3	1
carbonyl cyanide p-trifluoromethoxyphenylhydrazone	low	1	0
fentanyl	medium	1	1
fluorouracil	medium	23	4
guaifenesin	low	1	0
ethidium	low	1	0
ifosfamide	low	2	0
iohexol	low	1	0
iopromide	low	1	0
ketorolac	low	1	0
khellin	low	1	0
losartan	low	1	0
mitotane	low	1	0
oxonic acid	medium	2	2
propofol	medium	1	1
propranolol	low	1	0
protoporphyrin ix	low	4	0
sevoflurane	medium	1	1
tegafur	medium	2	2
temozolomide	low	3	0
mitomycin	medium	3	1
corticosterone	low	1	0
benzimidazole	low	1	0
serine	low	1	0
edetic acid	low	2	0
methylene blue	low	4	0
tryptophan	low	1	0
isoprene	low	1	0
tolonium chloride	low	3	0
quinazolines	low	1	0
perfluorobutane	low	1	0
hematoxylin	low	6	0
eosine yellowish-(ys)	low	5	0
gentian violet	low	2	0
c.i. 42510	low	1	0
norflurane	medium	1	1
deoxycytidine	medium	9	1
fluorescein	low	3	0
sulfur hexafluoride	low	2	0
neodymium	low	1	0
thulium	low	1	0
titanium	low	3	0
gadolinium	low	4	0
camptothecin	medium	5	1
iodine	low	1	0
tridemorph	low	1	0
paclitaxel	medium	2	1
epirubicin	low	2	0
propiconazole	low	2	0
finasteride	low	1	0
imiquimod	medium	8	1
gemcitabine	medium	10	1
temoporfin	low	1	0
irinotecan	medium	7	1
capecitabine	medium	7	1
acridine orange	medium	4	1
glucose, (beta-d)-isomer	low	1	0
delphinidin	low	1	0
fluorodeoxyglucose f18	medium	6	1
zoledronic acid	low	1	0
fibrinogen	low	1	0
arginyl-glycyl-aspartic acid	low	1	0
sulforhodamine 101	low	1	0
imatinib mesylate	low	7	0
methotrexate	low	1	0
n-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane	low	1	0
docetaxel anhydrous	low	1	0
moxifloxacin	medium	1	1
povidone-iodine	low	1	0
inositol 3-phosphate	low	1	0
bromochloroacetic acid	low	5	0
flavin-adenine dinucleotide	low	1	0
indigo carmine	medium	8	2
tamoxifen	low	4	0
osteoprotegerin	low	1	0
bilirubin	low	2	0
phenylephrine hydrochloride	low	5	0
andrographolide	low	1	0
palbociclib	low	1	0
bismuth	low	1	0
silicon	low	1	0
thallium-201	low	1	0
carbocyanines	low	1	0
radium	low	1	0
1,3'-diethyl-4,2'-quinolylthiacyanine iodide	low	1	0
gadolinium dtpa	low	3	0
dutasteride	low	1	0
abiraterone acetate	low	1	0
mart-1 antigen	low	9	0
aluminum oxide	low	1	0
odanacatib	medium	1	1
binimetinib	low	1	0
pirarubicin	low	1	0
trametinib	low	1	0
indocyanine green	medium	62	7
nad	low	2	0
mdv 3100	low	1	0
glucagon	low	1	0
technetium tc 99m sestamibi	low	1	0
gdc 0449	medium	2	1
incb-018424	low	1	0
plx4032	low	1	0
dabrafenib	low	1	0
encorafenib	low	1	0
s 1 (combination)	medium	2	2
cyclin d1	low	1	0
gadoxetic acid disodium	low	1	0
peoniflorin	low	1	0
cyclosporine	low	1	0
levoleucovorin	medium	12	2
dacarbazine	low	1	0
aprepitant	low	1	0
blz-100	medium	1	1
chlorotoxin	medium	1	1
trypsinogen	low	1	0
forssman glycolipid	low	1	0
pyrimidinones	low	1	0

Protein Targets (1,378)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
Chain A, RNA-directed RNA polymerase NS5	0	3	0	3
acid sphingomyelinase	2	0	0	2
thioredoxin reductase	16	0	0	16
USP1 protein, partial	12	0	0	12
TDP1 protein	35	0	0	35
vitamin D3 receptor isoform VDRA	11	0	0	11
importin subunit beta-1 isoform 1	5	0	0	5
flap endonuclease 1	9	0	0	9
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	5	0	0	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
DNA polymerase eta isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	12	0	0	12
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
urokinase plasminogen activator surface receptor precursor	6	0	0	6
geminin	25	0	0	25
DNA polymerase kappa isoform 1	12	0	0	12
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	1	2
Beta-lactamase	0	1	0	1
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	2	2	4
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	3	0	3
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	3	9	12
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	1	2
Guanine nucleotide-binding protein G	3	0	0	3
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	7	8
Mitogen-activated protein kinase 14	0	2	7	9
estrogen nuclear receptor alpha	41	0	0	41
thyroid hormone receptor beta isoform 2	27	0	0	27
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cytochrome P450 3A4	0	9	2	13
Androgen receptor	0	3	3	6
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	1	8	9
Tyrosine-protein kinase Fyn	0	5	8	13
Fibrinogen C domain-containing protein 1	0	1	0	1
Telomerase reverse transcriptase	0	2	0	2
Amyloid-beta precursor protein	1	3	0	4
Reverse transcriptase/RNaseH	0	2	1	3
Chain A, Beta-lactamase	7	0	0	7
Luciferase	13	0	0	13
glp-1 receptor, partial	8	0	0	8
hypoxia-inducible factor 1 alpha subunit	14	0	0	14
RAR-related orphan receptor gamma	21	0	0	21
ATAD5 protein, partial	7	0	0	7
Fumarate hydratase	15	0	0	15
GLI family zinc finger 3	27	0	0	27
AR protein	34	0	0	34
caspase 7, apoptosis-related cysteine protease	9	0	0	9
nuclear receptor subfamily 1, group I, member 3	22	0	0	22
progesterone receptor	22	0	0	22
glucocorticoid receptor [Homo sapiens]	27	0	0	27
retinoic acid nuclear receptor alpha variant 1	27	0	0	27
retinoid X nuclear receptor alpha	24	0	0	24
estrogen-related nuclear receptor alpha	30	0	0	30
farnesoid X nuclear receptor	21	0	0	21
pregnane X nuclear receptor	22	0	0	22
polyprotein	15	0	0	15
67.9K protein	13	0	0	13
peroxisome proliferator activated receptor gamma	24	0	0	24
vitamin D (1,25- dihydroxyvitamin D3) receptor	15	0	0	15
caspase-3	9	0	0	9
IDH1	9	0	0	9
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
aryl hydrocarbon receptor	16	0	0	16
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	20	0	0	20
v-jun sarcoma virus 17 oncogene homolog (avian)	14	0	0	14
nuclear receptor subfamily 1, group I, member 2	8	0	0	8
Histone H2A.x	16	0	0	16
cellular tumor antigen p53 isoform a	8	0	0	8
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
chromobox protein homolog 1	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
transcriptional regulator ERG isoform 3	3	0	0	3
histone deacetylase 9 isoform 3	7	0	0	7
heat shock protein beta-1	12	0	0	12
mitogen-activated protein kinase 1	10	0	0	10
Vif	0	1	0	2
peripheral myelin protein 22	10	0	0	10
survival motor neuron protein isoform d	12	0	0	12
muscleblind-like protein 1 isoform 1	7	0	0	7
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	1	0	2
lamin isoform A-delta10	18	0	0	18
neuropeptide S receptor isoform A	3	0	0	3
ATP-binding cassette sub-family C member 3	0	18	0	18
Multidrug resistance-associated protein 4	0	18	0	19
Voltage-dependent calcium channel gamma-2 subunit	17	0	0	17
Bile salt export pump	0	23	0	23
Interferon beta	24	0	0	24
Cellular tumor antigen p53	28	0	0	28
Integrin beta-3	8	2	0	10
Integrin alpha-IIb	8	1	0	9
Methionine aminopeptidase	0	1	0	1
Glutamate receptor 2	18	0	0	18
Fatty-acid amide hydrolase 1	1	2	0	3
Inositol monophosphatase 1	8	0	0	8
Canalicular multispecific organic anion transporter 1	0	18	0	18
ATPase family AAA domain-containing protein 5	13	0	0	13
Ataxin-2	15	0	0	15
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	1	1	0	2
Solute carrier family 15 member 1	0	1	0	1
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
PPM1D protein	12	0	0	12
cytochrome P450 family 3 subfamily A polypeptide 4	22	0	0	22
G	16	0	0	16
HLA class I histocompatibility antigen, B alpha chain	16	0	0	16
Replicase polyprotein 1ab	0	3	2	5
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Signal transducer and activator of transcription 3	0	0	1	1
Hexokinase-2	0	1	0	1
Inositol hexakisphosphate kinase 1	16	0	0	16
Bile acid receptor	0	1	0	1
cytochrome P450 2C9, partial	16	0	0	16
GALC protein	5	0	0	5
estrogen receptor 2 (ER beta)	15	0	0	15
cytochrome P450 2D6	11	0	0	11
peroxisome proliferator-activated receptor delta	17	0	0	17
thyroid stimulating hormone receptor	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 1	23	0	0	23
Substance-P receptor	0	4	1	5
Neuromedin-K receptor	0	1	0	1
Spike glycoprotein	20	0	2	22
cGMP-dependent protein kinase 1	0	0	8	8
Substance-P receptor	0	1	0	1
Integrin beta-1	0	1	0	1
Integrin alpha-V	0	2	0	2
Integrin alpha-5	0	1	0	1
Integrin beta-5	0	1	0	1
Chain A, GTPase KRas, isoform 2B	0	0	1	1
Chain A, GTPase KRas, isoform 2B	0	0	1	1
Membrane primary amine oxidase	0	1	0	1
Cytochrome P450 2B1	0	1	0	2
Cytochrome P450 1A1	0	1	0	2
GTPase KRas	0	2	1	3
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Glutaminyl-peptide cyclotransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Membrane primary amine oxidase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	11	0	0	11
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	12	0	0	12
Chain A, Cruzipain	6	0	0	6
phosphopantetheinyl transferase	12	0	0	12
Microtubule-associated protein tau	15	0	0	16
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	6	0	8
Solute carrier organic anion transporter family member 1B1	0	6	0	7
Bone morphogenetic protein receptor type-1B	0	0	7	7
Membrane-associated progesterone receptor component 1	0	0	6	6
Cell division cycle 7-related protein kinase	0	0	6	6
Serine/threonine-protein kinase PLK4	0	0	7	7
ATP-dependent RNA helicase DDX3X	0	0	7	7
Pyridoxal kinase	0	0	7	7
Citron Rho-interacting kinase	0	0	7	7
Serine/threonine-protein kinase Chk1	0	0	8	8
Aurora kinase A	0	0	7	7
Cyclin-G-associated kinase	0	1	7	8
Ephrin type-B receptor 6	0	0	7	7
Peroxisomal acyl-coenzyme A oxidase 3	0	0	7	7
Receptor-interacting serine/threonine-protein kinase 2	0	1	7	8
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	7	7
Dynamin-like 120 kDa protein, mitochondrial	0	0	7	7
Eukaryotic translation initiation factor 5B	0	0	5	5
Rho-associated protein kinase 2	0	0	7	7
Serine/threonine-protein kinase ULK1	0	0	7	7
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	7	7
Ribosomal protein S6 kinase alpha-5	0	0	7	7
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	7	7
Ribosomal protein S6 kinase alpha-4	0	0	7	7
Serine/threonine-protein kinase 16	0	0	7	7
Serine/threonine-protein kinase 10	0	0	7	7
Serine/threonine-protein kinase D3	0	1	7	8
Structural maintenance of chromosomes protein 2	0	0	7	7
Mitogen-activated protein kinase kinase kinase 6	0	0	7	7
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	7	7
Serine/threonine-protein kinase LATS1	0	0	7	7
Serine/threonine-protein kinase PAK 4	0	0	7	7
Tyrosine-protein kinase ABL1	0	4	9	13
Epidermal growth factor receptor	0	7	7	14
High affinity nerve growth factor receptor	0	0	7	7
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	7	7
ADP/ATP translocase 2	0	0	7	7
Protein kinase C beta type	0	1	7	8
Insulin receptor	0	0	7	7
Cyclin-dependent kinase 1	0	2	7	9
Glycogen phosphorylase, liver form	0	0	7	7
Tyrosine-protein kinase Fes/Fps	0	0	7	7
Adenine phosphoribosyltransferase	0	0	5	5
Tyrosine-protein kinase Yes	0	0	7	7
Tyrosine-protein kinase Lyn	0	0	7	7
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	7	7
Insulin-like growth factor 1 receptor	0	0	7	7
Signal recognition particle receptor subunit alpha	0	0	5	5
Cytochrome c1, heme protein, mitochondrial	0	0	7	7
Hepatocyte growth factor receptor	0	0	7	7
Tyrosine-protein kinase HCK	0	0	7	7
Platelet-derived growth factor receptor beta	0	1	7	8
Tyrosine-protein kinase Fgr	0	0	5	5
Serine/threonine-protein kinase A-Raf	0	2	7	9
Glycogen phosphorylase, brain form	0	0	7	7
Breakpoint cluster region protein	0	0	8	8
Serine/threonine-protein kinase pim-1	0	0	7	7
Fibroblast growth factor receptor 1	0	2	7	9
DNA topoisomerase 2-alpha	0	1	6	8
Cyclin-dependent kinase 4	0	2	7	9
ADP/ATP translocase 3	0	0	7	7
Inosine-5'-monophosphate dehydrogenase 2	0	0	6	6
Proto-oncogene tyrosine-protein kinase Src	0	1	7	8
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	7	7
Serine/threonine-protein kinase B-raf	0	3	9	14
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	7	7
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	7	7
Tyrosine-protein kinase Fer	0	0	7	7
Protein kinase C alpha type	0	1	7	8
cAMP-dependent protein kinase catalytic subunit alpha	0	0	7	7
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	7	7
Casein kinase II subunit alpha'	0	0	7	7
Ras-related protein Rab-6A	0	0	6	6
Ephrin type-A receptor 1	0	0	6	6
Multifunctional protein ADE2	0	0	7	7
cAMP-dependent protein kinase catalytic subunit gamma	0	0	6	6
cAMP-dependent protein kinase catalytic subunit beta	0	0	7	7
Ferrochelatase, mitochondrial	0	0	8	8
Ribosomal protein S6 kinase beta-1	0	0	7	7
Tyrosine-protein kinase JAK1	0	2	8	10
Beta-adrenergic receptor kinase 1	0	0	7	7
Probable ATP-dependent RNA helicase DDX6	0	0	7	7
Mitogen-activated protein kinase 3	0	0	7	7
MAP/microtubule affinity-regulating kinase 3	0	0	7	7
Deoxycytidine kinase	0	0	7	9
Mitogen-activated protein kinase 1	0	0	7	7
Ephrin type-A receptor 2	0	0	7	7
Ephrin type-B receptor 2	0	0	7	7
Non-receptor tyrosine-protein kinase TYK2	0	2	8	10
UMP-CMP kinase	0	0	5	5
Phosphatidylethanolamine-binding protein 1	0	0	6	6
Wee1-like protein kinase	0	0	7	7
Heme oxygenase 2	0	0	7	7
S-adenosylmethionine synthase isoform type-2	0	0	7	7
DnaJ homolog subfamily A member 1	0	0	7	7
RAC-alpha serine/threonine-protein kinase	0	0	7	7
RAC-beta serine/threonine-protein kinase	0	0	7	7
DNA replication licensing factor MCM4	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 2	0	3	7	10
Receptor-type tyrosine-protein kinase FLT3	0	1	7	8
Bone morphogenetic protein receptor type-1A	0	0	7	7
Activin receptor type-1B	0	0	7	7
TGF-beta receptor type-1	0	1	7	8
Serine/threonine-protein kinase receptor R3	0	0	4	4
TGF-beta receptor type-2	0	0	7	7
Electron transfer flavoprotein subunit beta	0	0	6	6
Tyrosine-protein kinase CSK	0	0	7	7
Glycine--tRNA ligase	0	0	7	7
Protein kinase C iota type	0	1	7	8
Exosome RNA helicase MTR4	0	0	7	7
Tyrosine-protein kinase Tec	0	0	7	7
Tyrosine-protein kinase ABL2	0	1	7	8
Tyrosine-protein kinase FRK	0	0	7	7
Tyrosine-protein kinase SYK	0	0	7	7
26S proteasome regulatory subunit 6B	0	0	7	7
Mitogen-activated protein kinase 8	0	0	7	7
Mitogen-activated protein kinase 9	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 4	0	0	6	6
Dual specificity mitogen-activated protein kinase kinase 3	0	0	7	7
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	7	7
Casein kinase I isoform alpha	0	0	7	7
Casein kinase I isoform delta	0	0	7	7
MAP kinase-activated protein kinase 2	0	0	7	7
Elongation factor Tu, mitochondrial	0	0	7	7
Choline-phosphate cytidylyltransferase A	0	0	5	5
Cysteine--tRNA ligase, cytoplasmic	0	0	6	6
Casein kinase I isoform epsilon	0	0	7	7
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	7	7
Dual specificity protein kinase CLK1	0	0	7	7
Dual specificity protein kinase CLK2	0	0	7	7
Glycogen synthase kinase-3 alpha	0	0	7	7
Glycogen synthase kinase-3 beta	0	0	7	7
Cyclin-dependent kinase 7	0	2	7	9
Cyclin-dependent kinase 9	0	2	7	9
Ras-related protein Rab-27A	0	0	7	7
Interleukin-1 receptor-associated kinase 1	0	0	7	7
Ribosomal protein S6 kinase alpha-3	0	0	7	7
Serine/threonine-protein kinase Nek2	0	0	7	7
Serine/threonine-protein kinase Nek3	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 6	0	0	7	7
Serine/threonine-protein kinase PLK1	0	0	5	5
LIM domain kinase 1	0	0	7	7
LIM domain kinase 2	0	0	7	7
Mitogen-activated protein kinase 10	0	0	7	7
Tyrosine--tRNA ligase, cytoplasmic	0	0	7	7
5'-AMP-activated protein kinase subunit gamma-1	0	0	7	8
Ephrin type-B receptor 3	0	0	7	7
Ephrin type-A receptor 5	0	0	7	7
Ephrin type-B receptor 4	0	0	7	7
Ephrin type-A receptor 4	0	0	7	7
Adenylate kinase 2, mitochondrial	0	0	7	7
Adenosine kinase	0	0	7	7
Ras-related protein Rab-10	0	0	7	7
Actin-related protein 3	0	0	7	7
Actin-related protein 2	0	0	7	7
GTP-binding nuclear protein Ran	0	0	7	7
Casein kinase I isoform gamma-2	0	0	7	7
Cyclin-dependent kinase 3	0	0	7	7
Cyclin-dependent kinase 6	0	2	7	9
Cyclin-dependent-like kinase 5	0	1	7	8
Cyclin-dependent kinase 16	0	0	7	7
Cyclin-dependent kinase 17	0	0	7	7
ATP-dependent 6-phosphofructokinase, platelet type	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 1	0	3	7	10
DNA topoisomerase 2-beta	0	0	7	8
Protein kinase C theta type	0	1	7	8
Activin receptor type-1	0	0	7	7
Macrophage-stimulating protein receptor	0	0	7	7
Focal adhesion kinase 1	0	0	7	7
Protein kinase C delta type	0	1	7	8
Tyrosine-protein kinase BTK	0	0	7	7
Activated CDC42 kinase 1	0	0	7	7
Epithelial discoidin domain-containing receptor 1	0	0	7	7
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	7	7
Tyrosine-protein kinase Mer	0	1	6	7
Serine/threonine-protein kinase 4	0	0	7	7
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	7	8
Dual specificity mitogen-activated protein kinase kinase 5	0	0	7	7
Mitogen-activated protein kinase 7	0	0	7	7
Serine/threonine-protein kinase PAK 2	0	0	6	6
Serine/threonine-protein kinase 3	0	0	7	7
Mitogen-activated protein kinase kinase kinase 1	0	0	7	7
Integrin-linked protein kinase	0	0	7	7
Rho-associated protein kinase 1	0	0	7	7
Non-receptor tyrosine-protein kinase TNK1	0	0	7	7
Serine/threonine-protein kinase ATR	0	0	3	3
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	7	7
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	7	7
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	7	7
Activin receptor type-2B	0	0	7	7
Bone morphogenetic protein receptor type-2	0	0	7	7
Protein-tyrosine kinase 6	0	0	7	7
Cyclin-dependent kinase 13	0	0	7	7
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	7	7
Protein-tyrosine kinase 2-beta	0	0	7	7
Maternal embryonic leucine zipper kinase	0	0	7	7
Structural maintenance of chromosomes protein 1A	0	0	6	6
Chromodomain-helicase-DNA-binding protein 4	0	0	6	6
Peroxisomal acyl-coenzyme A oxidase 1	0	0	6	6
Cyclin-dependent kinase 10	0	0	5	5
Ephrin type-A receptor 7	0	0	6	6
Delta(24)-sterol reductase	0	0	7	7
Ribosomal protein S6 kinase alpha-1	0	0	7	7
Dual specificity testis-specific protein kinase 1	0	0	5	5
Myosin light chain kinase, smooth muscle	0	0	7	7
Serine/threonine-protein kinase STK11	0	0	7	7
Serine/threonine-protein kinase N1	0	0	7	7
Serine/threonine-protein kinase N2	0	0	7	7
Calcium/calmodulin-dependent protein kinase type IV	0	0	7	7
Mitogen-activated protein kinase kinase kinase 11	0	0	7	7
MAP kinase-activated protein kinase 3	0	0	3	3
Discoidin domain-containing receptor 2	0	0	7	7
AP2-associated protein kinase 1	0	1	7	8
Myosin light chain kinase 3	0	0	7	7
Uncharacterized aarF domain-containing protein kinase 5	0	0	6	6
Putative heat shock protein HSP 90-beta 2	0	0	7	7
Rab-like protein 3	0	0	6	6
Serine/threonine-protein kinase MRCK alpha	0	0	7	7
Serine/threonine-protein kinase MRCK gamma	0	0	7	7
Acyl-CoA dehydrogenase family member 10	0	0	7	7
Serine/threonine-protein kinase N3	0	0	7	7
Serine/threonine-protein kinase ULK3	0	0	7	7
Uncharacterized protein FLJ45252	0	0	7	7
Acyl-CoA dehydrogenase family member 11	0	0	7	7
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	7	7
Serine/threonine-protein kinase MARK2	0	0	7	7
ATP-dependent RNA helicase DHX30	0	0	4	4
Serine/threonine-protein kinase TAO1	0	0	7	7
STE20-related kinase adapter protein alpha	0	0	7	7
Myosin-14	0	0	7	7
AarF domain-containing protein kinase 1	0	0	7	7
ATP-dependent RNA helicase DDX42	0	0	6	6
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	7	7
MAP kinase-activated protein kinase 5	0	0	7	7
Atypical kinase COQ8A, mitochondrial	0	0	7	7
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	7	7
Mitogen-activated protein kinase 15	0	0	7	7
Serine/threonine-protein kinase Nek9	0	0	7	7
ATP-dependent RNA helicase DDX1	0	0	7	7
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	7	7
Aurora kinase B	0	0	7	7
MAP/microtubule affinity-regulating kinase 4	0	0	7	7
Serine/threonine-protein kinase Nek1	0	0	7	7
PAS domain-containing serine/threonine-protein kinase	0	0	6	6
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	7	7
EKC/KEOPS complex subunit TP53RK	0	0	7	7
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	7	7
Mitogen-activated protein kinase kinase kinase 5	0	0	7	7
Mitogen-activated protein kinase kinase kinase 3	0	0	7	7
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	7	7
Nucleolar GTP-binding protein 1	0	0	7	7
Serine/threonine-protein kinase D2	0	0	7	7
NUAK family SNF1-like kinase 2	0	0	7	7
RNA cytidine acetyltransferase	0	0	7	7
Serine/threonine-protein kinase SIK2	0	0	7	7
STE20-like serine/threonine-protein kinase	0	0	7	7
Serine/threonine-protein kinase TAO3	0	0	7	7
dCTP pyrophosphatase 1	0	0	7	7
Dual specificity protein kinase CLK4	0	0	7	7
Casein kinase I isoform gamma-1	0	0	7	7
Phenylalanine--tRNA ligase beta subunit	0	0	7	7
BMP-2-inducible protein kinase	0	0	7	7
Obg-like ATPase 1	0	0	5	5
Midasin	0	0	7	7
Interleukin-1 receptor-associated kinase 4	0	0	7	7
Mitogen-activated protein kinase kinase kinase 20	0	1	7	8
Cyclin-dependent kinase 12	0	0	7	7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	7	7
Serine/threonine-protein kinase pim-2	0	0	6	6
Serine/threonine-protein kinase 26	0	0	7	7
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	6	6
Serine/threonine-protein kinase NLK	0	0	7	7
5'-AMP-activated protein kinase subunit gamma-2	0	0	7	8
Serine/threonine-protein kinase TBK1	0	0	7	7
Septin-9	0	0	7	7
Ribosomal protein S6 kinase alpha-6	0	0	7	7
TRAF2 and NCK-interacting protein kinase	0	0	7	7
Serine/threonine-protein kinase TAO2	0	0	7	7
Long-chain-fatty-acid--CoA ligase 5	0	0	3	3
Serine/threonine-protein kinase ICK	0	0	7	7
RAC-gamma serine/threonine-protein kinase	0	0	7	7
Serine/threonine-protein kinase 38-like	0	0	4	4
Serine/threonine-protein kinase SIK3	0	0	7	7
Mitogen-activated protein kinase kinase kinase 2	0	0	7	7
Thyroid hormone receptor-associated protein 3	0	0	6	6
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	7	7
Receptor-interacting serine/threonine-protein kinase 3	0	1	7	8
Serine/threonine-protein kinase MRCK beta	0	0	7	7
Interleukin-1 receptor-associated kinase 3	0	0	7	7
Serine/threonine-protein kinase 24	0	0	6	6
Casein kinase I isoform gamma-3	0	0	7	7
Mitogen-activated protein kinase kinase kinase 4	0	0	7	7
Nuclear receptor ROR-gamma	5	0	0	5
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Ferritin light chain	10	0	0	10
DNA topoisomerase	0	1	0	1
15-lipoxygenase, partial	6	0	0	6
NFKB1 protein, partial	3	0	0	3
Thrombopoietin	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
thyroid stimulating hormone receptor	11	0	0	11
regulator of G-protein signaling 4	4	0	0	4
EWS/FLI fusion protein	19	0	0	19
glucocerebrosidase	4	0	0	4
putative alpha-glucosidase	1	0	0	1
alpha-galactosidase	2	0	0	2
Bloom syndrome protein isoform 1	12	0	0	12
lysosomal alpha-glucosidase preproprotein	3	0	0	3
peripheral myelin protein 22 isoform 1	4	0	0	4
hemoglobin subunit beta	2	0	0	2
cytochrome P450 2C19 precursor	3	0	0	3
huntingtin isoform 2	5	0	0	5
ras-related protein Rab-9A	3	0	0	3
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
nuclear receptor ROR-gamma isoform 1	11	0	0	11
cytochrome P450 3A4 isoform 1	11	0	0	11
M-phase phosphoprotein 8	6	0	0	6
histone acetyltransferase KAT2A isoform 1	11	0	0	11
relaxin receptor 1 isoform 1	1	0	0	1
lethal factor (plasmid)	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	11	2	2	15
Histone deacetylase 3	0	1	0	1
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	0	0	1
DNA ligase	0	1	0	1
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	1	1	7
Gamma-aminobutyric acid receptor subunit beta-1	11	2	2	15
Gamma-aminobutyric acid receptor subunit delta	11	2	2	15
Gamma-aminobutyric acid receptor subunit gamma-2	11	2	2	15
Gamma-aminobutyric acid receptor subunit alpha-5	11	2	2	15
Gamma-aminobutyric acid receptor subunit alpha-3	11	2	2	15
Gamma-aminobutyric acid receptor subunit gamma-1	11	2	2	15
Gamma-aminobutyric acid receptor subunit alpha-2	11	2	2	15
Type-2 restriction enzyme BamHI	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	11	2	2	15
Gamma-aminobutyric acid receptor subunit gamma-3	11	2	2	15
Gamma-aminobutyric acid receptor subunit alpha-6	11	2	2	15
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
5-hydroxytryptamine receptor 2B	0	10	1	11
Type-2 restriction enzyme HindIII	0	1	0	1
D(1A) dopamine receptor	2	0	0	2
Histone deacetylase 4	0	1	0	1
Ribonuclease pancreatic	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	11	2	2	15
Gamma-aminobutyric acid receptor subunit beta-3	11	2	2	15
Gamma-aminobutyric acid receptor subunit beta-2	11	2	2	15
DNA topoisomerase 1	0	1	0	2
Histone deacetylase 1	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Integrase	0	1	0	1
Histone deacetylase 7	0	1	0	1
GABA theta subunit	11	2	2	15
Histone deacetylase 2	0	1	0	1
DNA topoisomerase type IB small subunit	0	0	1	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	11	2	2	15
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Liver carboxylesterase 1	0	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Polyunsaturated fatty acid lipoxygenase ALOX15B	7	0	0	7
Histamine H2 receptor	7	0	0	7
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
endonuclease IV	2	0	0	2
arylsulfatase A	6	0	0	6
thyroid hormone receptor beta isoform a	10	0	0	10
muscarinic acetylcholine receptor M1	4	0	0	4
Bile salt export pump	0	4	0	4
Glutathione reductase, mitochondrial	0	2	0	3
Alpha-synuclein	3	1	0	4
Glutathione reductase	0	1	0	1
ATP-dependent phosphofructokinase	9	0	0	9
acetylcholinesterase	10	0	0	10
PINK1	1	0	0	1
Parkin	1	0	0	1
activating transcription factor 6	13	0	0	13
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	11	0	0	11
Caspase-7	4	0	0	4
serine-protein kinase ATM isoform a	4	0	0	4
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
prostaglandin E2 receptor EP2 subtype	0	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
caspase-3	4	0	0	4
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
Acetylcholinesterase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
ORF73	0	0	1	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	3	1	4
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
pregnane X receptor	6	0	0	6
nonstructural protein 1	3	0	0	3
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 1	0	5	0	6
Solute carrier family 22 member 3	0	2	0	2
Solute carrier family 22 member 3	0	1	0	1
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	0	1	1
Androgen receptor	0	8	0	9
C-8 sterol isomerase	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	3	1	4
Solute carrier family 22 member 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	7	0	7
Solute carrier family 22 member 2	0	2	0	2
Pirin	0	2	0	2
Tyrosine-protein kinase JAK2	0	2	6	8
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Cyclin-dependent kinase-like 5	0	0	5	5
RAF proto-oncogene serine/threonine-protein kinase	0	2	2	6
Dual specificity protein kinase TTK	0	0	4	4
Myosin-10	0	0	6	6
Dual specificity protein kinase CLK3	0	0	5	5
Heat shock factor protein 1	0	2	0	2
Protein kinase C zeta type	0	1	2	3
Receptor-interacting serine/threonine-protein kinase 1	0	1	1	2
Dual serine/threonine and tyrosine protein kinase	0	1	1	2
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	5	5
Misshapen-like kinase 1	0	0	5	5
Dual specificity testis-specific protein kinase 2	0	0	5	5
Serine/threonine-protein kinase PAK 6	0	0	4	4
Isoleucine--tRNA ligase, mitochondrial	0	0	5	5
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	6	6
interleukin 8	3	0	0	3
Matrix metalloproteinase-9	0	2	0	2
Isocitrate lyase	0	1	0	1
Vascular endothelial growth factor receptor 2	0	2	1	3
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
CREB-binding protein	0	1	0	1
Thymidine kinase 2	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	2
AAA family ATPase	0	0	0	2
Serum paraoxonase/arylesterase 1	0	3	0	3
Kinesin-like protein KIF11	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	3	0	3
Glycine receptor subunit alpha-1	0	0	1	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	2	0	2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	0	2	0	2
Eyes absent homolog 2	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
G protein-coupled receptor kinase 6	0	0	4	4
Calcium/calmodulin-dependent protein kinase type 1G	0	0	2	2
Genome polyprotein	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
Smad3	3	0	0	3
ATP-dependent translocase ABCB1	0	6	2	11
D(2) dopamine receptor	0	6	1	7
Amine oxidase [flavin-containing] A	0	2	0	2
D(4) dopamine receptor	0	3	0	3
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	2	0	2
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	7	2	9
D(3) dopamine receptor	0	5	0	5
Delta-type opioid receptor	0	7	1	8
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	7	1	8
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	6	0	7
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
SMAD family member 2	8	0	0	8
SMAD family member 3	8	0	0	8
Cytochrome P450 2C9	0	5	0	6
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	2	0	2
Cytochrome P450 2C19	0	5	0	5
thyrotropin-releasing hormone receptor	3	0	0	3
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Vpr	3	0	0	3
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	3	0	3
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Albumin	0	2	2	4
Albumin	0	0	1	1
Cytochrome P450 1A2	0	6	0	6
Cytochrome P450 2D6	0	5	0	5
Sodium-dependent dopamine transporter	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Smoothened homolog	0	1	1	2
Glutamate receptor ionotropic, NMDA 2B	0	0	0	2
Sonic hedgehog protein	0	1	0	2
Sonic hedgehog protein	0	1	0	1
Smoothened homolog	0	2	2	4
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Transmembrane protease serine 2	0	0	2	2
Procathepsin L	0	2	2	4
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	2	2	4
Equilibrative nucleoside transporter 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	2	2
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
alpha synuclein, partial	1	0	0	1
hypothetical protein, conserved	3	0	0	3
luciferase	3	0	0	3
tumor necrosis factor	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Muscarinic acetylcholine receptor M2	0	5	1	6
Muscarinic acetylcholine receptor M4	0	6	0	6
Muscarinic acetylcholine receptor M5	0	4	0	4
Alpha-2A adrenergic receptor	0	7	2	10
60 kDa chaperonin	0	3	0	3
Adenosine receptor A3	0	7	1	8
60 kDa heat shock protein, mitochondrial	0	3	0	3
Muscarinic acetylcholine receptor M1	0	5	1	6
Alpha-1B adrenergic receptor	0	8	1	9
Alpha-2B adrenergic receptor	0	4	1	6
Alpha-2C adrenergic receptor	0	5	2	8
Muscarinic acetylcholine receptor M3	0	5	1	6
Substance-K receptor	0	6	0	6
D(1A) dopamine receptor	0	5	1	6
Acetylcholinesterase	0	4	0	4
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Histamine H2 receptor	0	6	0	6
Alpha-1D adrenergic receptor	0	6	1	8
5-hydroxytryptamine receptor 2A	0	6	1	7
Adenosine receptor A2a	0	7	1	8
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Alpha-1A adrenergic receptor	0	8	1	9
10 kDa heat shock protein, mitochondrial	0	3	0	3
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Sodium-dependent dopamine transporter	0	6	0	6
Leukotriene B4 receptor 1	1	0	0	1
Thiosulfate sulfurtransferase	0	3	0	3
60 kDa chaperonin	0	3	0	3
Glutamate receptor ionotropic, kainate 5	1	0	0	1
10 kDa chaperonin	0	3	0	3
Leukotriene B4 receptor 2	1	0	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Chain E, Fibrin beta chain	0	2	0	2
WRN	2	0	0	2
Mcl-1	0	1	0	1
MPI protein	0	1	0	1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	3	0	0	3
apical membrane antigen 1, AMA1	3	0	0	3
pyruvate kinase	2	0	0	2
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
DNA polymerase beta	5	0	0	5
Tat	0	1	0	1
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Pyruvate kinase PKM	0	1	1	2
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
phosphoglycerate kinase	3	0	0	3
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
DNA repair protein RAD52 homolog isoform a	0	0	0	2
Cytochrome P450 2C8	0	1	0	2
Mast/stem cell growth factor receptor Kit	0	1	2	3
Platelet-derived growth factor receptor alpha	0	1	2	3
Cytochrome P450 3A5	0	0	0	1
7,8-dihydro-8-oxoguanine triphosphatase	0	1	0	1
Toll-like receptor 8	0	0	1	1
Toll-like receptor 7	0	0	1	1
Leukotriene C4 synthase	0	0	1	1
tyrosine-protein kinase Yes	3	0	0	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	1	2
Serine/threonine-protein kinase 25	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	2
Peripheral plasma membrane protein CASK	0	0	1	1
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
NUAK family SNF1-like kinase 1	0	1	1	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	2	1	3
Macrophage colony-stimulating factor 1 receptor	0	1	1	2
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Insulin receptor-related protein	0	0	1	1
Vascular endothelial growth factor receptor 1	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
Protein kinase C eta type	0	1	1	2
Activin receptor type-2A	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	1	1
Serine/threonine-protein kinase mTOR	0	0	1	1
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase TXK	0	0	1	1
Tyrosine-protein kinase ZAP-70	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	0	1	1
Cyclin-dependent kinase 8	0	0	1	1
Tyrosine-protein kinase Blk	0	0	1	1
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	3	1	4
Death-associated protein kinase 1	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	2
Ephrin type-B receptor 1	0	0	1	1
Oxysterols receptor LXR-beta	0	1	0	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Angiopoietin-1 receptor	0	0	1	1
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	3	3
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Serine/threonine-protein kinase PAK 1	0	1	1	2
cGMP-dependent protein kinase 2	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Serine/threonine-protein kinase D1	0	1	1	2
Serine/threonine-protein kinase 38	0	0	2	2
Receptor tyrosine-protein kinase erbB-4	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	2	2
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
SRSF protein kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Phosphatidylinositol 4-kinase beta	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Carbonic anhydrase 1	0	6	0	7
Carbonic anhydrase 2	0	6	1	8
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 15	0	2	0	3
Chain A, Acetylcholinesterase	0	1	0	1
interferon gamma precursor	0	0	0	2
Interstitial collagenase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
Fatty acid-binding protein, liver	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Caspase-1	0	1	0	1
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Cell division control protein 42 homolog	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	1	0	1
cytochrome P450 2D6 isoform 1	3	0	0	3
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1B1	0	1	0	1
Neprilysin	0	1	0	1
Atrial natriuretic peptide receptor 3	0	1	0	1
5-hydroxytryptamine receptor 1A	0	5	1	7
Thromboxane A2 receptor	0	1	0	2
Type-1A angiotensin II receptor	0	2	1	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Adenosine receptor A2a	0	1	0	1
Type-1 angiotensin II receptor	0	3	2	7
Type-1 angiotensin II receptor	0	1	1	2
Type-2 angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
Squalene synthase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Platelet glycoprotein VI	0	1	1	3
Type-1 angiotensin II receptor	0	1	1	2
HLA class I histocompatibility antigen, A alpha chain	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	3
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Glucocorticoid receptor	0	2	0	2
Prostate-specific antigen	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Amine oxidase [flavin-containing] B	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	1	0	0	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
isocitrate dehydrogenase 1, partial	2	0	0	2
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	2	2
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	3	1	4
Alpha-1D adrenergic receptor	0	2	1	3
Sodium-dependent noradrenaline transporter	0	6	2	8
Cruzipain	0	2	0	2
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	2	2
Indoleamine 2,3-dioxygenase 1	0	2	0	3
Aldo-keto reductase family 1 member B1	0	6	0	6
Sodium-dependent serotonin transporter	0	6	0	6
5-hydroxytryptamine receptor 6	0	6	1	7
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	2
DNA gyrase subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Cathepsin L2	0	1	0	1
Cathepsin B	0	1	0	1
Pro-cathepsin H	0	1	0	1
Cathepsin S	0	1	0	1
Cathepsin K	0	2	0	2
Cathepsin K	0	1	0	1
Dipeptidyl peptidase 1	0	1	0	1
Cathepsin Z	0	1	0	1
Cathepsin F	0	1	0	1
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Tubulin beta chain	0	1	1	3
Tubulin alpha-3C chain	0	1	1	3
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Cholecystokinin receptor type A	0	3	1	4
Melanocortin receptor 5	0	4	0	4
UDP-glucuronosyltransferase 2B10	0	1	0	1
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
Tubulin beta-2B chain	0	0	1	3
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
Similar to alpha-tubulin isoform 1	0	0	1	3
Similar to alpha-tubulin isoform 1	0	0	0	2
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Chain B, Cell division protein kinase 6	0	1	0	1
Chain B, Cell division protein kinase 6	0	1	0	1
Cyclin-T1	0	2	0	2
Cyclin-K	0	1	0	1
G2/mitotic-specific cyclin-B1	0	2	0	2
Acetylcholinesterase	0	1	0	1
G1/S-specific cyclin-D1	0	2	0	2
G1/S-specific cyclin-E1	0	1	0	1
G1/S-specific cyclin-D2	0	1	0	1
G1/S-specific cyclin-D3	0	2	0	2
Cyclin-H	0	2	0	2
CDK-activating kinase assembly factor MAT1	0	1	0	1
Cyclin-A1	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Chain A, AKAP9-BRAF fusion protein	0	1	0	1
Serine/threonine-protein kinase B-raf	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Aspartyl/asparaginyl beta-hydroxylase	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
GLS protein	3	0	0	3
D(1A) dopamine receptor	3	0	0	3
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
5-hydroxytryptamine receptor 4	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	6	1	7
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Beta-1 adrenergic receptor	0	1	1	3
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 1A	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	3
Beta-3 adrenergic receptor	0	4	1	5
Beta-1 adrenergic receptor	0	2	1	4
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Alpha-2C adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	0	1	1
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 1B	0	4	0	4
Neuromedin-K receptor	0	0	1	1
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Vasopressin V1a receptor	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
SUMO-1	0	1	0	1
cytochrome P450 2C9 precursor	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
chaperonin GroEL	1	0	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Exoribonuclease H	0	1	0	1
Coproheme decarboxylase	0	0	1	1
Protease	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Estrogen receptor beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
Carbonic anhydrase 12	0	3	0	4
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	2
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Carbonic anhydrase 6	0	1	0	2
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Carbonic anhydrase 7	0	1	0	2
Xanthine dehydrogenase/oxidase	0	1	0	1
Carbonic anhydrase 9	0	3	0	4
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	2
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
Carbonic anhydrase 14	0	2	0	3
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Acetylcholinesterase	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Cholinesterase	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
streptokinase A precursor	0	0	1	1
Estrogen receptor	0	2	1	4
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	2
Progesterone receptor	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Cytochrome P450 2B6	0	1	0	1
Thromboxane-A synthase	0	1	0	1
B2 bradykinin receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Estrogen receptor beta	0	2	1	3
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
polyadenylate-binding protein 1	0	1	0	1
Delta	0	1	0	1
Cycloeucalenol cycloisomerase	0	1	0	1
Sterol-8,7-isomerase	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Plasma kallikrein	0	0	0	1
Myeloperoxidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Substance-P receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Tryprostatin B synthase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Butyrophilin subfamily 3 member A1	0	0	1	2
Geranylgeranyl pyrophosphate synthase	0	2	0	3
72 kDa type IV collagenase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(6)

Research Excerpts

Overview

Context

Treatment

Research

Studies (325)

Protein Targets (1,378)

Margins of Excision

Synonyms(6)

Research Excerpts

Overview

Context

Treatment

Research

Studies (325)

Drugs Studied (151)

Protein Targets (1,378)