Necrotizing Sialometaplasia

A benign, inflammatory, variably ulcerated, occasionally bilateral, self-healing lesion of the minor salivary glands that is often confused clinically and histologically with carcinoma.

Synonym
Necrotizing Sialometaplasia
Sialometaplasia, Necrotizing

Excerpt	Reference
"Necrotizing sialometaplasia is a benign disorder that histologically can mimic carcinoma."	( Benedetto, AV; Granick, MS; Hannegan, MW; Sohn, M; Solomon, MP, 1988)
"Necrotizing sialometaplasia is a self-limiting, variably ulcerated benign process affecting minor salivary glands."	( Flint, S; Keogh, PV; O'Regan, E; Toner, M, 2004)
"Necrotizing sialometaplasia is a non-neoplastic self-limiting inflammatory-ulcerous condition of the minor salivary glands."	( Gera, I; Kovács, V; Kövesi, G, 2005)
"Necrotizing sialometaplasia is a benign inflammatory lesion involving most frequently the minor salivary gland of the hard palate."	( Ben Slama, L; Goudot, P; Haen, P; Schouman, T, 2017)

Excerpt	Reference
"Familiarity with necrotizing sialometaplasia and correct differential diagnosis are paramount in avoiding misdiagnosis and inappropriate treatment."	( Gera, I; Kovács, V; Kövesi, G, 2005)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (18.18)	23.3326
1990's	2 (18.18)	12.5806
2000's	5 (45.45)	18.1394
2010's	2 (18.18)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies
lidocaine	low	1
prednisolone	low	1
methylprednisolone	low	1
benzydamine	low	1
triamcinolone	low	2
nicotine	low	1
inositol 3-phosphate	low	3
bromochloroacetic acid	low	1
chlorhexidine	low	1
tetracycline	low	1

Protein Targets (365)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
peripheral myelin protein 22	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Guanylate cyclase soluble subunit beta-2	0	0	1	1
Cytochrome P450 2C9	0	3	0	3
Guanylate cyclase soluble subunit alpha-2	0	0	1	1
Histamine H2 receptor	2	0	0	2
Cytochrome P450 2J2	0	3	0	3
Guanylate cyclase soluble subunit alpha-1	0	0	1	1
Guanylate cyclase soluble subunit beta-1	0	0	1	1
RAR-related orphan receptor gamma	5	0	0	5
AR protein	8	0	0	8
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
retinoic acid nuclear receptor alpha variant 1	3	0	0	3
thyroid stimulating hormone receptor	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	4	0	0	4
Cellular tumor antigen p53	3	0	0	3
Nuclear receptor ROR-gamma	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
Chain A, Cruzipain	1	0	0	1
Luciferase	1	0	0	1
acid sphingomyelinase	1	0	0	1
interleukin 8	2	0	0	2
acetylcholinesterase	2	0	0	2
PAX8	0	0	0	1
glp-1 receptor, partial	2	0	0	2
15-lipoxygenase, partial	1	0	0	1
pregnane X receptor	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
SMAD family member 2	2	0	0	2
USP1 protein, partial	1	0	0	1
SMAD family member 3	2	0	0	2
TDP1 protein	4	0	0	4
GLI family zinc finger 3	5	0	0	5
caspase 7, apoptosis-related cysteine protease	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
PINK1	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
progesterone receptor	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
glucocorticoid receptor [Homo sapiens]	5	0	0	5
retinoid X nuclear receptor alpha	2	0	0	2
estrogen-related nuclear receptor alpha	4	0	0	4
farnesoid X nuclear receptor	1	0	0	1
pregnane X nuclear receptor	4	0	0	4
estrogen nuclear receptor alpha	5	0	0	5
G	2	0	0	2
cytochrome P450 2D6	1	0	0	1
67.9K protein	1	0	0	1
glucocerebrosidase	1	0	0	1
Parkin	1	0	0	1
peroxisome proliferator-activated receptor delta	1	0	0	1
peroxisome proliferator activated receptor gamma	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
heat shock protein 90	0	0	1	1
caspase-3	1	0	0	1
IDH1	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
calcineurin A1, putative	0	0	1	1
aryl hydrocarbon receptor	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
activating transcription factor 6	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
Histone H2A.x	2	0	0	2
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
perilipin-5	0	1	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
perilipin-1	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
thyroid hormone receptor beta isoform 2	2	0	0	2
heat shock protein beta-1	2	0	0	2
huntingtin isoform 2	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
mitogen-activated protein kinase 1	2	0	0	2
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
flap endonuclease 1	2	0	0	2
protein AF-9 isoform a	0	0	0	1
snurportin-1	1	0	0	1
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
bcl-2-related protein A1	0	1	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
geminin	6	0	0	6
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
DNA polymerase kappa isoform 1	1	0	0	1
cytochrome P450 3A4 isoform 1	3	0	0	3
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
lethal factor (plasmid)	1	0	0	1
lamin isoform A-delta10	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	3	0	0	3
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	1	0	2
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Glutathione reductase, mitochondrial	0	1	0	2
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Integrin beta-3	1	0	0	1
72 kDa type IV collagenase	0	2	0	2
Integrin alpha-IIb	1	0	0	1
Matrix metalloproteinase-9	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit delta	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	3	0	0	3
Glutamate receptor 2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	3	0	0	3
Trypanothione reductase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	3	0	0	3
Alpha-synuclein	1	1	0	2
Spike glycoprotein	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	3	0	0	3
TAR DNA-binding protein 43	2	0	0	2
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
GABA theta subunit	3	0	0	3
Inositol hexakisphosphate kinase 1	2	0	0	2
Multidrug and toxin extrusion protein 1	0	2	0	2
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	4	0	0	4
Gamma-aminobutyric acid receptor subunit epsilon	3	0	0	3
Spermine oxidase	0	1	0	1
cytochrome P450 2C9, partial	2	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, Beta-lactamase	1	0	0	1
thioredoxin reductase	3	0	0	3
GLS protein	1	0	0	1
Microtubule-associated protein tau	2	0	0	2
chromobox protein homolog 1	3	0	0	3
muscarinic acetylcholine receptor M1	1	0	0	1
Potassium channel subfamily K member 3	0	1	0	1
ATP-binding cassette sub-family C member 3	0	5	0	5
Multidrug resistance-associated protein 4	0	5	0	5
Potassium channel subfamily K member 2	0	1	0	1
Bile salt export pump	0	6	0	6
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	5	0	5
Sodium channel protein type 3 subunit alpha	0	2	0	2
PPM1D protein	1	0	0	1
nonstructural protein 1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucocorticoid receptor	0	6	1	12
Glycine receptor subunit alpha-1	0	6	0	6
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATP-dependent phosphofructokinase	1	0	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
Smad3	2	0	0	2
regulator of G-protein signaling 4	1	0	0	1
arylsulfatase A	2	0	0	2
D(1A) dopamine receptor	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	2	5
Cytochrome P450 1A2	0	1	0	1
Acetylcholine receptor subunit gamma	0	2	1	3
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	2	0	2
Cytochrome P450 3A4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	2	5
Muscarinic acetylcholine receptor M2	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Cytochrome P450 2A6	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Neuronal acetylcholine receptor subunit beta-4	0	2	2	5
Translocator protein	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Muscarinic acetylcholine receptor M4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-6	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Mu-type opioid receptor	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	5
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Transporter	0	1	1	3
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
EWS/FLI fusion protein	1	0	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Stromelysin-1	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
ATAD5 protein, partial	1	0	0	1
NFKB1 protein, partial	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Necrotizing Sialometaplasia

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (11)

Protein Targets (365)

Necrotizing Sialometaplasia

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (11)

Drugs Studied (10)

Protein Targets (365)