Necrobiotic Xanthogranuloma

A cutaneous necrobiotic disorder characterized by firm, yellow plaques or nodules, often in a periorbital distribution. It is often accompanied by an elevated ERYTHROCYTE SEDIMENTATION RATE; LEUKOPENIA; and MONOCLONAL GAMMOPATHY (IgG-kappa type) and systemic involvement.

Synonym
Necrobiotic Xanthogranuloma

Excerpt	Reference
"Necrobiotic xanthogranuloma is a non-Langerhans histiocytic disorder characterized by chronic and progressively enlarging cutaneous plaques and nodules predominantly at the head and facial regions."	( Nguyen, BD, 2014)
"Necrobiotic xanthogranuloma is a rare non-Langerhans-cell histiocytosis."	( Hansel, G; Klingner, M; Schönlebe, J; Wollina, U, 2016)
"Necrobiotic xanthogranuloma is a rare chronic condition, belonging to the group C non-Langerhans cell histiocytoses, which is relevant due to the possibility of extracutaneous involvement and association with systemic diseases, particularly hematologic malignancies."	( Mello, RB; Vale, ECSD, 2019)
"Necrobiotic xanthogranuloma is a rare form of non-Langerhans histiocytosis characterized by development of chronic cutaneous nodules that enlarge over time to form plaques."	( Eltilib, M; Fenner, J; Oldan, J; Saramago, I, 2020)
"Necrobiotic xanthogranuloma is a rare disease that is part of the non-Langerhans cell histiocytoses."	( Abeck, F; Booken, N; Ghandili, S; Hansen, I; Schneider, SW, 2023)

Excerpt	Reference
"Necrobiotic xanthogranulomas have a predilection for the bilateral periorbital region and often present with consequential ophthalmic findings."	( Bookout, A; Hogan, DJ; Seastrom, S, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	26 (72.22)	28.8240
2020's	10 (27.78)	9.53

Drug	Relationship Strength	Studies
salicylic acid	low	1
chlorambucil	low	2
isoniazid	low	1
mechlorethamine	low	1
thalidomide	low	6
prednisolone	low	2
prednisone	low	2
triamcinolone acetonide	low	1
methylprednisolone	low	2
cladribine	low	1
vidarabine	low	1
propiconazole	low	1
fluorodeoxyglucose f18	low	4
methotrexate	low	2
lenalidomide	low	5
bortezomib	low	2
tacrolimus	low	1
fludarabine	low	1
bilirubin	low	1
acitretin	low	1
clobetasol	low	1
an2728	low	1
cyclosporine	low	1
orabase	low	1
rifampin	low	1
eye	low	1

Protein Targets (455)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Luciferase	3	0	0	3
USP1 protein, partial	4	0	0	4
TDP1 protein	15	0	0	15
Microtubule-associated protein tau	6	0	0	6
AR protein	17	0	0	17
aldehyde dehydrogenase 1 family, member A1	8	0	0	8
glucocorticoid receptor [Homo sapiens]	11	0	0	11
estrogen nuclear receptor alpha	17	0	0	17
peroxisome proliferator activated receptor gamma	8	0	0	8
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	10	0	0	10
vitamin D3 receptor isoform VDRA	6	0	0	6
thyroid hormone receptor beta isoform 2	11	0	0	11
flap endonuclease 1	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
geminin	13	0	0	13
peripheral myelin protein 22	4	0	0	4
survival motor neuron protein isoform d	5	0	0	5
histone acetyltransferase KAT2A isoform 1	4	0	0	4
ATP-binding cassette sub-family C member 3	0	13	0	13
Multidrug resistance-associated protein 4	0	13	0	14
Bile salt export pump	0	7	0	7
Bile salt export pump	0	15	0	15
Rap guanine nucleotide exchange factor 3	1	0	0	1
Cellular tumor antigen p53	12	0	0	12
Rap guanine nucleotide exchange factor 4	2	0	0	2
Fumarate hydratase	5	0	0	5
EWS/FLI fusion protein	11	0	0	11
polyprotein	5	0	0	5
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Spike glycoprotein	4	0	0	4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Beta-lactamase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Chain A, Cruzipain	2	0	0	2
phosphopantetheinyl transferase	4	0	0	4
DNA polymerase kappa isoform 1	3	0	0	3
caspase-1 isoform alpha precursor	2	0	0	2
lamin isoform A-delta10	7	0	0	7
Caspase-7	2	0	0	2
Inositol monophosphatase 1	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	6	0	9
Solute carrier organic anion transporter family member 1B1	0	5	0	7
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	1	0	1
RAR-related orphan receptor gamma	6	0	0	6
PPM1D protein	3	0	0	3
caspase 7, apoptosis-related cysteine protease	2	0	0	2
estrogen receptor 2 (ER beta)	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
progesterone receptor	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
retinoid X nuclear receptor alpha	10	0	0	10
estrogen-related nuclear receptor alpha	10	0	0	10
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	9	0	0	9
peroxisome proliferator-activated receptor delta	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	8	0	0	8
caspase-3	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Histone H2A.x	4	0	0	4
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
heat shock protein beta-1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
26S proteasome non-ATPase regulatory subunit 11	0	1	0	1
26S proteasome non-ATPase regulatory subunit 12	0	1	0	1
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Histone deacetylase 3	0	1	0	1
26S proteasome non-ATPase regulatory subunit 3	0	1	0	1
Carbonic anhydrase 12	0	3	0	3
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Prothrombin	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Carbonic anhydrase 1	0	4	0	4
Carbonic anhydrase 2	0	4	1	5
Interferon beta	6	0	0	6
Carbonic anhydrase 3	0	2	0	2
Cathepsin B	0	1	0	1
Neutrophil elastase	0	1	0	1
Cathepsin G	0	2	0	2
Lysosomal protective protein	0	1	0	1
Chymotrypsinogen B	0	1	0	1
26S proteasome regulatory subunit 6A	0	1	0	1
Glutamate receptor 2	4	0	0	4
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Proteasome subunit beta type-1	0	1	0	2
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 6	0	2	0	2
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	3
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
26S proteasome regulatory subunit 7	0	1	0	1
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	1	0	1
Carbonic anhydrase 7	0	2	0	2
26S proteasome regulatory subunit 6B	0	1	0	1
26S proteasome non-ATPase regulatory subunit 8	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	1	0	2
26S proteasome non-ATPase regulatory subunit 7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 4	0	1	0	1
26S proteasome complex subunit SEM1	0	1	0	1
Proteasome subunit alpha type-6	0	1	0	1
26S proteasome regulatory subunit 4	0	1	0	1
26S proteasome regulatory subunit 8	0	1	0	1
26S proteasome regulatory subunit 10B	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	1	0	1
Histone deacetylase 1	0	1	0	1
26S proteasome non-ATPase regulatory subunit 6	0	1	0	1
Proteasomal ubiquitin receptor ADRM1	0	1	0	1
Carbonic anhydrase 9	0	3	0	3
ATP-dependent Clp protease proteolytic subunit	0	1	1	2
Carbonic anhydrase 13	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Histone deacetylase 2	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	12	0	12
ATPase family AAA domain-containing protein 5	9	0	0	9
Proteasome subunit beta type-7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 1	0	1	0	1
Ataxin-2	9	0	0	9
Carbonic anhydrase 15	0	2	0	2
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Carbonic anhydrase 14	0	2	0	2
26S proteasome non-ATPase regulatory subunit 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
interleukin 8	3	0	0	3
thioredoxin reductase	4	0	0	4
NFKB1 protein, partial	1	0	0	1
GALC protein	1	0	0	1
GLS protein	2	0	0	2
GLI family zinc finger 3	9	0	0	9
Thrombopoietin	1	0	0	1
thioredoxin glutathione reductase	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
thyroid stimulating hormone receptor	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
activating transcription factor 6	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
Bloom syndrome protein isoform 1	3	0	0	3
peripheral myelin protein 22 isoform 1	1	0	0	1
chromobox protein homolog 1	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
muscleblind-like protein 1 isoform 1	5	0	0	5
muscarinic acetylcholine receptor M1	1	0	0	1
Cytochrome P450 2D6	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
glp-1 receptor, partial	2	0	0	2
Smad3	3	0	0	3
G	3	0	0	3
67.9K protein	6	0	0	6
IDH1	5	0	0	5
cellular tumor antigen p53 isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
huntingtin isoform 2	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
nuclear receptor ROR-gamma isoform 1	7	0	0	7
relaxin receptor 1 isoform 1	1	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Deoxycytidine kinase	0	0	0	1
Adenosine receptor A3	0	2	0	2
Inositol hexakisphosphate kinase 1	3	0	0	3
cytochrome P450 2C9, partial	3	0	0	3
aryl hydrocarbon receptor	5	0	0	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
cytochrome P450 2C9 precursor	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Myeloperoxidase	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Dihydrofolate reductase	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Histamine H2 receptor	3	0	0	3
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
GABA theta subunit	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Chain A, Beta-lactamase	3	0	0	3
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
5'-nucleotidase	0	1	0	1
Adenosine deaminase	0	0	0	2
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	2	0	3
Cytochrome P450 1A2	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Cytochrome P450 3A4	0	3	0	3
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	3
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
Cereblon isoform 4	0	3	0	3
Bromodomain-containing protein 4	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	2
Breakpoint cluster region protein	0	0	0	1
DNA-binding protein Ikaros	0	0	1	4
DNA damage-binding protein 1	0	2	1	3
Protein cereblon	0	4	2	9
Zinc finger protein Aiolos	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, Ferritin light chain	3	0	0	3
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	1	0	0	1
ClpP	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
ATAD5 protein, partial	2	0	0	2
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
snurportin-1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
M-phase phosphoprotein 8	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
acetylcholinesterase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
nonstructural protein 1	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Cytochrome P450 2C9	0	1	0	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	2	2
Prostaglandin G/H synthase 2	0	2	0	2
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	1	0	1
Estrogen receptor beta	0	2	0	2
pregnane X receptor	2	0	0	2
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Guanine nucleotide-binding protein G	1	0	0	1
heat shock protein 90, putative	0	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Albumin	0	1	1	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Cytochrome P450 2B6	0	0	1	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Alpha-synuclein	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 3A5	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
cytochrome P450 2D6	2	0	0	2
arylsulfatase A	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
Thymidine kinase, cytosolic	0	0	0	1
Dipeptidyl peptidase 4	0	1	0	1
Adenosylhomocysteinase	0	1	0	1
RNA-directed RNA polymerase	0	1	1	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Necrobiotic Xanthogranuloma

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (36)

Protein Targets (455)

Necrobiotic Xanthogranuloma

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (36)

Drugs Studied (29)

Protein Targets (455)