alpha-L-Iduronidase Deficiency

Synonym
Hurler-Scheie Syndrome
Hurler Syndrome
Mucopolysaccharidosis I-S
Scheie Syndrome
Scheie's Syndrome
Mucopolysaccharidosis 5
Mucopolysaccharidosis 1
Lipochondrodystrophy
Hurler's Syndrome
Hurler's Disease
Gargoylism
Mucopolysaccharidosis Type Ih S
Gargoylism, Hurler Syndrome
Mucopolysaccharidosis V
Mucopolysaccharidosis Type Is
Hurler Disease
Mucopolysaccharidosis Type I
Mucopolysaccharidosis Type Ih
alpha-L-Iduronidase Deficiency
Pfaundler-Hurler Syndrome

Excerpt	Reference
"Hurler syndrome is the most severe form of a lysosomal storage disease caused by loss of the enzyme alpha-L-iduronidase (encoded by the IDUA gene), which participates in the degradation of glycosaminoglycans (GAGs) within the lysosome."	( Bedwell, DM; Brooks, DA; Hopwood, JJ; Keeling, KM; Li, P; Thompson, JN, 2001)
"Hurler Syndrome is corrected by allogeneic BMT by the action of donor enzyme on recipient tissue."	( Carr, T; Church, H; Cooper, A; Mercer, J; O'Meara, A; Thornley, M; Tylee, K; Wraith, E; Wynn, RF, 2007)
"Hurler's syndrome is an inborn error of mucopolysaccharide metabolism leading to premature death in childhood."	( Beilken, A; Erttmann, R; Fuchs, D; Grigull, L; Gruhn, B; Kabisch, H; Luecke, T; Meissner, B; Sauer, M; Suttorp, M; Sykora, KW; Welte, K, 2009)
"Mucopolysaccharidosis type I is a lysosomal storage disease with alterations in several organs."	( Andrades, ME; Braga, LM; Camassola, M; Dal-Pizzol, F; de Oliveira, MR; Moreira, JC; Nardi, NB; Reinke, A; Reolon, GK; Roesler, R, 2009)
"Mucopolysaccharidosis type I is a rare autosomal recessive genetic disease caused by deficient activity of α-L-iduronidase."	( Cerón, M; Jiménez-Mariscal, JL; Peña-Gomar, I; Reyes-López, CA; Rosas-Trigueros, J, 2021)

Excerpt	Reference
"Mucopolysaccharidosis type I has been classified into 3 clinical subtypes, ranging from a severe Hurler form to the more attenuated Hurler-Scheie and Scheie phenotypes."	( Cerón, M; Jiménez-Mariscal, JL; Peña-Gomar, I; Reyes-López, CA; Rosas-Trigueros, J, 2021)

Excerpt	Reference
"For patients with mucopolysaccharidosis type IH (MPS1-H; Hurler syndrome), early allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice."	( Benesch, M; Brunner-Krainz, M; Lackner, H; Paschke, E; Plecko, B; Raicht, A; Schwinger, W; Seidel, M; Sovinz, P; Sperl, D; Strenger, V; Urban, C, 2014)
"Severe mucopolysaccharidosis type I, (MPS IH) is a rare inherited lysosomal disorder resulting in progressive storage of proteoglycans (GAGs) in central nervous system and somatic tissues and, if left untreated, causing death within the first decade of life."	( Braunlin, E; Elsbecker, SA; Gupta, AO; Lund, TC; Orchard, PJ; Pillai, NR, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	158 (49.84)	23.3326
1990's	18 (5.68)	12.5806
2000's	50 (15.77)	18.1394
2010's	68 (21.45)	28.8240
2020's	23 (7.26)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
carbon monoxide	low	1	0
methane	low	1	0
chlorine	low	2	0
creatine	low	1	0
lactic acid	low	1	0
glycine	low	1	0
spermine	low	1	0
toluene	low	1	0
urea	low	1	0
1-anilino-8-naphthalenesulfonate	low	2	0
azathioprine	low	3	0
bupivacaine	low	1	0
busulfan	medium	9	2
cetylpyridinium	low	2	0
cystamine	low	1	0
droperidol	low	1	0
ebselen	low	1	0
fentanyl	low	2	0
gentamicin	low	6	0
halothane	low	1	0
hydroxychloroquine	low	1	0
hydroxyurea	low	1	0
lidocaine	low	1	0
isoflurane	low	1	0
2-propanol	low	2	0
losartan	low	3	0
milrinone	low	1	0
apnea	medium	2	1
propofol	low	2	0
resorcinol	low	1	0
sevoflurane	low	2	0
thalidomide	low	1	0
thiotepa	low	1	0
triamterene	low	1	0
prednisolone	low	1	0
hydroxyproline	low	1	0
serine	low	2	0
chloramphenicol	low	1	0
aspartic acid	low	1	0
galactose	low	2	0
edetic acid	low	1	0
tyrosine	low	1	0
methylene blue	low	1	0
leucine	low	2	0
lactose	low	1	0
phenylalanine	low	1	0
cycloheximide	low	3	0
mannitol	low	1	0
histidine	low	1	0
methandrostenolone	low	1	0
tryptophan	low	1	0
arginine	low	2	0
acetonitrile	low	1	0
methylprednisolone	low	1	0
carbazole	low	1	0
tolonium chloride	low	2	0
boric acid	low	1	0
pyrroles	low	1	0
ethyl acetate	low	1	0
mequinol	low	1	0
catechin	low	1	0
quinazolines	low	1	0
thiazoles	low	1	0
hydrazine	low	1	0
malondialdehyde	low	1	0
glycopyrrolate	low	1	0
fucose	low	4	0
fluorescein-5-isothiocyanate	low	1	0
mannose	low	8	0
dithiothreitol	low	1	0
vidarabine	medium	3	2
technetium	low	1	0
cupric chloride	low	1	0
galactosamine	low	7	0
deuterium	low	1	0
galactose	low	6	0
trolamine salicylate	low	4	0
phenyl acetate	low	6	0
glucaric acid	low	1	0
tobramycin	low	1	0
dobutamine	low	1	0
amikacin	low	1	0
nitazoxanide	low	1	0
atracurium	low	1	0
alfentanil	low	1	0
simvastatin	low	1	0
atomoxetine hydrochloride	low	1	0
adenosine	low	1	0
acridine orange	low	1	0
cisatracurium	low	1	0
glucose, (beta-d)-isomer	low	1	0
triazoles	low	2	0
delphinidin	low	1	0
tyloxapol	low	1	0
eletriptan	low	1	0
fibrinogen	low	1	0
glucuronic acid	low	3	0
n-succinimidyl-3-(4-hydroxyphenyl)propionate	low	1	0
pyridinoline	low	1	0
deoxypyridinoline	low	1	0
gefitinib	low	1	0
antibiotic g 418	low	1	0
1,9-dimethylmethylene blue	low	1	0
methotrexate	low	1	0
4-methylumbelliferyl iduronide	low	6	0
xylose	low	1	0
proline	low	4	0
nepafenac	low	1	0
glycogen	low	3	0
mannose-6-phosphate	low	3	0
glucosamine	low	9	0
elastin	low	5	0
epiglucan	low	1	0
puromycin	low	2	0
paromamine	low	1	0
iduronate	low	9	0
retinol	low	5	0
tacrolimus	medium	1	1
mycophenolic acid	medium	1	1
keratan sulfate	low	4	0
melphalan	medium	1	1
glycosides	low	3	0
flavin-adenine dinucleotide	low	1	0
fludarabine	medium	3	2
D-fructopyranose	low	1	0
lithium	low	1	0
dermatan sulfate	medium	41	1
myelin basic protein	low	1	0
linoleic acid	low	1	0
hymecromone	low	10	0
kaempferol	low	1	0
genistein	low	4	0
amphotericin b	low	1	0
daidzein	low	1	0
su 5402	low	1	0
cytochalasin b	low	1	0
sulfur	low	2	0
1,2-dioleoyloxy-3-(trimethylammonium)propane	low	2	0
dioleoyl phosphatidylethanolamine	low	2	0
i(3)so3-galactosylceramide	low	3	0
treosulfan	low	1	0
g(m2) ganglioside	low	3	0
gentamicin sulfate	low	1	0
g(m1) ganglioside	low	4	0
oxadiazoles	low	1	0
ptc 124	low	1	0
scopolamine hydrobromide	low	1	0
acid phosphatase	low	11	0
vendex	low	1	0
thimerosal	low	1	0
sodium ethylxanthate	low	1	0
glycolipids	low	13	0
interleukin-8	low	1	0
eliglustat tartrate	low	1	0
chondroitin	low	31	0
heparitin sulfate	low	49	0
ascorbic acid	low	5	0
g(m3) ganglioside	low	1	0
hyaluronoglucosaminidase	low	6	0
cyclosporine	low	4	0
lactoferrin	low	1	0
technetium tc 99m medronate	low	1	0
amyloid beta-peptides	low	1	0
chondroitin sulfates	medium	11	1
amg531	low	1	0
alcian blue	low	1	0
eye	low	13	0

Protein Targets (1,604)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	3	0	0	3
thioredoxin reductase	27	0	0	27
USP1 protein, partial	13	0	0	13
TDP1 protein	45	0	0	45
vitamin D3 receptor isoform VDRA	15	0	0	15
importin subunit beta-1 isoform 1	7	0	0	7
flap endonuclease 1	15	0	0	15
serine/threonine-protein kinase PLK1	5	0	0	5
snurportin-1	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
DNA polymerase eta isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	17	0	0	17
urokinase-type plasminogen activator precursor	17	0	0	17
plasminogen precursor	17	0	0	17
urokinase plasminogen activator surface receptor precursor	17	0	0	17
geminin	36	0	0	36
DNA polymerase kappa isoform 1	10	0	0	10
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	1	2
Beta-lactamase	0	2	0	2
Transthyretin	0	2	1	3
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	3	1	4
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	1	1	2
Cyclin-dependent kinase 2	0	1	3	4
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	1	2
Guanine nucleotide-binding protein G	2	0	0	2
Fatty acid-binding protein 5	0	1	1	2
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	1	2
Mitogen-activated protein kinase 14	0	3	1	4
hypoxia-inducible factor 1 alpha subunit	16	0	0	16
RAR-related orphan receptor gamma	36	0	0	36
GLI family zinc finger 3	40	0	0	40
AR protein	53	0	0	53
aldehyde dehydrogenase 1 family, member A1	27	0	0	27
retinoic acid nuclear receptor alpha variant 1	40	0	0	40
retinoid X nuclear receptor alpha	33	0	0	33
estrogen nuclear receptor alpha	56	0	0	56
peroxisome proliferator-activated receptor delta	28	0	0	28
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	30	0	0	30
activating transcription factor 6	20	0	0	20
v-jun sarcoma virus 17 oncogene homolog (avian)	22	0	0	22
Histone H2A.x	28	0	0	28
thyroid hormone receptor beta isoform a	12	0	0	12
heat shock protein beta-1	21	0	0	21
nuclear factor erythroid 2-related factor 2 isoform 1	43	0	0	43
lamin isoform A-delta10	41	0	0	41
Voltage-dependent calcium channel gamma-2 subunit	23	0	0	23
Glutamate receptor 2	23	1	0	24
pregnane X receptor	7	0	0	7
Telomerase reverse transcriptase	0	1	0	1
Amyloid-beta precursor protein	1	6	0	7
Reverse transcriptase/RNaseH	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	20	0	0	20
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	9	0	0	9
glucocorticoid receptor [Homo sapiens]	34	0	0	34
NPYLR7B	0	0	2	2
arylsulfatase A	11	0	0	11
IDH1	18	0	0	18
glycogen synthase kinase-3 beta isoform 1	0	0	5	5
mitogen-activated protein kinase 1	10	0	0	10
nuclear receptor ROR-gamma isoform 1	13	0	0	13
peripheral myelin protein 22	19	0	0	19
survival motor neuron protein isoform d	15	0	0	15
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	8	2	10
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	3	1	4
Insulin receptor	0	1	1	3
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	1	1	3
Adenosine receptor A3	0	2	2	5
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	1	1	3
Inosine-5'-monophosphate dehydrogenase 2	0	3	1	4
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	3	0	3
Fibroblast growth factor receptor 2	0	0	1	2
Fibroblast growth factor receptor 4	0	0	1	2
Fibroblast growth factor receptor 3	0	0	1	2
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	3	1	7
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	3	2	6
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	4	2	7
Adenosine receptor A2a	0	4	1	8
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	1	2
Adenosine deaminase	0	0	0	3
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	1	4
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Bile salt export pump	0	28	0	28
ATP-dependent translocase ABCB1	0	5	3	9
Mu-type opioid receptor	0	7	2	12
Kappa-type opioid receptor	0	5	0	5
Mu-type opioid receptor	0	6	0	6
Sigma non-opioid intracellular receptor 1	0	4	0	4
Luciferase	18	0	0	18
acetylcholinesterase	21	0	0	21
estrogen receptor 2 (ER beta)	30	0	0	30
progesterone receptor	31	0	0	31
cytochrome P450 family 3 subfamily A polypeptide 4	28	0	0	28
EWS/FLI fusion protein	23	0	0	23
farnesoid X nuclear receptor	25	0	0	25
G	21	0	0	21
cytochrome P450 2D6	22	0	0	22
peroxisome proliferator activated receptor gamma	28	0	0	28
vitamin D (1,25- dihydroxyvitamin D3) receptor	28	0	0	28
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	17	0	0	17
Solute carrier family 22 member 1	0	4	0	4
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Interferon beta	25	0	0	25
HLA class I histocompatibility antigen, B alpha chain	21	0	0	21
Replicase polyprotein 1ab	0	6	4	10
Replicase polyprotein 1ab	0	5	5	10
Thrombopoietin receptor	0	0	1	1
Potassium voltage-gated channel subfamily H member 2	0	10	0	10
Sodium channel protein type 5 subunit alpha	0	2	0	2
Inositol hexakisphosphate kinase 1	21	0	0	21
Solute carrier organic anion transporter family member 1B3	0	5	0	6
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	7	1	9
Solute carrier organic anion transporter family member 1B1	0	7	0	7
cytochrome P450 2C9, partial	21	0	0	21
histone acetyltransferase KAT2A isoform 1	12	0	0	12
ATP-binding cassette sub-family C member 3	0	19	0	19
Multidrug resistance-associated protein 4	0	19	0	20
Canalicular multispecific organic anion transporter 1	0	18	0	18
Aminoglycoside 3'-phosphotransferase	0	0	0	1
ATP-dependent phosphofructokinase	14	0	0	14
Chain A, HADH2 protein	19	0	0	19
Chain B, HADH2 protein	19	0	0	19
Chain A, Cruzipain	9	0	0	9
interleukin 8	7	0	0	7
phosphopantetheinyl transferase	16	0	0	16
GLS protein	15	0	0	15
tumor necrosis factor	2	0	0	2
Cytochrome P450 1A2	0	3	0	3
Cytochrome P450 3A4	0	6	1	8
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	5	0	5
Cytochrome P450 2C19	0	2	0	2
Nuclear receptor ROR-gamma	12	0	0	12
Aurora kinase B	0	3	1	4
30S ribosomal protein S6	0	4	0	5
30S ribosomal protein S7	0	4	0	5
50S ribosomal protein L15	0	4	0	5
50S ribosomal protein L10	0	4	0	5
50S ribosomal protein L11	0	4	0	5
50S ribosomal protein L7/L12	0	4	0	5
50S ribosomal protein L19	0	4	0	5
50S ribosomal protein L1	0	4	0	5
50S ribosomal protein L20	0	4	0	5
50S ribosomal protein L27	0	4	0	5
50S ribosomal protein L28	0	4	0	5
50S ribosomal protein L29	0	4	0	5
50S ribosomal protein L31	0	4	0	5
50S ribosomal protein L31 type B	0	4	0	5
50S ribosomal protein L32	0	4	0	5
50S ribosomal protein L33	0	4	0	5
50S ribosomal protein L34	0	4	0	5
50S ribosomal protein L35	0	4	0	5
50S ribosomal protein L36	0	4	0	5
30S ribosomal protein S10	0	4	0	5
30S ribosomal protein S11	0	4	0	5
30S ribosomal protein S12	0	4	0	5
30S ribosomal protein S13	0	4	0	5
30S ribosomal protein S16	0	4	0	5
30S ribosomal protein S18	0	4	0	5
30S ribosomal protein S19	0	4	0	5
30S ribosomal protein S20	0	4	0	5
30S ribosomal protein S2	0	4	0	5
30S ribosomal protein S3	0	4	0	5
30S ribosomal protein S4	0	4	0	5
30S ribosomal protein S5	0	4	0	5
30S ribosomal protein S8	0	4	0	5
30S ribosomal protein S9	0	4	0	5
50S ribosomal protein L13	0	4	0	5
50S ribosomal protein L14	0	4	0	5
50S ribosomal protein L16	0	4	0	5
50S ribosomal protein L23	0	4	0	5
30S ribosomal protein S15	0	4	0	5
50S ribosomal protein L17	0	4	0	5
50S ribosomal protein L21	0	4	0	5
50S ribosomal protein L30	0	4	0	5
50S ribosomal protein L6	0	4	0	5
30S ribosomal protein S14	0	4	0	5
30S ribosomal protein S17	0	4	0	5
30S ribosomal protein S1	0	4	0	5
50S ribosomal protein L18	0	4	0	5
50S ribosomal protein L2	0	4	0	5
50S ribosomal protein L3	0	4	0	5
50S ribosomal protein L24	0	4	0	5
50S ribosomal protein L4	0	4	0	5
50S ribosomal protein L22	0	4	0	5
50S ribosomal protein L5	0	4	0	5
30S ribosomal protein S21	0	4	0	5
50S ribosomal protein L25	0	4	0	5
50S ribosomal protein L36 2	0	4	0	5
ATAD5 protein, partial	14	0	0	14
Microtubule-associated protein tau	18	0	0	18
estrogen-related nuclear receptor alpha	47	0	0	47
euchromatic histone-lysine N-methyltransferase 2	29	0	0	29
Bloom syndrome protein isoform 1	14	0	0	14
D(1A) dopamine receptor	5	0	0	5
neuropeptide S receptor isoform A	6	0	0	6
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
NFKB1 protein, partial	5	0	0	5
thyroid stimulating hormone receptor	15	0	0	15
alpha-galactosidase	5	0	0	5
cytochrome P450 2C19 precursor	8	0	0	8
chromobox protein homolog 1	18	0	0	18
muscarinic acetylcholine receptor M1	9	0	0	9
lethal factor (plasmid)	17	0	0	17
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	14	0	0	14
thyroid hormone receptor beta isoform 2	38	0	0	38
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Polyphenol oxidase 2	0	3	0	7
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	3	0	3
Alpha-2B adrenergic receptor	0	6	1	7
Spike glycoprotein	17	2	4	23
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	16	0	0	16
Chain A, Ferritin light chain	13	0	0	13
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	9	0	15
Carbonic anhydrase 2	0	10	1	18
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	1	5	2	12
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	1	4	1	10
Glutamate receptor ionotropic, NMDA 2B	1	4	2	11
Glutamate receptor ionotropic, NMDA 2C	1	4	1	10
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	5
Glutamate receptor ionotropic, NMDA 2D	1	4	1	10
Glutamate receptor ionotropic, NMDA 3B	1	4	1	10
Carbonic anhydrase 4	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	1	4	1	10
glp-1 receptor, partial	14	0	0	14
nuclear receptor subfamily 1, group I, member 3	29	0	0	29
thyroid stimulating hormone receptor	12	0	0	12
Cellular tumor antigen p53	39	0	0	39
Sodium-dependent noradrenaline transporter	0	5	1	6
Amine oxidase [flavin-containing] A	0	1	1	2
Small conductance calcium-activated potassium channel protein 3	0	2	1	3
SMAD family member 2	16	0	0	16
Fumarate hydratase	11	0	0	11
SMAD family member 3	16	0	0	16
pregnane X nuclear receptor	33	0	0	33
polyprotein	11	0	0	11
P53	3	0	0	3
aryl hydrocarbon receptor	24	0	0	24
peripheral myelin protein 22 isoform 1	8	0	0	8
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	11	0	0	11
cytochrome P450 3A4 isoform 1	21	0	0	21
M-phase phosphoprotein 8	5	0	0	5
muscleblind-like protein 1 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	21	3	1	25
Bile salt export pump	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	21	3	1	25
Gamma-aminobutyric acid receptor subunit delta	21	3	1	25
Gamma-aminobutyric acid receptor subunit gamma-2	21	3	2	26
Gamma-aminobutyric acid receptor subunit alpha-5	21	3	1	25
Gamma-aminobutyric acid receptor subunit alpha-3	21	3	1	25
Gamma-aminobutyric acid receptor subunit gamma-1	21	3	1	25
Gamma-aminobutyric acid receptor subunit alpha-2	21	3	1	25
Gamma-aminobutyric acid receptor subunit alpha-4	21	3	1	25
Gamma-aminobutyric acid receptor subunit gamma-3	21	3	1	25
Gamma-aminobutyric acid receptor subunit alpha-6	21	3	1	25
Gamma-aminobutyric acid receptor subunit alpha-1	21	3	2	26
Gamma-aminobutyric acid receptor subunit beta-3	21	3	1	25
Gamma-aminobutyric acid receptor subunit beta-2	21	3	2	26
GABA theta subunit	21	3	1	25
ATPase family AAA domain-containing protein 5	19	0	0	19
Ataxin-2	21	0	0	21
Gamma-aminobutyric acid receptor subunit epsilon	21	3	1	25
Protein-arginine deiminase type-4	0	2	0	2
Beta-lactamase	0	1	0	1
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	15	0	0	15
15-lipoxygenase, partial	10	0	0	10
apical membrane antigen 1, AMA1	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Matrix metalloproteinase-9	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
ClpP	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	8	0	0	8
histone deacetylase 9 isoform 3	10	0	0	10
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
DNA polymerase beta	6	0	0	6
Prostaglandin G/H synthase 1	0	3	0	3
Arginase	0	3	0	3
Pancreatic triacylglycerol lipase	0	3	0	3
Prothrombin	0	1	1	2
Prostaglandin G/H synthase 1	0	1	2	3
Aldo-keto reductase family 1 member B1	0	7	0	7
Carbonic anhydrase 4	0	8	0	12
Prostaglandin G/H synthase 1	0	6	0	6
Carbonic anhydrase 6	0	4	0	8
Sucrase-isomaltase, intestinal	0	1	0	1
Prostaglandin G/H synthase 2	0	4	1	5
Mu-type opioid receptor	0	4	2	8
Delta-type opioid receptor	0	4	1	7
Kappa-type opioid receptor	0	4	1	7
Xanthine dehydrogenase/oxidase	0	4	0	4
Melatonin receptor type 1A	0	0	1	1
Melatonin receptor type 1B	0	0	1	1
Death-associated protein kinase 1	0	3	1	4
Beta-secretase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	3	0	3
Carbonic anhydrase 3	0	2	0	2
Dihydroorotate dehydrogenase	0	2	0	2
Smad3	11	0	0	11
67.9K protein	12	0	0	12
interferon gamma precursor	0	0	0	1
Alpha-synuclein	6	2	0	8
streptokinase A precursor	0	0	2	2
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase 15	0	4	0	8
PPM1D protein	7	0	0	7
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	2	0	2
Spike glycoprotein	0	2	4	6
Replicase polyprotein 1ab	0	2	4	6
glucose-6-phosphate 1-dehydrogenase isoform b	0	2	0	2
Transmembrane protease serine 2	0	2	4	6
Dihydrofolate reductase	0	3	0	3
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Histidine-rich protein PFHRP-II	0	1	0	2
Procathepsin L	0	3	4	7
Muscarinic acetylcholine receptor M2	0	6	0	6
Muscarinic acetylcholine receptor M4	0	7	0	7
Muscarinic acetylcholine receptor M5	0	6	0	6
Alpha-2A adrenergic receptor	0	4	1	5
Replicase polyprotein 1a	0	2	4	6
Replicase polyprotein 1ab	0	2	4	6
Spike glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M1	0	5	0	5
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	1	2
Alpha-2C adrenergic receptor	0	4	0	4
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	5	0	5
Serine/threonine-protein kinase mTOR	0	3	1	4
Nuclear receptor subfamily 4 group A member 2	0	0	3	3
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	2	0	2
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Sigma non-opioid intracellular receptor 1	1	7	0	8
Angiotensin-converting enzyme 2	0	2	4	6
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
endonuclease IV	2	0	0	2
GALC protein	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	11	0	0	11
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	7	0	8
RPL19A	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	5	0	0	5
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
ras-related protein Rab-9A	5	0	0	5
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
COUP transcription factor 2 isoform a	0	1	0	1
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Solute carrier family 2, facilitated glucose transporter member 1	0	4	0	4
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	1	5
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
TAR DNA-binding protein 43	11	0	0	11
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	2
Thrombopoietin	5	0	0	5
PINK1	2	0	0	2
Parkin	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
neutrophil cytosol factor 1	0	3	0	3
Solute carrier family 2, facilitated glucose transporter member 3	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
caspase 7, apoptosis-related cysteine protease	10	0	0	10
Neuraminidase	0	4	0	4
pyruvate kinase	5	0	0	5
caspase-3	10	0	0	10
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
cytochrome P450 2D6 isoform 1	4	0	0	4
cytochrome P450 2C9 precursor	7	0	0	7
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	13	0	0	13
rac GTPase-activating protein 1 isoform a	0	2	0	2
pyruvate kinase PKM isoform b	4	0	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	1	0	7
Carbonic anhydrase 12	0	6	0	10
Aldo-keto reductase family 1 member B10	0	1	0	1
Estrogen receptor	0	6	1	7
Glucocorticoid receptor	0	6	2	16
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Integrin beta-3	7	0	0	7
Integrin alpha-IIb	7	0	0	7
Ornithine decarboxylase	4	0	0	4
Androgen receptor	0	4	0	7
Tyrosinase	0	2	0	2
Aromatase	0	3	0	3
Urease subunit alpha	0	5	0	5
Aldo-keto reductase family 1 member B1	0	5	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	1	0	1
Amine oxidase [flavin-containing] A	0	4	0	4
UDP-glucuronosyltransferase 1A1	0	2	0	3
UDP-glucuronosyltransferase 1A4	0	0	0	2
Amine oxidase [flavin-containing] B	0	4	0	4
Proteasome subunit beta type-5	0	3	0	3
Substance-P receptor	0	4	0	4
Carbonic anhydrase 7	0	5	0	9
Histamine H2 receptor	11	0	0	11
Estrogen receptor	0	0	1	1
Urease subunit beta	0	5	0	5
Inositol monophosphatase 1	5	0	0	5
Transporter	0	1	0	1
Substance-K receptor	0	3	0	3
Estrogen receptor beta	0	6	1	7
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	2	0	2
Prenyltransferase homolog	0	0	0	2
Estrogen receptor beta	0	0	1	1
Vascular endothelial growth factor receptor 2	0	3	1	4
Lactoylglutathione lyase	0	2	0	2
Histone acetyltransferase p300	0	1	0	1
CREB-binding protein	0	1	0	1
Chain A, Beta-lactamase	7	0	0	7
Vpr	3	0	0	3
Glutathione S-transferase omega-1	0	1	0	1
dopamine D1 receptor	3	0	0	3
mu-type opioid receptor isoform MOR-1	0	0	1	1
huntingtin isoform 2	5	0	0	5
5-hydroxytryptamine receptor 2A	0	0	1	1
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	2	1	3
Carbonic anhydrase 3	0	3	0	7
Beta-2 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
POU domain, class 2, transcription factor 1	0	0	0	1
Alpha-1D adrenergic receptor	0	6	0	6
Sodium-dependent serotonin transporter	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	4	0	8
D(3) dopamine receptor	0	5	0	5
Sodium-dependent dopamine transporter	0	4	0	4
Carbonic anhydrase 9	0	5	0	10
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 14	0	3	0	7
Carbonic anhydrase 5B, mitochondrial	0	3	0	7
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	6	0	6
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	3	0	3
D(1A) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	6	0	6
5-hydroxytryptamine receptor 1B	0	2	0	2
Histamine H1 receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	4	0	4
N-acetyltransferase Eis	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
RNA polymerase beta subunit (EC 2.7.7.6), partial	0	1	0	1
Nrf2	2	0	0	2
RGS12	1	0	0	1
Arrestin, beta 1	0	1	0	1
MPI protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
hypothetical protein, conserved	4	0	0	4
isocitrate dehydrogenase 1, partial	2	0	0	2
nonstructural protein 1	3	0	0	3
glucocerebrosidase	7	0	0	7
luciferase	2	0	0	2
TPA: protein transporter TIM10	0	1	0	1
TPA: protein transporter TIM23	0	1	0	1
hexokinase	0	1	0	1
hexokinase-4 isoform 1	2	0	0	2
hexokinase-1 isoform HKI	0	0	1	1
phosphomannomutase 2	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
perilipin-5	0	1	0	1
fructose-bisphosphate aldolase A	1	0	0	1
phosphoethanolamine/phosphocholine phosphatase isoform 1	0	1	0	1
perilipin-1	0	1	0	1
glucokinase regulatory protein	2	0	0	2
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
pyruvate kinase PKM isoform a	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
hexokinase HKDC1	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Sulfhydryl oxidase 1	0	1	0	1
Acetylcholinesterase	0	4	0	4
Gamma-butyrobetaine dioxygenase	0	1	1	2
Sodium channel protein type 1 subunit alpha	1	1	0	2
Sodium channel protein type 2 subunit alpha	1	1	0	2
Sodium channel protein type 3 subunit alpha	1	1	0	2
Macrophage migration inhibitory factor	0	2	0	2
Neutrophil cytosol factor 1	0	1	0	1
Insulin-degrading enzyme	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	3
Toxin B	0	1	0	1
Endothelin receptor type B	2	0	0	2
Acetylcholinesterase	0	3	0	3
Endothelin-1 receptor	2	0	0	2
Caspase-1	0	2	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Methionine aminopeptidase 2	0	1	0	1
Cholinesterase	0	3	0	3
UDP-glucose 4-epimerase	0	1	0	1
Structural capsid protein	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	2	0	2
Eyes absent homolog 2	0	1	0	1
Angiotensin-converting enzyme	0	3	0	3
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
5-hydroxytryptamine receptor 1B	0	0	1	1
Cytochrome P450 2J2	0	2	0	2
Beta-2 adrenergic receptor	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
D(4) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	3	0	4
Delta-type opioid receptor	0	5	1	7
Kappa-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	3	1	6
Sigma non-opioid intracellular receptor 1	0	1	0	1
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
5'-nucleotidase	0	1	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
Fucose-binding lectin PA-IIL	0	2	0	2
CD209 antigen	0	3	0	3
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	3	3
transcriptional regulator ERG isoform 3	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	2	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	3	2	5
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	2	4
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	2	4
Gamma-aminobutyric acid receptor subunit beta-2	0	2	2	4
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	2	4
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	2	4
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	1	2	4
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
epidermal growth factor receptor isoform a precursor	1	1	0	2
tyrosine-protein kinase Yes	2	0	0	2
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	1	2
Serine/threonine-protein kinase PLK4	0	0	1	1
Serine/threonine-protein kinase 25	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Aurora kinase A	0	1	1	2
Cyclin-G-associated kinase	0	1	1	2
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
NUAK family SNF1-like kinase 1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
Tyrosine-protein kinase ABL1	0	2	2	4
RAF proto-oncogene serine/threonine-protein kinase	0	0	1	1
High affinity nerve growth factor receptor	0	0	1	1
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Cytochrome P450 2E1	0	1	0	1
Protein kinase C beta type	0	0	1	1
Cyclin-dependent kinase 1	0	2	1	3
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Macrophage colony-stimulating factor 1 receptor	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	1	1	2
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	1	1	2
Insulin-like growth factor 1 receptor	0	1	1	2
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	1	1	2
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Quinolone resistance protein NorA	0	1	0	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Cytochrome P450 2C8	0	1	0	1
Mast/stem cell growth factor receptor Kit	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Serine/threonine-protein kinase pim-1	0	1	1	2
DNA topoisomerase 2-alpha	0	1	1	2
Myosin light chain kinase, smooth muscle	0	0	1	1
Cyclin-dependent kinase 4	0	2	1	3
ADP/ATP translocase 3	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	3	1	4
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Insulin receptor-related protein	0	0	1	1
Serine/threonine-protein kinase B-raf	0	1	1	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Platelet-derived growth factor receptor alpha	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	1	1	2
cAMP-dependent protein kinase catalytic subunit alpha	0	1	1	2
Vascular endothelial growth factor receptor 1	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Casein kinase II subunit alpha'	0	1	1	2
Ras-related protein Rab-6A	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	1	1	2
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Sodium-dependent dopamine transporter	0	1	0	1
Protein kinase C eta type	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Cruzipain	0	3	0	3
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Activin receptor type-2A	0	0	1	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	1	1	2
RAC-beta serine/threonine-protein kinase	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Dual specificity protein kinase TTK	0	1	1	2
DNA replication licensing factor MCM4	0	0	1	1
Type-1 angiotensin II receptor	0	2	1	3
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	1	1	2
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	1	1	2
Glycine--tRNA ligase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 8	0	1	0	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	1	2
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase TXK	0	0	1	1
Tyrosine-protein kinase ABL2	0	1	1	2
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase ZAP-70	0	0	1	1
Tyrosine-protein kinase SYK	0	1	1	2
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 4	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	2	1	3
Casein kinase I isoform delta	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	1	2
MAP kinase-activated protein kinase 2	0	0	1	1
Cyclin-dependent kinase 8	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	1	1	2
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	1	1	2
Glycogen synthase kinase-3 beta	0	1	1	2
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Tyrosine-protein kinase Blk	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Cytoplasmic tyrosine-protein kinase BMX	0	1	1	2
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	2	1	3
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	1	1	2
Ephrin type-B receptor 1	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Tubulin alpha-1A chain	0	0	1	1
Casein kinase II subunit alpha	0	1	1	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Cyclin-dependent kinase 6	0	1	1	2
Cyclin-dependent-like kinase 5	0	1	1	2
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Synaptic vesicular amine transporter	0	1	0	1
Protein kinase C epsilon type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
Angiopoietin-1 receptor	0	0	1	1
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Transcription factor p65	0	1	0	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	0	1	1
Tyrosine-protein kinase BTK	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Serine/threonine-protein kinase PAK 1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Serine/threonine-protein kinase D1	0	0	1	1
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	1	1	2
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
ATP-dependent RNA helicase DDX42	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
SRSF protein kinase 1	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Long-chain-fatty-acid--CoA ligase 5	0	0	1	1
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase 38-like	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Chain A, Estrogen receptor 1 (alpha)	0	1	0	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
BRCA1	1	0	0	1
Alpha-mannosidase	0	1	0	1
Maltase-glucoamylase, intestinal	0	2	0	2
Steroid hormone receptor ERR2	0	1	0	1
Triosephosphate isomerase	0	1	0	1
Sex hormone-binding globulin	0	0	1	1
Sialidase	0	2	0	2
Steroid hormone receptor ERR1	0	2	0	2
Ornithine decarboxylase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	2
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
G2/mitotic-specific cyclin-B1	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
Androgen receptor	0	4	0	4
Amine oxidase [flavin-containing] A	0	1	0	1
G1/S-specific cyclin-D1	0	2	0	2
Thromboxane-A synthase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Dipeptidyl peptidase 4	0	3	0	3
Sodium-dependent serotonin transporter	0	3	0	3
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Testosterone 17-beta-dehydrogenase 3	0	2	0	2
17-beta-hydroxysteroid dehydrogenase type 2	0	2	0	2
Acetylcholinesterase	0	1	0	1
Alpha-glucosidase MAL32	0	1	0	1
Signal transducer and activator of transcription 3	0	2	0	2
Quinone oxidoreductase	0	0	0	1
Oxysterols receptor LXR-beta	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Aldehyde oxidase	0	1	0	1
Oxysterols receptor LXR-alpha	0	1	0	1
Tissue alpha-L-fucosidase	0	1	0	1
Integrase	0	2	0	2
Carboxylic ester hydrolase	0	1	0	1
Dipeptidyl peptidase 3	0	2	0	2
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
Sialidase-2	0	2	0	2
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Dihydrofolate reductase	0	5	0	6
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	6	0	7
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Albumin	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	4
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase	0	0	0	4
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase 13	0	2	0	5
Genome polyprotein	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Neutral amino acid transporter A	0	3	0	3
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	3	0	3
Amino acid transporter	0	3	0	3
Stromelysin-1	0	1	1	2
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
caspase-1 isoform alpha precursor	3	0	0	3
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Genome polyprotein	0	1	0	1
Caspase-7	3	0	0	3
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Oleandomycin glycosyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
G2/mitotic-specific cyclin-B2	0	1	0	1
Cationic trypsin	0	1	0	1
Protein E6	0	1	0	1
Neuraminidase	0	1	0	1
Interstitial collagenase	0	1	0	1
Cytochrome P450 1A1	0	2	0	2
Myeloperoxidase	0	2	0	2
Beta-glucuronidase	0	1	0	1
G2/mitotic-specific cyclin-B	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
ATP-dependent translocase ABCB1	0	1	1	2
Multidrug resistance-associated protein 1	0	1	0	2
Aryl hydrocarbon receptor	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	2	0	2
Cyclin homolog	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Casein kinase II subunit alpha 3	0	1	0	1
Inositol polyphosphate multikinase	0	1	0	1
Histone-lysine N-methyltransferase SETD7	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	1	0	1
3-oxoacyl-acyl-carrier protein reductase	0	1	0	1
Cyclin-dependent kinase 1	0	1	0	1
NADPH oxidase 4	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Inositol hexakisphosphate kinase 2	0	1	0	1
Short transient receptor potential channel 5	0	1	0	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	3	0	3
Phospholipase A-2-activating protein	0	3	0	3
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Free fatty acid receptor 1	0	0	1	1
Sterol O-acyltransferase 1	0	1	0	1
Trypsin	0	1	0	1
Fatty acid-binding protein, heart	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Dual specificity protein phosphatase 3	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Free fatty acid receptor 4	0	0	1	1
Neprilysin	0	1	0	1
Atrial natriuretic peptide receptor 3	0	1	0	1
Thromboxane A2 receptor	0	1	0	2
Type-1A angiotensin II receptor	0	2	1	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	2	1	5
Type-2 angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
Squalene synthase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
Type-1 angiotensin II receptor	0	1	1	2
Alpha-mannosidase 2C1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	2
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
serine-protein kinase ATM isoform a	1	0	0	1
caspase-9 isoform alpha precursor	0	1	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	3	1	4
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Phosphodiesterase	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Inner centromere protein	0	1	0	1
Phosphodiesterase	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	3	0	3
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M2	0	3	1	4
Translocator protein	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Pyruvate-flavodoxin oxidoreductase	0	1	0	1
Anoctamin-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
SLC16A10 protein	0	0	0	3
Monocarboxylate transporter 10	0	0	0	3
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	2	2
Nociceptin receptor	0	0	1	1
Glutamate 5-kinase	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Puromycin-sensitive aminopeptidase	0	1	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Chain A, Bacterial regulatory proteins, tetR family	0	0	1	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
photoreceptor-specific nuclear receptor	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Caspase-2	0	0	1	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	1	1
Fibroblast growth factor receptor 1	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 3A5	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Cereblon isoform 4	0	2	0	2
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
toll-like receptor 9	0	1	0	1
caspase recruitment domain family, member 15	0	1	0	1
neurotensin receptor type 1	0	0	1	1
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
Beta lactamase (plasmid)	0	1	0	1
Cytochrome P450 2B1	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Protein Rev	0	0	1	1
Endolysin	0	0	1	1
Chain A, PAPAIN	1	0	0	1
putative alpha-glucosidase	1	0	0	1
Janus kinase 2 (a protein tyrosine kinase)	0	1	0	1
Cathepsin G	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Thymidine kinase, cytosolic	0	0	0	1
Adenosylhomocysteinase	0	1	0	1
RNA-directed RNA polymerase	0	1	1	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

alpha-L-Iduronidase Deficiency

Synonyms(20)

Research Excerpts

Overview

Context

Treatment

Research

Studies (317)

Protein Targets (1,604)

alpha-L-Iduronidase Deficiency

Synonyms(20)

Research Excerpts

Overview

Context

Treatment

Research

Studies (317)

Drugs Studied (194)

Protein Targets (1,604)