Page last updated: 2024-09-27

Mixed Tumor, Mesodermal

A sarcoma of the body of the uterus arising in older women, composed of more than one mesenchymal tissue, especially including striated muscle cells. It is associated with previous pelvic radiation exposure in 20% of patients. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1702)

Synonyms(1)

Synonym
Mixed Tumor, Mesodermal

Research

Studies (20)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (5.00)23.3326
1990's7 (35.00)12.5806
2000's11 (55.00)18.1394
2010's1 (5.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0medium11
uric acid0medium11
hydroxyurea0medium11
ifosfamide0medium53
trimetrexate0medium11
mitomycin0low20
2-amino-1,3,4-thiadiazole0medium11
camptothecin0low10
tetradecanoylphorbol acetate0low10
etoposide0medium11
amonafide0medium11
irinotecan0low10
naphthalimides0medium11
organophosphonates0medium11
carboplatin0medium21
bromochloroacetic acid0low10
tamoxifen0low30
radium0low10
gadolinium dtpa0low10
mesna0medium22
cyclosporine0medium11
dacarbazine0medium11
allopurinol0medium11

Protein Targets (428)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Pteridine reductase 10202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
RAR-related orphan receptor gamma9009
TDP1 protein8008
AR protein9009
nuclear receptor subfamily 1, group I, member 36006
cytochrome P450 family 3 subfamily A polypeptide 43003
glucocorticoid receptor [Homo sapiens]6006
estrogen-related nuclear receptor alpha8008
pregnane X nuclear receptor6006
estrogen nuclear receptor alpha9009
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
nuclear factor erythroid 2-related factor 2 isoform 24004
heat shock protein beta-13003
importin subunit beta-1 isoform 11001
snurportin-11001
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
lamin isoform A-delta106006
Voltage-dependent calcium channel gamma-2 subunit6006
Bile salt export pump0909
Cyclin-dependent kinase 10101
Heat shock protein HSP 90-beta0101
Glutamate receptor 26006
Xanthine dehydrogenase/oxidase0303
TAR DNA-binding protein 432002
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 53003
Ataxin-23003
interleukin 82002
thyroid stimulating hormone receptor4004
estrogen receptor 2 (ER beta)4004
progesterone receptor5005
IDH12002
euchromatic histone-lysine N-methyltransferase 26006
Bloom syndrome protein isoform 14004
transcriptional regulator ERG isoform 32002
thyroid hormone receptor beta isoform 25005
ras-related protein Rab-9A3003
nuclear factor erythroid 2-related factor 2 isoform 16006
geminin6006
survival motor neuron protein isoform d3003
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40808
Polyphenol oxidase 20101
Hypoxanthine-guanine phosphoribosyltransferase0001
Cellular tumor antigen p536006
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase 0101
Adenosine receptor A2a0213
Nuclear receptor ROR-gamma0101
Xanthine dehydrogenase/oxidase0214
Purine nucleoside phosphorylase0011
Canalicular multispecific organic anion transporter 109010
Shiga toxin subunit A0101
Histamine H3 receptor0101
Fumarate hydratase7007
PPM1D protein5005
EWS/FLI fusion protein8008
polyprotein7007
Interferon beta6006
Cytochrome P450 2D60101
DNA topoisomerase 102110
aldehyde dehydrogenase 1 family, member A14004
retinoic acid nuclear receptor alpha variant 17007
thyroid stimulating hormone receptor4004
Nuclear receptor ROR-gamma1001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, Ferritin light chain2002
Chain A, Cruzipain1001
DNA topoisomerase 0101
thioredoxin reductase3003
15-lipoxygenase, partial2002
ATAD5 protein, partial1001
NFKB1 protein, partial2002
Thrombopoietin1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
regulator of G-protein signaling 42002
67.9K protein5005
glucocerebrosidase2002
putative alpha-glucosidase1001
alpha-galactosidase1001
lysosomal alpha-glucosidase preproprotein1001
peripheral myelin protein 22 isoform 12002
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
chromobox protein homolog 14004
huntingtin isoform 21001
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor0011
serine/threonine-protein kinase mTOR isoform 12002
DNA polymerase iota isoform a (long)3003
nuclear receptor ROR-gamma isoform 13003
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 82002
muscleblind-like protein 1 isoform 11001
histone acetyltransferase KAT2A isoform 12002
relaxin receptor 1 isoform 11001
lethal factor (plasmid)2002
Gamma-aminobutyric acid receptor subunit pi3003
Telomerase reverse transcriptase0101
Serine/threonine-protein kinase Chk10011
Histone deacetylase 30101
Type-2 restriction enzyme ScaI0101
Deoxyribonuclease-2-alpha0101
Tyrosyl-DNA phosphodiesterase 20101
Deoxyribonuclease-10101
Type-2 restriction enzyme PstI0101
Type-2 restriction enzyme EcoRI0101
Prothrombin0002
DNA ligase0101
Integrin beta-32002
Integrin alpha-IIb2002
Heterogeneous nuclear ribonucleoprotein A10011
DNA topoisomerase 2-alpha0218
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Type-2 restriction enzyme BamHI0101
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Somatostatin receptor type 10101
Somatostatin receptor type 20101
Somatostatin receptor type 40101
Somatostatin receptor type 30101
Somatostatin receptor type 50101
5-hydroxytryptamine receptor 2B0404
Type-2 restriction enzyme HindIII0101
D(1A) dopamine receptor2002
Histone deacetylase 40101
Ribonuclease pancreatic0101
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Inositol monophosphatase 13003
DNA topoisomerase 2-beta0119
DNA topoisomerase 10102
Histone deacetylase 10101
DNA topoisomerase 10101
Integrase 0202
Histone deacetylase 70101
GABA theta subunit3003
Histone deacetylase 20101
DNA topoisomerase type IB small subunit 0011
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit epsilon3003
Tyrosyl-DNA phosphodiesterase 10101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
acetylcholinesterase4004
phosphopantetheinyl transferase3003
G1001
cytochrome P450 2D63003
vitamin D3 receptor isoform VDRA4004
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
DNA polymerase kappa isoform 13003
HLA class I histocompatibility antigen, B alpha chain 1001
Inositol hexakisphosphate kinase 11001
cytochrome P450 2C9, partial1001
ATP-dependent phosphofructokinase2002
hypoxia-inducible factor 1 alpha subunit4004
peroxisome proliferator activated receptor gamma4004
activating transcription factor 63003
Matrix metalloproteinase-90101
Isocitrate lyase0101
glp-1 receptor, partial1001
SMAD family member 22002
SMAD family member 32002
GLI family zinc finger 35005
caspase 7, apoptosis-related cysteine protease3003
retinoid X nuclear receptor alpha4004
peroxisome proliferator-activated receptor delta4004
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
caspase-33003
LMP1 [Human herpesvirus 4]0001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x4004
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Regulatory protein E20011
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10416
Cytochrome P450 3A40303
Cytochrome P450 2C9 0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0001
Serum paraoxonase/arylesterase 10202
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0001
Solute carrier organic anion transporter family member 1B30202
Glutamate receptor ionotropic, NMDA 3A0001
GLS protein1001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Carbonic anhydrase 20102
Stromelysin-10011
Gamma-aminobutyric acid receptor subunit alpha-10101
Urease subunit alpha0101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Carbonic anhydrase 40101
Ribonucleoside-diphosphate reductase large subunit0101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Carbonic anhydrase 5A, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Urease subunit beta0101
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Carbonic anhydrase 90102
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit theta0101
Chain A, Beta-lactamase2002
GALC protein1001
Chain A, Acetylcholinesterase0101
interferon gamma precursor0002
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0101
Solute carrier family 22 member 30101
Interstitial collagenase0101
Acetylcholinesterase0101
Muscarinic acetylcholine receptor M40404
Alpha-2C adrenergic receptor0202
Acetylcholinesterase0202
Liver carboxylesterase 10001
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Luciferase1001
Microtubule-associated protein tau4004
farnesoid X nuclear receptor2002
aryl hydrocarbon receptor2002
nuclear receptor subfamily 1, group I, member 21001
Indoleamine 2,3-dioxygenase 10101
Spike glycoprotein2013
Chain A, Cholix toxin0101
Beta-hexosaminidase subunit alpha0101
Poly [ADP-ribose] polymerase 10101
Chain A, CES1 protein0101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
USP1 protein, partial2002
apical membrane antigen 1, AMA11001
DNA polymerase III, partial1001
bromodomain adjacent to zinc finger domain 2B1001
arylsulfatase A1001
thyrotropin-releasing hormone receptor1001
Caspase-71001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
cytochrome P450 2D6 isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
D(1A) dopamine receptor1001
caspase-31001
ubiquitin-conjugating enzyme E2 N0101
streptokinase A precursor0011
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20011
5-hydroxytryptamine receptor 40202
Serine/threonine-protein kinase D30112
Epidermal growth factor receptor0101
Estrogen receptor0214
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Protein kinase C gamma type0213
Protein kinase C alpha type0101
Protein kinase C beta type0213
Estrogen receptor0012
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Progesterone receptor0101
Procathepsin L0011
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Beta-1 adrenergic receptor0202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Adenosine receptor A30202
Replicase polyprotein 1ab0011
Muscarinic acetylcholine receptor M10202
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Beta-3 adrenergic receptor0202
D(2) dopamine receptor0202
Androgen receptor0202
Alpha-1B adrenergic receptor0202
Protein kinase C alpha type0213
Alpha-2B adrenergic receptor0202
5-hydroxytryptamine receptor 1A0202
Muscarinic acetylcholine receptor M30202
Cytochrome P450 2B60101
Substance-K receptor0202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Prostaglandin G/H synthase 10101
Sodium-dependent noradrenaline transporter 0202
Thromboxane-A synthase 0101
Protein kinase C eta type0112
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Sodium-dependent serotonin transporter0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Alpha-synuclein1001
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Protein kinase C iota type0112
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0202
Histamine H2 receptor1001
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Sodium-dependent dopamine transporter 0202
Protein kinase C epsilon type0213
Protein kinase C theta type0112
Protein kinase C zeta type0112
Protein kinase C delta type0213
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Potassium voltage-gated channel subfamily H member 20202
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10112
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Estrogen receptor beta0213
Sigma non-opioid intracellular receptor 10202
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Luciferin 4-monooxygenase0011
Beta-1 adrenergic receptor0101
Ras guanyl-releasing protein 30011
peripheral myelin protein 221001
Dihydrofolate reductase 0101
Dihydrofolate reductase0202
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
5-hydroxytryptamine receptor 2A0101
Dihydrofolate reductase0202
Dihydrofolate reductase0202
Dipeptidyl peptidase 40101
5-hydroxytryptamine receptor 2B0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Dihydrofolate reductase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 22 member 60001
Solute carrier family 22 member 80101
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]