Page last updated: 2024-09-28

Mikulicz Disease

A chronic, benign, and usually painless inflammatory swelling of the lacrimal and salivary glands. It is considered by some to include the glandular enlargement associated with other diseases, such as Sjogren's syndrome, sarcoidosis, lupus erythematosus, etc.

Synonyms(3)

Synonym
Mikulicz' Disease
Mikulicz's Disease
Mikulicz Disease

Research Excerpts

Overview

ExcerptReference
"Mikulicz's disease is considered one of the IgG4-related diseases that are characterized by elevated serum IgG4 concentrations and the immunohistochemical finding of IgG4-positive plasma cells."( Fujimoto, M; Hamaguchi, Y; Kawano, M; Kitamura-Sawada, S; Matsushita, Y; Takehara, K, 2011)

Treatment

ExcerptReference
"We report a case of Mikulicz's disease, IgG4-related plasmacytic syndrome, successfully treated with corticosteroid and mizoribine, followed by mizoribine alone."( Kamatani, N; Kobashigawa, T; Kotake, S; Nanke, Y; Yago, T, 2010)

Research

Studies (73)

TimeframeStudies, This Condition (%)All Conditions %
pre-199029 (39.73)23.3326
1990's2 (2.74)12.5806
2000's15 (20.55)18.1394
2010's25 (34.25)28.8240
2020's2 (2.74)9.53
DrugIndicatedRelationship StrengthStudiesTrials
choline0low10
phenytoin0low10
azathioprine0low30
chloroquine0low10
chlorpheniramine0medium11
guaifenesin0low10
isoniazid0low10
mechlorethamine0low10
corticosterone0low10
prednisolone0low290
prednisone0low80
tyrosine0low10
triamcinolone acetonide0low10
methylprednisolone0low60
technetium0low20
trolamine salicylate0low10
zidovudine0low10
propiconazole0low20
fluorodeoxyglucose f180low50
cobalt0low20
mizoribine0low20
methotrexate0low20
inositol 3-phosphate0low10
thiouracil0low10
pica0low10
ubiquinol0low10
pituitrin0low10
ubiquinone0low10
muramidase0low10
eye0low40

Protein Targets (487)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain B, pheromone binding protein0011
Chain A, pheromone binding protein0011
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, RNA-directed RNA polymerase NS50101
acid sphingomyelinase2002
thioredoxin reductase6006
USP1 protein, partial2002
TDP1 protein110011
vitamin D3 receptor isoform VDRA4004
importin subunit beta-1 isoform 12002
flap endonuclease 16006
serine/threonine-protein kinase PLK12002
snurportin-12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
GTP-binding nuclear protein Ran isoform 11001
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)6006
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
geminin100010
DNA polymerase kappa isoform 12002
fibroblast growth factor 22 isoform 1 precursor0001
Mitogen-activated protein kinase 130101
Beta-lactamase0101
Transthyretin0011
Fatty acid-binding protein, intestinal0112
Fatty acid-binding protein, adipocyte0112
Cyclin-A20101
Cannabinoid receptor 10011
Cyclin-dependent kinase 20123
Choline O-acetyltransferase0101
Mitogen-activated protein kinase 120101
Guanine nucleotide-binding protein G2002
Fatty acid-binding protein 50011
Fatty acid-binding protein 50011
Mitogen-activated protein kinase 110101
Mitogen-activated protein kinase 140101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Ferritin light chain3003
interleukin 81001
acetylcholinesterase4004
phosphopantetheinyl transferase6006
RAR-related orphan receptor gamma6006
SMAD family member 25005
ATAD5 protein, partial3003
Fumarate hydratase2002
SMAD family member 35005
GLI family zinc finger 3110011
Microtubule-associated protein tau4004
AR protein100010
thioredoxin glutathione reductase2002
nuclear receptor subfamily 1, group I, member 39009
EWS/FLI fusion protein4004
glucocorticoid receptor [Homo sapiens]7007
retinoic acid nuclear receptor alpha variant 1100010
retinoid X nuclear receptor alpha100010
estrogen-related nuclear receptor alpha110011
farnesoid X nuclear receptor6006
pregnane X nuclear receptor100010
estrogen nuclear receptor alpha130013
G5005
polyprotein2002
P531001
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma3003
arylsulfatase A4004
IDH15005
euchromatic histone-lysine N-methyltransferase 29009
aryl hydrocarbon receptor6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
thyroid stimulating hormone receptor2002
activating transcription factor 61001
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x2002
Bloom syndrome protein isoform 14004
peripheral myelin protein 22 isoform 12002
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a3003
thyroid hormone receptor beta isoform 27007
heat shock protein beta-13003
nuclear factor erythroid 2-related factor 2 isoform 18008
peripheral myelin protein 223003
survival motor neuron protein isoform d4004
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 82002
muscleblind-like protein 1 isoform 13003
muscarinic acetylcholine receptor M13003
lamin isoform A-delta104004
Gamma-aminobutyric acid receptor subunit pi3104
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010011
Bile salt export pump0303
Voltage-dependent calcium channel gamma-2 subunit5005
Bile salt export pump011011
Interferon beta8008
HLA class I histocompatibility antigen, B alpha chain 5005
Cellular tumor antigen p536006
Gamma-aminobutyric acid receptor subunit beta-13104
Gamma-aminobutyric acid receptor subunit delta3104
Gamma-aminobutyric acid receptor subunit gamma-23104
Glutamate receptor 25005
Gamma-aminobutyric acid receptor subunit alpha-53104
Gamma-aminobutyric acid receptor subunit alpha-33104
Gamma-aminobutyric acid receptor subunit gamma-13104
Gamma-aminobutyric acid receptor subunit alpha-23104
Gamma-aminobutyric acid receptor subunit alpha-43104
Gamma-aminobutyric acid receptor subunit gamma-33104
Gamma-aminobutyric acid receptor subunit alpha-63104
Nuclear receptor ROR-gamma3003
Gamma-aminobutyric acid receptor subunit alpha-13104
Gamma-aminobutyric acid receptor subunit beta-33104
Gamma-aminobutyric acid receptor subunit beta-23104
GABA theta subunit3104
Inositol hexakisphosphate kinase 15005
Canalicular multispecific organic anion transporter 1010010
ATPase family AAA domain-containing protein 56006
Ataxin-28008
Gamma-aminobutyric acid receptor subunit epsilon3104
Protein-arginine deiminase type-40202
cytochrome P450 2C9, partial5005
PPM1D protein3003
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
Spike glycoprotein0112
Replicase polyprotein 1ab0112
glucose-6-phosphate 1-dehydrogenase isoform b0101
Transmembrane protease serine 20112
Dihydrofolate reductase 0303
DNA ligase0101
Riboflavin-binding protein0011
Major prion protein0011
Amyloid-beta precursor protein0101
Histidine-rich protein PFHRP-II0102
Procathepsin L0112
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40101
Cytochrome P450 3A40303
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0101
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Spike glycoprotein0101
Replicase polyprotein 1ab0112
Muscarinic acetylcholine receptor M10101
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
DNA ligase 10101
Muscarinic acetylcholine receptor M30101
Serine/threonine-protein kinase mTOR0101
Nuclear receptor subfamily 4 group A member 20011
Beta-secretase 10101
Spike glycoprotein2114
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0101
DNA ligase A0101
Potassium voltage-gated channel subfamily H member 20404
Sigma intracellular receptor 20101
Phosphoethanolamine N-methyltransferase0101
Sigma non-opioid intracellular receptor 10202
Angiotensin-converting enzyme 2 0112
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
atrial natriuretic peptide receptor 1 precursor2002
atrial natriuretic peptide receptor 2 precursor1001
Histamine H1 receptor0202
MBT domain-containing protein 10101
Solute carrier family 22 member 10405
Lethal(3)malignant brain tumor-like protein 40101
Lethal(3)malignant brain tumor-like protein 30101
Chloroquine resistance transporter0101
Solute carrier family 22 member 20405
Lethal(3)malignant brain tumor-like protein 10101
ATP-dependent phosphofructokinase6006
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20102
Solute carrier family 22 member 1 0203
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-50101
Acetylcholinesterase0101
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0001
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70101
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
pregnane X receptor3003
NFKB1 protein, partial1001
GALC protein1001
Thrombopoietin1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
progesterone receptor7007
nonstructural protein 13003
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
chromobox protein homolog 15005
thyroid hormone receptor beta isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 26006
mitogen-activated protein kinase 11001
serine/threonine-protein kinase mTOR isoform 12002
Solute carrier family 22 member 30101
Solute carrier family 22 member 30101
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0202
Mineralocorticoid receptor 0224
Androgen receptor0404
C-8 sterol isomerase0101
Solute carrier organic anion transporter family member 1A10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Rap guanine nucleotide exchange factor 31001
Chain A, 2-oxoglutarate Oxygenase3003
Luciferase1001
GLS protein3003
cytochrome P450 family 3 subfamily A polypeptide 45005
67.9K protein2002
bromodomain adjacent to zinc finger domain 2B2002
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
cytochrome P450 2D6 isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d1001
nuclear receptor ROR-gamma isoform 16006
histone acetyltransferase KAT2A isoform 13003
N-glycosylase/DNA lyase0101
Polyphenol oxidase 20102
Myeloperoxidase0101
Cytochrome P450 1A20101
Formamidopyrimidine-DNA glycosylase0101
DNA gyrase subunit A0101
DNA gyrase subunit B0101
Cytochrome P450 2C80101
Cytochrome P450 2A60101
Macrophage migration inhibitory factor0101
Cytochrome P450 2C190101
Endonuclease III-like protein 10101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0102
Pantothenate synthetase0101
Isocitrate lyase0101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0202
Endonuclease 8-like 10101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
dopamine D1 receptor1001
ClpP1001
15-lipoxygenase, partial1001
aldehyde dehydrogenase 1 family, member A14004
estrogen receptor 2 (ER beta)3003
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
transcriptional regulator ERG isoform 32002
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
transactivating tegument protein VP16 [Human herpesvirus 1]0101
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20012
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30002
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 433003
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60002
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80002
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110002
Broad substrate specificity ATP-binding cassette transporter ABCG20001
hypoxia-inducible factor 1 alpha subunit3003
nuclear receptor subfamily 1, group I, member 24004
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor08215
Glycine receptor subunit alpha-10808
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Nuclear receptor subfamily 1 group I member 20011
regulator of G-protein signaling 42002
lysosomal alpha-glucosidase preproprotein1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
glycogen synthase kinase-3 beta isoform 10011
huntingtin isoform 21001
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Gamma-aminobutyric acid 0101
endonuclease IV1001
cytochrome P450 2C9 precursor1001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Sodium channel protein type 2 subunit alpha0101
Cytochrome P450 2C9 0202
Gamma-aminobutyric acid receptor subunit alpha-10101
Aldo-keto reductase family 1 member B10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
5-hydroxytryptamine receptor 1A0101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0102
Histamine H2 receptor2002
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit epsilon0101
Inositol monophosphatase 11001
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0101
Sodium channel protein type 2 subunit alpha0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Sodium channel protein type 3 subunit alpha0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit theta0101
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
Chain A, Beta-lactamase2002
glp-1 receptor, partial1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
heat shock protein 90, putative0001
caspase 7, apoptosis-related cysteine protease2002
cytochrome P450 2D62002
caspase-32002
Taste receptor type 2 member 380012
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Carbonic anhydrase 120001
Carbonic anhydrase 10001
Plasma kallikrein0001
Carbonic anhydrase 30001
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Adenosine receptor A10001
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0001
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Tubulin--tyrosine ligase0101
Glutamate receptor ionotropic, NMDA 3B0001
Monocarboxylate transporter 100001
Carbonic anhydrase 150001
Taste receptor type 2 member 140001
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
Caspase-71001
caspase-31001
pyruvate kinase PKM isoform a1001
tyrosine-protein kinase Yes1001
Ectonucleoside triphosphate diphosphohydrolase 10001
Solute carrier family 22 member 60001
Albumin0011
Thymidine kinase, cytosolic0203
Protein kinase C beta type0101
DNA polymerase beta0101
UDP-glucuronosyltransferase 2B70001
Thymidine kinase, cytosolic 0001
Thymidylate kinase0101
Protein kinase C epsilon type0101
Thymidine kinase 0102
Solute carrier family 22 member 70001
Reverse transcriptase/RNaseH 0126
Protease 0112
Thymidine kinase0102
Solute carrier family 22 member 70001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]