Mesothelioma, Cystic

A peritoneal mesothelioma affecting mainly young females and producing cysts of variable size and number lined by a single layer of benign mesothelial cells. The disease follows a benign course and is compatible with a normal life expectancy, requiring occasionally partial excision or decompression for relief of pain or other symptoms. Malignant potential is exceptional. (From Holland et al., Cancer Medicine, 3d ed, p1345)

Synonym
Mesothelioma, Cystic

Excerpt	Reference
"Benign cystic mesothelioma is a tumor characteristically found in women during the reproductive years."	( Letterie, GS; Yon, JL, 1998)
"Multicystic mesothelioma is a well recognized but rare serosal tumor which mainly arises from the peritoneum in women and is considered as a benign lesion."	( Fukayama, M; Goto, A; Maeda, E; Morita, S; Murakawa, T; Nakajima, J; Ota, S; Sakatani, T, 2011)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	6 (37.50)	12.5806
2000's	4 (25.00)	18.1394
2010's	6 (37.50)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies
iohexol	low	1
deoxycytidine	low	1
titanium	low	1
paclitaxel	low	1
gemcitabine	low	1
fluorodeoxyglucose f18	low	1
potassium titanylphosphate	low	1
bromochloroacetic acid	low	5
tamoxifen	low	1
sirolimus	low	1
pemetrexed	low	1

Protein Targets (587)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	2	0	0	2
AR protein	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
Cellular tumor antigen p53	3	0	0	3
Nuclear receptor ROR-gamma	1	0	0	1
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	0	1	3
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	2
AAA family ATPase	0	0	0	2
Reverse transcriptase/RNaseH	0	0	1	1
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Transmembrane protease serine 2	0	0	2	2
Procathepsin L	0	0	2	2
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Spike glycoprotein	1	0	2	3
Equilibrative nucleoside transporter 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	2	2
ATAD5 protein, partial	1	0	0	1
geminin	4	0	0	4
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	3
Bile salt export pump	0	4	0	4
Canalicular multispecific organic anion transporter 1	0	3	0	3
Chain A, Beta-lactamase	2	0	0	2
Genome polyprotein	0	1	0	1
Luciferase	1	0	0	1
pregnane X receptor	1	0	0	1
phosphopantetheinyl transferase	2	0	0	2
TDP1 protein	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
glucocorticoid receptor [Homo sapiens]	2	0	0	2
retinoid X nuclear receptor alpha	2	0	0	2
pregnane X nuclear receptor	2	0	0	2
estrogen nuclear receptor alpha	2	0	0	2
67.9K protein	3	0	0	3
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
IDH1	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
thyroid hormone receptor beta isoform 2	2	0	0	2
peripheral myelin protein 22	1	0	0	1
lamin isoform A-delta10	1	0	0	1
Tyrosine-protein kinase ABL1	0	1	1	2
Epidermal growth factor receptor	0	2	1	3
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Integrin beta-3	1	1	0	2
Tyrosine-protein kinase Fyn	0	2	1	3
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
ATP-dependent translocase ABCB1	0	4	1	7
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3C chain	0	1	1	3
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Fibroblast growth factor receptor 1	0	1	1	2
Proto-oncogene tyrosine-protein kinase Src	0	1	1	2
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Substance-K receptor	0	4	0	4
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Melanocortin receptor 5	0	4	0	4
UDP-glucuronosyltransferase 2B10	0	1	0	1
Delta-type opioid receptor	0	4	0	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	1	1	2
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Thiosulfate sulfurtransferase	0	1	0	1
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin beta-2B chain	0	0	1	3
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
10 kDa chaperonin	0	1	0	1
Similar to alpha-tubulin isoform 1	0	0	1	3
Similar to alpha-tubulin isoform 1	0	0	0	2
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	3	0	3
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
EWS/FLI fusion protein	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
tyrosine-protein kinase Yes	1	0	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	2	0	2
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Serine hydroxymethyltransferase, cytosolic	0	1	1	2
Reduced folate transporter	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Proton-coupled folate transporter	0	2	0	3
USP1 protein, partial	2	0	0	2
Smad3	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	1	1	2
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
High affinity nerve growth factor receptor	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	1	1	2
Insulin receptor	0	0	1	1
Tyrosine-protein kinase Lck	0	1	1	2
Cyclin-dependent kinase 1	0	0	1	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Cytochrome P450 3A4	0	2	0	2
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
DNA topoisomerase 2-alpha	0	0	1	1
Cytochrome P450 2C9	0	1	0	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	1	1	2
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Cyclin-dependent kinase 2	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
Cytochrome P450 2C19	0	1	0	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Alpha-synuclein	2	0	0	2
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	1	1	2
Exosome RNA helicase MTR4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	1	2
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	1	1	2
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	1	1	2
Protein kinase C delta type	0	1	1	2
Tyrosine-protein kinase BTK	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Misshapen-like kinase 1	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Serine/threonine-protein kinase ICK	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Chain A, CES1 protein	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
acetylcholinesterase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
SMAD family member 2	1	0	0	1
Fumarate hydratase	1	0	0	1
PPM1D protein	1	0	0	1
SMAD family member 3	1	0	0	1
GLI family zinc finger 3	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
DNA polymerase III, partial	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
progesterone receptor	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
estrogen-related nuclear receptor alpha	1	0	0	1
farnesoid X nuclear receptor	1	0	0	1
polyprotein	1	0	0	1
glucocerebrosidase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
arylsulfatase A	1	0	0	1
caspase-3	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
activating transcription factor 6	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
Histone H2A.x	1	0	0	1
Caspase-7	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
interferon gamma precursor	0	0	0	1
D(1A) dopamine receptor	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
chromobox protein homolog 1	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
caspase-3	1	0	0	1
heat shock protein beta-1	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
streptokinase A precursor	0	0	1	1
lethal factor (plasmid)	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Interferon beta	1	0	0	1
Estrogen receptor	0	2	1	4
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	2
Progesterone receptor	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Integrin alpha-IIb	1	0	0	1
Beta-1 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Adenosine receptor A3	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Androgen receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Glutamate receptor 2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Muscarinic acetylcholine receptor M3	0	2	0	2
Cytochrome P450 2B6	0	1	0	1
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Protein kinase C eta type	0	1	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
5-hydroxytryptamine receptor 1B	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
B2 bradykinin receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Histamine H2 receptor	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Protein kinase C epsilon type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
GABA theta subunit	1	0	0	1
Estrogen receptor beta	0	2	1	3
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (16)

Protein Targets (587)

Mesothelioma, Cystic

Synonyms(1)

Research Excerpts

Overview

Research

Studies (16)

Drugs Studied (15)

Protein Targets (587)