Melorheostosis

A form of osteosclerosis extending in a linear track mainly through one of the long bones of the upper and lower limbs.

Synonym
Melorheostosis
Melorheostosis of Leri

Excerpt	Reference
"Melorheostosis is a benign sclerosing bone dysplasia with a very unusual and characteristic roentgenographic appearance."	( Cole, RL; Davis, DC; Syklawer, R, 1992)
"Melorheostosis is a rare congenital disease, some 300 cases have been reported in the literature."	( Bonetti, MF; Chiodera, P; Ippolito, V; Mirra, JM; Motta, C, 1993)
"Melorheostosis is a rare bone disease characterized by linear hyperostosis and associated soft tissue abnormalities."	( Han, EH; Jun, SH; Kim, EH; Kim, IS; Kim, JC; Kim, JE; Park, IH; Park, RW; Young, MF, 2000)
"Melorheostosis is an unusual mesenchymal dysplasia, which commonly presents on radiographs as longitudinal bars of hyperostosis in osseous structures."	( Brown, RR; Lehman, WB; Steiner, GC, 2000)
"Summary."	( Christopoulos, G; Kall, S; Prommersberger, KJ; von Gossler, C, 2001)
"Melorheostosis is a rare chronic bone disease of unknown etiology that often affects a single limb."	( Bouhaouala, H; Charfi, MR; Dougui, MH; Fejraoui, N; Ksontini, I; Mourali, S; Rahali, H; Saadallaoui Ben Hamida, K, 2009)
"Melorheostosis is an uncommon and rare linear hyperostosis, which can be complicated by soft tissue changes."	( De Loore, G; De Vos, J; Mulliez, A, 2010)
"Melorheostosis is a rare benign sclerosing bone dysplasia."	( Allende, V; Masquijo, JJ, 2010)
"Melorheostosis is a very rare sclerosing bone disorder that involves frequently one limb."	( Makhloufi, H; Nezzar, A; Slimani, S, 2013)
"Melorheostosis is a rare, progressive bone disease accompanied by hyperostosis and soft tissue fibrosis."	( Abdullah, S; Mat Nor, NF; Mohamed Haflah, NH, 2014)
"Melorheostosis is quite a rare bone disease with still unclear ethiology."	( Koudela, K; Pavelka, T; Stajdlova, K; Suchy, D; Vyskocil, V, 2015)
"Melorheostosis is a rare, nonhereditary, benign, sclerotic bone dysplasia with no sex predilection, typically occurring in late childhood or early adulthood, which can lead to substantial functional morbidity, depending on the sites of involvement."	( Bagci, U; Bhattacharyya, T; Jha, S; Karantanas, AH; Marias, K; Millo, C; Papadakis, GZ; Patronas, NJ; Tu, TW, 2017)
"Melorheostosis is a benign hyperostotic disease of the peripheral skeleton, rarely involving the axial skeleton."	( Al Subaie, AM; Alkhamees, L; Alothman, M, 2018)
"Melorheostosis is an exceptionally rare sclerosing hyperostosis that typically affects the appendicular skeleton in a limited segmental fashion."	( Chan, M; Wordsworth, P, 2019)
"Melorheostosis is a rare sclerosing dysostosis characterized by asymmetric exuberant bone formation."	( Bhattacharyya, T; Cabral, WA; Cowen, EW; Dale, RK; Deng, Z; Fratzl-Zelman, N; Hanson, EP; Ivovic, A; Jha, S; Kang, H; Katz, J; Klaushofer, K; Lange, E; Marini, JC; Mitra, A; Roschger, P; Siegel, RM, 2020)

Excerpt	Reference
"Because melorheostosis has a variable tendency towards progression and association with tumors, a close follow-up of these patients is recommended."	( Allende, V; Masquijo, JJ, 2010)

Excerpt	Reference
"A case of melorheostosis affecting the C7 sclerotome is described, in association with synchronous multicentric fibromatosis."	( Davies, AM; Grimer, RJ; Mangham, DC; Rhys, R, 1998)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	27 (43.55)	23.3326
1990's	6 (9.68)	12.5806
2000's	9 (14.52)	18.1394
2010's	13 (20.97)	28.8240
2020's	7 (11.29)	9.53

Drug	Relationship Strength	Studies
acetaminophen	low	1
etidronate	low	3
nafronyl	low	1
pamidronate	low	2
procaine	low	1
sodium fluoride	low	1
technetium	low	5
trolamine salicylate	low	1
fluorodeoxyglucose f18	low	3
zoledronic acid	low	1
deoxyglucose	low	1
technetium tc 99m hydroxymethylene diphosphonate	low	1
pyrophosphate	low	2
sirolimus	low	1
trametinib	low	1
transforming growth factor beta	low	4
technetium tc 99m medronate	low	6
pyrimidinones	low	1

Protein Targets (588)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	4	0	0	4
ATAD5 protein, partial	3	0	0	3
GLS protein	3	0	0	3
Microtubule-associated protein tau	2	0	0	2
Smad3	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
thyroid stimulating hormone receptor	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
progesterone receptor	2	0	0	2
EWS/FLI fusion protein	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
retinoid X nuclear receptor alpha	3	0	0	3
estrogen-related nuclear receptor alpha	2	0	0	2
estrogen nuclear receptor alpha	4	0	0	4
peroxisome proliferator activated receptor gamma	2	0	0	2
aryl hydrocarbon receptor	4	0	0	4
chromobox protein homolog 1	3	0	0	3
thyroid hormone receptor beta isoform 2	3	0	0	3
peripheral myelin protein 22	3	0	0	3
cytochrome P450 3A4 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	3	0	0	3
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Bile salt export pump	0	8	0	8
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	4	0	4
Carbonic anhydrase 2	0	4	0	4
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	1	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 3A4	0	4	0	4
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	4	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	3	0	0	3
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	3	0	0	3
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	3	0	0	3
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	3	0	0	3
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Carbonic anhydrase 7	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Cytochrome P450 2J2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	3	0	0	3
Carbonic anhydrase 9	0	2	0	2
GABA theta subunit	3	0	0	3
Canalicular multispecific organic anion transporter 1	0	4	0	4
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	3	0	0	3
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
toxin B	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
acid sphingomyelinase	1	0	0	1
GLI family zinc finger 3	2	0	0	2
apical membrane antigen 1, AMA1	1	0	0	1
farnesoid X nuclear receptor	2	0	0	2
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
IDH1	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
DNA polymerase iota isoform a (long)	2	0	0	2
histone acetyltransferase KAT2A isoform 1	4	0	0	4
lamin isoform A-delta10	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
cytochrome P450 2D6	2	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, Beta-lactamase	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Luciferase	2	0	0	2
thioredoxin reductase	3	0	0	3
pregnane X receptor	1	0	0	1
phosphopantetheinyl transferase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
Fumarate hydratase	3	0	0	3
USP1 protein, partial	2	0	0	2
NFKB1 protein, partial	2	0	0	2
TDP1 protein	3	0	0	3
Thrombopoietin	1	0	0	1
AR protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
hypothetical protein, conserved	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
nonstructural protein 1	2	0	0	2
glucocorticoid receptor [Homo sapiens]	2	0	0	2
pregnane X nuclear receptor	2	0	0	2
G	2	0	0	2
polyprotein	3	0	0	3
67.9K protein	2	0	0	2
Parkin	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
peroxisome proliferator-activated receptor delta	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
Bloom syndrome protein isoform 1	2	0	0	2
cytochrome P450 2D6 isoform 1	3	0	0	3
peripheral myelin protein 22 isoform 1	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
D(1A) dopamine receptor	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
perilipin-5	0	1	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
perilipin-1	0	1	0	1
heat shock protein beta-1	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
geminin	4	0	0	4
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
survival motor neuron protein isoform d	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	3	0	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Potassium channel subfamily K member 2	0	0	1	1
Glutathione reductase, mitochondrial	0	2	0	2
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Cellular tumor antigen p53	1	0	0	1
Integrin beta-3	1	0	0	1
Muscarinic acetylcholine receptor M2	0	0	0	1
Muscarinic acetylcholine receptor M4	0	0	0	1
ATP-dependent translocase ABCB1	0	2	1	3
Integrin alpha-IIb	1	0	0	1
Muscarinic acetylcholine receptor M5	0	0	0	1
Adenosine receptor A3	0	2	0	2
Muscarinic acetylcholine receptor M1	0	0	0	1
Phospholipase A2, membrane associated	0	0	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	2	0	2
Adenosine receptor A2a	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Histamine H2 receptor	2	0	0	2
Spike glycoprotein	2	0	0	2
Inositol monophosphatase 1	1	0	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	2	3
Sodium channel protein type 9 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Beta-2 adrenergic receptor	0	0	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
ATPase family AAA domain-containing protein 5	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Ataxin-2	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
cytochrome P450 2C9, partial	2	0	0	2
ATP-dependent phosphofructokinase	2	0	0	2
Geranylgeranyl pyrophosphate synthase	0	3	0	4
Farnesyl pyrophosphate synthase	0	4	0	4
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	3	0	3
15-lipoxygenase, partial	1	0	0	1
arylsulfatase A	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Alpha-synuclein	2	0	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
Solute carrier family 22 member 6	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 11	0	1	0	1
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
Carbonic anhydrase	0	2	0	2
Bone morphogenetic protein receptor type-1B	0	0	2	2
Cell division cycle 7-related protein kinase	0	0	2	2
Serine/threonine-protein kinase PLK4	0	0	2	2
ATP-dependent RNA helicase DDX3X	0	0	2	2
Pyridoxal kinase	0	0	2	2
Citron Rho-interacting kinase	0	0	2	2
Serine/threonine-protein kinase Chk1	0	0	2	2
Aurora kinase A	0	0	2	2
Cyclin-G-associated kinase	0	0	2	2
Ephrin type-B receptor 6	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 3	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 2	0	0	2	2
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	2	2
Dynamin-like 120 kDa protein, mitochondrial	0	0	2	2
Tyrosine-protein kinase JAK2	0	0	2	2
Eukaryotic translation initiation factor 5B	0	0	2	2
Rho-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase ULK1	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	2	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	2	2
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	2	2
Ribosomal protein S6 kinase alpha-4	0	0	2	2
Serine/threonine-protein kinase 16	0	0	2	2
Cyclin-dependent kinase-like 5	0	0	2	2
Serine/threonine-protein kinase 10	0	0	2	2
Serine/threonine-protein kinase D3	0	0	2	2
Structural maintenance of chromosomes protein 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 6	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	2	2
Serine/threonine-protein kinase LATS1	0	0	2	2
Serine/threonine-protein kinase PAK 4	0	0	2	2
Tyrosine-protein kinase ABL1	0	0	2	2
Epidermal growth factor receptor	0	0	2	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
High affinity nerve growth factor receptor	0	0	2	2
ADP/ATP translocase 2	0	0	2	2
Protein kinase C beta type	0	0	2	2
Insulin receptor	0	0	2	2
Tyrosine-protein kinase Lck	0	0	2	2
Tyrosine-protein kinase Fyn	0	0	2	2
Cyclin-dependent kinase 1	0	0	2	2
Eukaryotic translation initiation factor 4E	0	0	1	1
Glycogen phosphorylase, liver form	0	0	2	2
Tyrosine-protein kinase Fes/Fps	0	0	2	2
Adenine phosphoribosyltransferase	0	0	2	2
Tyrosine-protein kinase Yes	0	0	2	2
Tyrosine-protein kinase Lyn	0	0	2	2
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	2	2
Insulin-like growth factor 1 receptor	0	0	2	2
Signal recognition particle receptor subunit alpha	0	0	2	2
Cytochrome c1, heme protein, mitochondrial	0	0	2	2
Hepatocyte growth factor receptor	0	0	2	2
Tyrosine-protein kinase HCK	0	0	2	2
Platelet-derived growth factor receptor beta	0	0	2	2
Tyrosine-protein kinase Fgr	0	0	2	2
Serine/threonine-protein kinase A-Raf	0	0	2	2
Glycogen phosphorylase, brain form	0	0	2	2
Breakpoint cluster region protein	0	0	2	2
Serine/threonine-protein kinase pim-1	0	0	2	2
Fibroblast growth factor receptor 1	0	0	2	2
DNA topoisomerase 2-alpha	0	0	2	2
Cyclin-dependent kinase 4	0	0	2	2
ADP/ATP translocase 3	0	0	2	2
Inosine-5'-monophosphate dehydrogenase 2	0	0	2	2
Proto-oncogene tyrosine-protein kinase Src	0	0	2	2
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	2	2
Serine/threonine-protein kinase B-raf	0	0	2	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	2	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	2	2
Tyrosine-protein kinase Fer	0	0	2	2
Protein kinase C alpha type	0	0	2	2
cAMP-dependent protein kinase catalytic subunit alpha	0	0	2	2
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	2	2
Casein kinase II subunit alpha'	0	0	2	2
Ras-related protein Rab-6A	0	0	2	2
Ephrin type-A receptor 1	0	0	2	2
Multifunctional protein ADE2	0	0	2	2
cAMP-dependent protein kinase catalytic subunit beta	0	0	2	2
Ferrochelatase, mitochondrial	0	0	2	2
Ribosomal protein S6 kinase beta-1	0	0	2	2
Tyrosine-protein kinase JAK1	0	0	2	2
Cyclin-dependent kinase 2	0	0	2	2
Beta-adrenergic receptor kinase 1	0	0	2	2
Probable ATP-dependent RNA helicase DDX6	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Mitogen-activated protein kinase 3	0	0	2	2
MAP/microtubule affinity-regulating kinase 3	0	0	2	2
Deoxycytidine kinase	0	0	2	2
Mitogen-activated protein kinase 1	0	0	2	2
Ephrin type-A receptor 2	0	0	2	2
Ephrin type-B receptor 2	0	0	2	2
Non-receptor tyrosine-protein kinase TYK2	0	0	2	2
UMP-CMP kinase	0	0	2	2
Phosphatidylethanolamine-binding protein 1	0	0	2	2
Wee1-like protein kinase	0	0	2	2
Heme oxygenase 2	0	0	2	2
S-adenosylmethionine synthase isoform type-2	0	0	2	2
DnaJ homolog subfamily A member 1	0	0	2	2
RAC-alpha serine/threonine-protein kinase	0	0	2	2
RAC-beta serine/threonine-protein kinase	0	0	2	2
Cytochrome P450 2C19	0	1	0	1
Dual specificity protein kinase TTK	0	0	2	2
DNA replication licensing factor MCM4	0	0	2	2
Myosin-10	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 2	0	1	2	3
Receptor-type tyrosine-protein kinase FLT3	0	0	2	2
Bone morphogenetic protein receptor type-1A	0	0	2	2
Activin receptor type-1B	0	0	2	2
TGF-beta receptor type-1	0	0	2	2
Serine/threonine-protein kinase receptor R3	0	0	2	2
TGF-beta receptor type-2	0	0	2	2
Electron transfer flavoprotein subunit beta	0	0	2	2
Tyrosine-protein kinase CSK	0	0	2	2
Glycine--tRNA ligase	0	0	2	2
Protein kinase C iota type	0	0	2	2
Exosome RNA helicase MTR4	0	0	2	2
Serine/threonine-protein kinase mTOR	0	1	1	2
Tyrosine-protein kinase Tec	0	0	2	2
Tyrosine-protein kinase ABL2	0	0	2	2
Tyrosine-protein kinase FRK	0	0	2	2
G protein-coupled receptor kinase 6	0	0	2	2
Tyrosine-protein kinase SYK	0	0	2	2
26S proteasome regulatory subunit 6B	0	0	2	2
Mitogen-activated protein kinase 8	0	0	2	2
Mitogen-activated protein kinase 9	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 3	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	2	2
Casein kinase I isoform alpha	0	0	2	2
Casein kinase I isoform delta	0	0	2	2
MAP kinase-activated protein kinase 2	0	0	2	2
Elongation factor Tu, mitochondrial	0	0	2	2
Choline-phosphate cytidylyltransferase A	0	0	2	2
Cysteine--tRNA ligase, cytoplasmic	0	0	2	2
Casein kinase I isoform epsilon	0	0	2	2
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	2	2
Dual specificity protein kinase CLK1	0	0	2	2
Dual specificity protein kinase CLK2	0	0	2	2
Dual specificity protein kinase CLK3	0	0	2	2
Glycogen synthase kinase-3 alpha	0	0	2	2
Glycogen synthase kinase-3 beta	0	0	2	2
Cyclin-dependent kinase 7	0	0	2	2
Cyclin-dependent kinase 9	0	0	2	2
Ras-related protein Rab-27A	0	0	2	2
Interleukin-1 receptor-associated kinase 1	0	0	2	2
Ribosomal protein S6 kinase alpha-3	0	0	2	2
Serine/threonine-protein kinase Nek2	0	0	2	2
Serine/threonine-protein kinase Nek3	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 6	0	0	2	2
Serine/threonine-protein kinase PLK1	0	0	2	2
LIM domain kinase 1	0	0	2	2
LIM domain kinase 2	0	0	2	2
Mitogen-activated protein kinase 10	0	0	2	2
Tyrosine--tRNA ligase, cytoplasmic	0	0	2	2
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
Ephrin type-B receptor 3	0	0	2	2
Ephrin type-A receptor 5	0	0	2	2
Ephrin type-B receptor 4	0	0	2	2
Ephrin type-A receptor 4	0	0	2	2
Adenylate kinase 2, mitochondrial	0	0	2	2
Adenosine kinase	0	0	2	2
Ras-related protein Rab-10	0	0	2	2
Actin-related protein 3	0	0	2	2
Actin-related protein 2	0	0	2	2
GTP-binding nuclear protein Ran	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Casein kinase I isoform gamma-2	0	0	2	2
Cyclin-dependent kinase 6	0	0	2	2
Cyclin-dependent-like kinase 5	0	0	2	2
Cyclin-dependent kinase 16	0	0	2	2
Cyclin-dependent kinase 17	0	0	2	2
ATP-dependent 6-phosphofructokinase, platelet type	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 1	0	1	2	3
DNA topoisomerase 2-beta	0	0	2	2
Protein kinase C theta type	0	0	2	2
Activin receptor type-1	0	0	2	2
Macrophage-stimulating protein receptor	0	0	2	2
Focal adhesion kinase 1	0	0	2	2
Protein kinase C zeta type	0	0	2	2
Protein kinase C delta type	0	0	2	2
Tyrosine-protein kinase BTK	0	0	2	2
Cyclin-dependent kinase 18	0	0	2	2
Activated CDC42 kinase 1	0	0	2	2
Epithelial discoidin domain-containing receptor 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	2	2
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase 7	0	0	2	2
Serine/threonine-protein kinase PAK 2	0	0	2	2
Serine/threonine-protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 1	0	0	2	2
Integrin-linked protein kinase	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Rho-associated protein kinase 1	0	0	2	2
Non-receptor tyrosine-protein kinase TNK1	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	2	2
Activin receptor type-2B	0	0	2	2
Bone morphogenetic protein receptor type-2	0	0	2	2
Protein-tyrosine kinase 6	0	0	2	2
cGMP-dependent protein kinase 1	0	0	2	2
Cyclin-dependent kinase 13	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	2	2
Protein-tyrosine kinase 2-beta	0	0	2	2
Maternal embryonic leucine zipper kinase	0	0	2	2
Structural maintenance of chromosomes protein 1A	0	0	2	2
Chromodomain-helicase-DNA-binding protein 4	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 1	0	0	2	2
Delta(24)-sterol reductase	0	0	2	2
Ribosomal protein S6 kinase alpha-1	0	0	2	2
Dual specificity testis-specific protein kinase 1	0	0	2	2
Mitogen-activated protein kinase 11	0	0	2	2
Serine/threonine-protein kinase STK11	0	0	2	2
Serine/threonine-protein kinase N1	0	0	2	2
Serine/threonine-protein kinase N2	0	0	2	2
Mitogen-activated protein kinase 14	0	0	2	2
Calcium/calmodulin-dependent protein kinase type IV	0	0	2	2
Mitogen-activated protein kinase kinase kinase 11	0	0	2	2
Discoidin domain-containing receptor 2	0	0	2	2
AP2-associated protein kinase 1	0	0	2	2
Myosin light chain kinase 3	0	0	2	2
Uncharacterized aarF domain-containing protein kinase 5	0	0	2	2
Programmed cell death protein 4	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	2	2
Serine/threonine-protein kinase MRCK alpha	0	0	2	2
Serine/threonine-protein kinase MRCK gamma	0	0	2	2
Acyl-CoA dehydrogenase family member 10	0	0	2	2
Serine/threonine-protein kinase N3	0	0	2	2
Serine/threonine-protein kinase ULK3	0	0	2	2
Uncharacterized protein FLJ45252	0	0	2	2
Acyl-CoA dehydrogenase family member 11	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	2	2
Serine/threonine-protein kinase MARK2	0	0	2	2
ATP-dependent RNA helicase DHX30	0	0	2	2
Serine/threonine-protein kinase TAO1	0	0	2	2
STE20-related kinase adapter protein alpha	0	0	2	2
Myosin-14	0	0	2	2
AarF domain-containing protein kinase 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	2	2
MAP kinase-activated protein kinase 5	0	0	2	2
Regulatory-associated protein of mTOR	0	1	0	1
Misshapen-like kinase 1	0	0	2	2
Atypical kinase COQ8A, mitochondrial	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	2	2
Mitogen-activated protein kinase 15	0	0	2	2
Serine/threonine-protein kinase Nek9	0	0	2	2
ATP-dependent RNA helicase DDX1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	2	2
Aurora kinase B	0	0	2	2
MAP/microtubule affinity-regulating kinase 4	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	2	2
PAS domain-containing serine/threonine-protein kinase	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	2	2
EKC/KEOPS complex subunit TP53RK	0	0	2	2
Dual specificity testis-specific protein kinase 2	0	0	2	2
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase kinase kinase 3	0	0	2	2
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	2	2
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	2	2
Serine/threonine-protein kinase D2	0	0	2	2
RNA cytidine acetyltransferase	0	0	2	2
Serine/threonine-protein kinase SIK2	0	0	2	2
STE20-like serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO3	0	0	2	2
dCTP pyrophosphatase 1	0	0	2	2
Dual specificity protein kinase CLK4	0	0	2	2
Casein kinase I isoform gamma-1	0	0	2	2
Serine/threonine-protein kinase mTOR	0	1	0	1
Phenylalanine--tRNA ligase beta subunit	0	0	2	2
Isoleucine--tRNA ligase, mitochondrial	0	0	2	2
BMP-2-inducible protein kinase	0	0	2	2
Obg-like ATPase 1	0	0	2	2
Midasin	0	0	2	2
Interleukin-1 receptor-associated kinase 4	0	0	2	2
Mitogen-activated protein kinase kinase kinase 20	0	0	2	2
Cyclin-dependent kinase 12	0	0	2	2
Serine/threonine-protein kinase 26	0	0	2	2
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	2	2
Serine/threonine-protein kinase NLK	0	0	2	2
5'-AMP-activated protein kinase subunit gamma-2	0	0	2	2
Serine/threonine-protein kinase TBK1	0	0	2	2
Septin-9	0	0	2	2
Ribosomal protein S6 kinase alpha-6	0	0	2	2
TRAF2 and NCK-interacting protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO2	0	0	2	2
Serine/threonine-protein kinase ICK	0	0	2	2
RAC-gamma serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase SIK3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 2	0	0	2	2
Thyroid hormone receptor-associated protein 3	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 3	0	0	2	2
Serine/threonine-protein kinase MRCK beta	0	0	2	2
Interleukin-1 receptor-associated kinase 3	0	0	2	2
Serine/threonine-protein kinase 24	0	0	2	2
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Casein kinase I isoform gamma-3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 4	0	0	2	2
Carbonic anhydrase	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Membrane-associated progesterone receptor component 1	0	0	1	1
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase 10	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
MAP kinase-activated protein kinase 3	0	0	1	1
Rab-like protein 3	0	0	1	1
ATP-dependent RNA helicase DDX42	0	0	1	1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	0	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Butyrophilin subfamily 3 member A1	0	0	1	2
72 kDa type IV collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

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Overview

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Research

Studies (62)

Protein Targets (588)

Melorheostosis

Synonyms(2)

Research Excerpts

Overview

Context

Actions

Research

Studies (62)

Drugs Studied (21)

Protein Targets (588)