Page last updated: 2024-09-27

Melanoameloblastoma

A benign, rapidly growing, deeply pigmented tumor of the jaw and occasionally of other sites, consisting of an infiltrating mass of cells arranged in an alveolar pattern, and occurring almost exclusively in infants. Its source of origin is in dispute, the various theories giving rise to its several names. (Dorland, 27th ed)

Synonyms(4)

Synonym
Neuroectodermal Tumor, Melanotic
Progonoma, Melanotic
Retinal Anlage Tumor
Melanoameloblastoma

Research Excerpts

Treatment

ExcerptReference
"Recommended treatment of melanotic neuroectodermal tumor of infancy has consisted of complete excision with wide tissue margins, although success has been reported after incomplete resection."( Goldstein, JD; Hered, RW; Sandler, E; Smithwick, W, 2007)

Research

Studies (22)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's2 (9.09)12.5806
2000's10 (45.45)18.1394
2010's8 (36.36)28.8240
2020's2 (9.09)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
vanilmandelic acid0low30
ifosfamide0low30
metformin0low10
daunorubicin0low10
etoposide0low40
propiconazole0low20
carboplatin0low20
tretinoin0low20
retinol0low10
dactinomycin0low10
bromochloroacetic acid0low50
myelin basic protein0low10
cholecalciferol0low10
jaw0low10

Protein Targets (307)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma8008
AR protein9009
aldehyde dehydrogenase 1 family, member A17007
nuclear receptor subfamily 1, group I, member 37007
retinoic acid nuclear receptor alpha variant 17007
thyroid stimulating hormone receptor5005
nuclear factor erythroid 2-related factor 2 isoform 19009
Cellular tumor antigen p538008
Nuclear receptor ROR-gamma4116
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
acetylcholinesterase3003
phosphopantetheinyl transferase5005
estrogen receptor 2 (ER beta)6006
G2002
cytochrome P450 2D62002
euchromatic histone-lysine N-methyltransferase 26006
vitamin D3 receptor isoform VDRA7007
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
DNA polymerase kappa isoform 14004
histone acetyltransferase KAT2A isoform 15005
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 2002
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
ATP-dependent phosphofructokinase5005
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, Ferritin light chain6006
Chain A, Cruzipain5005
Luciferase3003
interleukin 83003
15-lipoxygenase, partial3003
USP1 protein, partial5005
Microtubule-associated protein tau5005
glucocorticoid receptor [Homo sapiens]7007
retinoid X nuclear receptor alpha9009
farnesoid X nuclear receptor5005
pregnane X nuclear receptor8008
estrogen nuclear receptor alpha100010
peroxisome proliferator-activated receptor delta7007
peroxisome proliferator activated receptor gamma7007
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
thyroid hormone receptor beta isoform a5005
nuclear receptor ROR-gamma isoform 16006
geminin8008
survival motor neuron protein isoform d4004
cytochrome P450 3A4 isoform 15005
Gamma-aminobutyric acid receptor subunit pi5005
60 kDa chaperonin0202
60 kDa heat shock protein, mitochondrial0202
Vitamin D3 receptor0114
Gamma-aminobutyric acid receptor subunit beta-15005
Gamma-aminobutyric acid receptor subunit delta5005
Gamma-aminobutyric acid receptor subunit gamma-25005
Gamma-aminobutyric acid receptor subunit alpha-55005
Gamma-aminobutyric acid receptor subunit alpha-35005
Glycine receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit gamma-15005
Gamma-aminobutyric acid receptor subunit alpha-25005
Gamma-aminobutyric acid receptor subunit alpha-45005
Gamma-aminobutyric acid receptor subunit gamma-35005
Gamma-aminobutyric acid receptor subunit alpha-65005
Vitamin D3 receptor0011
10 kDa heat shock protein, mitochondrial0202
Gamma-aminobutyric acid receptor subunit alpha-15005
Gamma-aminobutyric acid receptor subunit beta-35005
Gamma-aminobutyric acid receptor subunit beta-25005
Thiosulfate sulfurtransferase0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
GABA theta subunit5005
Gamma-aminobutyric acid receptor subunit epsilon5005
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
hypoxia-inducible factor 1 alpha subunit4004
TDP1 protein6006
GLI family zinc finger 37007
caspase 7, apoptosis-related cysteine protease3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
progesterone receptor4004
cytochrome P450 family 3 subfamily A polypeptide 43003
estrogen-related nuclear receptor alpha8008
caspase-33003
RAD510101
aryl hydrocarbon receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
activating transcription factor 64004
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x3003
Caspase-73003
Bloom syndrome protein isoform 14004
caspase-33003
thyroid hormone receptor beta isoform 27007
huntingtin isoform 22002
peripheral myelin protein 224004
caspase-1 isoform alpha precursor1001
Voltage-dependent calcium channel gamma-2 subunit5005
ATP-dependent translocase ABCB10306
Glutamate receptor 25005
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Caspase-71001
Spike glycoprotein2002
Growth factor receptor-bound protein 20101
Pantothenate synthetase0101
Discoidin domain-containing receptor 20101
Growth factor receptor-bound protein 2 0101
Reverse transcriptase/RNaseH 0202
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
ATPase family AAA domain-containing protein 55005
Ataxin-25005
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, 2-oxoglutarate Oxygenase3003
PPM1D protein1001
cellular tumor antigen p53 isoform a1001
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
mitogen-activated protein kinase 12002
lethal factor (plasmid)1001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Transthyretin0101
NADH-ubiquinone oxidoreductase chain 40001
Integrin beta-31001
72 kDa type IV collagenase0101
Integrin alpha-IIb1001
DNA topoisomerase 2-alpha0118
Carbonyl reductase [NADPH] 10001
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Platelet-activating factor receptor1001
Multidrug resistance-associated protein 1 0203
Histamine H2 receptor2002
Inositol monophosphatase 11001
Histone deacetylase 10101
Canalicular multispecific organic anion transporter 10607
Histone deacetylase 80101
Histone deacetylase 60101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
glp-1 receptor, partial2002
SMAD family member 23003
SMAD family member 33003
67.9K protein1001
LMP1 [Human herpesvirus 4]0001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
chromobox protein homolog 14004
nuclear factor erythroid 2-related factor 2 isoform 22002
heat shock protein beta-13003
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
DNA polymerase iota isoform a (long)3003
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Bile salt export pump0505
Prothrombin0001
Regulatory protein E20011
ATP-dependent translocase ABCB10101
Cytochrome P450 3A40213
DNA topoisomerase 10102
Cytochrome P450 2C9 0112
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0001
Serum paraoxonase/arylesterase 10202
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0001
Solute carrier organic anion transporter family member 1B30202
Glutamate receptor ionotropic, NMDA 3A0001
Chain A, Beta-lactamase4004
GALC protein1001
EWS/FLI fusion protein2002
lamin isoform A-delta102002
ATAD5 protein, partial1001
Chymotrypsinogen A0101
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0101
Dihydrofolate reductase0101
Dipeptidyl peptidase 40101
Solute carrier family 22 member 10001
Multidrug and toxin extrusion protein 10101
pregnane X receptor3003
nonstructural protein 12002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
Guanine nucleotide-binding protein G1001
TAR DNA-binding protein 431001
heat shock protein 90, putative0001
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
thioredoxin reductase3003
thyroid stimulating hormone receptor1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Retinol-binding protein 40011
Beta-lactoglobulin0011
Amyloid-beta precursor protein0202
Alpha-synuclein0202
Disintegrin and metalloproteinase domain-containing protein 171001
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Bile salt export pump0101
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Albumin0101
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
Chain A, Nuclear Receptor ROR-beta0101
GLS protein2002
thioredoxin glutathione reductase2002
regulator of G-protein signaling 41001
Parkin1001
bromodomain adjacent to zinc finger domain 2B1001
thyrotropin-releasing hormone receptor1001
M-phase phosphoprotein 81001
Ornithine decarboxylase0001
Cytochrome P450 1A20011
Ornithine decarboxylase0001
Adenosine receptor A30202
Retinoic acid receptor alpha0227
Cytochrome P450 2D60011
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Alpha-1B adrenergic receptor0202
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
5-hydroxytryptamine receptor 1A0101
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Alpha-1D adrenergic receptor0101
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2C190011
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0202
Retinoic acid receptor RXR-gamma0224
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
atrial natriuretic peptide receptor 1 precursor1001
flap endonuclease 11001
neuropeptide S receptor isoform A1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]