Page last updated: 2024-09-27

Medial Neuropathy, Distal

Disease involving the median nerve, from its origin at the BRACHIAL PLEXUS to its termination in the hand. Clinical features include weakness of wrist and finger flexion, forearm pronation, thenar abduction, and loss of sensation over the lateral palm, first three fingers, and radial half of the ring finger. Common sites of injury include the elbow, where the nerve passes through the two heads of the pronator teres muscle (pronator syndrome) and in the carpal tunnel (CARPAL TUNNEL SYNDROME).

Synonyms(10)

Synonym
Medial Neuropathy, Distal
Median Neuropathy, Proximal
Median Nerve Neuropathy
Median Nerve Neuralgia
Median Nerve Entrapment Neuropathy
Median Nerve Entrapment
Median Nerve Diseases
Neuropathy, Median
Median Mononeuropathy
Median Neuropathy

Research Excerpts

Overview

ExcerptReference
"Median nerve entrapment is a frequent disorder encountered by all clinicians at some point of their career."( Elmgreen, SB, 2023)

Research

Studies (78)

TimeframeStudies, This Condition (%)All Conditions %
pre-19906 (7.69)23.3326
1990's0 (0.00)12.5806
2000's36 (46.15)18.1394
2010's28 (35.90)28.8240
2020's8 (10.26)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
3-hydroxybutyric acid0medium11
phaclofen0low10
baclofen0low10
carbamazepine0low10
chlorothiazide0low10
clonidine0low10
deferoxamine0low10
lidocaine0low30
lamotrigine0low10
prilocaine0low10
triclosan0low10
prednisone0low10
dichloroacetic acid0medium11
methylprednisolone0low10
dexamethasone 21-phosphate0low10
betamethasone0low10
levonorgestrel0low10
titanium0low10
trolamine salicylate0low20
triamcinolone0low10
fomesafen0low20
fluorodeoxyglucose f180low10
fluorocitrate0low10
y 276320low10
lead0low10
tetrodotoxin0low10
dizocilpine maleate0low10
psd 5020low10
neuropeptide y0low20
heme0low10
minocycline0low10
phenprocoumon0low10
metallothionein0low10

Protein Targets (388)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Protein skinhead-10101
Monocarboxylate transporter 20101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
thioredoxin reductase6006
phosphopantetheinyl transferase1001
ATAD5 protein, partial6006
NFKB1 protein, partial3003
GLI family zinc finger 37007
AR protein110011
regulator of G-protein signaling 45005
67.9K protein2002
euchromatic histone-lysine N-methyltransferase 2110011
activating transcription factor 63003
Bloom syndrome protein isoform 15005
D(1A) dopamine receptor3003
cytochrome P450 3A4 isoform 14004
histone acetyltransferase KAT2A isoform 13003
lamin isoform A-delta10110011
Gamma-aminobutyric acid receptor subunit pi4206
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Gamma-aminobutyric acid type B receptor subunit 20224
Gamma-aminobutyric acid type B receptor subunit 20303
Bile salt export pump0707
Gamma-aminobutyric acid receptor subunit beta-14206
Gamma-aminobutyric acid receptor subunit delta4206
Gamma-aminobutyric acid receptor subunit gamma-24228
Gamma-aminobutyric acid receptor subunit alpha-54206
Gamma-aminobutyric acid receptor subunit alpha-34206
Gamma-aminobutyric acid receptor subunit gamma-14206
Gamma-aminobutyric acid receptor subunit alpha-24206
Gamma-aminobutyric acid receptor subunit alpha-44206
Gamma-aminobutyric acid receptor subunit gamma-34206
Gamma-aminobutyric acid receptor subunit alpha-64206
Gamma-aminobutyric acid receptor subunit alpha-14228
Gamma-aminobutyric acid receptor subunit beta-34206
Gamma-aminobutyric acid receptor subunit beta-24228
GABA theta subunit4206
Canalicular multispecific organic anion transporter 10606
Gamma-aminobutyric acid receptor subunit epsilon4206
Gamma-aminobutyric acid type B receptor subunit 10224
Gamma-aminobutyric acid type B receptor subunit 10202
ATP-dependent phosphofructokinase4004
pregnane X receptor2002
progesterone receptor7007
cytochrome P450 family 3 subfamily A polypeptide 43003
glucocorticoid receptor [Homo sapiens]8008
estrogen-related nuclear receptor alpha100010
farnesoid X nuclear receptor3003
pregnane X nuclear receptor8008
estrogen nuclear receptor alpha100010
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
IDH16006
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
nuclear receptor subfamily 1, group I, member 22002
thyroid hormone receptor beta isoform a6006
nuclear factor erythroid 2-related factor 2 isoform 28008
galanin receptor type 30101
nuclear factor erythroid 2-related factor 2 isoform 17007
Voltage-dependent calcium channel gamma-2 subunit3003
Glucocorticoid receptor0819
Glycine receptor subunit alpha-10808
Glutamate receptor 23003
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
ORF730022
Chain A, Beta-lactamase4004
acetylcholinesterase5005
RAR-related orphan receptor gamma6006
USP1 protein, partial4004
TDP1 protein9009
thyroid stimulating hormone receptor3003
retinoic acid nuclear receptor alpha variant 15005
mitogen-activated protein kinase 13003
geminin110011
Vpr2002
Bile salt export pump0101
Albumin0011
Major prion protein0011
Cellular tumor antigen p535005
Sodium channel protein type 1 subunit alpha0303
Sodium channel protein type 2 subunit alpha0303
Sodium channel protein type 3 subunit alpha0303
Cytochrome P450 2C9 0303
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 2B60011
Sodium channel protein type 4 subunit alpha0305
Cytochrome P450 2J20303
Potassium voltage-gated channel subfamily H member 20404
Sodium channel protein type 9 subunit alpha0505
Frizzled-80011
P2X purinoceptor 40101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
GLS protein4004
EWS/FLI fusion protein4004
nonstructural protein 12002
arylsulfatase A6006
transcriptional regulator ERG isoform 33003
muscarinic acetylcholine receptor M14004
Chain A, Ferritin light chain3003
Chain A, Cruzipain1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
nuclear receptor subfamily 1, group I, member 34004
cytochrome P450 2D64004
Beta-1 adrenergic receptor 0011
Alpha-1B adrenergic receptor 0011
cytochrome P450 2D6 isoform 12002
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
Membrane primary amine oxidase 0101
Solute carrier family 22 member 1 0203
5-hydroxytryptamine receptor 3A0011
Solute carrier family 22 member 30202
5-hydroxytryptamine receptor 1A0101
Alpha-2A adrenergic receptor0213
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0213
Alpha-1A adrenergic receptor0011
Alpha-2C adrenergic receptor0213
D0101
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0202
Alpha-2B adrenergic receptor0202
Amine oxidase [flavin-containing] A0101
Alpha-2C adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Alpha-1D adrenergic receptor0101
Alpha-1D adrenergic receptor0213
D(1B) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2b0011
Adenosine receptor A2a0011
Alpha-2B adrenergic receptor0001
D(4) dopamine receptor0101
Delta-type opioid receptor0101
Alpha-1A adrenergic receptor0112
Alpha-1B adrenergic receptor0112
Alpha-1A adrenergic receptor0112
Histamine H2 receptor1001
5-hydroxytryptamine receptor 70101
Spike glycoprotein3003
D(2) dopamine receptor0101
Mu-type opioid receptor0101
Inositol monophosphatase 11001
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
Alpha-2A adrenergic receptor0101
Nischarin0202
Solute carrier family 22 member 10101
Multidrug and toxin extrusion protein 10202
Nischarin0101
apical membrane antigen 1, AMA11001
DNA polymerase iota isoform a (long)4004
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Lysine-specific demethylase 4A0101
Guanine nucleotide-binding protein G1001
Hypoxia-inducible factor 1-alpha0011
Methylcytosine dioxygenase TET20101
Deoxyhypusine hydroxylase0101
retinoid X nuclear receptor alpha5005
thyroid hormone receptor beta isoform 25005
lethal factor (plasmid)1001
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial0101
potassium voltage-gated channel subfamily H member 2 isoform d2002
Glutamate receptor ionotropic, NMDA 1 0101
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Glutamate receptor ionotropic, NMDA 3A0101
Luciferase1001
hypoxia-inducible factor 1 alpha subunit4004
peroxisome proliferator activated receptor gamma2002
Histone H2A.x3003
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B2002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
peripheral myelin protein 222002
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 432002
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50101
GALC protein1001
peripheral myelin protein 22 isoform 13003
Dihydrofolate reductase0202
Potassium voltage-gated channel subfamily E member 10101
Potassium voltage-gated channel subfamily KQT member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0202
Sigma non-opioid intracellular receptor 10101
Sodium channel protein type 10 subunit alpha0101
SMAD family member 23003
SMAD family member 33003
estrogen receptor 2 (ER beta)3003
G3003
peroxisome proliferator-activated receptor delta2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
thyroid stimulating hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)3003
chromobox protein homolog 14004
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
DNA polymerase beta1001
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 3003
Progesterone receptor0011
Inositol hexakisphosphate kinase 13003
ATPase family AAA domain-containing protein 54004
Ataxin-24004
cytochrome P450 2C9, partial3003
Microtubule-associated protein tau3003
aldehyde dehydrogenase 1 family, member A12002
flap endonuclease 11001
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20101
Potassium voltage-gated channel subfamily A member 50101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
PPM1D protein1001
muscleblind-like protein 1 isoform 12002
Nuclear receptor subfamily 1 group I member 20011
Androgen receptor0202
Nuclear receptor subfamily 1 group I member 20011
Albumin0011
Stromelysin-10101
Matrilysin0101
Multidrug transporter MdfA0101
Matrix metalloproteinase-90101
Protein mono-ADP-ribosyltransferase PARP150101
Protein-arginine deiminase type-40202
Neuropeptide Y receptor type 10202
Neuropeptide Y receptor type 20202
endonuclease IV1001
DNA polymerase eta isoform 11001
survival motor neuron protein isoform d1001
Gag-Pol polyprotein0101
Cytochrome P450 2D60101
Gag-Pol polyprotein0101
Protease 0202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
thioredoxin glutathione reductase2002
vitamin D3 receptor isoform VDRA1001
nuclear receptor ROR-gamma isoform 11001
Nuclear receptor ROR-gamma1001
glp-1 receptor, partial2002
Smad32002
heat shock protein beta-12002
procathepsin L isoform 1 preproprotein0101
Chain A, enoyl-acyl carrier reductase0101
Chain C, enoyl-acyl carrier reductase0101
Chain A, enoyl-acyl carrier reductase0101
Chain C, enoyl-acyl carrier reductase0101
Chain A, enoyl-acyl carrier reductase0101
Chain C, enoyl-acyl carrier reductase0101
Chain A, Repressor0011
Fumarate hydratase1001
caspase 7, apoptosis-related cysteine protease1001
PINK11001
polyprotein1001
Parkin1001
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
caspase-31001
thyrotropin-releasing hormone receptor1001
Caspase-71001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
caspase-31001
heat shock protein HSP 90-alpha isoform 20001
twin arginine protein translocation system - TatA protein0001
Transthyretin0112
Polyunsaturated fatty acid 5-lipoxygenase0101
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
DNA gyrase subunit A0101
DNA gyrase subunit B0101
Replicase polyprotein 1ab0101
Replicase polyprotein 1ab0101
Endoplasmic reticulum chaperone BiP0101
Carbonyl reductase [NADPH] 10202
Alpha-synuclein1001
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0202
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI0202
Enoyl-acyl carrier reductase0101
Enoyl-acyl-carrier protein reductase 0202
Enoyl-ACP reductase II 0101
heat shock protein 90, putative0001
Chain E, cAMP-dependent protein kinase, alpha-catalytic subunit0101
Chain I, cAMP-dependent protein kinase inhibitor, alpha form0101
Chain B, Rho-associated protein kinase 10101
Chain A, Rho-associated protein kinase 10101
Chain A, Rho-associated protein kinase 10101
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit0101
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit0101
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit0101
Chain I, cAMP-dependent protein kinase inhibitor alpha0101
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit0101
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit0101
Chain I, cAMP-dependent protein kinase inhibitor alpha0101
Chain A, Rho-associated protein kinase 10101
dopamine D1 receptor1001
atrial natriuretic peptide receptor 1 precursor1001
Rho-associated protein kinase 20202
Ribosomal protein S6 kinase alpha-50101
cAMP-dependent protein kinase catalytic subunit alpha0101
cAMP-dependent protein kinase catalytic subunit alpha 0101
C-C motif chemokine 20101
cAMP-dependent protein kinase catalytic subunit alpha0101
cAMP-dependent protein kinase catalytic subunit gamma0101
cAMP-dependent protein kinase catalytic subunit beta0101
Rho-associated protein kinase 10202
Serine/threonine-protein kinase N20101
Rho-associated protein kinase 20101
Rho-associated protein kinase 20101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]