Acetyl-CoA:alpha-Glucosaminide N-Acetyltransferase Deficiency

Synonym
San Filippo's Syndrome
MPS3C
MPS3B
Sanfilippo Syndrome
Sanfilippo Syndrome A
Acetyl-CoA:alpha-Glucosaminide N-Acetyltransferase Deficiency
MPS III A
Sanfilippo Syndrome B
MPS IIIA
Sulfamidase Deficiency
NAGLU Deficiency
Mucopolysaccharidosis Type IIID
Mucopolysaccharidosis Type IIIC
Mucopolysaccharidosis Type IIIB
Mucopolysaccharidosis Type IIIA
Mucopolysaccharidosis 3
Sanfilippo Syndrome C
Sanfilippo Syndrome D
Sanfilippo's Syndrome
MPS III D
N-Acetyl-alpha-D-Glucosaminidase Deficiency
MPS IIID
MPS IIIC
MPS IIIB
MPS III B
MPS 3 D
MPS III C
N-Acetylglucosamine-6-Sulfatase Deficiency
Mucopolysaccharidosis Type 3 A
Mucopolysaccharidosis Type 3 A Sanfilippo Syndrome
Mucopolysaccharidosis Type 3 B
MPS 3 A
N-Acetylglucosamine-6-Sulfate Sulfatase Deficiency
Mucopolysaccharidosis Type 3 C
Heparan Sulfate Sulfatase Deficiency
Mucopolysaccharidosis Type 3 D
Polydystrophic Oligophrenia
MPS3A
MPS 3 B
MPS 3 C

Excerpt	Reference
"Sanfilippo syndrome is a mucopolysaccharidosis (MPS) caused by a lysosomal enzyme defect interrupting the degradation pathway of heparan sulfates."	( Bréjot, T; Cressant, A; Desmaris, N; Froissart, R; Heard, JM; Maire, I; Vanier, MT; Verot, L, 2004)
"MPS IIIB is attributable to the decreased activity of a lysosomal alpha-N-acetylglucosaminidase (NAGLU)."	( Boraston, AB; Ficko-Blean, E; Nemirovsky, O; Stubbs, KA; Vocadlo, DJ, 2008)
"Mucopolysaccharidosis type IIIA is a neurodegenerative lysosomal storage disorder characterized by progressive loss of learned skills, sleep disturbance and behavioural problems."	( Beard, H; Crawley, AC; Fuller, M; Hassiotis, S; Hemsley, KM; Hopwood, JJ; King, B; Luck, AJ; Rozaklis, T; Rozek, T, 2009)
"Sanfilippo disease (MPS IIIA) is an autosomal recessive lysosomal storage disorder resulting from sulfamidase deficiency, which is characterized by severe neurological impairment."	( Arfi, A; Bonnefont-Rousselot, D; Gandolphe, C; Richard, M; Scherman, D; Thérond, P, 2011)
"MPS IIIA is an inherited neurodegenerative lysosomal storage disorder characterized by cognitive impairment, sleep-wake cycle disturbance, speech difficulties, eventual mental regression and early death."	( Beard, H; Hassiotis, S; Hemsley, KM; Hopwood, JJ; King, B; Luck, AJ; Snel, MF; Trim, PJ, 2015)
"Sanfilippo syndrome is a rare lysosomal storage disorder caused by an impaired degradation of heparan sulfate (HS)."	( Benetó, N; Canals, I; Cozar, M; Grinberg, D; Vilageliu, L, 2015)
"MPS IIIA is characterized by severe neurological symptoms, clinically presenting as Sanfilippo syndrome, for which no effective therapy is available."	( Choo, A; Hemsley, KM; Hewson, LJ; Hopwood, JJ; O'Keefe, LV; Richards, RI; Snel, MF; Trim, PJ; Webber, DL, 2018)
"Sanfilippo syndrome is an untreatable form of childhood-onset dementia."	( Beard, H; Casson, RJ; Chidlow, G; Douglass, M; Hemsley, KM; Nazri, N; Neumann, D; Snel, MF; Trim, PJ, 2020)
"Mucopolysaccharidosis type IIIB is a lysosomal storage disease caused by a deficiency of the N-acetyl-alpha-d-glucosaminidase enzyme involved in the catabolism of heparan sulfate, causing its accumulation in various tissues."	( Barbed Ferrández, SM; García Romero, R; Pérez Delgado, R; Romagosa Sánchez-Monge, I; Ros Arnal, I; Torrecilla Idoipe, N, 2021)
"Mucopolysaccharidosis type IIIB is a devastating neurological disease caused by a lack of the lysosomal enzyme, α-N-acetylglucosaminidase (NAGLU), leading to a toxic accumulation of heparan sulfate."	( Alonzi, DS; Blériot, Y; Boraston, A; Butters, TD; Charollais-Thoenig, J; Demotz, S; Désiré, J; Imaeda, S; Jagadeesh, Y; Jiménez-Barbero, J; Kato, A; Poveda, A; Sollogoub, M; Tran, AT; Zhang, Y; Zhu, S, 2021)
"Mucopolysaccharidosis type IIIB is a rare autosomal recessive disorder characterized by deficiency of the enzyme N-acetyl-alpha-d-glucosaminidase (NAGLU), caused by biallelic pathogenic variants in the NAGLU gene, which leads to storage of heparan sulfate and a series of clinical consequences which hallmark is neurodegeneration."	( Baldo, G; Burin, MG; Cardoso-Dos-Santos, AC; Castro, MAA; de Souza, CFM; Embiruçu, EK; Facchin, ACB; Giugliani, L; Giugliani, R; Kim, CA; Kubaski, F; Leistner-Segal, S; Lourenço, CM; Medeiros, FS; Michelin-Tirelli, K; Montano, HQ; Montenegro, YHA; Moreira, MLC; Ribeiro, EM; Ribeiro, MG; Steiner, CE; Trapp, FB, 2022)
"MPS IIIC is characterized by severe neuropsychiatric symptoms and mild somatic symptoms."	( Gao, X; Liang, Y; Lu, D; Zhang, H, 2023)

Excerpt	Reference
"Body weight gain of male MPS IIIA mice treated with 1 mg/kg rhodamine B was reduced compared with untreated MPS IIIA mice and was indistinguishable from that of normal mice."	( Byers, S; Fletcher, JM; Roberts, AL; Thomas, BJ; Wilkinson, AS, 2006)
"Currently, there is no therapy for Sanfilippo syndrome, however, clinical trials are ongoing for enzyme replacement therapy, gene therapy and substrate reduction therapy (particularly gene expression-targeted isoflavone therapy)."	( Banecka-Majkutewicz, Z; Banecki, B; Gabig-Ciminska, M; Jakobkiewicz-Banecka, J; Kloska, A; Malinowska, M; Piotrowska, E; Wegrzyn, A; Wegrzyn, G, 2016)
"The established treatments for the MPS III do not cure the disease but only ameliorate non-neurological clinical symptoms."	( D'Agostino, M; De Pasquale, V; Pavone, LM; Scarcella, M; Scerra, G, 2021)
"Patients aged ≥3 years with MPS IIIA who had previously completed a phase 1/2 study and received ≥5 of the 6 planned rhHNS infusions via IT administration, were eligible for inclusion."	( Alexanderian, D; de Ruijter, J; Heap, F; Jones, SA; Marchal, JP; Nestrasil, I; Rust, S; Shapiro, E; Tump, E; Wijburg, FA, 2021)
"Mucopolysaccharidosis type IIIB (MPS IIIB; Sanfilippo syndrome B; OMIM #252920) is a lethal, pediatric, neuropathic, autosomal recessive, and lysosomal storage disease with no approved therapy."	( Assis, AB; Butt, MT; Chandra, S; Cherala, G; Cherukuri, A; Cooper, JD; Crawford, BE; Egeland, MT; Ellinwood, NM; Grover, A; Hess, AS; Hostetter, SJ; Jamil, M; Jeffery, ND; Jens, JK; Kovalchin, J; Labounek, R; Lawrence, R; Liu, XY; McCullagh, E; Melton, AC; Millman, ST; Mueller, BA; Nelvagal, HR; Nestrasil, I; O'Neill, CA; Parsons, RL; Paulson, A; Pinkstaff, J; Prill, H; Smith, JD; Snella, EM; Valentine, BN; Vuillemenot, BR; Wait, JCM; Zanelli, E; Zhou, H, 2022)
"Urinary GAG levels were normalized in MPS IIIB mice treated with 50 mg/kg/day resveratrol for 12 weeks or longer."	( Cyske, Z; Gaffke, L; Pierzynowska, K; Podlacha, M; Rintz, E; Węgrzyn, G, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	61 (25.74)	23.3326
1990's	20 (8.44)	12.5806
2000's	44 (18.57)	18.1394
2010's	80 (33.76)	28.8240
2020's	32 (13.50)	9.53

Drug	Relationship Strength	Studies	Trials
carnitine	low	1	0
methane	low	1	0
glycine	low	1	0
melatonin	low	3	0
aspirin	low	1	0
fentanyl	low	1	0
fluoxetine	low	1	0
gentamicin	low	1	0
lamotrigine	low	1	0
propofol	low	2	0
risperidone	medium	2	1
sevoflurane	low	1	0
succinylcholine	low	1	0
suramin	low	1	0
prednisolone	low	2	0
estrone	low	1	0
serine	low	1	0
aspartic acid	low	1	0
glutamine	low	1	0
mannitol	low	1	0
asparagine	low	1	0
histidine	low	1	0
arginine	low	2	0
rhodamine b	low	1	0
trehalose	low	1	0
thiazoles	low	1	0
evans blue	low	1	0
isovaleric acid	low	1	0
uridine diphosphate n-acetylglucosamine	low	1	0
galactitol	low	1	0
erythromycin	low	1	0
fucose	low	1	0
mannose	low	1	0
mercury	low	1	0
technetium	low	1	0
gadolinium	low	1	0
acetylglucosamine	low	10	0
galactosamine	low	4	0
galactose	low	1	0
1-deoxynojirimycin	medium	3	1
s-adenosylmethionine	low	1	0
acetylgalactosamine	low	2	0
miglustat	medium	3	1
acridine orange	low	1	0
thiazolyl blue	low	1	0
6-sulfatoxymelatonin	low	1	0
coenzyme a	low	1	0
paxilline	low	1	0
4-methylumbelliferyl 2-acetamido-2-deoxy-beta-d-glucopyranoside	low	3	0
antibiotic g 418	low	1	0
proline	low	1	0
n-acetylglucosaminitol	low	1	0
n-acetylgalactosaminitol	low	1	0
mannose-6-phosphate	low	3	0
glucosamine	low	18	0
elastin	low	1	0
naringenin	low	1	0
n-acetylglucosamine-6-sulfate	low	4	0
betadex	low	1	0
acetyl coenzyme a	low	2	0
resveratrol	low	1	0
keratan sulfate	low	5	0
glycosides	low	1	0
arginine vasopressin	low	1	0
nadp	low	1	0
dermatan sulfate	low	8	0
sch 23390	low	1	0
apigenin	low	1	0
hymecromone	low	4	0
kaempferol	low	1	0
genistein	medium	11	4
daidzein	low	1	0
coenzyme q10	low	1	0
irosustat	low	1	0
dexmedetomidine	low	1	0
sulfur	low	2	0
cysteine	low	1	0
triolein	low	1	0
estradiol-3-o-sulfamate	low	1	0
n-acetylglucosaminono-1,5-lactone o-(phenylcarbamoyl)oxime	low	1	0
g(m2) ganglioside	low	7	0
g(m1) ganglioside	low	3	0
alpha-synuclein	low	3	0
acid phosphatase	low	3	0
oligonucleotides	low	1	0
ubiquinone	low	1	0
calpain	low	1	0
glycolipids	low	5	0
vasoactive intestinal peptide	low	1	0
chondroitin	low	2	0
heparitin sulfate	medium	125	8
warfarin	low	1	0
transforming growth factor beta	low	1	0
g(m3) ganglioside	low	9	0
hyaluronoglucosaminidase	low	1	0
muramidase	low	1	0
amyloid beta-peptides	low	1	0
chondroitin sulfates	low	10	0
olanzapine	low	1	0
sildenafil citrate	low	1	0
alcian blue	low	1	0
eye	low	3	0

Protein Targets (1,020)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	12	0	0	12
glucocerebrosidase	7	0	0	7
Alpha-mannosidase	0	2	0	2
alpha-galactosidase	3	0	0	3
Trehalase	0	2	0	2
lysosomal alpha-glucosidase preproprotein	4	0	0	4
Trehalase	0	1	0	1
Maltase-glucoamylase, intestinal	0	4	0	4
Trehalase	0	2	0	2
Lysosomal acid glucosylceramidase	0	4	0	4
Alpha-galactosidase A	0	1	0	1
Alpha-glucosidase MAL62	0	1	0	1
Lactase-phlorizin hydrolase	0	2	0	2
Lysosomal alpha-glucosidase	0	4	0	4
Beta-glucosidase A	0	1	0	1
Sucrase-isomaltase, intestinal	0	2	0	2
Alpha-1B adrenergic receptor	0	6	0	6
Sucrase-isomaltase, intestinal	0	3	0	3
Alpha-1D adrenergic receptor	0	6	0	6
Beta-glucosidase	0	1	0	1
Protein-lysine 6-oxidase	0	4	0	4
Alpha-mannosidase 2	0	2	0	2
Glycogen debranching enzyme	0	2	0	2
Glycogen debranching enzyme	0	1	0	1
Alpha-glucosidase MAL32	0	2	0	2
Alpha-1A adrenergic receptor	0	7	0	7
Oligo-1,6-glucosidase IMA1	0	1	0	1
Alpha-glucosidase MAL12	0	3	0	3
Oxysterols receptor LXR-beta	0	2	0	2
Spike glycoprotein	6	1	1	8
Alpha-amylase	0	1	0	1
Trehalose synthase/amylase TreS	0	1	0	1
Lactase-phlorizin hydrolase	0	2	0	2
Oxysterols receptor LXR-alpha	0	2	0	2
Neutral alpha-glucosidase AB	0	2	0	2
Ceramide glucosyltransferase	0	2	0	2
Lysosomal acid glucosylceramidase	0	1	0	1
Probable maltase-glucoamylase 2	0	1	0	1
Beta-glucosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	3	0	3
Cytosolic beta-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	2	0	2
Putative alpha-glucosidase	0	2	0	2
N-alpha-acetyltransferase 50	0	0	2	2
Fibrinogen C domain-containing protein 1	0	1	0	1
Putative glycosyltransferase WbgO	0	0	0	1
Cytochrome P450 3A4	0	10	0	11
Cannabinoid receptor 1	0	1	0	1
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
Telomerase reverse transcriptase	0	1	0	1
Amyloid-beta precursor protein	0	5	1	6
Reverse transcriptase/RNaseH	0	3	0	3
30S ribosomal protein S6	0	2	1	3
30S ribosomal protein S7	0	2	1	3
50S ribosomal protein L15	0	2	1	3
50S ribosomal protein L10	0	2	1	3
50S ribosomal protein L11	0	2	1	3
50S ribosomal protein L7/L12	0	2	1	3
50S ribosomal protein L19	0	2	1	3
50S ribosomal protein L1	0	2	1	3
50S ribosomal protein L20	0	2	1	3
50S ribosomal protein L27	0	2	1	3
50S ribosomal protein L28	0	2	1	3
50S ribosomal protein L29	0	2	1	3
50S ribosomal protein L31	0	2	1	3
50S ribosomal protein L31 type B	0	2	1	3
50S ribosomal protein L32	0	2	1	3
50S ribosomal protein L33	0	2	1	3
50S ribosomal protein L34	0	2	1	3
50S ribosomal protein L35	0	2	1	3
50S ribosomal protein L36	0	2	1	3
30S ribosomal protein S10	0	2	1	3
30S ribosomal protein S11	0	2	1	3
30S ribosomal protein S12	0	2	1	3
30S ribosomal protein S13	0	2	1	3
30S ribosomal protein S16	0	2	1	3
30S ribosomal protein S18	0	2	1	3
30S ribosomal protein S19	0	2	1	3
30S ribosomal protein S20	0	2	1	3
30S ribosomal protein S2	0	2	1	3
30S ribosomal protein S3	0	2	1	3
30S ribosomal protein S4	0	2	1	3
30S ribosomal protein S5	0	2	1	3
30S ribosomal protein S8	0	2	1	3
30S ribosomal protein S9	0	2	1	3
50S ribosomal protein L13	0	2	1	3
50S ribosomal protein L14	0	2	1	3
50S ribosomal protein L16	0	2	1	3
50S ribosomal protein L23	0	2	1	3
30S ribosomal protein S15	0	2	1	3
50S ribosomal protein L17	0	2	1	3
50S ribosomal protein L21	0	2	1	3
50S ribosomal protein L30	0	2	1	3
50S ribosomal protein L6	0	2	1	3
30S ribosomal protein S14	0	2	1	3
30S ribosomal protein S17	0	2	1	3
30S ribosomal protein S1	0	2	1	3
50S ribosomal protein L18	0	2	1	3
50S ribosomal protein L2	0	2	1	3
50S ribosomal protein L3	0	2	1	3
50S ribosomal protein L24	0	2	1	3
50S ribosomal protein L4	0	2	1	3
50S ribosomal protein L22	0	2	1	3
50S ribosomal protein L5	0	2	1	3
30S ribosomal protein S21	0	2	1	3
50S ribosomal protein L25	0	2	1	3
50S ribosomal protein L36 2	0	2	1	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	12	0	0	12
Chain B, HADH2 protein	12	0	0	12
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, Cruzipain	2	0	0	2
Chain A, Transthyretin	0	0	3	3
Chain A, Transthyretin	0	0	3	3
Chain A, Transthyretin	0	0	3	3
Chain A, Transthyretin	0	0	3	3
Chain B, Transthyretin	0	0	3	3
Chain A, Transthyretin	0	0	3	3
Chain B, Transthyretin	0	0	3	3
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein Kinase Ii Subunit Alpha	0	1	0	1
Luciferase	10	0	0	10
interleukin 8	3	0	0	3
endonuclease IV	3	0	0	3
BRCA1	3	0	0	3
RGS12	1	0	0	1
15-lipoxygenase, partial	5	0	0	5
phosphopantetheinyl transferase	7	0	0	7
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
RAR-related orphan receptor gamma	12	0	0	12
ATAD5 protein, partial	7	0	0	7
USP1 protein, partial	7	0	0	7
NFKB1 protein, partial	4	0	0	4
GLS protein	11	0	0	11
PPM1D protein	4	0	0	4
TDP1 protein	17	0	0	17
GLI family zinc finger 3	19	0	0	19
Microtubule-associated protein tau	8	0	0	8
Thrombopoietin	3	0	0	3
AR protein	20	0	0	20
Smad3	3	0	0	3
apical membrane antigen 1, AMA1	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	11	0	0	11
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
thyroid stimulating hormone receptor	9	0	0	9
estrogen receptor 2 (ER beta)	11	0	0	11
nuclear receptor subfamily 1, group I, member 3	14	0	0	14
progesterone receptor	14	0	0	14
regulator of G-protein signaling 4	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	13	0	0	13
EWS/FLI fusion protein	12	0	0	12
glucocorticoid receptor [Homo sapiens]	13	0	0	13
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
retinoid X nuclear receptor alpha	12	0	0	12
estrogen-related nuclear receptor alpha	20	0	0	20
farnesoid X nuclear receptor	8	0	0	8
pregnane X nuclear receptor	15	0	0	15
estrogen nuclear receptor alpha	21	0	0	21
G	10	0	0	10
cytochrome P450 2D6	9	0	0	9
Neuraminidase	0	7	0	7
67.9K protein	5	0	0	5
Parkin	4	0	0	4
peroxisome proliferator-activated receptor delta	10	0	0	10
peroxisome proliferator activated receptor gamma	9	0	0	9
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
arylsulfatase A	6	0	0	6
pyruvate kinase	4	0	0	4
IDH1	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
aryl hydrocarbon receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
Histone H2A.x	8	0	0	8
Replicase polyprotein 1ab	0	2	1	3
cytochrome P450 2D6 isoform 1	8	0	0	8
NPC intracellular cholesterol transporter 1 precursor	5	0	0	5
peripheral myelin protein 22 isoform 1	9	0	0	9
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	6	0	0	6
cytochrome P450 2C19 precursor	9	0	0	9
cytochrome P450 2C9 precursor	7	0	0	7
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
thyroid hormone receptor beta isoform a	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	7	0	0	7
thyroid hormone receptor beta isoform 2	13	0	0	13
histone deacetylase 9 isoform 3	5	0	0	5
heat shock protein beta-1	4	0	0	4
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	3	3
mitogen-activated protein kinase 1	4	0	0	4
flap endonuclease 1	7	0	0	7
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	12	0	0	12
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	7	0	0	7
nuclear receptor ROR-gamma isoform 1	3	0	0	3
geminin	13	0	0	13
DNA polymerase kappa isoform 1	6	0	0	6
survival motor neuron protein isoform d	5	0	0	5
cytochrome P450 3A4 isoform 1	11	0	0	11
M-phase phosphoprotein 8	4	0	0	4
lamin isoform A-delta10	15	0	0	15
pyruvate kinase PKM isoform b	3	0	0	3
neuropeptide S receptor isoform A	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	11	2	1	14
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Polyphenol oxidase 2	0	3	0	3
Aldo-keto reductase family 1 member B10	0	3	0	3
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
G2/mitotic-specific cyclin-B2	0	2	0	2
Poly [ADP-ribose] polymerase tankyrase-1	0	1	0	1
Lysozyme C-1	0	1	0	1
Cationic trypsin	0	2	0	2
Carbonic anhydrase 1	0	10	0	16
Carbonic anhydrase 2	0	11	1	18
Interferon beta	14	0	0	14
HLA class I histocompatibility antigen, B alpha chain	10	0	0	10
Transthyretin	0	2	2	4
Estrogen receptor	0	11	2	14
Glucocorticoid receptor	0	2	1	12
Cellular tumor antigen p53	12	0	0	12
Cytochrome P450 1A1	0	7	0	7
Integrin beta-3	5	1	0	6
Myeloperoxidase	0	4	0	4
Cytochrome P450 1A2	0	5	0	5
Cyclin-dependent kinase 1	0	3	0	3
Beta-glucuronidase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	9	0	9
Seed linoleate 13S-lipoxygenase-1	0	2	0	4
ATP-dependent translocase ABCB1	0	5	3	11
Neutrophil elastase	0	2	0	2
Integrin alpha-IIb	5	1	0	6
Ornithine decarboxylase	3	0	0	3
Poly [ADP-ribose] polymerase 1	0	1	0	1
Replicase polyprotein 1a	0	2	1	3
Replicase polyprotein 1ab	0	2	1	3
Replicase polyprotein 1ab	0	3	1	4
Replicase polyprotein 1ab	0	2	1	3
Androgen receptor	0	5	0	9
Sialidase	0	3	0	3
Serine/threonine-protein kinase pim-1	0	2	0	3
Aromatase	0	9	0	9
Angiotensin-converting enzyme	0	6	0	6
Cystic fibrosis transmembrane conductance regulator	0	1	2	3
17-beta-hydroxysteroid dehydrogenase type 1	0	6	0	7
Pyruvate kinase PKM	0	1	1	2
G2/mitotic-specific cyclin-B1	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	1	4
Urease subunit alpha	0	2	0	2
Aldo-keto reductase family 1 member B1	0	6	0	6
G2/mitotic-specific cyclin-B	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	11	2	1	14
Mucin-1	0	1	0	1
Glycogen synthase kinase-3 beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	11	2	1	14
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	11	2	1	14
Glutamate receptor 2	9	0	0	9
Casein kinase II subunit alpha'	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	11	2	1	14
Gamma-aminobutyric acid receptor subunit alpha-3	11	2	1	14
Amine oxidase [flavin-containing] A	0	6	0	6
Acetylcholinesterase	0	6	0	6
Carbonic anhydrase 4	0	6	0	8
Gamma-aminobutyric acid receptor subunit gamma-1	11	2	1	14
Gamma-aminobutyric acid receptor subunit alpha-2	11	2	1	14
Amine oxidase [flavin-containing] B	0	7	0	7
Dipeptidyl peptidase 4	0	5	0	5
Proteasome subunit beta type-5	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	11	2	1	14
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-3	11	2	1	14
Gamma-aminobutyric acid receptor subunit alpha-6	11	2	1	14
Substance-P receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Multidrug resistance-associated protein 1	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Prostaglandin G/H synthase 2	0	6	0	6
Mu-type opioid receptor	0	2	2	6
Receptor-type tyrosine-protein kinase FLT3	0	3	0	3
Testosterone 17-beta-dehydrogenase 3	0	3	0	3
17-beta-hydroxysteroid dehydrogenase type 2	0	4	0	4
Acetylcholinesterase	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Delta-type opioid receptor	0	2	1	5
Kappa-type opioid receptor	0	2	1	5
Homeobox protein Nkx-2.5	0	1	0	1
Tyrosine-protein kinase SYK	0	2	1	3
Histamine H2 receptor	8	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Xanthine dehydrogenase/oxidase	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Glycogen synthase kinase-3 alpha	0	2	0	2
Glycogen synthase kinase-3 beta	0	2	0	2
Estrogen receptor	0	0	2	2
Nuclear receptor ROR-gamma	6	0	0	6
Death-associated protein kinase 1	0	3	0	3
Mitogen-activated protein kinase 10	0	3	0	3
Beta-secretase 1	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	11	3	1	15
Gamma-aminobutyric acid receptor subunit beta-3	11	2	1	14
Gamma-aminobutyric acid receptor subunit beta-2	11	2	1	14
Casein kinase II subunit beta	0	2	0	2
Casein kinase II subunit alpha	0	3	0	3
Urease subunit beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Lactoperoxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
MO15-related protein kinase Pfmrk	0	3	0	3
Inositol monophosphatase 1	7	0	0	7
Cyclin-dependent kinase 6	0	2	0	2
Cyclin-dependent-like kinase 5	0	2	0	2
Cyclin homolog	0	2	0	2
Transcription factor GATA-4	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Mitogen-activated protein kinase 14	0	3	0	3
Cytochrome P450 1B1	0	11	0	11
Carbonic anhydrase 3	0	1	0	1
Substance-K receptor	0	5	0	5
Integrase	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Casein kinase II subunit alpha 3	0	2	0	2
Inositol polyphosphate multikinase	0	3	0	3
G2/mitotic-specific cyclin-B3	0	2	0	2
GABA theta subunit	11	2	1	14
Inositol hexakisphosphate kinase 1	10	0	0	10
Estrogen receptor beta	0	9	2	12
Enoyl-acyl-carrier protein reductase	0	2	0	2
Aurora kinase B	0	2	0	2
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	8	0	0	8
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Myocilin	0	0	1	1
Cyclin-dependent kinase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	11	2	1	14
Prenyltransferase homolog	0	0	0	5
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	0	1
Carboxylic ester hydrolase	0	2	0	2
NADPH oxidase 4	0	2	0	2
Dipeptidyl peptidase 3	0	3	0	3
Estrogen receptor beta	0	0	2	2
Inositol hexakisphosphate kinase 2	0	3	0	3
Short transient receptor potential channel 5	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	4
Sialidase-2	0	3	0	3
cytochrome P450 2C9, partial	10	0	0	10
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
ATP-dependent phosphofructokinase	7	0	0	7
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	13	0	0	13
euchromatic histone-lysine N-methyltransferase 2	19	0	0	19
chromobox protein homolog 1	7	0	0	7
muscarinic acetylcholine receptor M1	7	0	0	7
lethal factor (plasmid)	9	0	0	9
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
peripheral myelin protein 22	7	0	0	7
ATP-binding cassette sub-family C member 3	0	10	0	10
Multidrug resistance-associated protein 4	0	10	0	10
Bile salt export pump	0	14	0	14
Translocator protein	0	0	1	1
Vasopressin V2 receptor	0	2	1	4
Oxytocin receptor	0	1	1	2
Vasopressin V1a receptor	0	0	2	2
Vasopressin V1a receptor	0	1	1	2
Vasopressin V1b receptor	0	1	1	2
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	1	0	2
Oxytocin receptor	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	10	0	10
Neutral amino acid transporter A	0	4	0	4
Neutral amino acid transporter B(0)	0	4	0	4
Carbonic anhydrase-like protein, putative	0	0	0	4
Amino acid transporter	0	4	0	4
Chain A, Ferritin light chain	6	0	0	6
Bloom syndrome protein isoform 1	10	0	0	10
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	4	1	6
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	5
Glutamate receptor ionotropic, NMDA 2B	0	3	1	5
Glutamate receptor ionotropic, NMDA 2C	0	3	1	5
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	3	1	5
Glutamate receptor ionotropic, NMDA 3B	0	3	1	5
Carbonic anhydrase 4	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	0	3	1	5
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	1	0	0	1
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Fatty acid-binding protein, liver	0	2	0	2
Prostaglandin G/H synthase 1	0	2	1	3
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	7	0	7
Adenosine receptor A1	0	2	0	3
Adenosine receptor A2a	0	2	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	6	1	7
Sigma non-opioid intracellular receptor 1	0	3	1	4
Chain A, D-MALTODEXTRIN BINDING PROTEIN	0	0	1	1
Chain A, Limit Dextrinase	0	0	1	1
Chain A, Solute-binding protein	0	0	1	1
Chain A, Solute-binding protein	0	0	1	1
Chain B, SusD	0	0	1	1
Chain A, SusD	0	0	1	1
Chain A, SusD	0	0	1	1
Chain A, Alpha-hemolysin	0	0	1	1
Chain B, Alpha-hemolysin	0	0	1	1
Chain C, Alpha-hemolysin	0	0	1	1
Chain D, Alpha-hemolysin	0	0	1	1
Chain E, Alpha-hemolysin	0	0	1	1
Chain F, Alpha-hemolysin	0	0	1	1
Chain G, Alpha-hemolysin	0	0	1	1
activating transcription factor 6	8	0	0	8
potassium voltage-gated channel subfamily H member 2 isoform d	9	0	0	9
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	1	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	1	2
Dihydrofolate reductase	0	1	0	1
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Histidine-rich protein PFHRP-II	0	1	0	2
Procathepsin L	0	1	1	2
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	4	0	4
Muscarinic acetylcholine receptor M5	0	6	0	6
Alpha-2A adrenergic receptor	0	7	1	8
Spike glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M1	0	5	1	6
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	5	1	6
Alpha-2B adrenergic receptor	0	7	0	7
Alpha-2C adrenergic receptor	0	6	1	7
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	7	0	7
Serine/threonine-protein kinase mTOR	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	11	0	11
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	1	1	2
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
acetylcholinesterase	4	0	0	4
GALC protein	5	0	0	5
Choline O-acetyltransferase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
caspase 7, apoptosis-related cysteine protease	5	0	0	5
caspase-3	5	0	0	5
thyroid stimulating hormone receptor	4	0	0	4
ras-related protein Rab-9A	5	0	0	5
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
rac GTPase-activating protein 1 isoform a	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	1	0	3
Carbonic anhydrase 12	0	6	0	8
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Tyrosinase	0	4	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	2
Carbonic anhydrase 7	0	5	0	7
Transporter	0	4	0	4
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	2	0	2
Alpha-1B adrenergic receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-2B adrenergic receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	4	0	4
Alpha-2A adrenergic receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	5	0	5
Chain A, Beta-lactamase	5	0	0	5
Motilin receptor	0	0	1	1
acid sphingomyelinase	2	0	0	2
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
streptokinase A precursor	0	0	1	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
Albumin	0	0	3	3
ATP-dependent translocase ABCB1	0	2	0	2
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Cytochrome P450 2C9	0	7	0	7
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	2	4
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 2J2	0	3	0	3
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Multidrug and toxin extrusion protein 1	0	2	0	2
Steryl-sulfatase	0	3	0	3
nonstructural protein 1	1	0	0	1
hexokinase-4 isoform 1	3	0	0	3
glucokinase regulatory protein	3	0	0	3
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	5	0	5
Androgen receptor	0	4	0	4
Sodium-dependent serotonin transporter	0	7	2	9
Mu-type opioid receptor	0	3	2	5
Alpha-synuclein	0	1	0	1
5-hydroxytryptamine receptor 2B	0	8	0	8
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Mu-type opioid receptor	0	2	1	3
TAR DNA-binding protein 43	3	0	0	3
Ghrelin O-acyltransferase	0	1	0	1
Luciferin 4-monooxygenase	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 1	0	4	0	4
Nuclear factor NF-kappa-B p105 subunit	0	2	0	3
Tyrosine-protein phosphatase 1	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
Vesicular glutamate transporter 3	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
D(2) dopamine receptor	0	7	0	7
D(4) dopamine receptor	0	4	0	4
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Histamine H1 receptor	0	5	1	6
D(3) dopamine receptor	0	5	0	5
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	4	0	4
Caspase-7	1	0	0	1
D(1A) dopamine receptor	5	0	0	5
caspase-3	1	0	0	1
huntingtin isoform 2	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
5-hydroxytryptamine receptor 4	0	10	0	10
Albumin	0	0	3	3
Sodium channel protein type 1 subunit alpha	0	2	0	2
5-hydroxytryptamine receptor 2C	0	7	0	7
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	4	0	4
Dipeptidyl peptidase 4	0	2	0	2
5-hydroxytryptamine receptor 2A	0	7	0	7
Acetylcholinesterase	0	2	0	2
Sodium-dependent noradrenaline transporter	0	7	3	10
Sodium-dependent dopamine transporter	0	3	0	3
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
5-hydroxytryptamine receptor 2A	0	8	0	8
5-hydroxytryptamine receptor 2C	0	10	0	10
5-hydroxytryptamine receptor 2B	0	7	0	7
Sodium-dependent serotonin transporter	0	3	0	3
Cytochrome P450 2C19	0	2	0	2
D(1A) dopamine receptor	2	1	0	3
5-hydroxytryptamine receptor 6	0	5	0	5
D(2) dopamine receptor	0	7	0	8
Gastrin/cholecystokinin type B receptor	0	1	0	1
Sodium-dependent dopamine transporter	0	4	1	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	5	0	5
Beta-2 adrenergic receptor	0	1	0	1
Transporter	0	3	0	3
Histamine H3 receptor	0	3	0	3
Fucose-binding lectin PA-IIL	0	2	0	2
CD209 antigen	0	3	0	3
Chain A, Estrogen receptor 1 (alpha)	0	1	0	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
glp-1 receptor, partial	3	0	0	3
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
P53	2	0	0	2
DNA polymerase beta	2	0	0	2
tyrosine-protein kinase Yes	1	0	0	1
Steroid hormone receptor ERR2	0	1	0	1
Tyrosine-protein kinase ABL1	0	2	0	3
Pancreatic triacylglycerol lipase	0	3	0	3
Triosephosphate isomerase	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	2	0	2
Steroid hormone receptor ERR1	0	2	0	2
Cyclin-dependent kinase 4	0	1	0	1
Ornithine decarboxylase	0	2	0	2
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Protein kinase C alpha type	0	2	1	3
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Cruzipain	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	2	0	2
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Signal transducer and activator of transcription 3	0	1	0	1
Tyrosine-protein kinase CSK	0	1	0	1
Tyrosine-protein kinase ABL2	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 4	0	1	0	1
Quinone oxidoreductase	0	0	0	1
Cytoplasmic tyrosine-protein kinase BMX	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Aldehyde oxidase	0	1	0	1
Tissue alpha-L-fucosidase	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Chain A, Glutamine Binding Protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Asc-type amino acid transporter 1	0	1	0	1
Glycine receptor subunit alpha-1	0	0	2	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Proton-coupled amino acid transporter 1	0	3	0	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	2	0	4
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 6	0	2	0	4
Carbonic anhydrase 5A, mitochondrial	0	2	0	4
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	3	0	5
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	1	0	2
Carbonic anhydrase 15	0	1	0	2
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 14	0	2	0	4
Carbonic anhydrase 5B, mitochondrial	0	2	0	4
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Acetylcholinesterase	0	4	0	4
Genome polyprotein	0	1	0	1
Caspase-7	1	0	0	1
Small conductance calcium-activated potassium channel protein 3	0	1	0	1
Cholinesterase	0	4	0	4
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Oleandomycin glycosyltransferase	0	0	0	1
Chain A, Carbonic anhydrase II	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Arginase	0	1	0	1
Protein E6	0	1	0	1
Neuraminidase	0	1	0	1
Interstitial collagenase	0	1	0	1
Tyrosine-protein kinase Yes	0	1	0	1
Beta-glucuronidase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Tyrosinase	0	2	0	2
Aryl hydrocarbon receptor	0	1	0	1
Prolyl endopeptidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Lactoylglutathione lyase	0	2	0	2
Dihydroorotate dehydrogenase	0	1	0	1
Histone-lysine N-methyltransferase SETD7	0	1	0	1
3-oxoacyl-acyl-carrier protein reductase	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
Alpha-mannosidase 2C1	0	1	0	1
ClpP	2	0	0	2
Cytochrome P450 1A2	0	1	0	1
Cholinesterase	0	2	0	2
Cytochrome P450 2C11	0	1	0	1
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	1	3
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	2	0	2
Sucrase-isomaltase	0	1	0	1
Ceramide glucosyltransferase	0	1	0	1
Beta-galactosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	1	0	1
Chain A, HYALURONIDASE	0	1	0	1
Chain A, Beta-hexosaminidase	0	1	0	1
Chain A, Alpha-n-acetylglucosaminidase	0	0	1	1
Chain A, Alpha-n-acetylglucosaminidase	0	0	1	1
Chain A, O-glcnacase Bt_4395	0	1	0	1
Chain A, N-acetylglucosaminidase	0	1	0	1
Chain A, N-acetylglucosaminidase	0	1	0	1
Protein O-GlcNAcase	0	1	0	1
Protein O-GlcNAcase	0	1	0	1
Beta-hexosaminidase	0	0	0	1
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	0	0	0	1
Chain A, Hth-type Transcriptional Regulator Ttgr	0	0	1	1
Chain A, Hth-type Transcriptional Regulator Ttgr	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Calmodulin-1	0	1	0	1
Carbonyl reductase [NADPH] 1	0	2	0	2
5-hydroxytryptamine receptor 3E	0	1	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	3	5
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
D	0	4	0	6
D(3) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 1A	0	3	0	4
D(1A) dopamine receptor	0	6	0	6
D(4) dopamine receptor	0	1	0	1
Histamine H1 receptor	0	2	1	3
5-hydroxytryptamine receptor 7	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
Alpha-1B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
TPA: protein transporter TIM10	0	1	0	1
tumor susceptibility gene 101 protein	1	0	0	1
POsterior Segregation	0	0	2	2
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	1	0	1
Zinc finger protein mex-5	0	0	2	2
BZLF2	0	1	0	1
luciferase	0	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Nociceptin receptor	0	0	1	1
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
M18 aspartyl aminopeptidase	0	1	0	1
cathepsin L1	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	0	0	1	1
Vif	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
transcription factor p65 isoform 1	0	0	1	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
Aryl hydrocarbon receptor	0	1	0	1
Estrogen receptor beta	0	0	1	1
Lysine-specific histone demethylase 1A	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Myc proto-oncogene protein	0	1	0	2
Tyrosine-protein kinase Lck	0	1	0	1
Cathepsin D	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Breakpoint cluster region protein	0	1	0	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Estrogen receptor	0	0	1	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Squalene synthase	0	1	0	1
Transcription factor p65	0	1	0	1
Bcl-2-like protein 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
N1L	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	2
Tubulin beta-2B chain	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	1	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	1	4
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
large T antigen	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Beta-1 adrenergic receptor	0	1	0	1
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Met repressor	0	0	2	2
Protein arginine N-methyltransferase 5	0	0	1	1
Histone H3K27 methylase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	0	1	2
S-adenosylmethionine decarboxylase proenzyme	0	1	0	2
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
Protein arginine N-methyltransferase 1	0	2	0	2
Methylosome protein 50	0	0	1	1
dopamine D1 receptor	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 3	0	1	0	1
Adenylate cyclase type 9	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
D(1B) dopamine receptor	0	2	0	2
D(1) dopamine receptor	0	1	0	1
Adenylate cyclase type 8	0	1	0	1
Adenylate cyclase type 7	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 1	0	1	0	1
D	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
D	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 2	0	1	0	1
Serine/threonine-protein kinase D3	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Cathepsin B	0	1	0	1
Protein kinase C eta type	0	1	0	1
P2Y purinoceptor 2	0	1	1	2
Protein kinase C iota type	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 2	0	1	1	2
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2Y purinoceptor 4	0	0	1	1
NAD-dependent protein deacetylase HST2	0	1	0	1
P2X purinoceptor 3	0	0	1	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	1	0	1
DNA primase	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
P2Y purinoceptor 6	0	1	0	1
Serine/threonine-protein kinase D1	0	1	0	1
Dual specificity protein phosphatase 5	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 8	0	1	0	1
RmtA	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 3	0	1	0	1
P2Y purinoceptor 11	0	1	1	2
P2X purinoceptor 7	0	0	1	1
P2Y purinoceptor 12	0	0	1	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with trehalose	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with cellobiose	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with maltose	0	1	0	1
Trehalose-phosphatase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Acetyl-CoA:alpha-Glucosaminide N-Acetyltransferase Deficiency

Synonyms(40)

Research Excerpts

Overview

Treatment

Research

Studies (237)

Protein Targets (1,020)

Acetyl-CoA:alpha-Glucosaminide N-Acetyltransferase Deficiency

Synonyms(40)

Research Excerpts

Overview

Treatment

Research

Studies (237)

Drugs Studied (117)

Protein Targets (1,020)