Page last updated: 2024-09-27

Lower Extremity Deformities, Congenital

Congenital structural abnormalities of the LOWER EXTREMITY.

Synonyms(2)

Synonym
Lower Extremity Deformities, Congenital
Lower Limb Deformities, Congenital

Research

Studies (48)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (4.17)23.3326
1990's0 (0.00)12.5806
2000's10 (20.83)18.1394
2010's32 (66.67)28.8240
2020's4 (8.33)9.53
DrugIndicatedRelationship StrengthStudiesTrials
phosphoserine0low10
salicylic acid0low10
cytosine0low10
carbamazepine0low10
cefuroxime0low10
valproic acid0low10
apnea0low10
pamidronate0low10
propranolol0low10
thalidomide0low40
thyroxine0low10
lysine0low10
colchicine0low10
arginine0low10
quinazolines0low10
methylnitrosourea0low10
vancomycin0low10
tricalcium phosphate0low10
ozone0low10
trolamine salicylate0low10
buquineran0low10
inositol 3-phosphate0low90
tretinoin0low10
retinol0low10
retinol palmitate0low10
misoprostol0low10
cysteine0low10
phosphorus0low10
atrial natriuretic factor0low10
lucifer yellow0low10
guanine0low10
eye0low10

Protein Targets (518)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
thioredoxin reductase8008
ATAD5 protein, partial4004
TDP1 protein110011
Microtubule-associated protein tau4004
estrogen-related nuclear receptor alpha8008
arylsulfatase A3003
euchromatic histone-lysine N-methyltransferase 2120012
Bloom syndrome protein isoform 15005
D(1A) dopamine receptor3003
lamin isoform A-delta107007
neuropeptide S receptor isoform A3003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
phosphopantetheinyl transferase3003
NFKB1 protein, partial2002
GLS protein3003
thyroid stimulating hormone receptor6006
alpha-galactosidase1001
cytochrome P450 2C19 precursor3003
chromobox protein homolog 14004
flap endonuclease 12002
DNA polymerase iota isoform a (long)3003
muscarinic acetylcholine receptor M14004
lethal factor (plasmid)3003
Cytochrome P450 3A40214
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30202
ATP-dependent phosphofructokinase3003
Atrial natriuretic peptide receptor 10011
Atrial natriuretic peptide receptor 1 0011
Chain A, Beta-lactamase3003
acetylcholinesterase3003
RAR-related orphan receptor gamma9009
USP1 protein, partial7007
AR protein7007
glucocorticoid receptor [Homo sapiens]7007
retinoic acid nuclear receptor alpha variant 17007
pregnane X nuclear receptor9009
estrogen nuclear receptor alpha140014
IDH13003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
thyroid hormone receptor beta isoform a6006
nuclear factor erythroid 2-related factor 2 isoform 23003
mitogen-activated protein kinase 12002
geminin100010
Vpr1001
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Bile salt export pump0404
Bile salt export pump0808
Albumin0011
Major prion protein0011
Cellular tumor antigen p539009
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 0314
UDP-glucuronosyltransferase 2B70103
Cytochrome P450 2B60011
Sodium channel protein type 4 subunit alpha0102
Cytochrome P450 2J20303
Potassium voltage-gated channel subfamily H member 20404
Sodium channel protein type 9 subunit alpha0202
Frizzled-80011
Canalicular multispecific organic anion transporter 10505
P2X purinoceptor 40101
Chain A, Ferritin light chain3003
Luciferase4004
interleukin 83003
endonuclease IV2002
PAX80001
pregnane X receptor4004
hypoxia-inducible factor 1 alpha subunit2002
Fumarate hydratase1001
PPM1D protein1001
GLI family zinc finger 38008
Thrombopoietin1001
Smad31001
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 35005
cytochrome P450 family 3 subfamily A polypeptide 48008
retinoid X nuclear receptor alpha7007
farnesoid X nuclear receptor5005
polyprotein1001
67.9K protein2002
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
aryl hydrocarbon receptor3003
activating transcription factor 63003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
nuclear receptor subfamily 1, group I, member 21001
cytochrome P450 2D6 isoform 11001
nuclear receptor subfamily 0 group B member 10101
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C9 precursor1001
thyroid hormone receptor beta isoform 25005
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
steroidogenic factor 10101
nuclear factor erythroid 2-related factor 2 isoform 16006
peripheral myelin protein 225005
cytochrome P450 3A4 isoform 15005
muscleblind-like protein 1 isoform 11001
caspase-1 isoform alpha precursor1001
Gamma-aminobutyric acid receptor subunit pi5229
Solute carrier family 22 member 30101
Voltage-dependent calcium channel gamma-2 subunit2002
Interferon beta6006
Tubulin alpha-1A chain0213
Tubulin beta chain0213
Plasma kallikrein0001
Tubulin beta-4A chain0225
ATP-dependent translocase ABCB10101
Tubulin beta chain0225
ATP-dependent translocase ABCB10405
Tubulin alpha-3C chain0225
Serine/threonine-protein kinase pim-10101
Gamma-aminobutyric acid receptor subunit beta-15229
Gamma-aminobutyric acid receptor subunit delta5229
Gamma-aminobutyric acid receptor subunit gamma-25229
Glutamate receptor 22002
Gamma-aminobutyric acid receptor subunit alpha-55229
Gamma-aminobutyric acid receptor subunit alpha-35229
ATP-dependent translocase ABCB10101
Gamma-aminobutyric acid receptor subunit gamma-15229
Gamma-aminobutyric acid receptor subunit alpha-25229
Gamma-aminobutyric acid receptor subunit alpha-45229
Gamma-aminobutyric acid receptor subunit gamma-35229
Gamma-aminobutyric acid receptor subunit alpha-65229
Histamine H2 receptor1001
Nuclear receptor ROR-gamma3115
Gamma-aminobutyric acid receptor subunit alpha-15229
Gamma-aminobutyric acid receptor subunit beta-35229
Gamma-aminobutyric acid receptor subunit beta-25229
Tubulin alpha-1B chain0225
Tubulin alpha-4A chain0225
Tubulin beta-4B chain0225
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0225
Tubulin beta-2A chain0225
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0225
Tubulin beta-2B chain0202
Tubulin alpha-3E chain0225
Tubulin alpha-1A chain0225
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
GABA theta subunit5229
CREB-binding protein1001
ATPase family AAA domain-containing protein 54004
Ataxin-25005
Tubulin alpha-1C chain0225
Tubulin beta-6 chain0225
Tubulin beta-2B chain0225
Gamma-aminobutyric acid receptor subunit epsilon5229
Tubulin beta-1 chain0225
Deoxycytidine kinase0001
potassium voltage-gated channel subfamily H member 2 isoform d5005
Solute carrier family 22 member 1 0303
Nuclear receptor subfamily 1 group I member 20022
D(2) dopamine receptor0213
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0202
Delta-type opioid receptor0202
Mu-type opioid receptor0213
Kappa-type opioid receptor0101
Histamine H1 receptor0101
Mu-type opioid receptor0325
D(3) dopamine receptor0101
Delta-type opioid receptor0314
Kappa-type opioid receptor0202
Kappa-type opioid receptor0314
Mu-type opioid receptor0101
Mu-type opioid receptor0303
Sigma non-opioid intracellular receptor 10303
Sigma non-opioid intracellular receptor 10404
Sigma non-opioid intracellular receptor 10101
Purine nucleoside phosphorylase0202
Hypoxanthine-guanine phosphoribosyltransferase0001
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Glutathione reductase, mitochondrial0202
heat shock protein beta-15005
Chain A, Cruzipain3003
thioredoxin glutathione reductase3003
aldehyde dehydrogenase 1 family, member A17007
G5005
cytochrome P450 2D62002
vitamin D3 receptor isoform VDRA3003
DNA polymerase beta1001
nuclear receptor ROR-gamma isoform 14004
HLA class I histocompatibility antigen, B alpha chain 5005
Inositol hexakisphosphate kinase 15005
cytochrome P450 2C9, partial5005
histone acetyltransferase KAT2A isoform 13003
Geranylgeranyl pyrophosphate synthase0101
Farnesyl pyrophosphate synthase0202
Hypoxanthine-guanine phosphoribosyltransferase0101
Farnesyl pyrophosphate synthase 0101
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
caspase 7, apoptosis-related cysteine protease1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
progesterone receptor2002
caspase-31001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
Histone H2A.x1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90002
5-hydroxytryptamine receptor 40404
Carbonic anhydrase 10303
Carbonic anhydrase 20303
Aldo-keto reductase family 1 member B10303
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Prostaglandin G/H synthase 10202
Sodium-dependent noradrenaline transporter 0202
Sodium- and chloride-dependent GABA transporter 10101
5-hydroxytryptamine receptor 2C0415
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30011
5-hydroxytryptamine receptor 2B0617
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-40011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-60011
UDP-glucuronosyltransferase 1A80001
Beta-1 adrenergic receptor 0113
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Albumin0123
Cytochrome P450 1A20112
Beta-2 adrenergic receptor0213
Muscarinic acetylcholine receptor M20112
Beta-1 adrenergic receptor0213
5-hydroxytryptamine receptor 1A0101
Alpha-2A adrenergic receptor0225
Adenosine receptor A30314
Beta-2 adrenergic receptor0203
Cytochrome P450 2C80101
Cytochrome P450 2D60112
Muscarinic acetylcholine receptor M10112
Beta-3 adrenergic receptor0213
Alpha-1B adrenergic receptor0415
Alpha-2B adrenergic receptor0012
Beta-1 adrenergic receptor0214
Alpha-2C adrenergic receptor0124
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0315
Alpha-2B adrenergic receptor0112
Muscarinic acetylcholine receptor M30112
D(1A) dopamine receptor0112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0112
Alpha-2A adrenergic receptor0112
Alpha-1D adrenergic receptor0314
Alpha-1D adrenergic receptor0012
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 2A0213
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Sodium-dependent serotonin transporter0202
Cholecystokinin receptor type A0112
Cytochrome P450 2C190112
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
Vasopressin V1a receptor0112
Alpha-1A adrenergic receptor0415
5-hydroxytryptamine receptor 60213
5-hydroxytryptamine receptor 70202
Beta-2 adrenergic receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0101
Sodium/bile acid cotransporter0101
Beta-2 adrenergic receptor0113
Nuclear receptor subfamily 2 group E member 10022
Epidermal growth factor receptor0101
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
15-lipoxygenase, partial1001
SMAD family member 21001
SMAD family member 31001
thyroid stimulating hormone receptor2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Retinol-binding protein 40011
Beta-lactoglobulin0011
Amyloid-beta precursor protein0202
Alpha-synuclein0202
Disintegrin and metalloproteinase domain-containing protein 171001
Rap guanine nucleotide exchange factor 32002
Guanine nucleotide-binding protein G1001
Chain A, 2-oxoglutarate Oxygenase2002
chaperonin-containing TCP-1 beta subunit homolog1001
survival motor neuron protein isoform d2002
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
Cereblon isoform 40202
EWS/FLI fusion protein2002
Prostaglandin G/H synthase 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Prostaglandin G/H synthase 20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
apical membrane antigen 1, AMA11001
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase kappa isoform 12002
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0246
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
Chain A, Nuclear Receptor ROR-beta0101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
regulator of G-protein signaling 41001
nonstructural protein 11001
Parkin1001
bromodomain adjacent to zinc finger domain 2B1001
thyrotropin-releasing hormone receptor1001
Caspase-71001
caspase-31001
M-phase phosphoprotein 81001
Ornithine decarboxylase0001
Ornithine decarboxylase0001
60 kDa chaperonin0101
Retinoic acid receptor alpha0227
60 kDa heat shock protein, mitochondrial0202
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
Retinoic acid receptor RXR-gamma0224
10 kDa heat shock protein, mitochondrial0202
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, Dihydrofolate Reductase0011
Chain A, Dihydrofolate reductase0101
Chain A, dihydrofolate reductase (DHFR)0101
Chain A, Dihydrofolate reductase0101
Chain A, Dihydrofolate reductase0101
dopamine D1 receptor1001
Dihydrofolate reductase 0102
Dihydrofolate reductase0202
Dihydrofolate reductase0101
Dihydrofolate reductase 0101
Dihydrofolate reductase0202
Dihydrofolate reductase0202
Dihydrofolate reductase type 10102
Dihydrofolate reductase0101
Thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Dihydrofolate reductase0101
NH(3)-dependent NAD(+) synthetase0101
Dihydrofolate reductase0202
Thymidylate synthase0101
Dihydrofolate reductase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Dihydrofolate reductase type 1 from Tn40030101
Dipeptidyl peptidase 40101
5-hydroxytryptamine receptor 2A0101
Dihydrofolate reductase0203
Dihydrofolate reductase0101
Dipeptidyl peptidase 40101
5-hydroxytryptamine receptor 2B0101
Metabotropic glutamate receptor 50101
Dihydrofolate reductase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0102
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Trace amine-associated receptor 50011
Dihydrofolate reductase 0202
Dihydrofolate reductase 0101
Dihydrofolate reductase0102
Protein-arginine deiminase type-40101
Dihydrofolate reductase 0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Cocaine esterase0101
Histone deacetylase 30202
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
Sodium-dependent serotonin transporter0101
D-alanyl-D-alanine dipeptidase0101
Transporter0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]