Page last updated: 2024-09-27

Lipedema

Lipedema with secondary LYMPHEDEMA involvement.

Synonyms(3)

Synonym
Lipedema
Lipolymphedema
Lipoedema

Research Excerpts

Overview

ExcerptReference
"Lipedema is a common, but often underdiagnosed masquerading disease of obesity, which almost exclusively affects females."( Groma, G; Kemény, L; Szél, E; Szolnoky, G, 2014)
"Lipedema is a hormone-related disease of women characterized by enlargement of the extremities caused by subcutaneous deposition of adipose tissue."( Hofer, V; Maier, J; Nuernberger, S; Peterbauer, A; Priglinger, E; Redl, H; Sandhofer, M; Steffenhagen, C; Wolbank, S; Wurzer, C, 2017)
"Lipedema is a chronic, progressive disorder of subcutaneous adipose tissue that usually affects the lower extremities of women."( Anderhuber, F; Barsch, M; Faulhaber, J; Habbema, L; Halk, AB; Hanke, CW; Herbst, K; Maier, S; Mindt, S; Moosbauer, W; Pilsl, U; Podda, M; Rapprich, S; Sandhofer, M; Sattler, G; Sattler, S; Schauer, P; Schmeller, W, 2020)
"Lipedema is a painful loose connective tissue disorder characterized by a bilaterally symmetrical fat deposition in the lower extremities."( Al-Ghadban, S; Bunnell, BA; Diaz, ZT; Mert, KB; Singer, HJ, 2020)
"Lipedema is characterized by pain, fatigue, and excessive adipose tissue and sodium accumulation of the lower extremities."( Crescenzi, R; Donahue, MJ; Donahue, PMC; Garza, M; Harkins, KD; Marton, A; Petersen, KJ; Titze, J, 2020)
"Lipedema is an often underdiagnosed chronic disorder that affects subcutaneous adipose tissue almost exclusively in women, which leads to disproportionate fat accumulation in the lower and upper body extremities."( Baglivo, M; Bertelli, M; Chiurazzi, P; Dautaj, A; Dell'Orco, D; Fiorentino, A; Herbst, KL; Maltese, PE; Manara, E; Marino, V; Michelini, S; Pinelli, M, 2020)
"Lipedema is a chronic, progressive disease that occurs almost exclusively in women and leads to pathological, painful fat growths at the extremities."( Barsch, M; Hofer, V; Moosbauer, W; Sandhofer, M; Sonani, M, 2021)
"Lipedema is an infrequently recognized disorder."( Alvarez Martinez, D; Cortes, B; Naef, V, 2021)
"Lipedema is a painful fat disorder that affects ~11% of the female population."( Foster, MT; Hill, JL; Katzer, K; McIver, KB, 2021)
"BACKGROUND Lipedema is a chronic progressive disease characterized by the abnormal accumulation of fat in the subcutaneous region."( Amato, ACM; Benitti, DA, 2021)
"Lipedema is a chronic and progressive disease associated with lymphatic impairment at later stages."( Buso, G; Depairon, M; Favre, L; Honorati, M; Lessert, C; Maufus, M; Mazzolai, L; Raffoul, W; Tomson, D, 2022)
"Lipoedema is an overlooked and often misdiagnosed condition, which mainly affects women."( Andersen, MT; Burian, EA; Karlsmark, T; Nissen, CV; Rungby, J, 2022)
"Lipoedema is characterized by disproportionate painful fat accumulation mostly in the lower limbs."( Blackwell, R; Heydon-White, A; Koelmeyer, LA; Mackie, H; Suami, H; Thompson, BM; Tisdall Blake, F, 2023)
"Lower limb lipoedema is a chronic condition of the adipose connective tissue of the skin that affects women."( Rastel, D; Urbinelli, R, 2023)
"Lipoedema is a frequent condition in phlebology consultations."( Rastel, D; Urbinelli, R, 2023)
"Lipedema is a disease that is currently little known worldwide, but it represents a public health problem and demands immediate, well-directed healthcare."( Carballeira Braña, A; Poveda Castillo, J, 2023)

Treatment

ExcerptReference
"Non-surgical treatment of lipedema is feasible in selected cases, and it can meet the criteria for achieving selected clinical objectives."( Amato, ACM; Benitti, DA, 2021)

Research

Studies (35)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (2.86)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's9 (25.71)28.8240
2020's25 (71.43)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low60
lidocaine0low20
minoxidil0low10
20-alpha-dihydroprogesterone0low10
glycyrrhizic acid0low10
dasatinib0low10
selenium0low10
indocyanine green0low30
leptin0low20

Protein Targets (743)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Beta-lactamase3003
Chain A, 2-oxoglutarate Oxygenase2002
Skn7p0001
ATAD5 protein, partial1001
Microtubule-associated protein tau2002
nonstructural protein 11001
euchromatic histone-lysine N-methyltransferase 24004
chromobox protein homolog 12002
nuclear factor erythroid 2-related factor 2 isoform 21001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
geminin5005
survival motor neuron protein isoform d3003
muscleblind-like protein 1 isoform 11001
Rap guanine nucleotide exchange factor 31001
TAR DNA-binding protein 432002
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
TDP1 protein3003
AR protein5005
glucocorticoid receptor [Homo sapiens]3003
retinoid X nuclear receptor alpha3003
pregnane X nuclear receptor2002
estrogen nuclear receptor alpha4004
Alkaline phosphatase, germ cell type0101
G protein-coupled receptor GPR350011
G-protein coupled receptor 350011
G-protein coupled receptor 350011
Leukotriene C4 synthase0011
acetylcholinesterase1001
RAR-related orphan receptor gamma3003
Fumarate hydratase1001
GALC protein2002
GLS protein3003
PPM1D protein1001
GLI family zinc finger 31001
Smad31001
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)1001
nuclear receptor subfamily 1, group I, member 31001
progesterone receptor1001
cytochrome P450 family 3 subfamily A polypeptide 41001
EWS/FLI fusion protein2002
retinoic acid nuclear receptor alpha variant 11001
estrogen-related nuclear receptor alpha1001
farnesoid X nuclear receptor1001
polyprotein1001
67.9K protein1001
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma1001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
caspase-31001
aryl hydrocarbon receptor1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
thyroid stimulating hormone receptor1001
nuclear receptor subfamily 1, group I, member 21001
Histone H2A.x1001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
thyroid hormone receptor beta isoform 22002
huntingtin isoform 21001
serine/threonine-protein kinase mTOR isoform 11001
tyrosine-protein kinase Yes1001
nuclear factor erythroid 2-related factor 2 isoform 11001
peripheral myelin protein 222002
Bone morphogenetic protein receptor type-1B0011
Membrane-associated progesterone receptor component 10011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0112
Serine/threonine-protein kinase PLK40011
Serine/threonine-protein kinase 250011
ATP-dependent RNA helicase DDX3X0011
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0011
Pyridoxal kinase0011
Citron Rho-interacting kinase0011
Serine/threonine-protein kinase RIO30011
Dual specificity mitogen-activated protein kinase kinase 70011
Serine/threonine-protein kinase Chk10011
Inhibitor of nuclear factor kappa-B kinase subunit beta0113
Peripheral plasma membrane protein CASK0011
Aurora kinase A0112
Cyclin-G-associated kinase0011
Serine/threonine-protein kinase DCLK10011
Inhibitor of nuclear factor kappa-B kinase subunit alpha0112
Muscle, skeletal receptor tyrosine-protein kinase0011
Ephrin type-B receptor 60011
Peroxisomal acyl-coenzyme A oxidase 30011
Mitogen-activated protein kinase 130112
Transmembrane protease serine 20011
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40303
3-phosphoinositide-dependent protein kinase 10011
Mitogen-activated protein kinase kinase kinase 130011
Death-associated protein kinase 30011
Mitogen-activated protein kinase kinase kinase 70011
Receptor-interacting serine/threonine-protein kinase 20213
Mitotic checkpoint serine/threonine-protein kinase BUB10011
NUAK family SNF1-like kinase 10011
Dynamin-like 120 kDa protein, mitochondrial0011
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0011
Tyrosine-protein kinase JAK20011
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20011
Serine/threonine-protein kinase ULK10011
Serine/threonine-protein kinase/endoribonuclease IRE10011
Ribosomal protein S6 kinase alpha-50011
U5 small nuclear ribonucleoprotein 200 kDa helicase0011
Ribosomal protein S6 kinase alpha-40011
Serine/threonine-protein kinase 160011
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0011
Serine/threonine-protein kinase PAK 30011
Cyclin-dependent kinase-like 50011
Voltage-dependent calcium channel gamma-2 subunit1001
Serine/threonine-protein kinase 17B0011
Serine/threonine-protein kinase 100011
Serine/threonine-protein kinase D30011
Cyclin-dependent kinase 140011
Bile salt export pump0505
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60011
Serine/threonine-protein kinase OSR10011
Mitogen-activated protein kinase kinase kinase kinase 40011
Serine/threonine-protein kinase LATS10011
Serine/threonine-protein kinase PAK 40011
Serine/threonine-protein kinase Chk20011
Tyrosine-protein kinase ABL10326
Tyrosine-protein kinase ABL10101
Proto-oncogene tyrosine-protein kinase Src0112
Epidermal growth factor receptor0112
Interferon beta1001
Transthyretin0011
RAF proto-oncogene serine/threonine-protein kinase0112
Receptor tyrosine-protein kinase erbB-20112
High affinity nerve growth factor receptor0011
Cellular tumor antigen p532002
Guanine nucleotide-binding protein G(i) subunit alpha-20011
ADP/ATP translocase 20011
Cytochrome P450 1A20101
Neuronal proto-oncogene tyrosine-protein kinase Src 0001
Protein kinase C beta type0011
Insulin receptor0112
Tyrosine-protein kinase Lck0314
Proto-oncogene tyrosine-protein kinase LCK 0202
Tyrosine-protein kinase Fyn0213
Cyclin-dependent kinase 10011
Glycogen phosphorylase, liver form0011
Tyrosine-protein kinase Fes/Fps0011
Macrophage colony-stimulating factor 1 receptor0213
Procathepsin L0011
Adenine phosphoribosyltransferase0011
Tyrosine-protein kinase Yes0112
Tyrosine-protein kinase Lyn0112
Proto-oncogene tyrosine-protein kinase receptor Ret0112
Insulin-like growth factor 1 receptor0112
Signal recognition particle receptor subunit alpha0011
Cytochrome c1, heme protein, mitochondrial0011
Hepatocyte growth factor receptor0011
Tyrosine-protein kinase HCK0213
Proto-oncogene tyrosine-protein kinase ROS0011
Platelet-derived growth factor receptor beta0213
Tyrosine-protein kinase Fgr0011
Quinolone resistance protein NorA0101
Wee1-like protein kinase 20011
Uncharacterized serine/threonine-protein kinase SBK30011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Serine/threonine-protein kinase A-Raf0011
Cytochrome P450 2D60101
Mast/stem cell growth factor receptor Kit0112
Glycogen phosphorylase, brain form0011
Breakpoint cluster region protein0225
Serine/threonine-protein kinase pim-10011
Fibroblast growth factor receptor 10112
Cytochrome P450 2A60101
Cytochrome P450 2C9 0101
Myosin light chain kinase, smooth muscle0011
Cyclin-dependent kinase 40011
ADP/ATP translocase 30011
Inosine-5'-monophosphate dehydrogenase 20011
Angiotensin-converting enzyme 0101
Proto-oncogene tyrosine-protein kinase Src0314
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Insulin receptor-related protein0011
Serine/threonine-protein kinase B-raf0011
Potassium voltage-gated channel subfamily E member 10101
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0011
Ribosyldihydronicotinamide dehydrogenase [quinone]0011
Platelet-derived growth factor receptor alpha0213
Tyrosine-protein kinase Blk0101
Tyrosine-protein kinase Fer0011
Protein kinase C alpha type0112
cAMP-dependent protein kinase catalytic subunit alpha0011
Vascular endothelial growth factor receptor 1 0011
General transcription and DNA repair factor IIH helicase subunit XPD0011
Glutamate receptor 21001
Interferon-induced, double-stranded RNA-activated protein kinase0011
Casein kinase II subunit alpha'0011
Ras-related protein Rab-6A0011
Serine/threonine-protein kinase MAK0011
Cytochrome P450 2B60101
Cyclin-dependent kinase 11B0011
Ephrin type-A receptor 10011
Fibroblast growth factor receptor 20011
Receptor tyrosine-protein kinase erbB-30011
Multifunctional protein ADE20011
Fibroblast growth factor receptor 40011
Fibroblast growth factor receptor 30011
cAMP-dependent protein kinase catalytic subunit gamma0011
cAMP-dependent protein kinase catalytic subunit beta0011
Ferrochelatase, mitochondrial0011
Ribosomal protein S6 kinase beta-10011
Tyrosine-protein kinase JAK10011
Protein kinase C eta type0011
Cyclin-dependent kinase 20112
Beta-adrenergic receptor kinase 10011
Probable ATP-dependent RNA helicase DDX60011
Activin receptor type-2A0011
Mitogen-activated protein kinase 3 0011
MAP/microtubule affinity-regulating kinase 30011
Deoxycytidine kinase0011
Mitogen-activated protein kinase 10011
Ephrin type-A receptor 20112
Ephrin type-A receptor 30011
Ephrin type-A receptor 80011
Ephrin type-B receptor 20112
Leukocyte tyrosine kinase receptor0011
Non-receptor tyrosine-protein kinase TYK20011
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0011
Heme oxygenase 20011
Tyrosine-protein kinase receptor UFO0011
Mitogen-activated protein kinase 40011
S-adenosylmethionine synthase isoform type-20011
DnaJ homolog subfamily A member 10011
RAC-alpha serine/threonine-protein kinase0112
RAC-beta serine/threonine-protein kinase0112
G protein-coupled receptor kinase 40011
Cytochrome P450 2C190101
Dual specificity protein kinase TTK0011
DNA replication licensing factor MCM40011
Prostaglandin G/H synthase 20112
Tyrosine-protein kinase receptor Tie-10011
Vascular endothelial growth factor receptor 30011
Vascular endothelial growth factor receptor 20112
Dual specificity mitogen-activated protein kinase kinase 20112
Receptor-type tyrosine-protein kinase FLT30112
Bone morphogenetic protein receptor type-1A0011
Activin receptor type-1B0011
TGF-beta receptor type-10011
Serine/threonine-protein kinase receptor R30011
TGF-beta receptor type-20011
Electron transfer flavoprotein subunit beta0011
Tyrosine-protein kinase CSK0112
Glycine--tRNA ligase0011
Protein kinase C iota type0011
Exosome RNA helicase MTR40011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0112
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0112
Serine/threonine-protein kinase mTOR0112
Megakaryocyte-associated tyrosine-protein kinase0011
Tyrosine-protein kinase Tec0112
Tyrosine-protein kinase TXK0112
Tyrosine-protein kinase ABL20011
Tyrosine-protein kinase FRK0011
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase ZAP-700011
Tyrosine-protein kinase SYK0112
26S proteasome regulatory subunit 6B0011
Mitogen-activated protein kinase 80011
Mitogen-activated protein kinase 90011
Dual specificity mitogen-activated protein kinase kinase 40011
Dual specificity mitogen-activated protein kinase kinase 30011
Casein kinase I isoform alpha0112
Casein kinase I isoform delta0011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0112
MAP kinase-activated protein kinase 20112
Cyclin-dependent kinase 80011
Elongation factor Tu, mitochondrial0011
Choline-phosphate cytidylyltransferase A0011
Cysteine--tRNA ligase, cytoplasmic0011
Casein kinase I isoform epsilon0011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0011
Dual specificity protein kinase CLK10011
Dual specificity protein kinase CLK20011
Dual specificity protein kinase CLK30011
Glycogen synthase kinase-3 alpha0011
Glycogen synthase kinase-3 beta0011
Cyclin-dependent kinase 70011
Cyclin-dependent kinase 90011
Ras-related protein Rab-27A0011
Tyrosine-protein kinase Blk0112
Interleukin-1 receptor-associated kinase 10011
Potassium voltage-gated channel subfamily KQT member 10101
Ribosomal protein S6 kinase alpha-30112
Cytoplasmic tyrosine-protein kinase BMX0011
cAMP-dependent protein kinase catalytic subunit PRKX0011
Serine/threonine-protein kinase Nek20011
Serine/threonine-protein kinase Nek30011
Serine/threonine-protein kinase Nek40011
Tyrosine-protein kinase JAK30011
Dual specificity mitogen-activated protein kinase kinase 60011
Serine/threonine-protein kinase PLK10011
Death-associated protein kinase 10011
LIM domain kinase 10112
LIM domain kinase 20112
Mitogen-activated protein kinase 120112
Mitogen-activated protein kinase 100011
Tyrosine--tRNA ligase, cytoplasmic0011
5'-AMP-activated protein kinase subunit gamma-10012
5'-AMP-activated protein kinase catalytic subunit alpha-20012
Ephrin type-B receptor 30011
Ephrin type-A receptor 50011
Ephrin type-B receptor 40112
Ephrin type-B receptor 10011
Ephrin type-A receptor 40011
Adenylate kinase 2, mitochondrial0011
Adenosine kinase0011
Hormonally up-regulated neu tumor-associated kinase0011
Serine/threonine-protein kinase SIK10213
Receptor-interacting serine/threonine-protein kinase 40011
Spike glycoprotein1012
Ras-related protein Rab-100011
Cell division control protein 2 homolog0011
Actin-related protein 30011
Actin-related protein 20011
Calcium-dependent protein kinase 10011
GTP-binding nuclear protein Ran0011
Tubulin alpha-1A chain0011
Casein kinase II subunit alpha0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0011
SRSF protein kinase 20011
Casein kinase I isoform gamma-20011
DNA-dependent protein kinase catalytic subunit0101
Mitogen-activated protein kinase kinase kinase 90011
Serine/threonine-protein kinase PknB0011
Cyclin-dependent kinase 30011
Cyclin-dependent kinase-like 10011
Cyclin-dependent kinase 60011
Cyclin-dependent-like kinase 5 0011
Cyclin-dependent kinase 160011
Cyclin-dependent kinase 170011
Myelin transcription factor 10101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
ATP-dependent 6-phosphofructokinase, platelet type0011
Protein kinase C epsilon type0011
Dual specificity mitogen-activated protein kinase kinase 10112
Angiopoietin-1 receptor0011
Mitogen-activated protein kinase kinase kinase 100011
DNA topoisomerase 2-beta0011
Protein kinase C theta type0011
Activin receptor type-10011
Macrophage-stimulating protein receptor0011
Focal adhesion kinase 10112
Protein kinase C zeta type0112
Protein kinase C delta type0112
Tyrosine-protein kinase BTK0213
Tyrosine-protein kinase receptor TYRO30011
Cyclin-dependent kinase 180011
Activated CDC42 kinase 10112
Epithelial discoidin domain-containing receptor 10314
Tyrosine-protein kinase ITK/TSK0112
Myotonin-protein kinase0011
Potassium voltage-gated channel subfamily H member 20202
Mitogen-activated protein kinase kinase kinase kinase 20011
Mitogen-activated protein kinase kinase kinase 120011
Tyrosine-protein kinase Mer0011
Serine/threonine-protein kinase 40011
5'-AMP-activated protein kinase catalytic subunit alpha-10012
Serine/threonine-protein kinase PAK 10011
Dual specificity mitogen-activated protein kinase kinase 50011
Mitogen-activated protein kinase 70011
Serine/threonine-protein kinase PAK 20011
Serine/threonine-protein kinase 30011
Mitogen-activated protein kinase kinase kinase 10011
cGMP-dependent protein kinase 20011
Integrin-linked protein kinase0011
Rho-associated protein kinase 10011
Non-receptor tyrosine-protein kinase TNK10011
Serine/threonine-protein kinase PRP4 homolog0011
Receptor-interacting serine/threonine-protein kinase 10011
Calcium/calmodulin-dependent protein kinase type II subunit beta0011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0011
Calcium/calmodulin-dependent protein kinase type II subunit delta0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0011
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Activin receptor type-2B0011
Bone morphogenetic protein receptor type-20011
Protein-tyrosine kinase 60112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
cGMP-dependent protein kinase 1 0011
Cyclin-dependent kinase 130011
Calcium/calmodulin-dependent protein kinase type 10011
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0011
Protein-tyrosine kinase 2-beta0011
Sodium channel protein type 5 subunit alpha0202
Maternal embryonic leucine zipper kinase0011
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40011
Peroxisomal acyl-coenzyme A oxidase 10011
Serine/threonine-protein kinase D10011
Serine/threonine-protein kinase 380011
Receptor tyrosine-protein kinase erbB-40011
Ribosomal protein S6 kinase alpha-20011
Ephrin type-A receptor 70011
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10112
Dual specificity testis-specific protein kinase 10011
Myosin light chain kinase, smooth muscle0011
Mitogen-activated protein kinase 110112
Serine/threonine-protein kinase STK110011
Rhodopsin kinase GRK10011
NT-3 growth factor receptor0011
Serine/threonine-protein kinase N10011
Serine/threonine-protein kinase N20011
Mitogen-activated protein kinase 140123
Calcium/calmodulin-dependent protein kinase type IV0011
Mitogen-activated protein kinase kinase kinase 110011
BDNF/NT-3 growth factors receptor0011
Mitogen-activated protein kinase 60011
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0011
Discoidin domain-containing receptor 20213
AP2-associated protein kinase 10011
Myosin light chain kinase 30011
Uncharacterized aarF domain-containing protein kinase 50011
Serine/threonine-protein kinase SBK10011
Mitogen-activated protein kinase kinase kinase 190011
Putative heat shock protein HSP 90-beta 20011
Serine/threonine-protein kinase TNNI3K0011
Leucine-rich repeat serine/threonine-protein kinase 20011
Serine/threonine-protein kinase MRCK alpha0011
Serine/threonine-protein kinase MRCK gamma0011
Acyl-CoA dehydrogenase family member 100011
Serine/threonine-protein kinase Nek50011
Serine/threonine-protein kinase N30011
Breakpoint cluster region protein0101
Serine/threonine-protein kinase ULK30011
Dual serine/threonine and tyrosine protein kinase0011
Mitogen-activated protein kinase kinase kinase 150011
Uncharacterized protein FLJ452520011
Acyl-CoA dehydrogenase family member 110011
Serine/threonine-protein kinase/endoribonuclease IRE20011
Serine/threonine-protein kinase MARK20011
Serine/threonine-protein kinase TAO10011
STE20-related kinase adapter protein alpha0011
Myosin-140011
AarF domain-containing protein kinase 10011
Serine/threonine-protein kinase tousled-like 20011
Serine/threonine-protein kinase 32C0011
Serine/threonine-protein kinase pim-30011
ATP-dependent RNA helicase DDX420011
Serine/threonine-protein kinase VRK20011
Myosin light chain kinase family member 40011
Homeodomain-interacting protein kinase 10011
Calcium/calmodulin-dependent protein kinase type 1D0011
Mitogen-activated protein kinase kinase kinase kinase 30011
Cyclin-dependent kinase-like 30011
MAP kinase-activated protein kinase 50011
Serine/threonine-protein kinase BRSK20011
Serine/threonine-protein kinase NIM10011
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0011
Serine/threonine-protein kinase ULK20011
Misshapen-like kinase 10011
Serine/threonine-protein kinase DCLK20011
Calcium/calmodulin-dependent protein kinase kinase 10011
Casein kinase I isoform alpha-like0011
Homeodomain-interacting protein kinase 40011
Myosin-IIIa0011
Ankyrin repeat and protein kinase domain-containing protein 10011
Serine/threonine-protein kinase Nek110011
Atypical kinase COQ8A, mitochondrial0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0011
Mitogen-activated protein kinase 150011
Serine/threonine-protein kinase Nek90011
Serine/threonine-protein kinase BRSK10011
Serine/threonine-protein kinase 350011
Serine/threonine-protein kinase Nek70011
Rhodopsin kinase GRK70011
Serine/threonine-protein kinase 32A0011
Myosin-IIIb0011
ATP-dependent RNA helicase DDX10011
Dual specificity tyrosine-phosphorylation-regulated kinase 20011
Cyclin-dependent kinase-like 20011
Canalicular multispecific organic anion transporter 10303
Mitogen-activated protein kinase kinase kinase kinase 10011
Serine/threonine-protein kinase Sgk30011
Atypical kinase COQ8B, mitochondrial0011
Aurora kinase B0112
MAP/microtubule affinity-regulating kinase 40011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase Nek10011
Cyclin-dependent kinase 150011
ATPase family AAA domain-containing protein 51001
PAS domain-containing serine/threonine-protein kinase0011
Calcium/calmodulin-dependent protein kinase kinase 20011
EKC/KEOPS complex subunit TP53RK0011
Dual specificity testis-specific protein kinase 20011
SRSF protein kinase 10011
Protein cereblon0012
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0213
Mitogen-activated protein kinase kinase kinase 50011
Ataxin-21001
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0011
Mitogen-activated protein kinase kinase kinase 30011
Eukaryotic translation initiation factor 2-alpha kinase 10011
Serine/threonine-protein kinase RIO10011
MAP kinase-interacting serine/threonine-protein kinase 10011
Serine/threonine-protein kinase RIO20011
Cyclin-dependent kinase 190011
Transient receptor potential cation channel subfamily M member 60011
Testis-specific serine/threonine-protein kinase 10011
Angiotensin-converting enzyme 2 0011
Serine/threonine-protein kinase 330011
Nucleolar GTP-binding protein 10011
Serine/threonine-protein kinase D20011
Serine/threonine-protein kinase DCLK30011
NUAK family SNF1-like kinase 20011
RNA cytidine acetyltransferase0011
Serine/threonine-protein kinase SIK20112
Myosin light chain kinase 2, skeletal/cardiac muscle0011
STE20-like serine/threonine-protein kinase 0011
Serine/threonine-protein kinase TAO30011
Homeodomain-interacting protein kinase 20011
Tyrosine-protein kinase Srms0011
Homeodomain-interacting protein kinase 30011
Serine/threonine-protein kinase PLK30011
dCTP pyrophosphatase 10011
Dual specificity protein kinase CLK40011
MAP kinase-interacting serine/threonine-protein kinase 20011
Serine/threonine-protein kinase Nek60011
Casein kinase I isoform gamma-10011
Serine/threonine-protein kinase PAK 60011
SNF-related serine/threonine-protein kinase0011
Serine/threonine-protein kinase LATS20011
Serine/threonine-protein kinase 360011
Phenylalanine--tRNA ligase beta subunit0011
Isoleucine--tRNA ligase, mitochondrial0011
BMP-2-inducible protein kinase0011
Obg-like ATPase 10011
Midasin0011
Interleukin-1 receptor-associated kinase 40011
Serine/threonine-protein kinase 32B0011
Mitogen-activated protein kinase kinase kinase 200011
Cyclin-dependent kinase 120011
Serine/threonine-protein kinase PLK20011
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130011
Serine/threonine-protein kinase MARK10011
Serine/threonine-protein kinase pim-20011
Serine/threonine-protein kinase PAK 50011
Serine/threonine-protein kinase 260011
eIF-2-alpha kinase GCN20011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0011
Serine/threonine-protein kinase NLK0011
Phosphatidylinositol 4-kinase beta0011
Serine/threonine-protein kinase 17A0011
STE20/SPS1-related proline-alanine-rich protein kinase0011
Ephrin type-A receptor 60011
5'-AMP-activated protein kinase subunit gamma-20012
Serine/threonine-protein kinase TBK10011
Septin-90011
Death-associated protein kinase 20011
Potassium voltage-gated channel subfamily D member 30101
Ribosomal protein S6 kinase alpha-60011
TRAF2 and NCK-interacting protein kinase0011
Serine/threonine-protein kinase tousled-like 10011
Serine/threonine-protein kinase TAO20011
Long-chain-fatty-acid--CoA ligase 50011
ALK tyrosine kinase receptor0011
Broad substrate specificity ATP-binding cassette transporter ABCG20101
SRSF protein kinase 30011
Serine/threonine-protein kinase ICK0011
Cyclin-dependent kinase 11A0011
Aurora kinase C0011
Calcium/calmodulin-dependent protein kinase type II subunit alpha0011
RAC-gamma serine/threonine-protein kinase0112
Serine/threonine-protein kinase 38-like0011
Microtubule-associated serine/threonine-protein kinase 10011
Serine/threonine-protein kinase SIK30112
Mitogen-activated protein kinase kinase kinase 20011
Thyroid hormone receptor-associated protein 30011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Mitogen-activated protein kinase kinase kinase kinase 50011
Receptor-interacting serine/threonine-protein kinase 30011
Serine/threonine-protein kinase MRCK beta0011
Interleukin-1 receptor-associated kinase 30011
Serine/threonine-protein kinase 240011
NF-kappa-B essential modulator0101
Casein kinase I isoform gamma-30011
Mitogen-activated protein kinase kinase kinase 40011
Glycogen phosphorylase, muscle form0101
Pancreatic alpha-amylase0101
Beta-glucuronidase0101
Beta-glucuronidase0101
High mobility group protein B10022
Tyrosine-protein phosphatase non-receptor type 10204
Corticosteroid 11-beta-dehydrogenase isozyme 10112
Corticosteroid 11-beta-dehydrogenase isozyme 10112
High mobility group protein B10001
Corticosteroid 11-beta-dehydrogenase isozyme 20112
Canalicular multispecific organic anion transporter 10101
Solute carrier organic anion transporter family member 1B30101
Solute carrier organic anion transporter family member 1B20101
Solute carrier organic anion transporter family member 1B10101
Chain A, CARBONIC ANHYDRASE II0011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
thioredoxin reductase4004
phosphopantetheinyl transferase2002
USP1 protein, partial2002
apical membrane antigen 1, AMA11001
thyroid stimulating hormone receptor2002
regulator of G-protein signaling 41001
bromodomain adjacent to zinc finger domain 2B1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
transforming acidic coiled-coil-containing protein 30001
DNA polymerase iota isoform a (long)1001
lamin isoform A-delta103003
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0001
Carbonic anhydrase 120102
Solute carrier family 22 member 30102
Carbonic anhydrase 10203
Carbonic anhydrase 20204
Plasma kallikrein0001
Carbonic anhydrase 30102
Macrophage migration inhibitory factor0202
Carbonic anhydrase 40102
Carbonic anhydrase 60102
Histamine H2 receptor0123
Adenosine receptor A10001
5-hydroxytryptamine receptor 1D0001
Adenosine receptor A2a0001
Histamine H1 receptor0123
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0102
Histamine H1 receptor0224
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Carbonic anhydrase 70102
Histamine H2 receptor0011
Carbonic anhydrase0002
Histamine H3 receptor0101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90102
Carbonic anhydrase 0002
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0002
Carbonic anhydrase0002
Glutamate receptor ionotropic, NMDA 2D0001
Solute carrier family 22 member 10102
Carbonic anhydrase 0002
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40001
Carbonic anhydrase 150102
Carbonic anhydrase 130102
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20102
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140102
Carbonic anhydrase 5B, mitochondrial0102
Histamine H3 receptor0123
aldehyde dehydrogenase 1 family, member A12002
IDH11001
mitogen-activated protein kinase 11001
flap endonuclease 11001
cytochrome P450 3A4 isoform 11001
muscarinic acetylcholine receptor M11001
Gamma-aminobutyric acid receptor subunit pi1001
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Potassium voltage-gated channel subfamily A member 50101
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Sodium channel protein type 4 subunit alpha0101
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Sodium channel protein type 9 subunit alpha0101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
GABA theta subunit1001
Multidrug and toxin extrusion protein 10101
Gamma-aminobutyric acid receptor subunit epsilon1001
Sodium channel protein type 3 subunit alpha0101
cytochrome P450 2D61001
transcriptional regulator ERG isoform 31001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
histone acetyltransferase KAT2A isoform 12002
lethal factor (plasmid)1001
Inositol monophosphatase 11001
ATP-dependent phosphofructokinase1001
chaperonin-containing TCP-1 beta subunit homolog1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
Estrogen receptor beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Bile salt export pump0101
Albumin0101
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Estrogen receptor0001
Acetylcholinesterase0101
Prostaglandin G/H synthase 10101
Cystathionine gamma-lyase0101
Xanthine dehydrogenase/oxidase0101
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit beta-10001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]